2-DIETHYLAMINOETHANOL

2-Diethylaminoethanol is the organic compound with the molecular formula (C2H5)2NCH2CH2OH.
A colorless liquid, is used as a precursor in the production of a variety of chemical commodities such as the local anesthetic procaine.

CAS Number: 100-37-8
IUPAC name: 2-(Diethylamino)ethan-1-ol
EC Number: 202-845-2
Chemical formula: C6H15NO

Other names: 2-(Diethylamino)ethanol, 2-Diethylaminoethanol, DIETHYLAMINOETHANOL, 100-37-8, N N-Diethylethanolamine, Diethylethanolamine, DEAE, (Diethylamino)ethanol, Ethanol, 2-(diethylamino)-, N,N-Diethyl-2-aminoethanol, (2-Hydroxyethyl)diethylamine, Diethyl(2-hydroxyethyl)amine, 2-(Diethylamino)Ethan-1-Ol, Diethylmonoethanolamine, 2-Hydroxytriethylamine, Pennad 150, Diaethylaminoaethanol, 2-(N,N-Diethylamino)ethanol, N,N-Diethylmonoethanolamine, N,N-Diethyl-2-hydroxyethylamine, beta-Diethylaminoethanol, beta-Hydroxytriethylamine, 2-(Diethylamino)ethyl alcohol, Diethylamino ethanol, N-Diethylaminoethanol, 2-diethylamino-ethanol, 2-N-Diethylaminoethanol, diethyl ethanolamine, DEEA, beta-Diethylaminoethyl alcohol, N-(Diethylamino)ethanol, N,N-Diethyl-N-(beta-hydroxyethyl)amine, NSC 8759, N,N-Diethylaminoethanol, 2-(diethylamino)-ethanol, 2-N-(Diethylamino)ethanol, .beta.-(Diethylamino)ethanol, ETHANOL,2-DIETHYLAMINO, S6DL4M053U, beta-(Diethylamino)ethyl alcohol, DTXSID5021837, CHEBI:52153, .beta.-(Diethylamino)ethyl alcohol, NSC-8759, N,N-Diethyl-N-(.beta.-hydroxyethyl)amine, DTXCID401837, CAS-100-37-8, CCRIS 4793, HSDB 329, EINECS 202-845-2, UN2686, UNII-S6DL4M053U, -diethylamino, AI3-16309, 2-Diethylamio, Diathylaminoathanol, Diethylamlnoethanol, MFCD00002850, N, N-Diethylethanolamine, beta-(Diethylamino)ethanol, N,N-diethyl ethanol amine, .beta.-Hydroxytriethylamine, EC 202-845-2, SCHEMBL3114, CHEMBL1183, 2-(diethylamino)-1-ethanol, MLS002174251, 2-(N,N-diethylamino)-ethanol, N-(beta-hydroxyethyl)diethylamine, NSC8759, HMS3039I08, WLN: Q2N2 & 2, N-(hydroxyethyl)-N,N-diethyl amine, Tox21_201463, Tox21_300037, BBL012211, STL163552, AKOS000119883, UN 2686, NCGC00090925-01, NCGC00090925-02, NCGC00090925-03, NCGC00253920-01, NCGC00259014-01, A 22, BP-20552, SMR001261425, VS-03234, DB-012722, D0465, NS00006343, D88192, Q209373, J-520312

Applications
2-Diethylaminoethanol is used as a corrosion inhibitor in steam and condensate lines by neutralizing carbonic acid and scavenging oxygen.

2-Diethylaminoethanol reacts with 4-aminobenzoic acid to make procaine.

2-Diethylaminoethanol is a precursor for 2-Diethylaminoethanol-cellulose resin, which is commonly used in ion exchange chromatography.

2-Diethylaminoethanol can decrease the surface tension of water when the temperature is increased.
Solutions of 2-Diethylaminoethanol absorb carbon dioxide (CO2).

Preparation
Diethylethanolamine is prepared commercially by the reaction of diethylamine and ethylene oxide.

(C2H5)2NH + cyclo(CH2CH2)O → (C2H5)2NCH2CH2OH
It is also possible to prepare it by the reaction of diethylamine and ethylene chlorohydrin.

Safety
2-Diethylaminoethanol is an irritant to the eyes, skin, and respiratory system.
The Occupational Safety and Health Administration and the National Institute for Occupational Safety and Health have set occupational exposure limits for workers handling the chemical at 10 ppm (50 mg/m3) over an eight-hour workday.

Service life
Release to the environment of 2-Diethylaminoethanol can occur from industrial use: of articles where the substances are not intended to be released and where the conditions of use do not promote release.

Other release to the environment of 2-Diethylaminoethanol is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

2-Diethylaminoethanol can be found in products with material based on: stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), paper used for packaging (excluding food packaging) and plastic used for packaging (excluding food packaging).

Widespread uses by professional workers
2-Diethylaminoethanol is used in the following products: lubricants and greases, metal working fluids, coating products, hydraulic fluids and laboratory chemicals.
2-Diethylaminoethanol is used in the following areas: building & construction work.
2-Diethylaminoethanol is used for the manufacture of: fabricated metal products and.

Other release to the environment of 2-Diethylaminoethanol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

Formulation and re-packing
2-Diethylaminoethanol is used in the following products: coating products, lubricants and greases and metal working fluids.
Release to the environment of 2-Diethylaminoethanol can occur from industrial use: formulation of mixtures.

Uses at industrial sites
2-Diethylaminoethanol is used in the following products: coating products, pH regulators and water treatment products, laboratory chemicals, lubricants and greases, metal working fluids and adhesives and sealants.

2-Diethylaminoethanol is used in the following areas: mining.
2-Diethylaminoethanol is used for the manufacture of: , chemicals and wood and wood products.
Release to the environment of 2-Diethylaminoethanol can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, in the production of articles and as an intermediate step in further manufacturing of another substance (use of intermediates).

2-diethylaminoethanol is a member of the class of ethanolamines that is aminoethanol in which the hydrogens of the amino group are replaced by ethyl groups.
2-Diethylaminoethanol is a member of ethanolamines, a tertiary amino compound and a primary alcohol. 2-Diethylaminoethanol is functionally related to an ethanolamine.
2-Diethylaminoethanol derives from a hydride of a triethylamine.

Molar mass: 117.192 g·mol−1
Appearance: Colourless liquid
Odor: Ammoniacal
Density: 884 mg mL−1

Melting point: −70 °C
Boiling point: 161.1 °C
Solubility in water: miscible
log P: 0.769

Vapor pressure: 100 Pa (at 20 °C)
Refractive index (nD): 1.441–1.442
XLogP3-AA: 0.3
Hydrogen Bond Donor Count: 1

Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 4
Exact Mass: 117.115364102 g/mol
Monoisotopic Mass: 117.115364102 g/mol

Topological Polar Surface Area: 23.5Å²
Heavy Atom Count: 8
Complexity: 43.8
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

2-Diethylaminoethanol is a chemical compound with the molecular formula C6H15NO.
2-Diethylaminoethanol is used as a corrosion inhibitor in steam and condensate lines by neutralizing carbonic acid and scavenging oxygen.
2-Diethylaminoethanol is a chemical product that has neutralizing and oxygen scavenging characteristics, and is used as a corrosion inhibitor for steam and condensate lines.

2-Diethylaminoethanol is a pH adjuster that can be found in pharmaceuticals, pesticides, and floor coatings, and is used to adjust a product to be more acidic, alkaline or neutral on the pH scale. In our products, it is used as coatings and cleaners to ensure the pH of these products are compatible with the flooring materials used in typical households.

Product description
2-Diethylaminoethanol is a clear liquid.
2-Diethylaminoethanol is used as a neutralizing amine for boiler water, coatings, etc.
2-Diethylaminoethanol is used as neutralizing agent and CO2 scavenger in boiler water.
The ideal vapor pressure and vapor-liquid distribution properties of 2-Diethylaminoethanol make it the best choice for pH adjustment of process water.

Beyond its application in the water treatment segment, 2-Diethylaminoethanol is also used as a neutralizing amine for indrustrial coatings and an intermediate for various surfactants.

2-Diethylaminoethanol is used as neutralizing agent and CO2 scavenger in boiler water.
The ideal vapor pressure and vapor-liquid distribution properties of 2-Diethylaminoethanol make it the best choice for pH adjustment of process water.
Beyond 2-Diethylaminoethanol's application in the water treatment segment, 2-Diethylaminoethanol is also used as a neutralizing amine for indrustrial coatings and an intermediate for various surfactants.

2-Diethylaminoethanol is a catalyst for urethane reaction, neutralization agent for anionic stabilized waterborne resins.
2-Diethylaminoethanol is well suitable for the production of polyurethanes and as catalyst for two-component paints.
N,N-Diethylamine is also used as neutralization agent in paints based on waterborne polyesters, alkyds, acrylic resins and polyurethanes.

2-Diethylaminoethanol offers an optimal compatibility with resins and film matrix.
2-Diethylaminoethanol supports the flow and leveling during film forming.
2-Diethylaminoethanol can be used as a precursor chemical to procaine.
2-Diethylaminoethanol is used as a corrosion inhibitor in steam and condensate lines by neutralizing carbonic acid and scavenging oxygen.

2-Diethylaminoethanol is used for the synthesis of drugs in the pharmaceutical industry and as a catalyst for the synthesis of polymers in the chemical industry. It is also used as a pH stabilizer.
2-Diethylaminoethanol is also hypothesized to cause onset-asthma to humans following brief exposure.
2-Diethylaminoethanol also has the ability to inhibit growth of tomato roots.

2-Diethylaminoethanol offers an optimal compatibility with resins and film matrix.
2-Diethylaminoethanol supports the flow and leveling during film forming.
2-Diethylaminoethanol is a chemical compound with the molecular formula C6H15NO. 2-Diethylaminoethanol is used as a corrosion inhibitor in steam and condensate lines by neutralizing carbonic acid and scavenging oxygen.

2-Diethylaminoethanol is a colorless, hygroscopic liquid, that is stable, and flammable.
2-Diethylaminoethanol is incompatible with strong oxidizing agents and acids.
2-Diethylaminoethanol is a tertiary amine and has the characteristics of alcohols and amines.

Applications
2-Diethylaminoethanol is used as a corrosion inhibitor in steam and condensate lines by neutralizing carbonic acid and scavenging oxygen.

2-Diethylaminoethanol is a Tertiary amine.
2-Diethylaminoethanol is used in textile lubricants, polishes, detergents, pesticides, and personal care products.
2-Diethylaminoethanol is capable of undergoing reactions typical of both alcohols and amines.

2-Diethylaminoethanol is used as a precursor in the production of a variety of chemical commodities such as the local anesthetic procaine.
2-Diethylaminoethanol can be reacted with 4-aminobenzoic acid to make procaine.
2-Diethylaminoethanol can be used as a precursor for 2-Diethylaminoethanol-cellulose resin, which is commonly used in ion exchange chromatography.

2-Diethylaminoethanol can also be conveniently obtained from renewable sources.
It is chemically stable and able to absorb carbon dioxide (CO2) from its surroundings.
In solution, it can decrease the surface tension of water when the temperature is increased.

2-Diethylaminoethanol is a chemical product that has neutralizing and oxygen scavenging characteristics, and is used as a corrosion inhibitor for steam and condensate lines.
As an alkanolamine, it maintains a constant alkalinity in boiler water and condensate, and it does not contribute solids to the boiler system.
2-Diethylaminoethanol is utilized in the water treatment, gas treating, water-based and solvent-based coatings, and pharmaceutical industries, among others.

Product description
2-Diethylaminoethanol is a clear liquid. It is used as a neutralizing amine for boiler water, coatings, etc.
2-Diethylaminoethanol is used as neutralizing agent and CO2 scavenger in boiler water.
The ideal vapor pressure and vapor-liquid distribution properties of 2-Diethylaminoethanol make it the best choice for pH adjustment of process water.

Key Features and Benefits
Condensate line treatment
Prevent of carbon dioxide corrosion
Prevents formation of carbonic acid in boiler steam system
Does not add to TDS of boiler water
Completely volatile
Prevents stress cracking corrosion
Reduces blow down requirement
Does not add TDS
Returns to the feed line with the condensate return so raises the feed water pH
Saves power
Compatible with other treatment chemicals

Foamed plastics are produced by reacting a polyester, a diisocyanate and, if necessary, water in the presence of catalyst of a tertiary amine containing an active hydrogen atom whereby the catalyst becomes bound in the polymer structure.
The products are substantially odourless.

Specified amines are methyl diethanolamine, 2-Diethylaminoethanol, 2-Diethylaminoethanol acid, methyl imino dipropionic acid and N-methyl dipropylene diamine.

Beyond its application in the water treatment segment, 2-Diethylaminoethanol is also used as a neutralizing amine for indrustrial coatings and an intermediate for various surfactants.

Diethylethanolamine2-Diethylaminoethanol belongs to the class of aminoalcohols with a tertiary amine and hydroxyl functionality.
It is a versatile intermediate with a variety of applications

2-Diethylaminoethanol is used mainly as a corrosion inhibitor.
Other applications of 2-Diethylaminoethanol include use in lubricants and as a building block in the agrochemical and pharmaceutical industries.

2-Diethylaminoethanol is colourless liquid type of amine.

Colorless, hygroscopic liquid with a nauseating, ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 50 μg/m3 (11 ppbv) and 190 μg/m3 (40 ppbv), respectively (Hellman and Small, 1974).

Uses
Water-soluble salts; textile softeners; antirust formulations; fatty acid derivatives; pharmaceuticals; curing agent for resins; emulsifying agents in acid media; organic synthesis.

Uses
Anticorrosive agent; chemical intermediate for the production of emulsifiers, detergents, solubilizers, cosmetics, drugs, and textile finishing agents

ChEBI: A member of the class of ethanolamines that is aminoethanol in which the hydrogens of the amino group are replaced by ethyl groups.

2-Diethylaminoethanol is a tertiary amine produced by reaction of ethylene oxide or ethylene chlorhydrin and diethylamine (RTECS 1988). Itokazu (1987) has modified this process for manufacture of 2-Diethylaminoethanol without eventual discoloration. Production in this country exceeds 2866 pounds per year (HSDB 1988).

A colorless liquid. Flash point 103-140°F. Less dense than water . Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Causes burns to the skin, eyes and mucous membranes.

Flammable. Soluble in water. 2-Diethylaminoethanol is sensitive to moisture. Slowly hydrolyzes.

2-Diethylaminoethanol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. 2-Diethylaminoethanol can react with strong oxidizers and acids.

The present invention relates to the use of a reactive amine catalyst, in particular diethylaminoethoxyethanol and/or 2-Diethylaminoethanol, in aqueous or organic solutions for producing flexible polyurethane foams having an increased recatalysis stability, and also a catalyst combination containing at least one reactive amine catalyst which can be used according to the invention; and at least one organic potassium, tin, bismuth and/or zinc compound; and/or at least one tertiary amine selected from the group consisting of triethylenediamine, triethylamine and/or silamorpholine; and/or at least one acid-blocked derivative of a tertiary amine.

2-Diethylaminoethanol is permitted by the U.S. Food and Drug Administration for some applications as a food additive. Applications include protective coatings for fresh fruits and vegetables, and as an additive in steam which directly contacts food products (excluding milk products). The National Research Council Committee on Toxicology has concluded that data on long-term, low-level airborne exposures of animals to 2-Diethylaminoethanol for extrapolation to human health risks are severely lacking. This, combined with the lack of data concerning the concentrations of 2-Diethylaminoethanol in humidified buildings did not allow sufficient information to set guidelines for long-term exposures or estimate the health risks from such exposures. The NRC was able to make some general recommendations based on the assumption that the nitrosation reactions (below) may occur, and that the amine should be considered as hazardous as the nitroso compound formed from it.

The recommendations are:
The Navy should use boiler additives that are least likely to be nitrosated and that do not have other adverse effects on health that would preclude their use.
2-Diethylaminoethanol and morpholine should not be used in concert in a steam generating system when human exposure to the steam may occur.

When amines are used in steam generating systems, the air in rooms where the steam is used and the steam condensate is found should be monitored for the presence of amines and nitrosamines.
If 2-Diethylaminoethanol, morpholine, or other nitrosatable volatile amines are used in steam generating systems where humans may be exposed to the steam, the amounts of amines added should be reduced as much as possible.

When amines are added to a steam generating system, they should be added continuously in small amounts, rather than in one large daily dose.

Industrial uses
2-Diethylaminoethanol is used in the pharmaceutical industry for the manufacture of the local anesthetics procaine and chloroquine; and in the chemical industry for the manufacture of water-soluble salts, fatty-acid derivatives, derivatives containing tertiary amine groups, emulsifiers, special soaps, cosmetics and textiles and fibers.

It also is used in chromatography in chemistry and biochemistry laboratories (2-Diethylaminoethanol is useful as an ion-exchange matrix; 2-Diethylaminoethanol-cellulose columns are used for purification of proteins and DNA, and 2-Diethylaminoethanol-silica for phospholipid separations).
In other industries 2-Diethylaminoethanol is used in some antirust compositions and in textile softeners.
It is also used widely as a steam additive in large buildings requiring humidifiers.

Carcinogenicity
2-Diethylaminoethanol was not mutagenic or clastogenic in a variety of in vitro and in vivo assays.

2-Diethylaminoethanol, when compared with other amino alcohols, was observed to be biologically undecomposable in an experiment using activated sludge

Metabolism
The absorption of 2-Diethylaminoethanol (administered orally as 2-Diethylaminoethanol acid malate or 'Cerebrol') in healthy adult rats is very rapid, reaching a peak plasma level in 30 min (Bismut et al 1986). The biological half-life is 3.5 h with 39% of the excreted product appearing in the urine after 48 h (Bismut et al 1986). In an earlier study, Schulte et al demonstrated that in rats, following a single oral dose, excretion occurs mainly through the kidneys with 37-59% being eliminated in the first 24 h.

After 48 h, elimination was independent of dose.
The brain and spinal cord showed the highest concentration after 7 d. Metabolites produced were observed to be 2-Diethylaminoethanol N-oxide, diethylaminoacetic acid, and ethylaminoethanol.

Preparation
2-Diethylaminoethanol is prepared commercially by the reaction of diethylamine and ethylene oxide.

2-Diethylaminoethanol is a member of the class of ethanolamines that is aminoethanol in which the hydrogens of the amino group are replaced by ethyl groups.
It is a member of ethanolamines, a tertiary amino compound and a primary alcohol. It derives from an ethanolamine. It derives from a hydride of a triethylamine.

Product Description
2-Diethylaminoethanol is a clear liquid. It is used as a neutralizing amine for boiler water, coatings, etc.
2-Diethylaminoethanol is used as neutralizing agent and CO2 scavenger in boiler water. The ideal vapor pressure and vapor-liquid distribution properties of 2-Diethylaminoethanol make it the best choice for pH adjustment of process water.

Beyond its application in the water treatment segment, 2-Diethylaminoethanol is also used as a neutralizing amine for indrustrial coatings and an intermediate for various surfactants.

2-Diethylaminoethanol is a chemical compound with the molecular formula C6H15NO. It is used as a precursor in the production of a variety of chemical commodities such as the local anesthetic procaine. It can be reacted with 4-aminobenzoic acid to make procaine. 2-Diethylaminoethanol can be used as a precursor for 2-Diethylaminoethanol-cellulose resin, which is commonly used in ion exchange chromatography.

2-Diethylaminoethanol can also be conveniently obtained from renewable sources. It is chemically stable and able to absorb carbon dioxide (CO2) from its surroundings. In solution, it can decrease the surface tension of water when the temperature is increased.

Uses
Water-soluble salts; textile softeners; antirust formulations; fatty acid derivatives; pharmaceuticals; curing agent for resins; emulsifying agents in acid media; organic synthesis.

Uses
Anticorrosive agent; chemical intermediate for the production of emulsifiers, detergents, solubilizers, cosmetics, drugs, and textile finishing agents

Production Methods
2-Diethylaminoethanol is a tertiary amine produced by reaction of ethylene oxide or ethylene chlorhydrin and diethylamine (RTECS 1988). Itokazu (1987) has modified this process for manufacture of 2-Diethylaminoethanol without eventual discoloration. Production in this country exceeds 2866 pounds per year (HSDB 1988).

General Description
A colorless liquid. Flash point 103-140°F. Less dense than water.
Vapors heavier than air.
Produces toxic oxides of nitrogen during combustion.
Causes burns to the skin, eyes and mucous membranes.

Air & Water Reactions
Flammable. Soluble in water. 2-Diethylaminoethanol is sensitive to moisture. Slowly hydrolyzes.

Reactivity Profile
2-Diethylaminoethanol is an aminoalcohol.
Amines are chemical bases.
They neutralize acids to form salts plus water.
These acid-base reactions are exothermic.
The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base.

Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
2-Diethylaminoethanol can react with strong oxidizers and acids.

In other industries 2-Diethylaminoethanol is used in some antirust compositions and in textile softeners.
It is also used widely as a steam additive in large buildings requiring humidifiers.

2-diethylaminoethanol appears as a colorless liquid.
Flash point 103-140 °F.
Less dense than water.
Vapors heavier than air.
Produces toxic oxides of nitrogen during combustion.
Causes burns to the skin, eyes and mucous membranes.