BAC 50

Other names: N-Alkyl-N-benzyl-N,N-dimethylammonium chloride; Alkyldimethylbenzylammonium chloride; ADBAC; BC50 BC80; Quaternary ammonium compounds; quats

Benzalkonium chlorides (BACs) are chemicals with widespread applications due to their broad-spectrum antimicrobial properties against bacteria, fungi, and viruses

Benzalkonium chlorides, also known as alkyl dimethyl benzyl ammonium chlorides, alkyl dimethyl (phenylmethyl) quaternary ammonium chlorides, ammonium alkyl dimethyl (phenylmethyl) chlorides, or ammonium alkyl dimethyl benzyl chlorides, are a class of quaternary ammonium compounds (QACs). 
They are usually commercialized as a mixture of compounds with different lengths for the alkyl chain, ranging from C8 to C18, with higher biocide activity for C12 and C14 derivatives

Benzalkonium chlorides (BACs) are chemicals with widespread applications due to their broad-spectrum antimicrobial properties against bacteria, fungi, and viruses

Benzalkonium chlorides were reported for the first time in 1935 by Gerhard Domagk, gaining the market as zephiran chlorides, and were marketed as promising and superior disinfectant and antiseptics. 
In 1947, the first product containing BACs was registered with the Environmental Protection Agency (EPA) in the United States.

Since then, Benzalkonium chloride has been used in a wide variety of products, both prescription and over the counter. 
Applications range from domestic to agricultural, industrial, and clinical. 

Domestic applications of Benzalkonium chloride include fabric softeners, personal hygiene and cosmetic products, such as shampoos, conditioners, and body lotions, as well as ophthalmic solutions and medications that use the nasal route of delivery. 

Benzalkonium chlorides are also among the most common active ingredients in disinfectants used in residential, industrial, agricultural, and clinical settings. 

Additional registered uses for Benzalkonium chloride in the United States include applications on indoor and outdoor surfaces (walls, floors, toilets, etc.), agricultural tools and vehicles, humidifiers, water storage tanks, products for use in residential and commercial pools, decorative ponds and fountains, water lines and systems, pulp and paper products, and wood preservation. 
The recommended or allowed concentrations of Benzalkonium chloride in different products vary considerably according to the application. 
With perhaps the exception of countries which adopted stricter regulations toward Benzalkonium chloride use, discussed in the next section, the potential use of BACs is likely on the rise. 
The global market for disinfectants alone, which includes Benzalkonium chloride, is expected to grow over 6% from 2016 and reach over $8 billion by 2021.


The mode of action of QACs, including Benzalkonium chloride, involves the perturbation and disruption of the membrane bilayers by the alkyl chains and disruption of charge distribution of the membrane by the charged nitrogen. 
Accordingly, susceptibility to BACs may emerge through a combination of mechanisms, with many of those related to the cell membrane. 

The mechanisms proposed in the literature include changes in the overall membrane composition, downregulation of porins, overexpression or modification of efflux pumps, horizontal gene transfer of transposon elements and stress factors, biofilm formation, and biodegradation.

Changes in the membrane composition have long been associated with decreased susceptibility to BACs. 
Resistant strains of P. aeruginosa were shown to have different phospholipid and fatty acid compositions compared to a susceptible strain. 
Other work has demonstrated that exposure of Bacillus cereus to BACs induced genes involved in fatty acid metabolism and caused changes in the fatty acid composition of the membrane


Benzalkonium chloride is a quaternary ammonium compound used in pharmaceutical formulations as an antimicrobial preservative in applications similar to other cationic surfactants. 

Solutions containing benzalkonium chloride are active against wide range of bacteria, yeasts and fungi. 

Activity is more marked against Gram-positive than Gram-negative bacteria and minimal against bacterial endospores and acid-fast bacteria. 
Benzalkonium chloride is usually non-irritating, non-sensitising and is well tolerated in the dilutions normally employed on the skin and mucous membranes. 
However benzalkonium chloride has been associated with adverse effects when used in some pharmaceutical formulations.


Benzalkonium chloride appears to be the main preservative in ophthalmic preparations on the EU market. 
Approximately 74% of ophthalmic preparations have benzalkonium chloride as a preservative. 
It is used as an antimicrobial preservative in numerous medicinal products for nasal route of administration and in many preparations for inhalation use authorised on EU markets. 
Only in limited cases the medicinal products that contain benzalkonium chloride are intended for cutaneous, oral, oromucosal, rectal, vaginal, auricular, intravenous/ subcutaneous and intramuscular/intralesional/intraarticular use.
Benzalkonium chloride has three main categories of use: as a biocide, a cationic surfactant, and phase transfer agent in the chemical industry. 
It is widely used in cosmetics, wet wipes, hand and surface sanitisers. 
Benzalkonium chloride was found to be an effective method of contraception. 
Lozenges containing benzalkonium chloride are used for the treatment of superficial infections of the mouth and throat.


Benzalkonium chloride is a quaternary ammonium antiseptic and disinfectant with actions and uses similar to those of other cationic surfactants. 
It is also used as an antimicrobial preservative for pharmaceutical products.

Benzalkonium chloride is a mixture of alkylbenzyldimethylammonium chlorides, the alkyl groups mainly having chain lengths of C12, C14 and C16


For most multidose aqueous nasal, ophthalmic and otic products, benzalkonium chloride is the preservative of choice. 
Benzalkonium chloride is a preservative that is commonly used in ophthalmic preparations. 
It has been used in eye drops as a preservative since the 1950s and in 2011 it was still the most common preservative used in ophthalmic solutions. 
It is an effective bactericidal and fungicidal agent that helps to minimise the growth of organisms in multidose containers.


Benzalkonium chloride is also used in many non-consumer processes and products, including as an active ingredient in surgical disinfection. 
A comprehensive list of uses includes industrial applications.
An advantage of benzalkonium chloride, not shared by ethanol-based antiseptics or hydrogen peroxide antiseptic, is that it does not cause a burning sensation when applied to broken skin


Other names
N-Alkyl-N-benzyl-N,N-dimethylammonium chloride; Alkyldimethylbenzylammonium chloride; ADBAC; BC50 BC80; Quaternary ammonium compounds; quats


CAS :68424-85-1  Chemical Name Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides
CAS :8001-54-5;  Chemical Name Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides benzalkonium chloridebenzyl-C12-18 -alkyldimethylammonium chlorides
CAS :85665-42-5; Chemical Name Quaternary ammonium compounds, benzyl-C7-17-alkyldimethyl, chlorides; Synonyms: benzyl-C7-18 -alkyldimethylammonium chlorides
CAS :63449-41-2; Chemical Name Quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides; Synonyms: benzyl-C8-18 -alkyldimethylammonium chlorides
CAS :68989-00-4; Chemical Name Quaternary ammonium compounds, benzyl-C10-16-alkyldimethyl,chlorides; Synonyms: benzyl-C10-16 -alkyldimethylammonium chloride
CAS :91080-30-7; Chemical Name Quaternary ammonium compounds, benzyl-C10-21-alkyldimethyl,chlorides; Synonyms: benzyl-C10-21 -alkyldimethylammonium chloride
CAS :85409-22-9; Chemical Name Quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl,chlorides; Synonyms: benzyl-C12-14 -alkyldimethylammonium chlorides
CAS :68424-85-1; Chemical Name Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl,chlorides; Synonyms: benzyl-C12-16 -alkyldimethylammonium chlorides
CAS :68391-01-5; Chemical Name Quaternary ammonium compounds, benzyl-C12-18-alkyldimethyl,chlorides; Synonyms: benzyl-C12-18 -alkyldimethylammonium chlorides
CAS :68607-20-5; Chemical Name Quaternary ammonium compounds, benzyl-C16-18-alkyldimethyl,chlorides; Synonyms: benzyl-C16-18 -alkyldimethylammonium chlorides
CAS :91080-31-8; Chemical Name Quaternary ammonium compounds, benzyl-C16-22-alkyldimethyl,chlorides; Synonyms: benzyl-C16-22 -alkyldimethylammonium chlorides
CAS :61789-75-1; Chemical Name Quaternary ammonium compounds, benzyldimethyltallow alkyl, chlorides; Synonyms: benzyl(tallow alkyl)dimethylammonium chloride
CAS :61789-72-8; Chemical Name Quaternary ammonium compounds, benzyl(hydrogenated tallow alkyl)dimethyl,chlorides; Synonyms: benzyl(hydrogenated tallow alkyl)dimethylammonium chloride
CAS :61789-71-7; Chemical Name Quaternary ammonium compounds, benzylcoco alkyldimethyl, chlorides; Synonyms: benzyl(coconut oil alkyl)dimethylammonium chloride
CAS :61789-74-0; Chemical Name Quaternary ammonium compounds, benzyldimethylsoya alkyl, chlorides; Synonyms: benzyl(soybean oil alkyl)dimethylammonium chloride


Showing 1 - 10 of 12 results for "alkyl dimethyl ammonium chloride"

Benzyl-C8-18-alkyldimethylammonium chloride; CAS: 63449-41-2
Dimethyl di(hydrogenated tallow) ammonium chloride; CAS: 61789-80-8 | Synonyms: Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, chlorides
Benzalkonium chloride; CAS: 8001-54-5 | Synonyms: Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides, alkyldimethylbenzylammonium chloride
Benzyl-C12-18-alkyldimethylammonium chloride; CAS: 68391-01-5
Quaternary ammonium compounds, benzylcoco alkyldimethyl, chlorides; CAS: 61789-71-7
Benzyl-C12-16-alkyldimethylammonium chloride, CAS: 68424-85-1
Benzyl-C12-18-alkyldimethylammonium chloride, CAS: 68391-01-5
Benzyl-C12-16-alkyldimethylammonium chloride, CAS: 68424-85-1
Alkyl dimethyl benzyl ammonium chloride, CAS: 63449-41-2
Benzyl-C12-18-alkyldimethylammonium chloride, CAS: 68391-01-5
Benzyl-C12-18-alkyldimethylammonium chloride, CAS: 68391-01-5
Benzyl-C12-16-alkyldimethylammonium chloride, CAS: 68424-85-1

CAS-Nummer    
8001-54-5 (Alkyl)
63449-41-2 (Alkyl: C8–C18)
68424-85-1 (Alkyl: C12–C16)
68391-01-5 (Alkyl: C12–C18)

Name    Benzalkonium chloride, 50% in water
Alt. name    alkyldimethylbenzylammonium chloride
CAS number    63449-41-2
Related CAS    55963-06-9, 68391-01-5, 68424-85-1, 8001-54-5, 8045-21-4


Benzalkyl quaternary ammonium surfactants:
CAS Registry Numbers: 8001-54-5, 85665-42-5, 63449-41-2,
68989-00-4, 91080-30-7, 85409-22-9, 68424-85-1, 68391-01-5,
68607-20-5, 91080-31-8, 61789-75-1, 61789-72-8, 61789-71-7,
61789-74-0.


Benzalkoniumchlorid; Alkylbenzyldimethylammoniumchlorid; Benzyldimethylalkylammoniumchlorid; BAC; N-Alkyl-N-benzyl-N,N-dimethylammoniumchlorid; BENZALKONIUM CHLORIDE (INCI)

Benzalkonium chloride

Synonym: Alkylbenzyldimethylammonium chloride, Alkyldimethylbenzylammonium chloride

CAS Number 63449-41-2 Linear Formula C6H5CH2N(CH3)2RCl (R=C8H17 to C18H37)  Beilstein/REAXYS Number 4062599  EC Number 264-151-6  MDL number MFCD00145757  NACRES NA.22

BAC is a quaternary ammonium compound used in pharmaceutical formulations as an antimicrobial preservative in applications similar to other cationic surfactants. 
Solutions containing benzalkonium chloride are active against wide range of bacteria, yeasts and fungi. 
Activity is more marked against Gram-positive than Gram-negative bacteria and minimal against bacterial endospores and acid-fast bacteria.
Benzalkonium chloride is usually non-irritating, non-sensitising and is well tolerated in the dilutions normally employed on the skin and mucous membranes. 
However benzalkonium chloride has been associated with adverse effects when used in some pharmaceutical formulations.

BAC-50 Antimicrobial contains the active substance C12-C16 Alkyl dimethyl benzyl ammonium chloride (ADBAC). 
The active is a cationic molecule offering good surfactant properties and can be formulated together with non-ionic and/or amphoteric surfactants. 
ADBAC has a broad antimicrobial efficacy against gram-positive and gram-negative bacteria, yeast, and enveloped viruses. ADBAC maintains its efficacy across a broad pH-range. 
Single-active C12-C16 ADBAC products are  available at different active concentrations, C-chain distributions and solvent combinations.


BAC appears to be the main preservative in ophthalmic preparations on the EU market. 
Approximately 74% of ophthalmic preparations have benzalkonium chloride as a preservative. 
It is used as an antimicrobial preservative in numerous medicinal products for nasal route of administration and in many preparations for inhalation use authorised on EU markets. 
Only in limited cases the medicinal products that contain benzalkonium chloride are intended for cutaneous, oral, oromucosal, rectal, vaginal, auricular, intravenous/ subcutaneous and intramuscular/intralesional/intraarticular use.
Benzalkonium chloride has three main categories of use: as a biocide, a cationic surfactant, and phase transfer agent in the chemical industry. 
It is widely used in cosmetics, wet wipes, hand and surface sanitisers. Benzalkonium chloride was found to be an effective method of contraception. 
Lozenges containing benzalkonium chloride are used for the treatment of superficial infections of the mouth and throat.

BACe is a quaternary ammonium antiseptic and disinfectant with actions and uses similar to those of other cationic surfactants.
It is also used as an antimicrobial preservative for pharmaceutical products.


BAC is a mixture of alkylbenzyldimethylammonium chlorides, the alkyl groups mainly having chain lengths of C12, C14 and C16.
It is presented as a white or yellowish-white powder or Benzalkonium chloride used as an excipient gelatinous, yellowish-white fragments. 
Benzalkonium chloride is hygroscopic. On heating it forms a clear molten mass 


For most multidose aqueous nasal, ophthalmic and otic products, BAC 50 is the preservative of choice. 
Benzalkonium chloride is a preservative that is commonly used in ophthalmic preparations. It has been used in eye drops as a preservative since the 1950s and in 2011 it was still the most common preservative used in ophthalmic solutions. 
It is an effective bactericidal and fungicidal agent that helps to minimise the growth of organisms in multidose containers.
Only a few medicinal products containing benzalkonium chloride are intended for other routes of administrations i.e. cutaneous, oral, oromucosal, rectal, vaginal, auricular and parenteral use.
Therefore the warnings will be developed only for the most commonly used routes of administration.
For other routes not mentioned in the proposal for update, the information included in the package leaflet should follow the same principles.


The acute toxicity (LD50) of benzalkonium chloride after oral administration was approximately
344 mg/kg while LD50 after dermal administration was 3.56 mL/kg (80% ethanol/water solution).


BENZALKONIUM CHLORIDE    ICSC: 1584
Quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl chlorides
Alkyldimethylbenzylammonium chloride
Alkyldimethyl(phenylmethyl) quaternary ammonium chloride
Ammonium alkyldimethyl(phenylmethyl) chloride
Ammonium alkyldimethylbenzyl chloride


What is BAC 50?
Benzalkonium Chloride is a powerful antiseptic and a cationic surfactant. Benzalkonium Chloride is also known as BZK, BKC, BAK, alkyl dimethyl benzyl ammonium chloride and ADBAC.

Our Benzalkonium Chloride products have proven efficacy against a broad spectrum of microorganisms (gram + and – & acid fast bacteria, yeasts, moulds and enveloped vira such as HIV, herpes and corona). 
They are effective through a wide pH range, are surface active/adhesive cationic agents and do not add unpleasant odour/colour to finished formulations.

Benzalkonium chlorides (BACs), also known as alkyl dimethyl benzyl ammonium chlorides, alkyl dimethyl (phenylmethyl) quaternary ammonium chlorides, ammonium alkyl dimethyl (phenylmethyl) chlorides, or ammonium alkyl dimethyl benzyl chlorides, are a class of quaternary ammonium compounds (QACs) 

They are usually commercialized as a mixture of compounds with different lengths for the alkyl chain, ranging from C8 to C18, with higher biocide activity for C12 and C14 derivatives 

BACs were reported for the first time in 1935 by Gerhard Domagk, gaining the market as zephiran chlorides, and were marketed as promising and superior disinfectant and antiseptics. 
In 1947, the first product containing BACs was registered with the Environmental Protection Agency (EPA) in the United States. 
Since then, they have been used in a wide variety of products, both prescription and over the counter. Applications range from domestic to agricultural, industrial, and clinical. 
Domestic applications include fabric softeners, personal hygiene and cosmetic products, such as shampoos, conditioners, and body lotions, as well as ophthalmic solutions and medications that use the nasal route of delivery. 
BACs are also among the most common active ingredients in disinfectants used in residential, industrial, agricultural, and clinical settings. 
Additional registered uses for BACs in the United States include applications on indoor and outdoor surfaces (walls, floors, toilets, etc.), agricultural tools and vehicles, humidifiers, water storage tanks, products for use in residential and commercial pools, decorative ponds and fountains, water lines and systems, pulp and paper products, and wood preservation. 
The recommended or allowed concentrations of BACs in different products vary considerably according to the application. 
With perhaps the exception of countries which adopted stricter regulations toward BAC use, discussed in the next section, the potential use of BACs is likely on the rise. 
The global market for disinfectants alone, which includes BACs, is expected to grow over 6% from 2016 and reach over $8 billion by 2021.


Benzalkonium chloride (BZK, BKC, BAK, BAC), also known as alkyldimethylbenzylammonium chloride (ADBAC) is a type of cationic surfactant. 
It is an organic salt classified as a quaternary ammonium compound. ADBACs have three main categories of use: as a biocide, a cationic surfactant, and a phase transfer agent.
ADBACs are a mixture of alkylbenzyldimethylammonium chlorides, in which the alkyl group has various even-numbered alkyl chain lengths.

KEYWORDS: alkyl dimethyl benzyl ammonium chlorides, antiseptic, BACs, benzalkonium chlorides, QACs, BAC 50

Solubility and physical properties
Depending on purity, benzalkonium chloride ranges from colourless to a pale yellow (impure). Benzalkonium chloride is readily soluble in ethanol and acetone. Dissolution in water is slow.
Aqueous solutions should be neutral to slightly alkaline. Solutions foam when shaken. Concentrated solutions have a bitter taste and a faint almond-like odour.

Standard concentrates are manufactured as 50% and 80% w/w solutions, and sold under trade names such as BC50, BC80, BAC50, BAC80, etc. 
The 50% solution is purely aqueous, while more concentrated solutions require incorporation of rheology modifiers (alcohols, polyethylene glycols, etc.) to prevent increases in viscosity or gel formation under low temperature conditions.

Cationic surfactant
Benzalkonium chloride also possesses surfactant properties, dissolving the lipid phase of the tear film and increasing drug penetration, making it a useful excipient, but at the risk of causing damage to the surface of the eye.


Laundry detergents and treatments
Softeners for textiles
Phase transfer agent
Main article: Phase transfer catalysis
Benzalkonium chloride is a mainstay of phase-transfer catalysis, an important technology in the synthesis of organic compounds, including drugs.

Bioactive agents
Especially for its antimicrobial activity, benzalkonium chloride is an active ingredient in many consumer products:

Pharmaceutical products such as eye, ear and nasal drops or sprays, as a preservative
Personal care products such as hand sanitizers, wet wipes, shampoos, soaps, deodorants and cosmetics
Skin antiseptics and wound wash sprays, such as Bactine.
Throat lozenges and mouthwashes, as a biocide
Spermicidal creams
Cleaners for floor and hard surfaces as a disinfectant, such as Lysol and Dettol antibacterial spray and wipes.
Algaecides for clearing of algae, moss, lichens from paths, roof tiles, swimming pools, masonry, etc.
Benzalkonium chloride is also used in many non-consumer processes and products, including as an active ingredient in surgical disinfection.
A comprehensive list of uses includes industrial applications. An advantage of benzalkonium chloride, not shared by ethanol-based antiseptics or hydrogen peroxide antiseptic, is that it does not cause a burning sensation when applied to broken skin.
However, prolonged or repeated skin contact may cause dermatitis.

During the course of the COVID-19 pandemic, from time to time there have been shortages of hand cleaner containing ethanol or isopropanol as active ingredients.
The FDA has stated that benzalkonium chloride is eligible as an alternative for use in the formulation of healthcare personnel hand rubs.
However, in reference to the FDA rule, the CDC states that it does not have a recommended alternative to ethanol or isopropanol as active ingredients, and adds that "available evidence indicates benzalkonium chloride has less reliable activity against certain bacteria and viruses than either of the alcohols.


Medicine
BAC 50 is a frequently used preservative in eye drops; typical concentrations range from 0.004% to 0.01%. Stronger concentrations can be caustic and cause irreversible damage to the corneal endothelium.

Avoiding the use of benzalkonium chloride solutions while contact lenses are in place is discussed in the literature.

In Russia and China, benzalkonium chloride is used as a contraceptive. Tablets are inserted vaginally, or a gel is applied, resulting in local spermicidal contraception.
It is not a failsafe method, and can cause irritation.

Beekeeping
It is used in beekeeping for the treatment of rotten diseases of the brood.

Adverse effects
Although historically benzalkonium chloride has been ubiquitous as a preservative in ophthalmic preparations, its ocular toxicity and irritant properties, in conjunction with consumer demand, have led pharmaceutical companies to increase production of preservative-free preparations, or to replace benzalkonium chloride with preservatives which are less harmful.

Many mass-marketed inhaler and nasal spray formulations contain benzalkonium chloride as a preservative, despite substantial evidence that it can adversely affect ciliary motion, mucociliary clearance, nasal mucosal histology, human neutrophil function, and leukocyte response to local inflammation.
Although some studies have found no correlation between use of benzalkonium chloride in concentrations at or below 0.1% in nasal sprays and drug-induced rhinitis, others have recommended that benzalkonium chloride in nasal sprays be avoided.
In the United States, nasal steroid preparations that are free of benzalkonium chloride include budesonide, triamcinolone acetonide, dexamethasone, and Beconase and Vancenase aerosol inhalers.

Benzalkonium chloride is irritant to middle ear tissues at typically used concentrations. Inner ear toxicity has been demonstrated.

Occupational exposure to benzalkonium chloride has been linked to the development of asthma. 
In 2011, a large clinical trial designed to evaluate the efficacy of hand sanitizers based on different active ingredients in preventing virus transmission amongst schoolchildren was re-designed to exclude sanitizers based on benzalkonium chloride due to safety concerns.


BAC 50 has been in common use as a pharmaceutical preservative and antimicrobial since the 1940s. While early studies confirmed the corrosive and irritant properties of benzalkonium chloride, investigations into the adverse effects of, and disease states linked to, benzalkonium chloride have only surfaced during the past 30 years.


BAC 50 is a human skin and severe eye irritant. It is a suspected respiratory toxicant, immunotoxicant, gastrointestinal toxicant, and neurotoxicant.

Benzalkonium chloride (BAC 50)  formulations for consumer use are dilute solutions. Concentrated solutions are toxic to humans, causing corrosion/irritation to the skin and mucosa, and death if taken internally in sufficient volumes.
0.1% is the maximum concentration of benzalkonium chloride that does not produce primary irritation on intact skin or act as a sensitizer.

Poisoning by benzalkonium chloride is recognised in the literature. A 2014 case study detailing the fatal ingestion of up to 8.1 oz (240ml) of 10% benzalkonium chloride in a 78-year-old male also includes a summary of the currently published case reports of benzalkonium chloride ingestion. 
While the majority of cases were caused by confusion about the contents of containers, one case cites incorrect pharmacy dilution of benzalkonium chloride as the cause of poisoning of two infants.
In 2018 a Japanese nurse was arrested and admitted to having poisoned approximately 20 patients at a hospital in Yokohama by injecting benzalkonium chloride into their intravenous drip bags.

Benzalkonium chloride poisoning of domestic pets has been recognised as a result of direct contact with surfaces cleaned with disinfectants using benzalkonium chloride as an active ingredient.

Biological activity
The greatest biocidal activity is associated with the C12 dodecyl and C14 myristyl alkyl derivatives. 
The mechanism of bactericidal/microbicidal action is thought to be due to disruption of intermolecular interactions. 
This can cause dissociation of cellular membrane lipid bilayers, which compromises cellular permeability controls and induces leakage of cellular contents. 
Other biomolecular complexes within the bacterial cell can also undergo dissociation. 
Enzymes, which finely control a wide range of respiratory and metabolic cellular activities, are particularly susceptible to deactivation. 
Critical intermolecular interactions and tertiary structures in such highly specific biochemical systems can be readily disrupted by cationic surfactants.

Benzalkonium chloride (BAC 50) solutions are fast-acting biocidal agents with a moderately long duration of action. 
They are active against bacteria and some viruses, fungi, and protozoa. Bacterial spores are considered to be resistant. 
Solutions are bacteriostatic or bactericidal according to their concentration. Gram-positive bacteria are generally more susceptible than gram-negative bacteria. 
Its activity depends on the surfactant concentration and also on the bacterial concentration (inoculum) at the moment of the treatment.
Activity is not greatly affected by pH, but increases substantially at higher temperatures and prolonged exposure times.

In a 1998 study using the FDA protocol, a non-alcohol sanitizer with benzalkonium chloride as the active ingredient met the FDA performance standards, while Purell, a popular alcohol-based sanitizer, did not. 
The study, which was undertaken and reported by a leading US developer, manufacturer and marketer of topical antimicrobial pharmaceuticals based on quaternary ammonium compounds, found that their own benzalkonium chloride-based sanitizer performed better than alcohol-based hand sanitizer after repeated use.

Advancements in the quality and efficacy of benzalkonium chloride in current non-alcohol hand sanitizers has addressed the CDC concerns regarding gram negative bacteria, with the leading products being equal if not more effective against gram negative, particularly New Delhi metallo-beta-lactamase 1 and other antibiotic resistant bacteria.

Newer formulations using benzalkonium blended with various quaternary ammonium derivatives can be used to extend the biocidal spectrum and enhance the efficacy of benzalkonium based disinfection products.
Formulation techniques have been used to great effect in enhancing the virucidal activity of quaternary ammonium-based disinfectants such as Virucide 100 to typical healthcare infection hazards such as hepatitis and HIV.[citation needed]
The use of appropriate excipients can also greatly enhance the spectrum, performance and detergency, and prevent deactivation under use conditions.
Formulation can also help minimise deactivation of benzalkonium solutions in the presence of organic and inorganic contamination.

Degradation

Biodegradation pathways of BAC with Fenton process (H2O2/Fe2+)[39]
Benzalkonium chloride degradation follows consecutive debenzylation, dealkylation, and demethylation steps producing benzyl chloride, alkyl dimethyl amine, dimethyl amine, long chain alkane, and ammonia.
The intermediates, major, and minor products can then be broken down into CO2, H2O, NH3, and Cl–. 
The first step to the biodegradation of BAC is the fission or splitting of the alkyl chain from the quaternary nitrogen as shown in the diagram. 
This is done by abstracting the hydrogen from the alkyl chain by using a hydroxyl radical leading to a carbon centered radical.
This results in benzyl dimethyl amine as the first intermediate and dodecanal as the major product.

From here, benzyl dimethyl amine can be oxidized to benzoic acid using the Fenton process. 
The trimethyl amine group in dimethylbenzylamine can be cleaved to form a benzyl that can be further oxidized to benzoic acid.
Benzoic acid uses hydroxylation (adding a hydroxyl group) to form p-hydroxybenzoic acid. 
Benzyldimethylamine can then be converted into ammonia by performing demethylation twice, which removes both methyl groups, followed by debenzylation, removing the benzyl group using hydrogenation.
The diagram represents suggested pathways of the biodegradation of BAC for both the hydrophobic and the hydrophilic regions of the surfactant. 
Since stearalkonium chloride is a type of BAC, the biodegradation process should happen in the same manner.


Regulation
Benzalkonium chloride is classed as a Category III antiseptic active ingredient by the United States Food and Drug Administration (FDA). 
Ingredients are categorized as Category III when "available data are insufficient to classify as safe and effective, and further testing is required”. 
Benzalkonium chloride was deferred from further rulemaking in the 2019 FDA Final Rule on safety and effectiveness of consumer hand sanitizers, "to allow for the ongoing study and submission of additional safety and effectiveness data necessary to make a determination" on whether it met these criteria for use in OTC hand sanitizers, but the agency indicated it did not intend to take action to remove benzalkonium chloride-based hand sanitizers from the market.
There is acknowledgement that more data are required on its safety, efficacy, and effectiveness, especially with relation to:

Human pharmacokinetic studies, including information on its metabolites
Studies on animal absorption, distribution, metabolism, and excretion
Data to help define the effect of formulation on dermal absorption
Carcinogenicity
Studies on developmental and reproductive toxicology
Potential hormonal effects
Assessment of the potential for development of bacterial resistance
Risks of using it as a contraceptive method
In September 2016, the FDA announced a ban on nineteen ingredients in consumer antibacterial soaps citing a lack of evidence for safety and effectiveness. 
A ban on three additional ingredients, including benzalkonium chloride, was deferred to allow ongoing studies to be completed.

In Europe, the European Commission (EC) is involved in the regulation of BACs. 
Recent rules in the European market included a change in the maximum residual levels of BACs allowed in food products from 0.5 mg/kg to 0.1 mg/kg, values which will undergo an additional review by the end of 2019.
Additionally, recent changes in legislation, Decision (EU) 2016/1950 and the Biocidal Products Regulation (EU) no. 528/2012 (the BPR) (10, 11), meant that BACs are no longer approved for use in several biocidal products, such as consumer hand and body wash antiseptics, which is in contrast with current legislation in the United States.

In the United States, the Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA) share the role of regulating BACs.
Such agencies regularly update regulations based on current scientific data, occasionally limiting the use of compounds found not to be safe or effective. 
Final determinations, however, can be delayed by requests from the industry sector that commercializes such products. 
As an example, the FDA recently published three proposed and final decisions regarding the use of chemicals as consumer hand rub antiseptics, consumer hand and body wash antiseptics, and health care antiseptics. 
The rules banned specific biocides, such as triclosan, or added additional and stricter regulatory approvals for several others, such as chlorhexidine, regarding the applications mentioned above. 
In all instances, however, BACs were excluded from the decisions and granted deferral letters as requested by manufacturers.
The decisions granted manufacturers extra time to provide data to fill gaps related to safety and efficacy.
Since 2015, letters and recommendations have been moving back and forth between the FDA and manufacturers and their representatives, such as the American Cleaning Institute, Lonza America, and Henkel Consumer Goods, Inc. 
Decisions to postpone any action regarding the regulation of BACs were taken based on the affirmation of lack of sufficient data in the literature.
Yet, multiple researchers have studied the safety aspects of BACs over the years, which include data on the toxicity to humans and the environment, as we discuss next.


Benzalkonium chloride (BAC) is a major non-alcohol-based active ingredient used for clinical, food line, and domestic household biocides.
A biocide is a general term for a chemical agent, that may be applied topically in/on living tissue (antiseptic) or on inanimate objects (disinfectant), in order to inhibit growth of (“-static”) or kill (“-cidal”) microorganisms .

In communities where people are in constant contact with one another and surfaces covered with microorganisms, hand hygiene is important for infection control. 
Studies found the use of antiseptic hand sanitizers subdued the prevalence of the common cold, acute respiratory syndromes, gastroenteritis, viral influenza, and more. 
Similarly, this practice is important in limiting hospital-acquired, or nosocomial, infections between patients and clinical staff by limiting spread of opportunists like Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus (MRSAs), and vancomycin-resistant Enterococcus (VREs).

For such preventative measures, there are a variety of hand sanitizers available with alcohol-based and alcohol-free antiseptic agents including ethanol, triclosan and benzalkonium chloride. 
Recently alcohol-free hand sanitizers with triclosan or benzalkonium chloride have been gaining ground due to concerns that ethanol is dries out the skin, is too toxic, and there are frequent cases of intentional ingestion. 
Additional concerns involve the extensive use of antiseptics risking the selective survival of antiseptic resistant pathogens, which may be simultaneously selecting for antibiotic resistance. 
This theory of simultaneous or “cross-selection” suggests that selection of either antiseptic or antibiotic resistance will also select for the other, ultimately resulting in weaker antibacterial therapy and pressure for careful use of both biocides. 
Despite speculations of evolving resistance mechanisms, BACs are extensively used biocides especially efficacious against enveloped microorganisms.

Quaternary Ammonium Compounds (QACs)

Benzalkonium chloride.
BACs are classified as Quaternary Ammonium Compounds, which are positively charged derivatives of ammonium compounds with the chemical formula NR4+, where R can be different carbon-hydrogen containing groups. 
QACs are commonly used as antiseptic agents because of their cationic amphiphilic property, having a distinct hydrophobic and hydrophilic region, resulting from nucleophilic substitution of alkyldimethylamine and benzyl chloride.
BAC’s hydrophilic cationic region destabilizes the pathogen’s surface by forming electrostatic interactions with negatively charged components. 
These interactions effectively outcompete the divalent cations, which normally stabilizes surface structures by linking adjacent negatively-charged components. 
Once close contact is accomplished by the hydrophilic region, the BAC’s hydrophobic region proceeds to penetrate the hydrophobic bilayer to cause cell leakage and lysis. 
The ultimate effect of BACs is to damage the pathogen’s membrane, thus for bacteria, disrupting essential cell processes like ATP synthesis or solute uptake. 
Therefore BAC’s amphiphilicity is critical in interacting with and perturbing target membranes for efficacious antimicrobial action.


Susceptible Microorganisms
The key component of BAC’s antimicrobial activity is membrane destruction, which is most effective against Gram-positive bacteria, some Gram-negative bacteria, some enveloped viruses, fungi, yeasts and protozoa.

Non-sporulating Gram-positive bacteria

A three-dimensional image of the surface of an enveloped measles virus.

General comparison of Gram-positive (a) and Gram-negative (b) bacterial cell wall structure.
Staphylococcus aureus is a Gram-positive bacterium that can survive on antiseptic-free hands for at least 150 minutes, which is enough time for it to spread and persist as a leading cause of nosocomial infections. 
However, S. aureus is readily killed with BACs because their cell walls are chiefly composed of slightly-negatively-charged peptidoglycan and techoic acids. 
These surface structures also lack effective permeability properties and allow uptake of more BACs and other antimicrobial substances.


Enveloped viruses
Some viruses require a lipid envelope, which serves a dual function: first, as a protective barrier from harsh environmental conditions of pH or desiccation, and secondly as an undesirable target for BAC-based antiseptics.
Therefore, enveloped viruses like human immunodeficiency virus (HIV), hepatitis B virus (HBV), influenza virus, measles virus, vaccinia virus, meningopneumonitis virus, Semliki Forest virus, canine distemper virus, rabies virus, fowl laryngotracheitis, and feline pneumonitis virus are all susceptible to BACs.


Impermeability of Benzalkonium Chloride

In particular, impermeability by additional or architecturally-complex surface layers in addition to the cellular membrane are commonly exhibited by a variety of microorganisms that render BAC less efficacious.
Not only is BAC prevented from causing cell lysis, but the uptake of BAC and other active agents in hand sanitizers is severely inhibited. 
Therefore, even at high concentrations, BACs tend to be “non-cidal” and are rather bacteriostatic, mycobacteriostatic, and sporostatic.


Bacteriostatic
Pseudomonas aeruginosa is a Gram-negative bacterium with reduced sensitivity to BACs, and is of clinical importance as a common opportunistic pathogen causing nosocomial respiratory tract infections like pneumonia.
 Generally, Gram-negative bacteria like P. aeruginosa are less permeable to QACs than non-sporulating, non-mycobacterial Gram-positive organisms. 
This marked difference in uptake regulation by Gram-negative bacteria is mediated by structural differences including an outer membrane, porins, and efflux pumps.
While inner membranes have a conventional phospholipid bilayer, the outer leaflet of an outer membrane is composed of lipopolysaccharides (LPS). 
The outer membrane’s reduced permeability is a result of strong LPS-LPS lateral interactions, where a highly anionic “R-core” region on the LPS links interacts with soluble divalent cations to link LPS molecules together. 
The outer membrane’s hydrophobic core has greater London dispersion forces as LPS has up to seven hydrocarbon tails per molecule compared to two per each phospholipid molecule of the inner membrane.
Small porins studding this outer membrane facilitates diffusion of hydrophilic solutes, but can strictly restrict larger molecules of BAC. 
Additionally, efflux proteins in the inner membrane may actively pump out BACs that make it past the outer membrane.
Although P. aeruginosa is only a model organism and there have been reports of BAC efficaciously destructing the outer membranes of other Gram-negative species, P. aeruginosa maximizes BAC impermeability as an antiseptic-resistance measure.


Schematic diagram of Mycobacterial cell wall structure.
Mycobacteriostatic
Mycobacteria are some of the most antiseptic-resistant opportunistic pathogens, characterized by highly hydrophobic cell walls of a complex mycoyl arabinogalactan-peptidoglycan skeletal architecture.
Although the specific component conferring antiseptic resistance remains undecided, experiments involving cell wall synthesis inhibitors suggests that a cell wall component like lipid content is responsible. 
Further studies supports the idea of lipid content determining BAC (im)permeability, as species with high lipid content like Mycobacterium tuberculosis were found to be less antiseptic sensitive than Mycobacterium phlei with lower lipid content.

Sporostatic
Clostridium difficile is a major spore forming bacteria, causing 15-55% of all nosocomial diarrheas.
Similar to Gram-negative and myco- bacteria, additional impermeability layers of complex spore coat(s) hinders the permeability and activity of BACs.


Roles Classification 
Chemical Role(s): surfactant: A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces.
detergent: A surfactant (or a mixture containing one or more surfactants) having cleaning properties in dilute solutions.
Biological Role(s): antibacterial agent: A substance (or active part thereof) that kills or slows the growth of bacteria.
disinfectant: An antimicrobial agent that is applied to non-living objects to destroy harmful microorganisms or to inhibit their activity.
Application(s):    detergent: A surfactant (or a mixture containing one or more surfactants) having cleaning properties in dilute solutions.
antiseptic drug: A substance used locally on humans and other animals to destroy harmful microorganisms or to inhibit their activity (cf. disinfectants, which destroy microorganisms found on non-living objects, and antibiotics, which can be transported through the lymphatic system to destroy bacteria within the body).

benzalkonium chloride (CHEBI:3020) has role antibacterial agent (CHEBI:33282)
benzalkonium chloride (CHEBI:3020) has role antiseptic drug (CHEBI:48218)
benzalkonium chloride (CHEBI:3020) has role detergent (CHEBI:27780)
benzalkonium chloride (CHEBI:3020) has role disinfectant (CHEBI:48219)
benzalkonium chloride (CHEBI:3020) has role surfactant (CHEBI:35195)
benzalkonium chloride (CHEBI:3020) is a organic chloride salt (CHEBI:36094)
benzalkonium chloride (CHEBI:3020) is a quaternary ammonium salt (CHEBI:35273)

INNs     Sources
benzalkonii chloridum LINGUA LATINA    
benzalkonium chloride    
chlorure de benzalkonium Français    
cloruro de benzalconio Español    ChemIDplus
Synonyms     
ADBAC    ChEBI
Alkyl dimethylbenzyl ammonium chloride    
Alkylbenzyldimethylammonium chloride    
Alkyldimethyl(phenylmethyl)quaternary ammonium chlorides    
Alkyldimethylbenzylammonium chloride    
Benzalkonium chloride    
benzalkonium chlorides

Benzalkonium Chloride Solutions


BC50: 50% Benzalkonium Chloride Solutions
BC50: Low foam
BC80: 80% Benzalkonium Chloride Solutions
BC80: Low foam
BAC70 WLF: Winterised, low foam oilfield biocide
Benzalkonium Chloride Solutions can be tailored to your specific industrial requirements.


Please CONTACT US for variations on concentration, solvents and other additives.

BIOCIDAL PROPERTIES:
Benzalkonium chloride is a member of the quaternary ammonium class of biocides, recognised for its dual biocidal and detergency properties.
Its biocidal efficacy depends on its capacity to act as a cationic surfactant in binding to and disrupting cellular and intracellular membranes, and associated biochemical processes. 
Functions such as cell adhesion, cell signaling, selective permeability to ions and nutritional organic molecules ensure cellular survival through its ability to interact with and respond effectively to environmental stimuli. 
Disruption of these processes ensures a high level of activity against bacteria, algae, fungi and enveloped viruses at exceptionally low concentrations.
BC50 passes stringent BS EN 1276 microbicidal testing (high organic contamination, hard water conditions) at a dilution of 1:1250, giving a 5-log kill (1:100,000 bacterial survival) against a range of the most problematic organisms.

CHARACTERISTICS OF BENZALKONIUM CHLORIDE DISINFECTANTS:
Benzalkonium chloride is widely used in the formulation of disinfectants and cleaner-sanitisers for the hospital, livestock, food & dairy and personal hygiene sectors.

Offers rapid, safe, powerful antimicrobial activity at low ppm
Strong detergency ensures ease of removal of organic soil which harbours microbes
Ease of formulation for biocidal activity under high organic contamination conditions
Compatible with non-ionic, amphoteric and cationic surface-active agents
Displays synergistic activity with other classes of biocide & excipients
Retains activity in highly acid to highly alkaline formulations
High molecular stability with retention of activity at extremes of temperature
Lends itself well to formulation optimisation for hard water conditions
Retains biocidal activity in aqueous and organic solvents
Benzalkonium chloride disinfectants are non-toxic, non-tainting & odour-free at typical use dilutions
For Quat-Chem disinfection products based on quaternary ammonium compounds, please click here.

INDUSTRIAL APPLICATIONS:
For industrial applications of benzalkonium chloride, please click here.

ENVIRONMENTAL CHARACTERISTICS:
Quaternary ammonium compounds display a high level of biodegradability when tested in accordance with OECD test protocol 301C. 
It is not known to accumulate in the natural environment under normal use conditions. 
Like all detergents, ADBAC is highly toxic to marine organisms under laboratory conditions, but does not bio-accumulate in organisms. 
In the natural environment it is readily deactivated by clays and humic substances which neutralises its aquatic toxicity and prevent its migration across environmental compartments.


Synonyms: Alkyl dimethyl benzyl ammonium chloride, ADBAC, BC50, BAC 50, BKC 50, BC80, BAC 80, BKC 80

REGULATORY:
Alkyl dimethyl benzyl ammonium chloride has been pre-registered under REACH regulation and notified under the Biocidal Product Directive 98/8/EC (ref: N501).

Regulatory process names
Benzalkonium chloride
Cosmetic Products Regulation, Annex V - Allowed Preservatives
Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
Pre-Registration process, Other
IUPAC names
Alkyldimethylbenzylammonium chloride
ammonium, alkylbenzyldimethyl-,chloride
Benzalkonium Chlorid
benzalkonium chloride
Benzalkonium chloride, alkyl distribution C8-C16
Benzalkónium-klorid
benzyl-dimethyl-tetradecylazanium chloride
benzyl-dodecyl-dimethylazanium chloride
N-alkyl(C8-C16)dimethylbenzylammonium chloride
Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides

Other names
Benzalkonium chloride
Benzalkonium Chloride C16

Other identifiers: 12741-06-9

CAS number: 39434-18-9
CAS number: 59890-14-1
CAS number: 75635-12-0
CAS number: 8001-54-5
CAS number: 8011-91-4
CAS number: 8036-90-6
CAS number: 8039-63-2
CAS number: 8045-21-4

Alkylbenzyldimethylammonium chlorides with alkyl chain lengths of C8, C10, C12, C14, C16 and C18
Benzalkonium chloride
C8-18-Alkydimethylbenzyl ammonium chlorides
Quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides
quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides

Translated names
(C8-18)alkylbenzyldimetylammoniumklorid (no)
(C8-18)alkylbenzyldimetylammoniumklorid (sv)
(C8-18)alkyylibentsyylidimetyyliammoniumkloridi (fi)
chlorki czwartorzedowych zwiazków amoniowych - chlorki benzylo(C8-18)alkilodimetyloamonium (pl)
composti di ammonio quaternario, benzil-C8-18-alchildimetil, cloruri (it)
compostos de amónio quaternário, benzil-C8-18-alquildimetil, cloretos (pt)
composés d'ammonium quaternaire, benzyl-C8-18-alkyldiméthyle, chlorures (fr)
compuestos de amonio cuaternario, bencil-C8-18-alquildimetil, cloruros (es)
compusi de amoniu cuaternari, benzil-C8-18-alildimetil, cloruri (ro)
ketvirtiniai amonio junginiai, benzil-C8-18-alkildimetil-, chloridai (lt)
kvarterne amonijeve spojine, benzil-C8-18-alkildimetil kloridi (sl)
kvarterni amonijevi spojevi,benzil-C8-18-alkildimetil, kloridi (hr)
kvarterní amoniové sloučeniny, alkyl(C8-C18)(benzyl) dimethylamonium-chlorid (cs)
kvartérne amóniové zlúčeniny, (C8-18-alkyl)(benzyl)di(metyl)amónium-chloridy (sk)
Kvaternaarsete bensüül-C 8-18-alküüldimetüülammooniumiühendite kloriidid (et)
kvaterner ammónium vegyületek, benzil-C8-18-alkildimetilammónium-klorid (hu)
kvaternääriset ammoniumyhdisteet, bentsyyli-C8-18-alkyylidimetyylikloridit (fi)
kvaternære ammoniumforbindelser, benzyl-C8-18-alkyldimethyl-, chlorider (da)
kvaternære ammoniumforbindelser, benzyl-C8-18-alkyldimetyl, klorider (no)
quaternaire ammoniumverbindingen, benzyl-C8-18-alkyldimethyl, chloriden (nl)
Quaternäre Ammoniumverbindungen, Benzyl-C8-18-alkyldimethyl-, Chloride (de)
četraizvietotie amonija savienojumi, benzil-C8-C18-alkildimetil-hlorīdi (lv)
χλωρίδια των βενζυλο-C8-18-αλκυλοδιμεθυλο τεταρτοταγών ενώσεων αμμωνίου (el)
кватернерни амониеви съединения, бензил-C8-18-aлкилдиметил, хлориди (bg)

CAS names
Alkylbenzyldimethylammonium chlorides, benzyl-C8-18-alkyldimethyl

IUPAC names
Alkylbenzyldimethylammonium chlorides, benzyl-C8-18-alkyldimethyl
Alkyldimethylbenzyl ammonium chloride
Benzalkonium chloride
Benzyl(dodecyl)dimethylammonium chloride, benzyl(tetradecyldimethylammonium chloride
benzyl-C8-18-alkyldimethyl chloride
benzyl-decyl-dimethylazanium chloride
benzyl-decyl-dimethylazanium;chloride
benzyl-dimethyl-tridecyl-azanium chloride
N-benzyl-N,N-dimethyldecan-1-aminium chloride
Quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides
quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzylcoco alkyldimethyl, chlorides

Other identifiers
50957-62-5
Other
CAS number
50957-62-5
Other
Deleted CAS number
51004-71-8
Other
CAS number
51004-71-8
Other
Deleted CAS number
51668-62-3

CAS number
51668-62-3

Deleted CAS number
612-140-00-5

Index Number
63449-41-2


Alkyl (C12-16) dimethylbenzyl ammonium chloride (ADBAC/BKC (C12-16))

Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides
EC Inventory, Other, Cosmetic Products Regulation, Annex III - Restricted Substances, Cosmetic Products Regulation, Annex V - Allowed Preservatives

Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides
Pre-Registration process, Other, Cosmetic Products Regulation, Annex III - Restricted Substances, Cosmetic Products Regulation, Annex V - Allowed Preservatives

Translated names
Alkil (C12-16) dimetilbenzil amonijev klorid (ADBAC/BKC (C12-16)) (hr)
Alkil (C12-16) dimetilbenzil amonio chloridas (ADBAC (C12-16)) (lt)
Alkil (C12-16) dimetilbenzilamonija hlorīds (ADBAC/BKC (C12-16)) (lv)
Alkil (C12-16)-chlorku dimetylobenzyloamonu (ADBAC/BKC (C12-16)) (pl)
Alkil (C12–16) dimetil-benzil-ammónium-klorid (ADBAC/BKC [C12–16]) (hu)
Alkil (C12–16) dimetilbenzil amonijev klorid (ADBAC/BKC (C12–16)) (sl)
Alkyl (C12-16) dimethylbenzyl ammonium chloride (ADBAC/BKC (C12-C16)) (mt)
Alkyl (C12-16) dimethylbenzyl ammonium chloride (ADBAC/BKC (C12-C16)) (no)
alkyl(C12-16)benzyldimetylamónium-chlorid [ADBAC/BKC (C12-C16)] (sk)
alkyl(C12-16)dimethylbenzylammoniumchlorid (ADBAC/BKC (C12-16)) (da)
Alkyl(C12-16)dimethylbenzylammoniumchlorid (ADBAC/BKC (C12-16)) (de)
alkyl(C12-16)dimethylbenzylammoniumchlorid (ADBAC/BKC (C12-C16)) (cs)
Alkyl(C12-16)dimethylbenzylammoniumchloride (ADBAC/BKC (C12-16)) (nl)
Alkyl(C12-16)dimetylbensylammoniumklorid (ADBAC/BKC (C12-C16)) (sv)
Alkyyli-(C12-16)-dimetyylibentsyyliammoniumkloridi (ADBAC/BKC (C12-16)) (fi)
C12–16-alküüldimetüülbensüülammooniumkloriid (ADBAC/BKC (C12–16)) (et)
Chlorure d'alkyl(C12-C16)diméthylbenzylammonium [ADBAC/BKC (C12-C16)] (fr)
Cloreto de alquil(C12-16)dimetilbenzilamónio (ADBAC/KBC C12-16) (pt)
Cloruro de C12-16-alquildimetilbencilamonio (ADBAC/BKC (C12-16)) (es)
Cloruro di alchil (C12-16) dimetilbenzilammonio (ADBAC/BKC (C12-C16)) (it)
Clorură de alchil (C12-16) dimetilbenzil amoniu [ADBAC/BKC (C12-C16)] (ro)
Χλωριούχο αλκυλο(C12-16)διμεθυλοβενζυλαμμώνιο (ADBAC/BKC (C12-C16)) (el)

Алкил(C12-16)диметилбензиламониев хлорид (ADBAC/BKC (C12-C16)) (bg)

CAS names
Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides

IUPAC names
Alkyl dimethyl benzyl ammonium chloride
benzyl-C12-16-alkyldimethyl, chlorides
Benzyl-dimethyl-tetradecyl azanium chloride
benzyl-dimethyl-tetradecylazanium chloride
dimethyl benzyl ammonium chloride
N-ALKYL(C12-16)-N,N-DIMETHYL-N-BENZYLAMMONIUM CHLORIDE
N-Alkyl-N,N-dimethyl-N-benzylammonium Chloride
N-benzyl-N,N-dimethyl-C12-16-(evennumbered)-alkyl-1-aminium chloride
N-Benzyl-N,N-dimethyltetradecan-1-aminium chloride
N-benzyl-N,N-dimethyltetradecan-1-aminium chloride


Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides
Quaternary ammoniumcompounds, benzyl-C12-16-alkyldimethyl, chlorides

Other identifiers: 284043-23-8
CAS number: 284043-23-8
Deleted CAS number:39403-41-3
CAS number: 39403-41-3
Deleted CAS number: 63449-42-3
CAS number: 63449-42-3
Deleted CAS number: 68424-85-1


----------------------------------------------------------------------------------------------------

EC/List no.: 270-325-2; CAS no.: 68424-85-1
CAS RN: 68424-85-1; Chemical Name: Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides
Substance names and other identifiers
Regulatory process names
Alkyl (C12-16) dimethylbenzyl ammonium chloride (ADBAC/BKC (C12-16))
Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides

Translated names
Alkil (C12-16) dimetilbenzil amonijev klorid (ADBAC/BKC (C12-16)) (hr)
Alkil (C12-16) dimetilbenzil amonio chloridas (ADBAC (C12-16)) (lt)
Alkil (C12-16) dimetilbenzilamonija hlorīds (ADBAC/BKC (C12-16)) (lv)
Alkil (C12-16)-chlorku dimetylobenzyloamonu (ADBAC/BKC (C12-16)) (pl)
Alkil (C12–16) dimetil-benzil-ammónium-klorid (ADBAC/BKC [C12–16]) (hu)
Alkil (C12–16) dimetilbenzil amonijev klorid (ADBAC/BKC (C12–16)) (sl)
Alkyl (C12-16) dimethylbenzyl ammonium chloride (ADBAC/BKC (C12-C16)) (mt)
Alkyl (C12-16) dimethylbenzyl ammonium chloride (ADBAC/BKC (C12-C16)) (no)
alkyl(C12-16)benzyldimetylamónium-chlorid [ADBAC/BKC (C12-C16)] (sk)
alkyl(C12-16)dimethylbenzylammoniumchlorid (ADBAC/BKC (C12-16)) (da)
Alkyl(C12-16)dimethylbenzylammoniumchlorid (ADBAC/BKC (C12-16)) (de)
alkyl(C12-16)dimethylbenzylammoniumchlorid (ADBAC/BKC (C12-C16)) (cs)
Alkyl(C12-16)dimethylbenzylammoniumchloride (ADBAC/BKC (C12-16)) (nl)
Alkyl(C12-16)dimetylbensylammoniumklorid (ADBAC/BKC (C12-C16)) (sv)
Alkyyli-(C12-16)-dimetyylibentsyyliammoniumkloridi (ADBAC/BKC (C12-16)) (fi)
C12–16-alküüldimetüülbensüülammooniumkloriid (ADBAC/BKC (C12–16)) (et)
Chlorure d'alkyl(C12-C16)diméthylbenzylammonium [ADBAC/BKC (C12-C16)] (fr)
Cloreto de alquil(C12-16)dimetilbenzilamónio (ADBAC/KBC C12-16) (pt)
Cloruro de C12-16-alquildimetilbencilamonio (ADBAC/BKC (C12-16)) (es)
Cloruro di alchil (C12-16) dimetilbenzilammonio (ADBAC/BKC (C12-C16)) (it)
Clorură de alchil (C12-16) dimetilbenzil amoniu [ADBAC/BKC (C12-C16)] (ro)
Χλωριούχο αλκυλο(C12-16)διμεθυλοβενζυλαμμώνιο (ADBAC/BKC (C12-C16)) (el)
Алкил(C12-16)диметилбензиламониев хлорид (ADBAC/BKC (C12-C16)) (bg)

CAS names
Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides

IUPAC names
Alkyl dimethyl benzyl ammonium chloride
benzyl-C12-16-alkyldimethyl, chlorides
Benzyl-dimethyl-tetradecyl azanium chloride
benzyl-dimethyl-tetradecylazanium chloride
dimethyl benzyl ammonium chloride
N-ALKYL(C12-16)-N,N-DIMETHYL-N-BENZYLAMMONIUM CHLORIDE
N-Alkyl-N,N-dimethyl-N-benzylammonium Chloride
N-benzyl-N,N-dimethyl-C12-16-(evennumbered)-alkyl-1-aminium chloride
N-Benzyl-N,N-dimethyltetradecan-1-aminium chloride
N-benzyl-N,N-dimethyltetradecan-1-aminium chloride

Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides
Quaternary ammoniumcompounds, benzyl-C12-16-alkyldimethyl, chlorides

Other identifiers
284043-23-8
Other
CAS number
284043-23-8
Other
Deleted CAS number
39403-41-3
Other
CAS number
39403-41-3
Other
Deleted CAS number
63449-42-3
Other
CAS number
63449-42-3
Other
Deleted CAS number
68424-85-1
CAS number
70294-44-9
Other
CAS number
70294-44-9
Other
Deleted CAS number


------------------------------------------------------------------------------------------

EC/List no.: 616-786-9; CAS no.: 8001-54-5
Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides; IUPAC name:  8001-54-5; CAS number:  8001-54-5
CAS RN: 8001-54-5;  Chemical Name: Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides benzalkonium chloride; benzyl-C12-18 -alkyldimethylammonium chlorides

Benzalkonium chloride
Cosmetic Products Regulation, Annex V - Allowed Preservatives
Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides

IUPAC names
Alkyldimethylbenzylammonium chloride
ammonium, alkylbenzyldimethyl-,chloride
Benzalkonium Chlorid
Benzalkonium chloride
benzalkonium chloride
Benzalkonium Chloride 
Benzalkonium chloride, alkyl distribution C8-C16
Benzalkónium-klorid
benzyl-dimethyl-tetradecylazanium chloride
benzyl-dodecyl-dimethylazanium chloride
N-alkyl(C8-C16)dimethylbenzylammonium chloride
Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides

Other names
Benzalkonium chloride
Benzalkonium Chloride C16
Other identifiers
12741-06-9
Other
CAS number
39434-18-9
Other
CAS number
59890-14-1
Other
CAS number
75635-12-0
Other
CAS number
8001-54-5
CAS number
8011-91-4
Other
CAS number
8036-90-6
Other
CAS number
8039-63-2
Other
CAS number
8045-21-4


------------------------------------------------------------------------------------------------------

EC / List no:288-131-1; CAS no:85665-42-5
CAS RN: 85665-42-5; Chemical Name Quaternary ammonium compounds, benzyl-C7-17-alkyldimethyl, chlorides; Synonyms: benzyl-C7-18 -alkyldimethylammonium chlorides
Quaternary ammonium compounds, benzyl-C7-17-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C7-17-alkyldimethyl, chlorides
EC Inventory
Quaternary ammonium compounds, benzyl-C7-17-alkyldimethyl, chlorides
Other identifiers
85665-42-5


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EC / List no.: 264-151-6; CAS no.: 63449-41-2
CAS RN: 63449-41-2; Chemical Name: Quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides; Synonyms: benzyl-C8-18 -alkyldimethylammonium chlorides
Quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides

Substance names and other identifiers
Regulatory process names
Alkylbenzyldimethylammonium chlorides with alkyl chain lengths of C8, C10, C12, C14, C16 and C18
Benzalkonium chloride
C8-18-Alkydimethylbenzyl ammonium chlorides
Other, Cosmetic Products Regulation, Annex III - Restricted Substances, Cosmetic Products Regulation, Annex V - Allowed Preservatives
Quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides
quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides

Translated names
(C8-18)alkylbenzyldimetylammoniumklorid (no)
(C8-18)alkylbenzyldimetylammoniumklorid (sv)
(C8-18)alkyylibentsyylidimetyyliammoniumkloridi (fi)
chlorki czwartorzedowych zwiazków amoniowych - chlorki benzylo(C8-18)alkilodimetyloamonium (pl)
composti di ammonio quaternario, benzil-C8-18-alchildimetil, cloruri (it)
compostos de amónio quaternário, benzil-C8-18-alquildimetil, cloretos (pt)
composés d'ammonium quaternaire, benzyl-C8-18-alkyldiméthyle, chlorures (fr)
compuestos de amonio cuaternario, bencil-C8-18-alquildimetil, cloruros (es)
compusi de amoniu cuaternari, benzil-C8-18-alildimetil, cloruri (ro)
ketvirtiniai amonio junginiai, benzil-C8-18-alkildimetil-, chloridai (lt)
kvarterne amonijeve spojine, benzil-C8-18-alkildimetil kloridi (sl)
kvarterni amonijevi spojevi,benzil-C8-18-alkildimetil, kloridi (hr)
kvarterní amoniové sloučeniny, alkyl(C8-C18)(benzyl) dimethylamonium-chlorid (cs)
kvartérne amóniové zlúčeniny, (C8-18-alkyl)(benzyl)di(metyl)amónium-chloridy (sk)
Kvaternaarsete bensüül-C 8-18-alküüldimetüülammooniumiühendite kloriidid (et)
kvaterner ammónium vegyületek, benzil-C8-18-alkildimetilammónium-klorid (hu)
kvaternääriset ammoniumyhdisteet, bentsyyli-C8-18-alkyylidimetyylikloridit (fi)
kvaternære ammoniumforbindelser, benzyl-C8-18-alkyldimethyl-, chlorider (da)
kvaternære ammoniumforbindelser, benzyl-C8-18-alkyldimetyl, klorider (no)
quaternaire ammoniumverbindingen, benzyl-C8-18-alkyldimethyl, chloriden (nl)
Quaternäre Ammoniumverbindungen, Benzyl-C8-18-alkyldimethyl-, Chloride (de)
četraizvietotie amonija savienojumi, benzil-C8-C18-alkildimetil-hlorīdi (lv)
χλωρίδια των βενζυλο-C8-18-αλκυλοδιμεθυλο τεταρτοταγών ενώσεων αμμωνίου (el)
кватернерни амониеви съединения, бензил-C8-18-aлкилдиметил, хлориди (bg)

CAS names
Alkylbenzyldimethylammonium chlorides, benzyl-C8-18-alkyldimethyl

IUPAC names
Alkylbenzyldimethylammonium chlorides, benzyl-C8-18-alkyldimethyl

Alkyldimethylbenzyl ammonium chloride
Benzalkonium chloride
Benzyl(dodecyl)dimethylammonium chloride, benzyl(tetradecyldimethylammonium chloride
benzyl-C8-18-alkyldimethyl chloride
benzyl-decyl-dimethylazanium chloride
benzyl-decyl-dimethylazanium;chloride
benzyl-dimethyl-tridecyl-azanium chloride
N-benzyl-N,N-dimethyldecan-1-aminium chloride
Quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides
quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzylcoco alkyldimethyl, chlorides

Other identifiers
50957-62-5
Other
CAS number
50957-62-5
Other
Deleted CAS number
51004-71-8
Other
CAS number
51004-71-8
Other
Deleted CAS number
51668-62-3
Other
CAS number
51668-62-3
Other
Deleted CAS number
612-140-00-5
Index Number
63449-41-2
CAS number
69344-71-4
Other
CAS number
69344-71-4
Other
Deleted CAS number

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EC / List no.: 273-544-1; CAS no.: 68989-00-4
CAS RN: 68989-00-4; Chemical Name: Quaternary ammonium compounds, benzyl-C10-16-alkyldimethyl,chlorides; Synonyms: benzyl-C10-16 -alkyldimethylammonium chloride
Quaternary ammonium compounds, benzyl-C10-16-alkyldimethyl, chlorides
This substance is identified by SDA Substance Name: C10-C16 alkyl benzyl dimethyl ammonium chloride and SDA

Substance names and other identifiers

Regulatory process names
Quaternary ammonium compounds, benzyl-C10-16-alkyldimethyl, chlorides
EC Inventory
Quaternary ammonium compounds, benzyl-C10-16-alkyldimethyl, chlorides
This substance is identified by SDA Substance Name: C10-C16 alkyl benzyl dimethyl ammonium chloride and SDA Reporting Number: 15-052-00.

Pre-Registration process
IUPAC names
Alkyldimethylbenzylammoniumchlorid
QUATERNARY AMMONIUM COMPOUNDS, BENZYL-C10-16-ALKYLDIMETHYL CHL0RIDES
Quaternary ammonium compounds, benzyl-C10-16-alkyldimethyl, chlorides

Other identifiers
68989-00-4


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EC / List no.: 293-523-0; CAS no.: 91080-30-7
CAS RN: 91080-30-7; Chemical Name: Quaternary ammonium compounds, benzyl-C10-21-alkyldimethyl,chlorides; Synonyms: benzyl-C10-21 -alkyldimethylammonium chloride
Quaternary ammonium compounds, benzyl-C10-21-alkyldimethyl, chlorides

Substance names and other identifiers
Regulatory process names
Quaternary ammonium compounds, benzyl-C10-21-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C10-21-alkyldimethyl, chlorides

IUPAC names
Quaternary ammonium compounds, benzyl-C10-21-alkyldimethyl, chlorides

Other identifiers
91080-30-7


----------------------------------------------------------------------------------------------------------------

CAS RN: 85409-22-9; Chemical Name: Quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl,chlorides; Synonyms: benzyl-C12-14 -alkyldimethylammonium chlorides
Quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl, chlorides
Benzyl-C12-14-alkyldimethylammonium chlorides
Quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl, chlorides

Substance names and other identifiers
Regulatory process names
Alkyl (C12-C14) dimethylbenzylammonium chloride (ADBAC (C12-C14))

Alkylbenzyldimethylammonium chlorides, benzyl-C12-14-alkyldimethyl
Barquat OJ
BAS 092-00E
Benzyl-C12-14-alkyldimethylammonium chlorides
C12-14-alkylbenzyldimethylammonium chlorides
Lutensit K-LC
Protectol KLC
Protectol KLC 50
Protectol KLC 80
Quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl, chlorides
EC Inventory, Other, Cosmetic Products Regulation, Annex III - Restricted Substances, Cosmetic Products Regulation, Annex V - Allowed Preservatives
Quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl, chlorides

Translated names
Alkil (C12-14) dimetilbenzil amonijev klorid (ADBAC (C12-14)) (hr)
Alkil (C12-C14) dimetilbenzilamonija hlorīds (ADBAC (C12-C14)) (lv)
Alkil (C12-C14) dimetilbenzilamonio chloridas (ADBAC (C12-C14)) (lt)
Alkil (C12–C14) dimetil-benzil-ammónium-klorid (ADBAC [C12–C14]) (hu)
Alkil (C12–C14) dimetilbenzilamonijev klorid (ADBAC (C12–C14)) (sl)
Alkyl (C12-C14) dimethylbenzylammonium chloride (ADBAC (C12-C14)) (mt)
Alkyl (C12-C14) dimethylbenzylammonium chloride (ADBAC (C12-C14)) (no)
alkyl(C12-C14)benzyldimetylamónium-chlorid [ADBAC (C12-C14)] (sk)
alkyl(C12-C14)dimethylbenzylammoniumchlorid (ADBAC (C12-C14)) (cs)
alkyl(C12-C14)dimethylbenzylammoniumchlorid (ADBAC (C12-C14)) (da)
Alkyl(C12-C14)dimethylbenzylammoniumchlorid (ADBAC (C12-C14)) (de)
Alkyl(C12-C14)dimethylbenzylammoniumchloride (ADBAC (C12-C14)) (nl)
Alkyl(C12-C14)dimetylbensylammoniumklorid (ADBAC (C12-C14)) (sv)
Alkyyli-(C12-C14)-dimetyylibentsyyliammoniumkloridi (ADBAC (C12-C14)) (fi)
C12–14-alküüldimetüülbensüülammooniumkloriid (ADBAC (C12–14)) (et)
Chlorek alkilo (C12-14)-dimetylobenzylo-amonowy (ADBAC (C12-C14)) (pl)
Chlorure d'alkyl(C12-C14)diméthylbenzylammonium [ADBAC (C12-C14)] (fr)
Cloreto de alquil(C12-C14)dimetilbenzilamónio (ADBAC C12-C14) (pt)
Cloruro de C12-14-alquildimetilbencilamonio (ADBAC (C12-14)) (es)
Cloruro di alchil(C12-C14)dimetilbenzilammonio (ADBAC (C12-C14)) (it)
Clorură de alchil (C12-C14) dimetilbenzilamoniu [ADBAC (C12-C14)] (ro)
Χλωριούχο αλκυλο(C12-14)διμεθυλοβενζυλαμμώνιο (ADBAC (C12-C14)) (el)
Алкил(C12-C14)диметилбензиламониев хлорид (ADBAC (C12-C14)) (bg)

IUPAC names
benzyl-C12-14-alkyldimethyl, chlorides
C12-C14 Alkyldimethylbenzylammoniumchlorid
N-Alkyl(C12-16)-N,N-dimethyl-N-benzylammonium chloride
Quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl,chlorides
Other identifiers
85409-22-9

Substance names and other identifiers
CAS names
Quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl, chlorides

IUPAC names
Benzalkonium Chloride

Benzyl-C12-14-alkyldimethylammonium chlorides
C12-14 ADBAC

Quaternary ammonium compounds, benzyl-C12-14 (even-numbered)-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C12-C14 (even-numbered)-alkyldimethyl, chlorides
ROQUAT BL 50

Trade names
BAC70
PR-1107A
PR-4951
PR-9010

Other identifiers
1097616-29-9
Other
Deleted CAS number
79177-05-2
Other
Deleted CAS number
85409-22-9
Other
CAS number


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EC / List no.: 270-325-2; CAS no.: 68424-85-1
CAS RN: 68424-85-1; Chemical Name: Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl,chlorides; Synonyms: benzyl-C12-16 -alkyldimethylammonium chlorides
Quaternary ammonium compounds, benzyl C12-C16 (even numbered)-alkyldimethyl chlorides
Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides

Substance names and other identifiers
Regulatory process names
Alkyl (C12-16) dimethylbenzyl ammonium chloride (ADBAC/BKC (C12-16))

Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides
EC Inventory, Other, Cosmetic Products Regulation, Annex III - Restricted Substances, Cosmetic Products Regulation, Annex V - Allowed Preservatives
Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides

Translated names
Alkil (C12-16) dimetilbenzil amonijev klorid (ADBAC/BKC (C12-16)) (hr)
Alkil (C12-16) dimetilbenzil amonio chloridas (ADBAC (C12-16)) (lt)
Alkil (C12-16) dimetilbenzilamonija hlorīds (ADBAC/BKC (C12-16)) (lv)
Alkil (C12-16)-chlorku dimetylobenzyloamonu (ADBAC/BKC (C12-16)) (pl)
Alkil (C12–16) dimetil-benzil-ammónium-klorid (ADBAC/BKC [C12–16]) (hu)
Alkil (C12–16) dimetilbenzil amonijev klorid (ADBAC/BKC (C12–16)) (sl)
Alkyl (C12-16) dimethylbenzyl ammonium chloride (ADBAC/BKC (C12-C16)) (mt)
Alkyl (C12-16) dimethylbenzyl ammonium chloride (ADBAC/BKC (C12-C16)) (no)
alkyl(C12-16)benzyldimetylamónium-chlorid [ADBAC/BKC (C12-C16)] (sk)
alkyl(C12-16)dimethylbenzylammoniumchlorid (ADBAC/BKC (C12-16)) (da)
Alkyl(C12-16)dimethylbenzylammoniumchlorid (ADBAC/BKC (C12-16)) (de)
alkyl(C12-16)dimethylbenzylammoniumchlorid (ADBAC/BKC (C12-C16)) (cs)
Alkyl(C12-16)dimethylbenzylammoniumchloride (ADBAC/BKC (C12-16)) (nl)
Alkyl(C12-16)dimetylbensylammoniumklorid (ADBAC/BKC (C12-C16)) (sv)
Alkyyli-(C12-16)-dimetyylibentsyyliammoniumkloridi (ADBAC/BKC (C12-16)) (fi)
C12–16-alküüldimetüülbensüülammooniumkloriid (ADBAC/BKC (C12–16)) (et)
Chlorure d'alkyl(C12-C16)diméthylbenzylammonium [ADBAC/BKC (C12-C16)] (fr)
Cloreto de alquil(C12-16)dimetilbenzilamónio (ADBAC/KBC C12-16) (pt)
Cloruro de C12-16-alquildimetilbencilamonio (ADBAC/BKC (C12-16)) (es)
Cloruro di alchil (C12-16) dimetilbenzilammonio (ADBAC/BKC (C12-C16)) (it)
Clorură de alchil (C12-16) dimetilbenzil amoniu [ADBAC/BKC (C12-C16)] (ro)
Χλωριούχο αλκυλο(C12-16)διμεθυλοβενζυλαμμώνιο (ADBAC/BKC (C12-C16)) (el)
Алкил(C12-16)диметилбензиламониев хлорид (ADBAC/BKC (C12-C16)) (bg)

CAS names
Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides

IUPAC names
Alkyl dimethyl benzyl ammonium chloride
benzyl-C12-16-alkyldimethyl, chlorides
Benzyl-dimethyl-tetradecyl azanium chloride
benzyl-dimethyl-tetradecylazanium chloride
dimethyl benzyl ammonium chloride
N-ALKYL(C12-16)-N,N-DIMETHYL-N-BENZYLAMMONIUM CHLORIDE
N-Alkyl-N,N-dimethyl-N-benzylammonium Chloride
N-benzyl-N,N-dimethyl-C12-16-(evennumbered)-alkyl-1-aminium chloride
N-Benzyl-N,N-dimethyltetradecan-1-aminium chloride
N-benzyl-N,N-dimethyltetradecan-1-aminium chloride
Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides
Quaternary ammoniumcompounds, benzyl-C12-16-alkyldimethyl, chlorides

Other identifiers
284043-23-8
Other
CAS number
284043-23-8
Other
Deleted CAS number
39403-41-3
Other
CAS number
39403-41-3
Other
Deleted CAS number
63449-42-3
Other
CAS number
63449-42-3
Other
Deleted CAS number
68424-85-1
CAS number
70294-44-9
Other
CAS number
70294-44-9
Other
Deleted CAS number


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EC / List no.: 269-919-4; CAS no.: 68391-01-5
CAS RN: 68391-01-5; Chemical Name: Quaternary ammonium compounds, benzyl-C12-18-alkyldimethyl,chlorides; Synonyms: benzyl-C12-18 -alkyldimethylammonium chlorides
Quaternary ammonium compounds, benzyl-C12-18-alkyldimethyl, chlorides
This substance is identified by SDA Substance Name: C12-C18 alkyl benzyl dimethyl ammonium chloride and SDA

Substance names and other identifiers
Expand all Collapse all
Regulatory process names
(C12-C18) Alkyldimethylbenzyl ammonium chloride
(C12-C18)Alkylbenzyldimethylammonium chloride
Alkyl (C12-18) dimethylbenzyl ammonium chloride (ADBAC (C12-18))
Alkyl(C12-C18)benzyldimethylammonium chloride
C12-18-Alkyldimethylbenzyl ammonium chlorides
N-Alkyl dimethyl benzyl ammonium chloride (C12-C18)
Quaternary ammonium compounds, benzyl-C12-18-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C12-18-alkyldimethyl, chlorides
SDA 16-052-00

Translated names
Alkil (C12-18) chlorku dimetylobenzyloamonu (ADBAC (C12-18)) (pl)
Alkil (C12-18) dimetilbenzil amonijev klorid (ADBAC (C12-18) (hr)
Alkil (C12-18) dimetilbenzil amonio chloridas (ADBAC (C12-18)) (lt)
Alkil (C12-18) dimetilbenzilamonija hlorīds (ADBAC (C12-18)) (lv)
Alkil (C12–16) dimetil-benzil-ammónium-klorid (ADBAC [C12–18]) (hu)
Alkil (C12–18) dimetilbenzil amonijev klorid (ADBAC (C12–18)) (sl)
Alkyl (C12-18) dimethylbenzyl ammonium chloride (ADBAC (C12-18)) (mt)
Alkyl (C12-18) dimethylbenzyl ammonium chloride (ADBAC (C12-18)) (no)
alkyl(C12-18)benzyldimetylamónium-chlorid [ADBAC (C12-18)] (sk)
alkyl(C12-18)dimethylbenzylammoniumchlorid (ADBAC (C12-18)) (cs)
alkyl(C12-18)dimethylbenzylammoniumchlorid (ADBAC (C12-18)) (da)
Alkyl(C12-18)dimethylbenzylammoniumchlorid (ADBAC (C12-18)) (de)
Alkyl(C12-18)dimethylbenzylammoniumchloride (ADBAC (C12-18)) (nl)
Alkyl(C12-18)dimetylbensylammoniumklorid (ADBAC (C12-18)) (sv)
Alkyyli-(C12-18)-dimetyylibentsyyliammoniumkloridi (ADBAC(C12-18)) (fi)
C12–18-alküüldimetüülbensüülammooniumkloriid (ADBAC (C12–18)) (et)
Chlorure d'alkyl(C12-C18)diméthylbenzylammonium [ADBAC (C12-18)] (fr)
Cloreto de alquil(C12-18)dimetilbenzilamónio (ADBAC C12-18) (pt)
Cloruro de C12-18-alquildimetilbencilamonio (ADBAC (C12-18)) (es)
Clorură de alchil (C12-18) dimetilbenzil amoniu [ADBAC (C12-18)] (ro)
Composti di ammonio quaternario, benzil- C12-18 -alchildimetil, cloruri (ADBAC (C12-18) (it)
Χλωριούχο αλκυλο(C12-18)διμεθυλοβενζυλαμμώνιο (ADBAC (C12-18)) (el)
Алкил(C12-18)диметилбензиламониев хлорид (ADBAC (C12-18)) (bg)

IUPAC names
ALKYL DIMETHYL BENZYL AMMONIUM CHLORIDE
Alkyl Dimethyl Benzyl Ammonium Chloride
Alkyldimethylbenzyl ammonium chloride
Benzalkonium Chloride
Benzalkonium chloride
benzyl-dimethyl-tetradecylazanium chloride
C12-C18 alkyl benzyl dimethyl ammonium chloride
N-benzyl-N,N-dimethyl-C12-18-(evennumbered)-alkyl-1-aminium chloride
N-benzyl-N,N-dimethyltetradecan-1-aminium chloride
Quaternary ammonium compounds, benzyl-C12-18-alkyldimethyl, chlorides

Other identifiers
56939-83-4
Other
CAS number
68391-01-5
CAS number
68424-86-2
Other
CAS number
959428-18-3
Other
CAS number

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EC / List no.: 271-754-8; CAS no.: 68607-20-5
CAS RN: 68607-20-5; Chemical Name: Quaternary ammonium compounds, benzyl-C16-18-alkyldimethyl,chlorides; Synonyms: benzyl-C16-18 -alkyldimethylammonium chlorides
Quaternary ammonium compounds, benzyl-C16-18-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C16-C18 (even numbered)-alkyldimethyl, chlorides
This substance is identified by SDA Substance Name: C16-C18 alkyl benzyl dimethyl ammonium chloride and SDA

Substance names and other identifiers
Regulatory process names
C16-18-Alkyldimethylbenzyl ammonium chlorides
C16-C18 Alkylbenzyldimethylammonium chloride
Quaternary ammonium compounds, benzyl(hydrogenated tallow alkyl)dimethyl, chlorides
Quaternary ammonium compounds, benzyl-C16-18-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C16-18-alkyldimethyl, chlorides
Pre-Registration process, Other
IUPAC names
Quaternary ammonium compounds, benzyl-C16-18-alkyldimethyl, chlorides
68607-20-5


Substance names and other identifiers
CAS names
Quaternary ammonium compounds, benzyl-C16-18-alkyldimethyl, chlorides

IUPAC names
C16-18 ADBAC; Quaternary ammonium compounds, benzyl(hydrogenated tallow alkyl)dimethyl, chlorides
C16-C18 ADBAC
Quaternary ammonium compounds, benzyl C16-C18-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl(hydrogenated tallow alkyl)dimethyl, chlorides
Quaternary ammonium compounds, benzyl-C16-C18 (even numbered)-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C16-C18 (even numbered)-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C16-C18 (even numbered)-alkyldimethyl, chlorides (C16-18 ADBAC)

Trade names
NORAMIUM
Other identifiers
68607-20-5
Other
CAS number

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EC/List no.: 293-524-6; CAS no.: 91080-31-8
Quaternary ammonium compounds, benzyl-C16-22-alkyldimethyl, chlorides
CAS RN: 91080-31-8; Chemical Name: Quaternary ammonium compounds, benzyl-C16-22-alkyldimethyl,chlorides; Synonyms: benzyl-C16-22 -alkyldimethylammonium chlorides

Substance names and other identifiers
Regulatory process names
Quaternary ammonium compounds, benzyl-C16-22-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C16-22-alkyldimethyl, chlorides
IUPAC names
Quaternary ammonium compounds, benzyl-C16-22-alkyldimethyl, chlorides
Other identifiers
91080-31-8

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EC / List no.: 263-085-5; CAS no.: 61789-75-1
CAS RN: 61789-75-1; Chemical Name: Quaternary ammonium compounds, benzyldimethyltallow alkyl, chlorides; Synonyms: benzyl(tallow alkyl)dimethylammonium chloride
Quaternary ammonium compounds, benzyldimethyltallow alkyl, chlorides

Substance names and other identifiers
Regulatory process names
Quaternary ammonium compounds, benzyldimethyltallow alkyl, chlorides

IUPAC names
Quaternary ammonium compounds, benzyldimethyltallow alkyl, chlorides
Other identifiers
61789-75-1


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EC / List no.: 263-081-3; CAS no.: 61789-72-8
CAS RN: 61789-72-8; Chemical Name: Quaternary ammonium compounds, benzyl(hydrogenated tallow alkyl)dimethyl,chlorides; Synonyms: benzyl(hydrogenated tallow alkyl)dimethylammonium chloride
Quaternary ammonium compounds, benzyl(hydrogenated tallow alkyl)dimethyl, chlorides

Substance names and other identifiers
Regulatory process names
Quaternary ammonium compounds, benzyl(hydrogenated tallow alkyl)dimethyl, chlorides

IUPAC names
Quaternary ammonium compounds, benzyl(hydrogenated tallow alkyl)dimethyl, chlorides
Other identifiers
61789-72-8


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EC / List no.: 263-080-8; CAS no.: 61789-71-7
CAS RN: 61789-71-7; Chemical Name: Quaternary ammonium compounds, benzylcoco alkyldimethyl, chlorides; Synonyms: benzyl(coconut oil alkyl)dimethylammonium chloride
Quaternary ammonium compounds, benzylcoco alkyldimethyl, chlorides

Substance names and other identifiers
Regulatory process names
Quaternary ammonium compounds, benzylcoco alkyldimethyl, chlorides

IUPAC names
benzyl-dimethyl-tridecylazanium chloride
Coco alkyl dimethyl benzyl ammonium chloride
Coco dimethyl benzyl ammonium chloride
Quaternary ammonium compounds, benzylcoco alkyldimethyl, chlorides

Other identifiers
102381-25-9
Other
CAS number
1082816-13-4
Other
CAS number
152618-11-6
Other
CAS number
159704-21-9
Other
CAS number
56573-46-7
Other
CAS number
61789-71-7
CAS number
8043-48-9
Other


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EC / List no.: 263-083-4; CAS no.: 61789-74-0
CAS RN: 61789-74-0; Chemical Name Quaternary ammonium compounds, benzyldimethylsoya alkyl, chlorides; Synonyms: benzyl(soybean oil alkyl)dimethylammonium chloride
Quaternary ammonium compounds, benzyldimethylsoya alkyl, chlorides
Substance names and other identifiers

Regulatory process names
Quaternary ammonium compounds, benzyldimethylsoya alkyl, chlorides
Quaternary ammonium compounds, benzyldimethylsoya alkyl, chlorides
IUPAC names
Quaternary ammonium compounds, benzyldimethylsoya alkyl, chlorides
Other identifiers
61789-74-0


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No CAS:  8001-54-5, Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides, Alkyldimethylbenzylammonium chloride, ammonium, alkylbenzyldimethyl-,chloride, Benzalkonium Chlorid, Benzalkonium chloride, Benzalkónium-klorid, benzyl-dimethyl-tetradecylazanium chloride, benzyl-dodecyl-dimethylazanium chloride, N-alkyl(C8-C16)dimethylbenzylammonium chlorideLe chlorure de benzalkonium, aussi connu sous le nom de chlorure d'alkyldiméthylbenzylammonium et ADBAC, est un mélange de chlorures d'alkylbenzyldiméthylammonium avec des chaînes carbonées de longueur variable. Ce produit est un agent de surface cationique de la famille des ammoniums quaternaires.Le chlorure de benzalkonium, aussi connu sous le nom de chlorure d'alkyldiméthylbenzylammonium et ADBAC, est un mélange de chlorures d'alkylbenzyldiméthylammonium avec des chaînes carbonées de longueur variable2. Ce produit est un agent de surface cationique de la famille des ammoniums quaternaires.Le chlorure de benzalkonium est facilement soluble dans l'éthanol et l'acétone. Bien que la dissolution dans l'eau soit lente, les solutions aqueuses sont plus faciles d'emploi et sont plus largement utilisées. Les solutions devraient être neutres à légèrement basiques avec une couleur allant de l'incolore au jaune pâle. Les solutions moussent fortement lorsqu'elles sont secouées1, ont un goût amer et ont une odeur d'amande détectable seulement dans les échantillons concentrés.Les applications sont très variées, allant de la formulation de désinfectants à l'inhibition de « corrosion microbienne » dans le pétrole ou les huiles minérales3. Il est utilisé dans les produits pharmaceutiques tels que les solutions cutanées antiseptiques ou les lingettes. L'activité biocide la plus importante est associée aux dérivés alkylés en C12 à C14. On pense que le mécanisme bactéricide est dû à la disruption des interactions intermoléculaires. Ceci peut causer la dissociation des lipides dans la membrane cellulaire, ce qui compromet la perméabilité de la cellule et induit une fuite de son contenu. D'autres complexes biomoléculaires à l'intérieur de la cellule bactérienne peuvent aussi se dissocier. Les enzymes, qui contrôlent les activités respiratoires et métaboliques de la cellule, sont particulièrement susceptibles d'être désactivées.

Les solutions de chlorure de benzalkonium sont des agents bactéricides à action rapide et de durée modérément longue. Ils sont actifs contre certains et certaines bactéries, virus, fungi et protozoaires. Les spores des bactéries sont considérées comme résistantes. Les bactéries à Gram positif sont généralement plus sensibles que les Gram négatif. L'activité n'est pas grandement influencée par le pH, mais augmente aux températures élevées et avec la durée d'exposition.

De nouvelles formulations utilisant du benzalkonium mélangé à d'autres ammoniums quaternaires peuvent être utilisées pour étendre le spectre biocide et augmenter l'efficacité du désinfectant. Cette technique a été utilisée pour améliorer l'activité virucide.

L'utilisation d'excipients appropriés peut améliorer l'efficacité et les propriétés détergentes, et éviter la désactivation lors de l'utilisation. La formulation requiert beaucoup de soin car les solutions de benzalkonium peuvent être désactivées en présence de contaminants organiques et inorganiques. Les solutions sont incompatibles avec les savons, les nitrates1 et ne doivent pas être mélangées avec des surfactants anioniques. Les sels des eaux dures peuvent aussi réduire l'activité biocide. Comme pour tous les désinfectants, il est recommandé de traiter des surfaces sans saletés visibles.

Bien que des niveaux dangereux ne puissent être atteints dans les conditions d'utilisation normale, le benzalkonium et les autres détergents peuvent être néfastes aux organismes marins. Les désinfectants à base d'ammoniums quaternaires sont actifs à faible concentration, si bien que des doses excessives devraient être évitées.Noms français :

ALKYL DIMETHYL BENZYL AMMONIUM CHLORIDE
Chlorure d'alkyldiméthyl benzylammonium
Chlorure d'alkyldiméthylbenzylammonium
Chlorure d'alkylebenzyldiméthylammonium
Chlorure de benzalkonium
CHLORURE DE N-ALKYL DIMETHYL BENZYL AMMONIUM
Chlorure de N-alkyle (C8-C18) N,N-Diméthyle benzylammonium
CHLORURE DE N-ALKYLE N,N-DIMETHYLE BENZYLAMMONIUM
Noms anglais :

ALKYL (C8H17 TO C18H37)DIMETHYLBENZYL AMMONIUM CHLORIDE
ALKYL BENZYL DIMETHYL AMMONIUM CHLORIDE
ALKYL DIMETHYLBENZYL AMMONIUM CHLORIDE
ALKYLDIMETHYL(PHENYLMETHYL)QUATERNARY AMMONIUM CHLORIDE
ALKYLDIMETHYLBENZYLAMMONIUM CHLORIDE
Benzalkonium chloride
Benzylalkonium chloride
N-ALKYL DIMETHYL BENZYL AMMONIUM CHLORIDE
N-ALKYL(C8-C18) N,N-DIMETHYL BENZYLAMMONIUM CHLORIDE
N-ALKYL-N,N-DIMETHYLBENZYLAMMONIUM CHLORIDE
Utilisation et sources d'émission: Germicide, agent antiseptique; Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides

IUPAC names
Alkyldimethylbenzylammonium chloride
ammonium, alkylbenzyldimethyl-,chloride
Benzalkonium Chlorid
Benzalkonium chloride
Benzalkonium Chloride 
Benzalkonium chloride, alkyl distribution C8-C16
Benzalkónium-klorid
benzyl-dimethyl-tetradecylazanium chloride
benzyl-dodecyl-dimethylazanium chloride
N-alkyl(C8-C16)dimethylbenzylammonium chloride
Germicide, agent antiseptique;  Benzenemethanaminium, N,N-dimethyl-N-tridecyl-, chloride (1:1) [ACD/Index Name]
Chlorure de N-benzyl-N,N-diméthyl-1-tridécanaminium [French] [ACD/IUPAC Name]
N-Benzyl-N,N-dimethyl-1-tridecanaminium chloride [ACD/IUPAC Name]
N-Benzyl-N,N-dimethyl-1-tridecanaminiumchlorid [German]
N-Benzyl-N,N-dimethyltridecan-1-aminium chloride
Ark Klens
Benzenemethanaminium, N,N-dimethyl-N-tridecyl-, chloride
Benzenemethanaminium,N,N-dimethyl-N-tridecyl-, chloride (1:1)
benzyldimethyl(tridecyl)ammonium chloride
BENZYLDIMETHYLTRIDECYLAZANIUM CHLORIDE
dodecylbenzyltrimethylammonium chloride


BAC 50, BAC 80, BKC 50, BKC 80, N° CAS : 63449-41-2. Principaux synonymes. Noms français : Chlorures d'ammonium quaternaires, benzyl (C8-C18)-alkyldiméthyl; Noms anglais :Quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides. (C8-18)alkylbenzyldimetylammoniumklorid (no); (C8-18)alkyylibentsyylidimetyyliammoniumkloridi (fi); chlorki czwartorzedowych zwiazków amoniowych - chlorki benzylo(C8-18)alkilodimetyloamonium (pl); composti di ammonio quaternario, benzil-C8-18-alchildimetil, cloruri (it); compostos de amónio quaternário, benzil-C8-18-alquildimetil, cloretos (pt); composés de l'ion ammonium quaternaire, alkyl en C8-18 benzyldiméthyles, chlorures (fr); compuestos de amonio cuaternario, bencil-C8-18-alquildimetil, cloruros (es); compusi de amoniu cuaternari, benzil-C8-18-alildimetil, cloruri (ro); ketvirtiniai amonio junginiai, benzil-C8-18-alkildimetil-, chloridai (lt); kvarterne amonijeve spojine, benzil-C8-18-alkildimetil kloridi (sl); kvarterni amonijevi spojevi,benzil-C8-18-alkildimetil, kloridi (hr); kvarterní amoniové sloučeniny, alkyl(C8-C18)(benzyl) dimethylamonium-chlorid (cs); kvartérne amóniové zlúčeniny, (C8-18-alkyl)(benzyl)di(metyl)amónium-chloridy (sk); Kvaternaarsete bensüül-C 8-18-alküüldimetüülammooniumiühendite kloriidid (et); kvaterner ammónium vegyületek, benzil-C8-18-alkildimetilammónium-klorid (hu); kvaternääriset ammoniumyhdisteet, bentsyyli-C8-18-alkyylidimetyylikloridit (fi); kvaternære ammoniumforbindelser, benzyl-C8-18-alkyldimethyl-, chlorider (da); kvaternære ammoniumforbindelser, benzyl-C8-18-alkyldimetyl, klorider (no); quaternaire ammoniumverbindingen, benzyl-C8-18-alkyldimethyl, chloriden (nl); Quaternäre Ammoniumverbindungen, Benzyl-C8-18-alkyldimethyl-, Chloride (de); četraizvietotie amonija savienojumi, benzil-C8-C18-alkildimetil-hlorīdi (lv); χλωρίδια των βενζυλο-C8-18-αλκυλοδιμεθυλο τεταρτοταγών ενώσεων αμμωνίου (el); кватернерни амониеви съединения, бензил-C8-18-aлкилдиметил, хлориди (bg). 213-521-5 [EINECS]; 264-151-6 [EINECS]; 3578562; 63449-41-2 [RN]; Benzenemethanaminium, N-decyl-N,N-dimethyl-, chloride
Benzenemethanaminium, N-decyl-N,N-dimethyl-, chloride (1:1) ; Benzyldecyldimethylammonium chloride; Benzyldimethyldecylammonium chloride; Chlorure de N-benzyl-N,N-diméthyl-1-décanaminium [French]; N-Benzyl-N,N-dimethyl-1-decanaminium chloride; N-Benzyl-N,N-dimethyl-1-decanaminiumchlorid [German]; N-benzyl-N,N-dimethyldecan-1-aminium chloride; [63449-41-2]; ammonium compounds, quaternary, benzyldecyldimethyl-, chloride; ammonium compounds, quaternary, benzyldimethyldecyl-, chloride;BENZALKONIUM CHLORIDE, PH EUR, 95-104%; benzyl(decyl)dimethylammonium chloride; benzyl(decyl)dimethylazanium chloride; BENZYLDECYLDIMETHYLAMMONIUMCHLORIDE; benzyl-decyl-dimethylazanium; benzyl-decyl-dimethylazanium and chloride; benzyl-decyl-dimethylazanium chloride; benzyl-decyl-dimethylazanium;chloride; Benzyldimethyl decylammonium chloride; Chloride; decyldimethylbenzylammonium chloride; MFCD00145757 [MDL number]; N-Benzyl-N-decyl-N,N-dimethylammonium chloride; N-Benzyl-N-decyl-N,N-dimethylammoniumchloride. Le chlorure de benzalkonium, aussi connu sous le nom de chlorure d'alkyldiméthylbenzylammonium et ADBAC, est un mélange de chlorures d'alkylbenzyldiméthylammonium avec des chaînes carbonées de longueur variable. Ce produit est un agent de surface cationique de la famille des ammoniums quaternaires.Le chlorure de benzalkonium est facilement soluble dans l'éthanol et l'acétone. Bien que la dissolution dans l'eau soit lente, les solutions aqueuses sont plus faciles d'emploi et sont plus largement utilisées. Les solutions devraient être neutres à légèrement basiques avec une couleur allant de l'incolore au jaune pâle. Les solutions moussent fortement lorsqu'elles sont secouées, ont un goût amer et ont une odeur d'amande détectable seulement dans les échantillons concentrés.Les applications sont très variées, allant de la formulation de désinfectants à l'inhibition de « corrosion microbienne » dans le pétrole ou les huiles minérales3. Il est utilisé dans les produits pharmaceutiques tels que les solutions cutanées antiseptiques ou les lingettes. Il est utilisé comme conservateur dans les cosmétiques tels que les gouttes pour les yeux et le nez. On a reporté des cas de sensibilisations associées à l'utilisation continue et prolongée du produit. Il faut mettre des gants avant toute utilisation. On pense que le mécanisme bactéricide est dû à la disruption des interactions intermoléculaires. Ceci peut causer la dissociation des lipides dans la membrane cellulaire, ce qui compromet la perméabilité de la cellule et induit une fuite de son contenu. D'autres complexes biomoléculaires à l'intérieur de la cellule bactérienne peuvent aussi se dissocier. Les enzymes, qui contrôlent les activités respiratoires et métaboliques de la cellule, sont particulièrement susceptibles d'être désactivées.

Les solutions de chlorure de benzalkonium sont des agents bactéricides à action rapide et de durée modérément longue. Ils sont actifs contre certains protozoaires, virus, bactéries et fungi. Les spores des bactéries sont considérées comme résistantes. Les bactéries à Gram positif sont généralement plus sensibles que les Gram négatif. L'activité n'est pas grandement influencée par le pH, mais augmente aux températures élevées et avec la durée d'exposition.

De nouvelles formulations utilisant du benzalkonium mélangé à d'autres ammoniums quaternaires peuvent être utilisées pour étendre le spectre biocide et augmenter l'efficacité du désinfectant. Cette technique a été utilisée pour améliorer l'activité virucide.

L'utilisation d'excipients appropriés peut améliorer l'efficacité et les propriétés détergentes, et éviter la désactivation lors de l'utilisation. La formulation requiert beaucoup de soin car les solutions de benzalkonium peuvent être désactivées en présence de contaminants organiques et inorganiques. Les solutions sont incompatibles avec les savons, les nitrates1 et ne doivent pas être mélangées avec des surfactants anioniques. Les sels des eaux dures peuvent aussi réduire l'activité biocide. Comme pour tous les désinfectants, il est recommandé de traiter des surfaces sans saletés visibles.

Bien que des niveaux dangereux ne puissent être atteints dans les conditions d'utilisation normale, le benzalkonium et les autres détergents peuvent être néfastes aux organismes marins. Les désinfectants à base d'ammoniums quaternaires sont actifs à faible concentration, si bien que des doses excessives devraient être évitées.

Le chlorure de benzalkonium a aussi une activité spermicide.Solubilité Très soluble dans l'eau, l'alcool, l'acétone ;
Presque insoluble dans l'éther ;
1g d'anhydre dans 6ml de benzène, 100ml d'éther1

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