BENZOPHENONE-4

Benzophenone-4 = Sulisobenzone = 5-Benzoyl-4-hydroxy-2-methoxybenzene-1-sulfonic acid


EC / List no.: 223-772-2
CAS no.: 4065-45-6
Mol. formula: C14H12O6S

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid
5-benzoyl-4-hydroxy-2-methoxybenzene sulfonic acid
benzophenone-4
BP-4 benzophenone
sulisobenzone
sulisobenzone, monosodium salt
Uval

Synonyms : 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid, Sulisobenzone, 3-Benzoyl-4-hydroxy-6-methoxybenzenesulfonic acid,Sulsisobenzone, 5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid, Sungard, Benzophenone 4, Uval, Cyasorb UV 284, Uvinul MS-40, Spectra-Sorb UV 284, Uvistat 1121


Benzophenone-4 is also known as sulisobenzone and is typically an ingredient in most sunscreens. Benzophenone-4 is used as a skin protectant from damage by short-wave UVA ultraviolet light and UVB. 


Benzophenone-4 is an ingredient found in bath, makeup, hair, sunscreens, and skin care products.

Sulisobenzoneis a UV filter which protects the skin from damage by UVB and short-wave UVA ultraviolet light Used in the preparation of sunscreen agents.
Benzophenone-4 is a water soluble UVB absorber and is also commonly used to protect formulations from degradation due to UV exposure. 
In combination with UVA absorbers, it offers broad spectrum protection against UV radiation for skin and hair.

Benzophenone-4 is photostabilizer and sunscreen agent used for its ability to absorb UV rays. 
Benzophenone-4 helps prevent the integrity of other cosmetic ingredients from deteriorating under the sun. 
Though Benzophenone-4 covers UVB and short UVA (UVA-2) range rays, it's an inadequate sunscreen agent when used alone. 
For this reason, Benzophenone-4 is often used in conjunction with other sun protecting ingredients. 
Benzophenone-4 is used in a variety of personal care products like sunscreen, nail polish, lotion/cream and lipstick.


Benefits of Benzophenone-4
When combined with an oil-soluble UV absorber, Benzophenone-4 enables formulations with very high Sun Protection Factor (SPF).
Benzophenone-4 prevents natural- and synthetic hair dyes from fading in the sun.
Benzophenone-4 stabilizes fragrances and active ingredients against degradation or oxidation.
Benzophenone-4 decreases the light sensitivity of wool and pesticides.
Instead of penetrating the skin to a large degree, Benzophenone-4 enhances the ability of other ingredients to penetrate.

Benzophenone 4 is an ingredient in some sunscreens which protects the skin from damage by UVB and UVA ultraviolet light. It is a water soluble broad band UV‐filter. It has worldwide approval for skin protection and it is widely used in sun preparations. It can also offer protection of colorants against fading and help stabilize fragrances and active ingredients against oxidation.

Benzophenone-4


Applications
Bath products
Cosmetics
Fragrance
Hair care
Skin care
Sunscreens


PROPERTIES

Solubility (at 5 % solution using the    : Soluble in water, Propylene Glycol, Glycerin, desired solvent, Ethyl alcohol and Isopropyl alcohol
Insoluble in Mineral oil and Isopropyl Myristate


Benzophenone-4 is readily soluble in water because of the presence of sulfonic acid group. The sulfonic acid group must be neutralized with one of the usual neutralizing agents like triethanolamine or sodium hydroxide.

It must be noted that the neutralizing agent has no effect on the UV-absorption characteristics. 
However, in case of over neutralization (pH > 9), the absorption shifts towards shorter wavelength. 
The colour of Benzophenone-4 is intensified by neutralization and thus it may alter the hue of coloured solutions.
The neutralized product has a pH value between 5.5 and 6.0.


APPEARANCE:
White to light beige crystalline powder


FUNCTION:
Benzophenone-4  is a photostabilizer and sunscreen agent used for its ability to absorb UV rays. 
Benzophenone-4  helps prevent the integrity of other cosmetic ingredients from deteriorating under the sun.

SYNONYMS:
Benzophenone 4, Uniphenone 4, 2-Hydroxy-4-Methoxybenzophenone-5-Sulfonic Acid; Benzophenone,4-bromo- (6CI,7CI,8CI); 1-Benzoyl-4-bromobenzene; 4-Bromobenzophenone

STORAGE:
Store in a cool, dry, well-ventilated place at room temperature.

APPLICATIONS

Benzophenone-4 is used as a UV-filter in sunscreen formulations. To get highest Sun Protection Factor (SPF), a combination of Benzophenone-4 with other oil- soluble UV-filters like Benzophenone-3 is recommended.

Benzophenone-4 can also be used in other applications like:

•    As a colourant protector in transparent packaging (the recommended concentration is 0.05 – 0.5%)
•    As a viscosity stabilizer for gels based on polyacrylic acid (Carbopol) when exposed to UV- radiation (the recommended concentration is 0.1%)
•    As a stabilizer for fragrance oils in conditioning shampoos and body cleansers
•    As a protector of hair against the ill effects of UV radiation in hair gels, shampoos and hair setting lotions, mousses and sprays
 
Benzophenone-4

Benzophenone-4 protects products from deterioration by absorbing, reflecting, or scattering UV rays. 
When used as sunscreen ingredients, Benzophenone-4 protects the skin and the hair from UV rays.

NOTES: Benzophenone-4 uses and applications include: UV absorber in cosmetics, sunscreens, hair products for dyed and tinted hair, pharmaceuticals; light stabilizer for plastics, leather, and textile fibers; viscous stabilizer for gels based on polyacrylic acid exposed to UV radiation

CLASS: Specialty Chemicals 

FUNCTIONS: UV Absorber,  Acid,  Stabilizer 

INDUSTRY: Cosmetic,  Pharmaceutical,  Plastics 

•    As a protection against the sunburn in aqueous based formulations
•    As a colour fastness improver of dye fabrics in textiles
•    As a preventer of yellowing of wool
•    As a preventer of discolouration of synthetic fibers

It must be noted that Benzophenone-4 is incompatible with Magnesium salts, particularly in W/O type emulsions


- Sunscreen UVB protection 

Benzophenone is used as an ultraviolet curing agent, flavor ingredient, fragrance enhancer and perfume fixative, and as an additive for plastics, coatings and adhesive formulations. Benzophenone is also used as a screen to prevent ultraviolet light-induced damage to cosmetics. Benzophenone-4 provides inadequate UVB protection when used alone. Does not penetrate the skin to a large degree, but enhances the ability of other ingredients to penetrate. Helps to stabilize UV sensitive formulations such as hair dyes, hair sprays and color enhanced formulations.

Benzophenone-4 is a water soluble broad UV-filter. It has worldwide approval for skin protection and it is widely used in sun preparations. It can also offer protections of  colorants against fading and help stabilize fragrances and active ingredients against oxidation.

FORMULATING :

Benzophenone-4 is approved world, the maximum concentration in ready for use preparation various according to local legislation.
The sulfonic acid group makes Benzophenone-4 soluble in water, these acid group must be neutralized with one of the usual neutralizing agents,e.g.Na OH. 
The yellow color of benzopheonone-4 is intensified bu neutralization, this may change the coloration of the solution.
It should be noted that Benzophenone-4 is not compatible with magnesium salts.  


Sulisobenzone is an ingredient in some sunscreens which protects the skin from damage by UVB and short-wave UVA ultraviolet light.

Properties & Applications:

•Water-soluble
•A secondary UVB absorber with activity in UVA region 
•Protects colorants against fading   
•Helps stabilize fragrances and active ingredients against oxidation  
•For anti-aging face care products and sunscreens  

Max concentration:6 % (EC)          10 % (US,AUS,JP)


Benzophenone 4 is an ingredient found in bath, makeup, hair, sunscreens, and
skin care products.

„ 1-Phenol-4-sulfonic acid, 2-benzoyl5-methoxy- (6CI)
„ 2-Hydroxy-4-
methoxybenzophenone-5-sulfonic acid
„ 5-Benzoyl-4-hydroxy-2-
methoxybenzenesulfonic acid
„ BRN 2889165
„ Benzophenone 4
„ EINECS 223-772-2
„ HSDB 7422
„ MS 40
„ NSC 60548
„ Seesorb 101S
„ Spectra-Sorb UV 284
„ Sulisobenzona
„ Sulisobenzona [INN-Spanish]
„ Sulisobenzone
„ Sulisobenzonum
„ Sulisobenzonum [INN-Latin]
„ Sungard
„ Syntase 230
„ Uval
„ Uvinuc ms 40
„ Uvinul
„ Uvinul MS 40 


Preferred IUPAC name: 5-Benzoyl-4-hydroxy-2-methoxybenzene-1-sulfonic acid
Other names: Benzophenone-4, Sulisobenzone


Benzophenone-4 is a white or pale yellow powder. 
Benzophenone-4 is used in bath products, makeup products, hair products, sunscreens and skin care products to protect cosmetics and personal care products from deterioration by absorbing, reflecting, or scattering UV rays. 
When used as a sunscreen ingredient, Benzophenone-4 protects the skin from UV rays.

Sulisobenzone (benzophenone-4) is an ingredient in some sunscreens which protects the skin from damage by UVB and UVA ultraviolet light.

Its sodium salt, sulisobenzone sodium, is also referred to as benzophenone-5.


Sulisobenzone is approved by the FDA in concentrations of up to 10% and in Canada, is approved by Health Canada at the same concentrations. 
Sulisobenzone works to filter out both UVA and UVB rays, protecting the skin from sun UV damage. 
The UV-filter substance, sulisobenzone (BP-4) is widely used an ingredient in sunscreens and other personal care products
It falls under the drug category of benzophenones.
The benzophenones are a group of aromatic ketones that have both pharmaceutical and industrial applications. 
Benzophenones may be found organically in fruits such as grapes. 
Benzophenones are used as photoinitiators, fragrance enhancers, ultraviolet curing agents, and, occasionally, as flavor ingredients; they are also used in the manufacture of insecticides, agricultural chemicals, and pharmaceuticals and as an additive for plastics, coatings, and adhesives. 
As a group, benzophenones may be used to delay photodegradation or extend shelf life in toiletries and plastic surface coatings.

Where is benzophenone found?


PHARMACEUTICAL USE:
Sunscreen
Perfume
Soap and detergent bar
Lip balm
Nail polish
Hair spray and hair dye
Body and face cleanser/cream/lotion
Shampoo
Anxiolytic and hypnotic drug

INDUSTRIAL USE:
Paint, varnish and lacquer
Pesticide
Textile and plastic
Ink
Adhesive and coating
Optical fibre
Printed circuit board


The four main benzophenone derivatives that have been used widely in sunscreens and cosmetics are listed below. 
They share similar chemical and physical properties. Often benzophenone is used in combination with other chemical absorbing sunscreens to augment and stabilise the final product.

Benzophenone 3 (2-hydroxy-4-methoxyphenyl: oxybenzone)
Benzophenone 4 (2-hydroxy-4-methoxy benzophenone-5-sulfonic acid: sulisobenzone)
Benzophenone 8 (2,2-dihydroxy-4-methoxybenzophenone: dioxybenzone)
Benzophenone 10 (2-hydroxy-4-methoxy-4-methylbenzophenone: mexenone)

Chemical formula: C14H12O6S
Molar mass: 308.31 g/mol
Appearance: Light-tan powder
Melting point: 145 °C (293 °F; 418 K)
Solubility in water: 1 g per 4 mL

Its functions (INCI)
UV Absorbent: Protects the cosmetic product against the effects of UV light
UV filter: Allows you to filter certain UV rays in order to protect the skin or hair from the harmful effects of these rays.

Sulisobenzone is approved by the FDA in concentrations of up to 10% and in Canada, is approved by Health Canada at the same concentrations. 
It works to filter out both UVA and UVB rays, protecting the skin from sun UV damage.

The UV-filter substance, sulisobenzone (BP-4) is widely used an ingredient in sunscreens and other personal care products. 
It falls under the drug category of benzophenones. The benzophenones are a group of aromatic ketones that have both pharmaceutical and industrial applications. 
Benzophenones may be found organically in fruits such as grapes.

Benzophenones are used as photoinitiators, fragrance enhancers, ultraviolet curing agents, and, occasionally, as flavor ingredients; they are also used in the manufacture of insecticides, agricultural chemicals, and pharmaceuticals and as an additive for plastics, coatings, and adhesives.

As a group, benzophenones may be used to delay photodegradation or extend shelf life in toiletries and plastic surface coatings.


Pharmacodynamics
Benzophenone sunscreens, applied topically, protect the skin from these harmful effects of ultraviolet light by chemically absorbing light energy (photons). 
Correct use of sunscreens serves to reduce the risk of sunburn. 
Sunscreen agents prevent the occurrence of squamous-cell carcinoma of the skin when used mainly during unintentional sun exposure. 
No conclusion can be drawn about the cancer-preventive activity of topical use of sunscreens against both basal-cell carcinoma and cutaneous melanoma. 
Use of sunscreens can extend the duration of intentional sun exposure, such as bathing in the sun.

Mechanism of action
A surface coating of benzophenones decreases the amount of UV radiation absorbed by the skin by limiting the total amount of energy that reaches the skin.

Benzophenone sunscreens, applied topically, protect the skin from these harmful effects of ultraviolet light by chemically absorbing light energy (photons). As this occurs, the benzophenone molecule becomes activated to higher energy levels. As the excited molecule returns to its ground state, the energy is released in the form of thermal energy. The hydroxyl group in the ortho position to the carbonyl group is believed to be a structural requirement for the benzophenones' absorption of UV light. This structural arrangement also contributes to the electronic stability of the molecule. Benzophenones absorb energy throughout the UV range, although the maximum UV absorbance is between 284 and 287 nm for the 2-hydroxybenzophenones 


BENZOPHENONE-4 is a water-soluble, chemical sunscreen agent that is a secondary UVB absorber with some activity in the short UVA range as well. 
Being a secondary UV absorber means that its protection is weak and it has to be combined with other sunscreen filters for proper sun protection. 

More often than not, Benzophenone-4 is not only used as a sunscreen agent but also as a photoprotectant to extend product shelf life, or as a color-protectant for products in clear packages. 


BENZOPHENONE-4
BENZOPHENONE-4 is classified as :
Uv absorber
Uv filter
CAS Number    4065-45-6
EINECS/ELINCS No:    223-772-2
Restriction (applies to EU only):    VII/22
COSING REF No:    32143
INN Name:    sulisobenzone
Chem/IUPAC Name:    5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid


Substance name : Sulisobenzone


Benzophenone-4 acts as a UV filter sunscreen agent. It is a photostable broadband UV absorber (UVA II and UVB). It forms a protective layer on hair and helps to prevent hair damage due to UV exposure, such as, color-fading & dryness. It is commonly used as a color protectant. 
Benzophenone-4 is used in sun care, liquid soap, hair styling, shampoo and shower products.

Claims    
Sunscreen Agents > UV Filters / Sunscreens
protections
color protection

Recommended use : UV absorber
Personal care
Home care
Cleaning solutions.
Water-borne coatings
Agrochemicals


Product Applications: Body Care, Color Cosmetics, Face Care, Sun Care
Product Category: UV absorber

Benzophenone-4 is an effective sunscreen agent with a broad spectrum absorbance ranging between 270 and 350 nm. 
Benzophenone-4 is also used as a light stabilizer for water based products. 
Benzophenone-4 can be used in combination with oil-soluble UV-filters in order to boost sun-screening properties especially in O/W emulsions. 
Benzophenone-4 is used in sun-care , skin-care, shower gels, shampoos, soaps, hair-care and shaving products

Claims: Sunscreen Agents > UV Filters / Sunscreens


2-hydroxy-4-methoxy Benzophenone-5-Sulphonic Acid acts as a UV-A and UV-B filter. 
When combined with an oil soluble UV absorber, it gives very high sun protection. 
2-hydroxy-4-methoxy Benzophenone-5-Sulphonic Acid isn’t compatible in water/oil emulsions. 
2-hydroxy-4-methoxy Benzophenone-5-Sulphonic Acid can help to stabilize the viscosity of gels based on polyacrylic acid under UV radiation. 
2-hydroxy-4-methoxy Benzophenone-5-Sulphonic Acid can also offer protection of colorants against fading and help stabilize fragrances and active ingredients against degradation or oxidation. 
It is widely used in sunscreen preparations. 
2-hydroxy-4-methoxy Benzophenone-5-Sulphonic Acid Complies with EU regulation (EC) No 1223/2009 Annex VI entry 22.

Benzophenone-4 acts as a sunscreen agent/ultraviolet light absorber. Benzophenone-4 is used in sun care applications.
Benzophenone-4 is a UV filter. Benzophenone-4 is a secondary UV-B absorber with activity in the UV-A region. 
Benzophenone-4 provides supplemental UV protection and boosts SPF activity. Moreover, Benzophenone-4 offers color protection for products in clear packages. 
Benzophenone-4  UV filter finds application in formulating sun-care (after-sun, self-tanning and sunscreen application), body- & facial-care formulas and color cosmetics.


Benzophenone-4 is a UV filter that offers protection against UV-A and UV-B radiation. 
Benzophenone-4 can be used in sunscreens, body and facial care formulas and colour cosmetics to deliver SPF protection.

Features & Benefits of Benzophenone-4
Secondary UVB absorber with activity in the UVA region
Relatively water soluble
Recommended at low levels (<0.5%) as a colour protestant for products in clear packages
Approved use level: up to 5.0% (E.U.) and up to 10.0% (U.S.)

Applications
Sunscreens
Body & Facial Care
Colour Cosmetics


Benzophenone-4 is a broad-spectrum, UV-A and UV-B filter. Benzophenone-4 finds application in anti-aging face care products and sunscreens.


Benzophenone-4 functions as a UV light absorber with properties of odorless, high resistable to thermal degradation and readily compatible with variety of polymers. 
Benzophenone-4 may be used as an anti-oxidation material in aqueous systems. It is made from 2-hydroxybenzophenone. 
Benzophenone-4 is mostly found in the formulation of nail polishes and enamels. Benzophenone-4 is also used in bath products, makeup products, hair products, sunscreens and skin care products.
Claims    
Sunscreen Agents > UV Filters / Sunscreens
Antioxidants


Benzophenone-4 is used as sunblocks for skin care, suntan lotions and creams.

Benzophenone-4 is a a water soluble Uv-a And Uv-b filter used in cosmetics. 
Benzophenone-4 is recommended for the highest sun protection factors. Benzophenone-4 stabilizes the viscosity of gels based on polyacrylic acid (Carbopol, Pemulen) when they are exposed to UV radiation. Benzophenone-4 also acts as ultra-violet stabilizer.


Sulisobenzone acts as a UV filter. Sulisobenzone is water soluble and it offers broad spectrum protection. 
Sulisobenzone is not compatible with magnesium salts, particularly in w/o emulsions. 
Sulisobenzone is a combination of an oil soluble UV filter and a water soluble UV filter gives the highest sun protection. 
Sulisobenzone is approved for skin protection and widely used in sun preparations with sulfonic acid group neutralized, eg with Triethanolamine, sodium hydroxide etc.

Claims    
Sunscreen Agents > UV Filters / Sunscreens
Protective Agents


Benzophenone-4 (Sulisobenzone) acts as a UV absorber. Benzophenone-4 (Sulisobenzone) finds application in formulating color cosmetics and hair-, sun- and body care products.

Uses & Benefits
In skincare products like soap and lip balm, benzophenone helps prevent the other product ingredients from degrading under UV light – protecting the product’s color and scent. Oxybenzone, a derivative of benzophenone, is also an ingredient in many sunscreens due to its ability to absorb harmful UV rays.

Benzophenone is also widely used in a range of household products and consumer goods. In laundry and cleaning products, benzophenone is added to the product formulation as a perfume compound, and it also helps to protect the product against degradation that could be caused by UV rays and exposure to air.

In consumer products like sunglasses, shoes and sports equipment, benzophenone helps to protect against UV rays that could damage or deteriorate the product. In addition, as an ingredient in non-food plastic packaging, it helps to prevent sun damage and fading of the product inside the packaging

What Is It?
Benzophenone-1, -3, -4, -5, -9 and-11 are compounds made from 2-hydroxybenzophenone. These compounds are powders. In cosmetics and personal care products, Benzophenone-1 and Benzophenone-3 are used mostly in the formulation of nail polishes and enamels. These Benzophenone ingredients are also used in bath products, makeup products, hair products, sunscreens and skin care products.

Why is it used in cosmetics and personal care products?
Benzophenone-1, Benzophenone-3, Benzophenone-4, Benzophenone-5, Benzophenone-9 and Benzophenone-11 protect cosmetics and personal care products from deterioration by absorbing, reflecting, or scattering UV rays. When used as sunscreen ingredients, Benzophenone-3 and Benzophenone-4 protect the skin from UV rays.


Benzophenone ingredients absorb and dissipate UV radiation, which serves to protect cosmetics and personal care products. As part of sunscreen products, which are OTC drugs in the United States, Benzophenone-3 (Oxybenzone) and Benzophenone-4 (Sulisobenzone) protect the skin from the harmful effects of the sun.

Exposing unprotected skin to UV light (primarily in the UV-B range) can result in sunburn and can promote premature aging of the skin and skin cancer.

Sulisobenzone
4065-45-6
Benzophenone-4
5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
Sungard
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
Benzophenone 4
Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-
Uval
Sulisobenzona
Sulisobenzonum
Seesorb 101S
Syntase 230
Uvinul MS 40
2-HYDROXY-4-METHOXY-5-SULFOBENZOPHENONE
Spectra-Sorb UV 284
Uvinuc ms 40
MS 40
UNII-1W6L629B4K
1-Phenol-4-sulfonic acid, 2-benzoyl-5-methoxy-
1W6L629B4K
3-Benzoyl-4-hydroxy-6-methoxybenzenesulfonic acid
2-Hydroxy-4-Methoxy-5-sulfonylbenzophenone(BP-4)
MFCD00024962
MFCD00977409
Uval sodium salt
NCGC00159404-02
NCGC00159404-04
2-Benzoyl-5-methoxy-1-phenol-4-sulfonic acid
DSSTox_CID_22436
DSSTox_RID_80023
DSSTox_GSID_42436
4-hydroxy-2-methoxy-5-(phenylcarbonyl)benzenesulfonic acid
Uvinul MS 40 sodium salt
6628-37-1
Cyasorb UV 284 sodium salt
Sulisobenzonum [INN-Latin]
Sulisobenzona [INN-Spanish]
CAS-4065-45-6
NSC60584
NSC-60584
NSC654266
C14H12O6S
HSDB 7422
Uvinul MS-40 substanz
EINECS 223-772-2
BRN 2889165
Sulfisobenzone
Sulisobenzone [USAN:USP:INN]
5-Benzoyl-4-hydroxy-2-methoxybenzene sulfonic acid
Sungard (TN)
NSC 60584
HMBS
Uvinul MS-40
Uval (*sodium salt*)
UVINUL MS40
CBMicro_016354
Sulisobenzone (USP/INN)
EC 223-772-2
5-Benzoyl-4-hydroxy-2-methoxybenzolsulfonsaeure
Spectra-Sorb U.V. 284
SCHEMBL16330
5-benzoyl-4-hydroxy-2-methoxy-benzenesulfonic acid
MLS004734662
Cyasorb UV 284 (Salt/Mix)
1-Phenol-4-sulfonic acid, 2-benzoyl-5-methoxy- (6CI)
CHEMBL2059073
DTXSID2042436
CHEBI:135312
Sulisobenzone, analytical standard
Uvinul MS 40 (*sodium salt*)
ALBB-025816
Cyasorb UV 284 (*sodium salt*)
HY-B1162
ZINC1690324
Tox21_111639
Tox21_202332
Tox21_303469
s4652
SBB002961
AKOS015895600
Tox21_111639_1
CCG-267557
CS-4610
DB11185
MCULE-1313711100
Sulisobenzone (USAN) (*sodium salt*)
NCGC00159404-03
NCGC00159404-05
NCGC00257488-01
NCGC00259881-01
AC-19869
AK110733
AS-12605
SMR001262265
ST055633
SY036839
5-benzoyl-4-hydroxy-2-methoxy-besylic acid
AB0012209
DB-049626
FT-0612547
2-benzoyl-5-methoxy-1-phenol-4-sulphonic acid
D05964
K-8670
J-509633
Q7636301
5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid ammoniate
1-Phenol-4-sulfonic acid, 2-benzoyl-5-methoxy-, sodium salt
4-hydroxy-2-methoxy-5-(oxo-phenylmethyl)benzenesulfonic acid
Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-, sodium salt
Sulisobenzone, United States Pharmacopeia (USP) Reference Standard
5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid, >=97.0% (HPLC)


1-Phenol-4-sulfonic acid, 2-benzoyl-5-methoxy- (6CI)
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
Cosmetic Products Regulation, Annex VI - Allowed UV Filters, Other
5-Benzoyl-4-hydroxy-2-methoxybenzene sulfonic acid
5-Benzoyl-4-hydroxy-2-methoxybenzolsulfonsaeure
Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-
Benzophenone-4
MS 40
Seesorb 101S
Spectra-Sorb UV 284
Sulisobenzona
Sulisobenzone
Sulisobenzone
sulisobenzone
Sulisobenzonum
Syntase 230
Uval
Uvinuc ms 40
Uvinul
Uvinul MS 40
Uvinul MS-40 substanz
CAS names
Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-


IUPAC names
2-HYDROXY-4-METHOXY- BENZOPHENONE--5-SULFONIC-ACID
2-hydroxy-4-methoxy-benzophenone-5-sulfonic acid
2-hydroxy-4-methoxy-bezophenone-5-sulfonic acid
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid Hydrate (contains 5-10% Isopropyl Alcohol)
4-Hydroxy-2-methoxy-5-(oxo-phenylmethyl)benzenesulfonic acid
5-(benzoyl)-4-hydroxy-2-methoxybenzenesulfonic acid
5-benzoyl-4-hydroxy-2-methoxybenzene-1-sulfonic acid
5-benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
Benzophenone-4
Benzophenone-4
BP4
Sulisobenzone

Trade names
Ben-4Eclipsogen BP4
Escalol 577

 1-Phenol-4-sulfonic acid, 2-benzoyl-5-methoxy- (6CI)
• 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
• 5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
• BRN 2889165
• Benzophenone 4
• EINECS 223-772-2
• HSDB 7422
• MS 40
• NSC 60548
• Seesorb 101S
• Spectra-Sorb UV 284
• Sulisobenzona
• Sulisobenzona [INN-Spanish]
• Sulisobenzone
• Sulisobenzonum
• Sulisobenzonum [INN-Latin]
• Sungard
• Syntase 230
• Uval
• Uvinuc ms 40
• Uvinul
• Uvinul MS 40


What are some products that may contain benzophenone-4?
Cosmetics
Hair Care
Liquids
Sunscreens


Synonyms:
     benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-
     benzophenone 4
5-    benzoyl-4-hydroxy-2-methoxybenzene sulfonic acid
5-    benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
3-    benzoyl-4-hydroxy-6-methoxybenzenesulfonic acid
2-    benzoyl-5-methoxy-1-phenol-4-sulfonic acid
4-    hydroxy-2-methoxy-5-(phenylcarbonyl)benzenesulfonic acid
2-    hydroxy-4-methoxybenzophenone-5-sulfonic acid
2-    hydroxy-4-methoxybenzophenone-5-sulfonicacid
2-    hydroxy-4-methoxybenzophenone-5-sulphonic acid
1-    phenol-4-sulfonic acid, 2-benzoyl-5-methoxy-
     seesorb 101S
     spectra-sorb UV 284
     sulisobenzona
     sulisobenzone
     sulisobenzonum
     sungard
     syntase 230
     uv absorber HMBS
     uval
     uvinuc MS 40
     uvinul


Benzophenone
Benzophenone is a sweet-smelling organic compound that occurs naturally in grapes and other fruits. 
The compound is used in some personal care and consumer products and packaging as a UV filter.

Benzophenones are a group of aromatic ketones that have both pharmaceutical and industrial applications. 
Benzophenones have UVB and some UVA absorbing properties and act like optical filters to block out harmful UV rays. 
Benzophenones may be used in a sunscreen product to reduce skin damage and to retard photodegradation or extend shelf life in toiletries and plastic surface coatings.


Benzophenone-4 is a white or pale yellow powder. It is used in bath products, makeup products, hair products, sunscreens and skin care products to protect cosmetics and personal care products from deterioration by absorbing, reflecting, or scattering UV rays. When used as a sunscreen ingredient, Benzophenone-4 protects the skin from UV rays.


In cosmetics and personal care products, Benzophenone-1 and Benzophenone-3 are used mostly in the formulation of nail polishes and enamels. 
These Benzophenone ingredients are also used in bath products, makeup products, hair products, sunscreens and skin care products. 
The Food and Drug Administration (FDA) has approved the use of Benzophenone-3 and Benzophenone-4 as safe and effective, over-the-counter (OTC) sunscreen ingredients. When used as a sunscreen ingredient in the United States, Benzophenone-3 is called Oxybenzone, and may be used at concentrations up to 6%, and Benzophenone-4 is called Sulisobenzone, and may be used at concentrations up to 10%. 
Benzophenone ingredients absorb and dissipate UV radiation, which serves to protect cosmetics and personal care products. 
As part of sunscreen products, which are OTC drugs in the United States, Benzophenone-3 (Oxybenzone) and Benzophenone-4 (Sulisobenzone) protect the skin from the harmful effects of the sun. Exposing unprotected skin to UV light (primarily in the UV-B range) can result in sunburn and can promote premature aging of the skin and skin cancer.


Description: Water-soluble UVA and UVB filter. Only short UVA (UVA-2, 290-360 nm) but not long UVA are filtered. 
Synonyms: Sulisobenzone, 1-phenol-4-sulfonic acid. Highly stable, does not degrade in sunlight but protects other UV blocking agents from UV-induced degradation. 
Benzophenone-4 is readily soluble in water, propylene glycol, glycerin, ethanol and isopropyl alcohol. Due to its high acidity (pH <2.5 in a 1% solution), a neutralizing agent (e.g. triethanolamine) must be added to elevate the pH to >3.5. 
Yellow to beige powder.
CAS: 4065-45-6
INCI Name: Benzophenone-4

Benefits:
-Water-soluble UVA & UVB filter. Used primarily as UVA filter
-Should be combined with other sunscreens (e.g. octocrylene, homosalate, ethylhexyl salicylate, OMcinnamate) for effective UVB protection. Benzophenone-4 provides inadequate UVB protection when used alone.
-Does not penetrate the skin to a large degree, but enhances the ability of other ingredients to penetrate
-Helps to stabilize UV sensitive formulations such as hair dyes, hair sprays and color enhanced formulations
-Provides protection of colorants against fading and help stabilize fragrances and active ingredients against oxidation

Use: Incorporate into water phase (pH 1.2-2.2). Allowed use levels: USA 10% (when used alone; 5-10% when used in combination), Brazil 10%, Japan 10%, EU 5%. For external use only.
Applications: Sun care products, color cosmetics with sun protection, various cosmetics & fragrances for product protection.

Raw material source: Benzophenone-3
Manufacture: Benzophenone-4 is prepared via sulfonation of benzophenone-3. The product is then purified by
precipitation from aqueous hydrochloric acid, isolated by centrifugation, washed with acidic water, and dried. 


Function(s): Sunscreen Agent; Ultraviolet Light Absorber; UV ABSORBER; UV FILTER

Other names: Sulisobenzone, 1-Phenol-4-Sulfonic Acid, 2-Benzoyl-5-Methoxy-; 1-Phenol-4-Sulfonic Acid, 2-Benzoyl-5-Methoxy- (6Ci) ; 2-Benzoyl-5-Methoxy- 1-Phenol-4-Sulfonic Acid; 2-Hydroxy-4-Methoxybenzophenone- 5-Sulfonic Acid; 2-Hydroxy-4-Methoxybenzophenone-5-Sulfonic Acid; 5-Benzoyl-4-Hydroxy-2-Methoxy- Benzenesulfonic Acid; 5-Benzoyl-4-Hydroxy-2-Methoxybenesulfonic Acid; 5-Benzoyl-4-Hydroxy-2-Methoxybenzene Sulfonic Acid; 5-Benzoyl-4-Hydroxy-2-Methoxybenzenesulfonic Acid; 5-Benzoyl-4-Hydroxy-2-Methoxybenzolsulfonsaeure; B4

Sulisobenzone (benzophenone-4) is an ingredient in some sunscreens which protects the skin from damage by UVB and UVA ultraviolet light

Benzophenone-1, Benzophenone-3, Benzophenone-4, Benzophenone-5, Benzophenone-9 and Benzophenone-11 protect cosmetics and personal care products from deterioration by absorbing, reflecting, or scattering UV rays. 
When used as sunscreen ingredients, Benzophenone-3 and Benzophenone-4 protect the skin from UV rays.

Why is it used in cosmetics and personal care products?

The Food and Drug Administration (FDA) has approved the use of Benzophenone-3 and Benzophenone-4 as safe and effective, over-the-counter (OTC) sunscreen ingredients. 
When used as a sunscreen ingredient in the United States, Benzophenone-3 is called Oxybenzone, and may be used at concentrations up to 6%, and Benzophenone-4 is called Sulisobenzone, and may be used at concentrations up to 10%. 
The safety of Benzophenone-3 and related ingredients has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. 
The CIR Expert Panel evaluated the scientific data and concluded that Benzophenone-1, -3, -4, -5, -9 and -11 were safe for use in cosmetics and personal care products. 
In 2002, the CIR Expert Panel considered available new data on these Benzophenone ingredients and reaffirmed the above conclusion.


CAS Numbers:
4065-45-6
EC/List Numbers:
223-772-2
Technical Names:
1-Phenol-4-Sulfonic Acid, 2-Benzoyl-5-Methoxy-
2-Hydroxy-4-Methoxybenzophenone-5-Sulfonic Acid
2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid (Trihydrate)
5-Benzoyl-4-Hydroxy-2-Methoxybenesulfonic Acid
5-Benzoyl-4-Hydroxy-2-Methoxybenzene Sulfonic Acid
Benzenesulfonic Acid, 5-Benzoyl-4-Hydroxy-2-Methoxy-
Benzophenone-4 (INCI)
Product Categories:
Cleaning Products

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