BENZOYL CHLORIDE

Benzoyl chloride is used for organic synthesis, dye and pharmaceutical raw material, manufacturing initiator benzoyl peroxide, t-butyl peroxybenzoate, pesticides and herbicides. Benzoyl chloride is an important benzoyl and benzyl reagent. Benzoyl chloride is used in the production of benzoyl peroxide, and secondly for the production of benzophenone, benzyl benzoate, benzyl cellulose. 
Benzoyl peroxide catalyzes polymerization initiator for the monomer plastic, polyester, epoxy, acrylic resin production, self-curing agent, which is a glass fiber material, fluorine rubber, silicone crosslinking agents, oil refined, bleached flour, fiber decolorizing . 


Benzoyl chloride Chemical Properties, Uses, Production

Physical and Chemical Properties
Its pure product is a colorless and transparent flammable liquid, which is smoking exposed to air in the air. 
In Industry, it is slightly pale yellow, with a strong pungent odor. 
Its steam has a strong stimulating effect for eye mucous membranes, skin and respiratory tract, by stimulating the mucous membranes and eyes tear. 
Benzoyl chloride Melting point is-1.0 ℃, boiling point is 197.2 ℃, and the relative density is 1.212 (20 ℃), while a flash point is 72 ℃, and refractive index (n20) is 1.554. 
Benzoyl chloride is soluble in the ether, chloroform, benzene and carbon disulfide. 
Benzoyl chloride can gradually decomposed in water or ethanol, ammonia, which generates benzoic acid, generating benzamide, ethyl benzoate and hydrogen chloride. 
In the laboratory, it can be obtained by distillation of benzoic acid and phosphorus pentachloride under anhydrous conditions. 
Industrial production process can be obtained by the use of thionyl chloride benzaldehyde. 
Benzoyl chloride is an important intermediate for preparing dyes, perfumes, organic peroxides, resins and drugs. 
Benzoyl chloride is also used in photography and artificial tannin production, which was formerly used as an irritant gas in chemical warfare.

Application
Used for dye intermediates, initiator, UV absorbers, rubber additives, medicine etc.
Benzoyl chloride is intermediate of herbicide metamitron, and insecticide propargite, benzene hydrazine or intermediate food.
Benzoyl chloride is used for organic synthesis, dye and pharmaceutical raw material, manufacturing initiator benzoyl peroxide, t-butyl peroxybenzoate, pesticides and herbicides. 
In pesticides, it is a new insecticide, which is inducible isoxazole parathion (Isoxathion, Karphos) intermediate. 
Benzoyl chloride is an important benzoyl and benzyl reagent. 
Most of benzoyl chloride is used in the production of benzoyl peroxide, and secondly for the production of benzophenone, benzyl benzoate, benzyl cellulose. 
Benzoyl peroxide catalyzes polymerization initiator for the monomer plastic, polyester, epoxy, acrylic resin production, self-curing agent, which is a glass fiber material, fluorine rubber, silicone crosslinking agents, oil refined, bleached flour, fiber decolorizing Wait. 
Domestic original benzoyl chloride manufacturing enterprises are more than 20. 
Some of the manufacturers also produce acid chloride, and the production capacity is 10,000t. 
However, according to the 2003 survey, the profit is too low, because of the use of small polluting production line, while the use of polluting route is controlled by the government restrictions, and a further raw material price increases. 
Therefore most of the manufacturers stop the production. 
Further reaction with the acid chloride can also produce acid anhydride,  and benzoic acid anhydride is the main purpose for acylation agents, which can also be used as a bleaching agent and flux of a component, as well as it can also be used for the preparation of benzoyl peroxide over.
Reagents for the analysis, but also for spices, organic synthesis.

Chemical Properties
Transparent, colorless liquid; pungent odor; vapor causes tears. 
Soluble in ether and carbon disulfide; decomposes in water. Combustible.

Chemical Properties
Benzoyl chloride is a colorless to slight brown liquid with a strong, penetrating odor.

Uses
Benzoyl Chloride is used in the manufacturing of dye intermediates.

Uses
For acylation, i.e., introduction of the benzoyl group into alcohols, phenols, and amines (Schotten-Baumann reaction); in the manufacture of benzoyl peroxide and of dye intermediates. 
In organic analysis for making benzoyl derivatives for identification purposes.

Definition
A liquid acyl chloride used as a benzoylating agent.

Production Methods
Benzoyl chloride can be prepared from benzoic acid by reaction with PCl5 or SOCl2, from benzaldehyde by treatment with POCl3 or SO2 Cl2, from benzotrichloride by partial hydrolysis in the presence of H2SO4 or FeCl3, from benzal chloride by treatment with oxygen in a radical source, and from several other miscellaneous reactions. 
Benzoyl chloride can be reduced to benzaldehyde, oxidized to benzoyl peroxide, chlorinated to chlorobenzoyl chloride and sulfonated to m-sulfobenzoic acid. 
It will undergo various reactions with organic reagents. 
For example, Benzoyl chloride will add across an unsaturated (alkene or alkyne) bond in the presence of a catalyst to give the phenylchloroketone:

General Description
A colorless fuming liquid with a pungent odor. Flash point 162°F. Lachrymator, irritating to skin and eyes. 
Corrosive to metals and tissue. Density 10.2 lb / gal. 
Used in medicine and in the manufacture of other chemicals.

Reactivity Profile
Benzoyl chloride reacts violently with protic solvents such as alcohols, with amines and amides and with inorganic bases. 
Causes the violent decomposition of dimethyl sulfoxide [Chem. Eng. News 35(9): 87 1957]. 
May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts. 
Friedel-Crafts acylation of naphthalene using Benzoyl chloride, catalyzed by AlCl3, must be conducted above the melting point of the mixture, or the reaction may be violent.

Hazard
Highly toxic. Strong irritant to skin, eyes, and mucous membranes, and via ingestion, inhala- tion. Upper respiratory tract irritant. Probable car- cinogen.

Health Hazard
INHALATION: may irritate eyes, nose and throat. INGESTION: causes acute discomfort. SKIN: causes irritation and burning.

Chemical Reactivity
Reactivity with Water Slow reaction with water to produce hydrochloric acid fumes. 
The reaction is more rapid with steam; Reactivity with Common Materials: Slow corrosion of metals but no immediate danger; Stability During Transport: Not pertinent; Neutralizing Agents for Acids and Caustics: Soda ash and water, lime; Polymerization: Does not occur; Inhibitor of Polymerization: Not pertinent.

Safety Profile
Confirmed carcinogen withexperimental tumorigenic data by skin contact. 
Humansystemic effects by inhalation: unspecified effects onolfaction and respiratory systems. 
Corrosive effects on theskin, eyes, and mucous membranes by inhalation.


Potential Exposure
Benzoyl chloride is used as a chemical intermediate; in organic synthesis; to produce other chemicals, dyes, perfumes, herbicides, and medicines.

Shipping
UN 1736 Benzoylchloride, Hazard class: 8; Labels: 8—Corrosive material.

Purification Methods
A solution of benzoyl chloride (300mL) in *C6H6 (200mL) is washed with two 100mL portions of cold 5% NaHCO3 solution, separated, dried with CaCl2 and distilled. 
Repeated fractional distillation at 4mm Hg through a glass helices-packed column gave benzoyl chloride that did not darken on addition of AlCl3. 
Further purification is achieved by adding 3 mole% each of AlCl3 and toluene, standing overnight, and distilling off the benzoyl chloride at 1-2mm. 
Refluxing for 2hours with an equal weight of thionyl chloride before distillation has also been used. 
Strong IRRITANT. Use in a fume cupboard.

Incompatibilities
May form explosive mixture with air. 
Contact with heat, hot surfaces, and flames causes decomposition, forming phosgene and hydrogen chloride. 
Water contact may be violent; forms hydrochloric acid. 
Reactions with amines, alcohols, alkali metals, dimethyl sulfoxide, strong oxidizers, and metal salts may be violent, causing fire and explosions. 
Attacks metals in the presence of moisture, forming explosive hydrogen gas. 
Attacks some plastics, rubber or coatings.

Waste Disposal
Pour into sodium bicarbonate solution and flush to sewer.
Benzoyl chloride Preparation Products And Raw materials

Raw materials
Toluene Chlorine Benzotrichloride Phosphorus trichloride PHOSGENE Benzoic acid


BENZOYL CHLORIDE; Benzenecarbonyl chloride; Benzoic acid chloride; alpha-Chlorobenzaldehyde; CAS #: 98-88-4; UN #: 1736;EC Number: 202-710-8
Preferred IUPAC name: Benzoyl chloride;Synonyms: Benzoic acid chloride.Product Information: CAS number: 98-88-4; EC index number: 607-012-00-0; EC number: 202-710-8;Formula: C₇H₅ClO; Chemical formula:C₆H₅COCl
;Molar Mass: 140.57 g/mol; HS Code: 2916 32 00

α-chlorobenzaldehyde; benzenecarbonyl chloride;benzoic acid chloride

The most important application of benzoyl chloride is the production of benzoyl peroxide, that is used as initiator in the polymer industry.
It is also used as precursor for benzophenone, in the pharmaceutical industry and as precursor of agro-chemicals.

Applications & Features:
Production of Benzoyl Peroxide (catalyst for the polymer industry)
Precursor of Benzophenone and several other UV-stabilizers
Precursor of Agrochemicals and Pharmaceutical applications
Dyes and pigments


Benzoyl chloride, also known as benzenecarbonyl chloride, is an organochlorine compound with the formula C6H5COCl. It is a colourless, fuming liquid with an irritating odour. 

It is mainly useful for the production of peroxides but is generally useful in other areas such as in the preparation of dyes, perfumes, pharmaceuticals, and resins.

Definition: An acyl chloride consisting of benzene in which a hydrogen is replaced by an acyl chloride group. It is an important chemical intermediate for the manufacture of other chemicals, dyes, perfumes, herbicides and pharmaceuticals.
    
CAS No.98-88-4; Chemical Name:Benzoyl chloride; Synonyms: BzCl;Basic Red 1;BENZOXALONE;Benzoylchlorid;BENZOYL CHLORIDE;BenzoylChlorideGr;chloruredebenzoyle;-Chlorobenzaldehyde;Benzoyl Chloride >BENZOYL CHLORIDE, ACS

Stability:Stable. Combustible. Incompatible with strong oxidizing agents, water, alcohols, strong bases. Reacts violently with DMSO and vigorously with alkalies.

Application:Benzoyl chloride is an organochlorine useful for the production of peroxides
Benzoyl chloride appears as a colorless fuming liquid with a pungent odor. Flash point 162°F. Lachrymator, irritating to skin and eyes. Corrosive to metals and tissue. Density 10.2 lb / gal. Used in medicine and in the manufacture of other chemicals.

Preparation: Benzoyl chloride is produced from benzotrichloride using either water or benzoic acid.

As with other acyl chlorides, it can be generated from the parent acid and other chlorinating agents phosphorus pentachloride, thionyl chloride, or oxalyl chloride. 
It was first prepared by treatment of benzaldehyde with chlorine.

An early method for production of benzoyl chloride involved chlorination of benzyl alcohol.

Reactions: It reacts with water to produce hydrochloric acid and benzoic acid.
Benzoyl chloride is a typical acyl chloride. It reacts with alcohols to give the corresponding esters. Similarly, it reacts with amines to give the amide.

It undergoes the Friedel-Crafts acylation with aromatic compounds to give the corresponding benzophenones and related derivatives.
With carbanions, it serves again as a source of "PhCO+"

Benzoyl peroxide, a common reagent in polymer chemistry, is produced industrially by treating benzoyl chloride with hydrogen peroxide and sodium hydroxide.

Benzoyl chloride appears as a colorless fuming liquid with a pungent odor. Flash point 162°F. Lachrymator, irritating to skin and eyes. Corrosive to metals and tissue.
Density 10.2 lb / gal. Used in medicine and in the manufacture of other chemicals.


Benzoyl chloride Chemical Properties,Uses,Production
Physical and Chemical Properties
Its pure product is a colorless and transparent flammable liquid, which is smoking exposed to air in the air. In Industry, it is slightly pale yellow, with a strong pungent odor. Its steam has a strong stimulating effect for eye mucous membranes, skin and respiratory tract, by stimulating the mucous membranes and eyes tear. Benzoyl chloride Melting point is-1.0 ℃, boiling point is 197.2 ℃, and the relative density is 1.212 (20 ℃), while a flash point is 72 ℃, and refractive index (n20) is 1.554. It is soluble in the ether, chloroform, benzene and carbon disulfide. It can gradually decomposed in water or ethanol, ammonia, which generates benzoic acid, generating benzamide, ethyl benzoate and hydrogen chloride. In the laboratory, it can be obtained by distillation of benzoic acid and phosphorus pentachloride under anhydrous conditions. Industrial production process can be obtained by the use of thionyl chloride benzaldehyde. Benzoyl chloride is an important intermediate for preparing dyes, perfumes, organic peroxides, resins and drugs. It is also used in photography and artificial tannin production, which was formerly used as an irritant gas in chemical warfare.


Application
Used for dye intermediates, initiator, UV absorbers, rubber additives, medicine etc.
Benzoyl chloride is intermediate of herbicide metamitron, and insecticide propargite, benzene hydrazine or intermediate food.
Benzoyl chloride is used for organic synthesis, dye and pharmaceutical raw material, manufacturing initiator benzoyl peroxide, t-butyl peroxybenzoate, pesticides and herbicides. Benzoyl chloride is an important benzoyl and benzyl reagent. Most of benzoyl chloride is used in the production of benzoyl peroxide, and secondly for the production of benzophenone, benzyl benzoate, benzyl cellulose. Benzoyl peroxide catalyzes polymerization initiator for the monomer plastic, polyester, epoxy, acrylic resin production, self-curing agent, which is a glass fiber material, fluorine rubber, silicone crosslinking agents, oil refined, bleached flour, fiber decolorizing.   Further reaction with the acid chloride can also produce acid anhydride,  and benzoic acid anhydride is the main purpose for acylation agents, which can also be used as a bleaching agent and flux of a component, as well as it can also be used for the preparation of benzoyl peroxide over.

Chemical Properties: Transparent, colorless liquid; pungent odor; vapor causes tears. Soluble in ether and carbon disulfide; decomposes in water. Combustible.
Chemical Properties: Benzoyl chloride is a colorless to slight brown liquid with a strong, penetrating odor.
Uses: Benzoyl Chloride is used in the manufacturing of dye intermediates.
Uses: For acylation, i.e., introduction of the benzoyl group into alcohols, phenols, and amines (Schotten-Baumann reaction); in the manufacture of benzoyl peroxide and of dye intermediates. In organic analysis for making benzoyl derivatives for identification purposes.
Definition: A liquid acyl chloride used as a benzoylating agent.
Production Methods: Benzoyl chloride can be prepared from benzoic acid by reaction with PCl5 or SOCl2, from benzaldehyde by treatment with POCl3 or SO2 Cl2, from benzotrichloride by partial hydrolysis in the presence of H2SO4 or FeCl3, from benzal chloride by treatment with oxygen in a radical source, and from several other miscellaneous reactions. Benzoyl chloride can be reduced to benzaldehyde, oxidized to benzoyl peroxide, chlorinated to chlorobenzoyl chloride and sulfonated to m-sulfobenzoic acid. It will undergo various reactions with organic reagents. For example, it will add across an unsaturated (alkene or alkyne) bond in the presence of a catalyst to give the phenylchloroketone:
Synthesis Reference(s)

General Description: A colorless fuming liquid with a pungent odor. Flash point 162°F. Lachrymator, irritating to skin and eyes. Corrosive to metals and tissue. Density 10.2 lb / gal. Used in medicine and in the manufacture of other chemicals.
Reactivity Profile: Benzoyl chloride reacts violently with protic solvents such as alcohols, with amines and amides (for example dimethylformamide [Bretherick 1979 p. 6] ) and with inorganic bases. Causes the violent decomposition of dimethyl sulfoxide [Chem. Eng. News 35(9): 87 1957]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. Friedel-Crafts acylation of naphthalene using Benzoyl chloride, catalyzed by AlCl3, must be conducted above the melting point of the mixture, or the reaction may be violent [Clar, E. et al., Tetrahedron, 1974, 30, 3296].
Hazard: Highly toxic. Strong irritant to skin, eyes, and mucous membranes, and via ingestion, inhala- tion. Upper respiratory tract irritant. Probable carcinogen.
Health Hazard
INHALATION: may irritate eyes, nose and throat. INGESTION: causes acute discomfort. SKIN: causes irritation and burning.
Chemical Reactivity: Reactivity with Water Slow reaction with water to produce hydrochloric acid fumes. The reaction is more rapid with steam; Reactivity with Common Materials: Slow corrosion of metals but no immediate danger; Stability During Transport: Not pertinent; Neutralizing Agents for Acids and Caustics: Soda ash and water, lime; Polymerization: Does not occur; Inhibitor of Polymerization: Not pertinent.
Safety Profile: Confirmed carcinogen with experimental tumorigenic data by skin contact.


Physicochemical Information 
Boiling point: 197.2 °C (1013 hPa)
Density: 1.21 g/cm3 (20 °C)
Explosion limit: 2.5 - 27 %(V)
Flash point: 93 °C
Ignition temperature: 600 °C
Melting Point: -0.6 °C
pH value: 2 (1 g/l, H₂O, 20 °C)
Vapor pressure: 0.5 hPa (20 °C)
Refractive Index: 1.5537 (20 °C, 589 nm)
Solubility(20 °C): (decomposition)

BENZOYL CHLORIDE
98-88-4
Benzenecarbonyl chloride
Benzoic acid, chloride
Benzoylchloride
alpha-Chlorobenzaldehyde
benzoic acid chloride
benzoylchlorid
Benzaldehyde, alpha-chloro-
HSDB 383
EINECS 202-710-8
UN1736
BRN 0471389
Benzoyl chloride, 99%, pure
Benzoyl chloride, 98+%, ACS reagent
Benzoyl chloride, ReagentPlus(R), >=99%
benzoyl chlorid
benzoyl choride
bezoyl chloride
benzoic chloride
BzCl
benzoyl chloride-
Benzoyl chloride [UN1736] [Corrosive]
.alpha.-Chlorobenzaldehyde
Benzaldehyde, |A-chloro-
Benzoyl chloride, ACS reagent, 99%
UN 1736
CAS-98-88-4
Benzoyl chloride


ALPHA-CHLOROBENZALDEHYDE
BENZALDEHYDE, ALPHA-CHLORO-
BENZENECARBONYL CHLORIDE
BENZOIC ACID CHLORIDE
BENZOYL CHLORIDE
DIBENZOYL CHLORIDE {BENZOYL CHLORIDE}

BENZOYL CHLORIDE
98-88-4
Benzenecarbonyl chloride
Benzoic acid, chloride
Benzoylchloride
alpha-Chlorobenzaldehyde
benzoic acid chloride
benzoylchlorid
Benzaldehyde, alpha-chloro-
EINECS 202-710-8
UN1736
BRN 0471389
Benzaldehyde, .alpha.-chloro-
benzoyl chlorid
benzoyl choride
bezoyl chloride
benzoic chloride
BzCl
benzoyl chloride-
PhCOCl
Bz-Cl
Benzoyl chloride [UN1736] [Corrosive]
.alpha.-Chlorobenzaldehyde
Benzaldehyde, |A-chloro-

247-558-3 [EINECS]
471389
98-88-4 [RN]
a-Chlorobenzaldehyde
Benzaldehyde, α-chloro-
benzoic acid chloride
Benzoic acid, chloride
Benzoyl chloride [ACD/Index Name] [ACD/IUPAC Name] [Wiki]
Benzoyl chloride [UN1736] [Corrosive]
Benzoylchlorid [German] [ACD/IUPAC Name]
Chlorure de benzoyle [French] [ACD/IUPAC Name]
DM6600000
VTY8706W36
100-09-4 [RN]
2719-27-9 [RN]
4-09-00-00721 (Beilstein Handbook Reference) [Beilstein]
43019-90-5 [RN]
52947-05-4 [RN]
59748-37-7 [RN]
ANISIC ACID
Benzaldehyde, α-chloro-
Benzenecarbonyl chloride
BENZOYL CHLORIDE-(RING-13C6)
Benzoyl Chloride, ACS reagent
BENZOYL CHLORIDE|BENZOYL CHLORIDE
benzoylchloride
Benzoyl-d5 Chloride
Cyclohexanecarbonyl chloride [ACD/Index Name] [ACD/IUPAC Name]
EINECS 202-710-8
Hexahydrobenzoyl chloride
InChI=1/C7H5ClO/c8-7(9)6-4-2-1-3-5-6/h1-5
MFCD01865658 [MDL number]
O-CHLOROFORMYLBENZENE
PS-10801
UNII:VTY8706W36
UNII-VTY8706W36
α-Chlorobenzaldehyde
α-Chlorobenzaldehyde
苯甲酰氯 [Chinese]

benzoilklorür (tr)
benzoil klorür (tr)
benzoil klorid (tr)
benzoilklorid (tr)
benzoilklorit (tr)
benzoil klorit (tr)
bensoüülkloriid (et)
bentsyylikloridi (fi)
benzoil klorid (sl)
benzoil-klorid (hr)
benzoil-klorid (hu)
benzoilchloridas (lt)
benzoile cloruro (it)
benzoilhlorīds (lv)
benzoylchlorid (cs)
benzoylchlorid (da)
Benzoylchlorid (de)
benzoylchlorid (sk)
benzoylchloride (nl)
benzoylklorid (no)
benzoylklorid (sv)
chlorek benzoilu (pl)
chlorek kwasu benzoesowego (pl)
chlorure de benzoyle (fr)
cloreto de benzoílo (pt)
cloruro de benzoílo (es)
cloruro di benzoile (it)
clorură de benzoil (ro)
klorur tal-benżojl (mt)
βενζοϋλοχλωρίδιο (el)
бензоил хлорид (bg)

CAS names: Benzoyl chloride

IUPAC names
Benzoic acid chloride
BENZOYL CHLORIDE
Benzoyl Chloride
Benzoyl chloride
benzoyl chloride
Benzoylchlorid

Trade names
BENZOESAEURECHLORID
BENZOLCARBONYLCHLORID
BENZOYL CHLORIDE
Benzoyl chloride
BENZOYLCHLORID
PHENYLCARBONYLCHLORID

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