Chloromethylisothiazolinone

Chloromethylisothiazolinone; CMIT; Substance identity: EC/List no:247-500-7; CAS no: 26172-55-4; Mol.formula:C4H4ClNOS; Methylchloroisothiazolinone; chloromethylisothiazolinone

CAS Number: 26172-55-4 ;IUPAC name: 5-Chloro-2-methyl-1,2-thiazol-3(2H)-one. Other names: 5-Chloro-2-methylisothiazol-3(2H)-one; 5-Chloro-2-methyl-4-isothiazolin-3-one; Chloromethylisothiazolinone;Chloromethylisothiazolone
;Methylchloroisothiazolinone;Methylchloroisothiazolone;CMI;CMIT;MCI; MCIT

Description: Isothiazolinone is a heterocyclic chemical compound related to isothiazole. Isothiazolinone is an antimicrobial preservative that is often used to control fungi, bacteria, and algae. Since water-containing solutions are the breeding grounds for bacteria, isothiazolinone can easily be used in such solutions.

Applications: Although isothiazolinones have no direct applications, their derivatives such as 5-chloro-2-methyl-4-isothiazolin-3-on and 2-methyl-4-isothiazolin-3 which are used together as preservatives in commercial households and cosmetics products, for instance, cleaners, shampoos, and washing materials. 
Notably, various products that use isothiazolinones are in the market, including shampoo, hand sanitizer, and lotions. Isothiazolinones is used in these products as an inhibitor of microbial activity that could lead to the product spoiling before the expected expiration date.

Description
Methylchloro-isothiazolinone (MCI) is contained, along with methylisothiazolinone (MI), in Kathon cosmetic grade (CG) and MCI/MI. It is irritant and sensitizer.
Chemical Properties
Liquid
Uses
Isocil(R) MW-14 is a high performance biocide for preserving metal working fluids, hydraulic fluids, polymer emulsions, pigment dispersions. Suggested applications: preservative concentrate. Very low level.
Uses
Isocil(R) PC is a cost-effective antimicrobial for personal care formulations. Suggested applications: personal care preservative.
Uses
Isocil(R) RW is a high performance industrial microbiocide for use in recirculating water cooling towers, wood, mold and mildew control, pulp and paper mills, air washer systems. Suggested applications: Industrial water treatment. Very low use levels.    
CAS No.26172-55-4. Chemical Name:Isothiazolinones.SynonymsCMI;MCI;CMIT;IDAS;mci/mi;CMI/MIT;KATHONFP;KATHONLX;CMIT/MIT;Danisol-K


Methylchloroisothiazolinone, also referred to as MCI, is a preservative with antibacterial and antifungal effects within the group of isothiazolinones. These compounds have an active sulphur moiety that is able to oxidize thiol-containing residues, thereby effectively killing most aerobic and anaerobic bacteria.[1] Methylchloroisothiazolinone is effective against gram-positive and gram-negative bacteria, yeast, and fungi.

Methylchloroisothiazolinone is found in many water-based personal care products and cosmetics.[2] Methylchloroisothiazolinone was first used in cosmetics in the 1970s. It is also used in glue production, detergents, paints, fuels, and other industrial processes. Methylchloroisothiazolinone is known by the registered tradename Kathon CG when used in combination with methylisothiazolinone.[3]

Methylchloroisothiazolinone may be used in combination with other preservatives including ethylparaben, benzalkonium chloride, and bronopol.
    
5-Chloro-2-methyl-4-isothiazolin-3-one
Chloromethylisothiazolinone is a 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. 
It is a powerful biocide and preservative and is the major active ingredient in the commercial product Kathon(TM). 
It has a role as an antimicrobial agent, a xenobiotic and an environmental contaminant. 
It is a member of 1,2-thiazoles and an organochlorine compound. It derives from a methylisothiazolinone.


Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties.
It is found within many commercially available cosmetics, lotions, and makeup removers. 
It is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area. 
The American Contact Dermatitis Society named Methylchloroisothiazolinone the Contact Allergen of the Year for 2013. 
Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.

Safety
Methylchloroisothiazolinone can cause allergic reactions in some people.[4] The first publication of the preservative as a contact allergen was in 1988.[5] Cases of photoaggravated allergic contact dermatitis, i.e. worsening of skin lesions after sun exposure, have also been reported.[4]

In pure form or in high concentrations, methylchloroisothiazolinone is a skin and membrane irritant and causes chemical burns. In the United States, maximum authorized concentrations are 15 ppm in rinse-offs (of a mixture in the ratio 3:1 of 5-chloro-2-methylisothiazol 3(2H)-one and 2-methylisothiazol-3 (2H)-one).[6] In Canada, methylchloroisothiazolinone may only be used in rinse-off products in combination with methylisothiazolinone, the total concentration of the combination may not exceed 15 ppm.[7]

As of 2008, the International Agency for Research on Cancer (IARC), did not list methylchloroisothiazolinone as a known, probable, or possible human carcinogen,[8] nor have in vivo tests found evidence of carcinogenic activity

5-chloro-2-methyl-2H-isothiazol-3-one
EC Inventory
5-chloro-2-methyl-2H-isothiazol-3-one
5-Chloro-2-methyl-2H-isothiazol-3-one (CIT)
Biocidal active substances
5-Chloro-2-methyl-4-isothiazolin-3-one
5-Chloro-2-methyl-isothiazolin-3(2H)-one
IUPAC names
3(2H) -Isothiazolone, 5-chloro-2-methyl-
3(2H)-Isothiazolone, 5-chloro-2-methyl-
5-chlor-2-methyl-4-isothiazol-3-one
5-chloro-2-methyl- 4-isothiazolin-3-one
5-chloro-2-methyl-1,2-thiazol-3-one
C&L Inventory, Other
5-chloro-2-methyl-1,2-thiazol-3-one hydrochloride
5-chloro-2-methyl-2,3-dihydro-1,2-thiazol-3-one
5-Chloro-2-methyl-2H-isothiazol-3-one
5-chloro-2-methyl-2H-isothiazol-3-one
5-Chloro-2-methyl-4-isothiazolin-3-one
5-chloro-2-methylisothiazol-3(2H)-one
CMIT
Iso-thiazolinon-Derivate
Plant preservative mixture
Other identifiers
137086-87-4
CAS number
137662-59-0
CAS number
26172-55-4


Synonyms:
5-chloro-2-methyl-1,2-thiazol-3-one
5-chloro-2-methyl-1,2-thiazol-3(2H)-one
5-chloro-2-methyl-2H-isothiazol-3-one
5-chloro-2-methyl-3(2H)-isothiazolone
5-chloro-2-methyl-4-isothiazolin-3-one
5-chloro-2-methylisothiazol-3(2h)-one
5-chloro-N-methylisothiazolone
chloromethylisothiazolinone
2,3-dihydro-2-methyl-3-oxo-5-chloroisothiazole
kathon IXE
MCI
2-methyl-5-chloro-3-isothiazolone
2-methyl-5-chloro-4-isothiazolin-3-one
2-methyl-5-chloroisothiazolin-3-one
methylchloroisothiazolinone
4-isothiazolin-3-one, 5-chloro-2-methyl-
isothiazolin-3-one, 5-chloro-2-methyl-


5-chloro-2-methyl-4-isothiazolin-3-one
5-chloro-2-methyl-4-isothiazolin-3-one hydrochloride
5-chloro-2-methylisothiazolin-3-one
5-chloro-N-methylisothiazolone
5243-K-Cg
methylchloro-isothiazolinone
methylchloroisothiazolinone
5-Chloro-2-methyl-4-isothiazolin-3-one
26172-55-4
Methylchloroisothiazolinone
CMIT
5-Chloro-2-methyl-3(2H)-isothiazolone
3(2H)-Isothiazolone, 5-chloro-2-methyl-
Kathon CG 5243
5-chloro-2-methylisothiazol-3(2h)-one
5-Chloro-2-methyl-2H-isothiazol-3-one
5-chloro-2-methylisothiazolin-3-one
5-chloro-N-methylisothiazolone
C4H4ClNOS
UNII-DEL7T5QRPN
Chloromethylisothiazolinone
5-Chloro-2-methyl-3-isothiazolone
5-Chloro-2-methyl-4-isothiazolin-3-one (CMI)
5-chloro-2-methyl-1,2-thiazol-3-one
DEL7T5QRPN
5-chloro-n-methylisothiazolin-3-one
EINECS 247-500-7
4-ISOTHIAZOLIN-3-ONE, 5-CHLORO-2-METHYL-
BRN 1210149
5-chloro-2-methyl-4-isothiazoline-3-one
5-chloro-2-methyl-1,2-thiazol-3(2H)-one
2,3-Dihydro-2-methyl-3-oxo-5-chloroisothiazole
Bioace
Kathon IXE
CAS-26172-55-4
A 33 (bactericide)
HS 818 (antiseptic)
HS 818
methylchloro-isothiazolinone
n-methyl-5-chloroisothiazolone
N-Methyl-5-chloroisothiazolin-3-one
5-chloro-2-methyl-2h-isothiazolin-3-one
5-chloro-2-methyl-3(2H)-isothiazolinone
2682-20-4 MIT
5-Chloro-2-methyl-isothiazol-3(2H)-one
CMI (5-Chloro-2-methyl-4-isothiazolin-3-on)
5-chloro-2-methyl-2,3-dihydro-1,2-thiazol-3-one
5-Chloro-2-methyl-4-isothiazolin-3-one (>14% solution in water)
CMI + MI in mixture 3:1 (CAS 55965-84-9) ( section sign)
CMI (also as part of mixture with CAS no. 55965-84-9, entry #870)
N-Methyl-5-chloroisothiazolone (5-Chloro-2-methyl-4-isothiazolin-3-one)
5-Chloro-2-methyl-3(2H)-isothiazolone; 5-Chloro-2-methyl-Isothiazolone; Kathon WT; MCI/MI
5-Chloro-2-methyl-4-isothiazolin-3-one, tech grade, >14% in water. CMI/MI >2.0
5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE (ACTIVE INGREDIENT >14%, CMI/MI 2.5 - 4.0)

Kathon biocide
2-Methyl-1,2-thiazol-3(2H)-on --5-chlor-2-methyl-1,2-thiazol-3(2H)-on (1:1) [German] [ACD/IUPAC Name]
2-Methyl-1,2-thiazol-3(2H)-one - 5-chloro-2-methyl-1,2-thiazol-3(2H)-one (1:1) [ACD/IUPAC Name]
2-Méthyl-1,2-thiazol-3(2H)-one - 5-chloro-2-méthyl-1,2-thiazol-3(2H)-one (1:1) [French] [ACD/IUPAC Name]
3(2H)-Isothiazolone, 2-methyl-, compd. with 5-chloro-2-methyl-3(2H)-isothiazolone (1:1) [ACD/Index Name]
55965-84-9 [RN]
5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one
[55965-84-9]
229619-22-1 [RN]
2-Methylisothiazol-3(2H)-one 5-chloro-2-methylisothiazol-3(2H)-one (1:1)
2-Methylisothiazol-3(2H)-one 5-chloro-2-methylisothiazol-3(2H)-one (1:1) 14% in water
2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one
2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one (1:1)
2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one(14%in H2O)
2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one(in H2O)
3(2H)-Isothiazolone, 5-chloro-2-methyl-, mixt. with 2-methyl-3(2H)-isothiazolone
5-CHLORO-2-METHYL-3(2H)-ISOTHIAZOLONE MIXT. WITH 2-METHYL-3(2H)-ISOTHIAZOLONE
5-Chloro-2-methyl-3(2H)-isothiazolone with 2-methyl-3(2H)-isothiazolone
5-Chloro-2-methyl-isothiazol-3-one
70294-89-2 [RN]
72980-78-0 [RN]
96118-96-6 [RN]
Bio-Perge
compound with 2-methyl-isothiazol-3-one
CS-17384
Kathon 886
Kathon 886 W
Kathon 886MW
Kathon CG
Kathon CG/ICP II
Kathon LX
Kathon RH 886
Kathon WT
KATHON-886
Legend MK
Methylchloroisothiazolinone [Wiki]
methylisothiazolinone [Wiki]
MFCD01716911 [MDL number]
Microcide III
ProClin 300
Slaoff 360
Somacide RS
Tret-O-Lite XC 215
Zonen F
CMIT/MIT14%

Name: 5-Chloro-2-Methyl-4-Isothiazolin-3-One
Synonyms: 5-Chloro-2-methyl-Isothiazolin-3-one
Metat GT
Metatin GT
5-Chloro-2-methyl-3(2H)-isothiazolone
5-Chloro-2-methylisothiazol-3-one
Acticide
Algucid CH50
Amerstat 250
Euxyl K 100
Fennosan IT 21
GR 856 Izolin
Grotan K
Grotan TK2
Isothiazolone,5-chloro-2-methyl-
Kathon DP
Kathon LX
Kathon UT
Kathon WT
MCI/MI
Mergal K7
Methylchloroisothiazolinone/Methylisothiazolinone
Mitco CC 32 L
P3 Multan D
Paretol
Parmetol DF 35, -DF 12, -A23, -K50, -K40, -DF 18
Piror P109
Special Mx 323
Isothiazolinones
5-Choro-2-methyl-4-isothiazolin-3-one/2-methyle-4-isothiazolin-3-one
Isothiazolinone Biocidescides
CIT
5-Chloride-2-Methyl-4-Isothiazoline-3-Ketone
CMIT ISOTHIAZOLONE
5-chloro-2-methyl-1,2-thiazol-3(2H)-one
5-chloro-2-methyl-1,2-thiazol-3(2H)-one hydrochloride (1:1)
CMIT
1-(4-CHLOROPHENYL)-3-(3,4-DICHLOROPHENYL)UREA

antimicrobial agent: A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.

Synonyms
chloromethylisothiazolinone
5-chloro-2-methylisothiazol-3(2h)-one
EINECS 247-500-7
5-Chloro-2-methyl-4-isothiazolin-3-one
5-Chloro-2-methyl-1,2-thiazol-3(2H)-one
Methylchloroisothiazolinone
MFCD00792550
3(2H)-Isothiazolone, 5-chloro-2-methyl-
5-Chloro-2-methyl-3-isothiazolone

1. 26172-55-4
2. Methylchloroisothiazolinone
3. Kathon Cg 5243
4. 5-chloro-2-methyl-3(2h)-isothiazolone
5. Cmit
6. 3(2h)-isothiazolone, 5-chloro-2-methyl-
7. Unii-del7t5qrpn
8. 5-chloro-2-methyl-2h-isothiazol-3-one
9. 5-chloro-2-methylisothiazol-3(2h)-one
10. Chebi:53621
11. Dhnrxbzyeksxim-uhfffaoysa-n
12. 5-chloro-2-methyl-3-isothiazolone
13. 4-isothiazolin-3-one, 5-chloro-2-methyl-
14. Einecs 247-500-7
15. Brn 1210149
16. Ncgc00181041-01
17. Dsstox_cid_14286
18. Dsstox_rid_79138
19. 2,3-dihydro-2-methyl-3-oxo-5-chloroisothiazole
20. 5-chloro-2-methyl-4-isothiazolin-3-one Solution
21. Dsstox_gsid_34286
22. Cas-26172-55-4
23. Methylchloro-isothiazolinone
24. Bioace
25. 5-chloro-n-methylisothiazolone
26. Kathon Ixe
27. 5243-k-cg
28. 5-chloro-2-methylisothiazolin-3-one
29. C4h4clnos
30. Chloromethylisothiazolone
31. Methylchloroisothiazolone
32. Del7t5qrpn
33. Ac1l1pfn
34. Chloromethylisothiazolinone
35. Ac1q3h9y
36. Schembl20686
37. Schembl111860
38. Jsp005147
39. Chembl1738962
40. 00344_fluka
41. Ctk1a1887
42. Molport-003-925-052
43. 26530-03-0 (hydrochloride)
44. 2-methyl-5-chloro-3-isothiazolone
45. Ebd15202
46. Tox21_112689
47. Tox21_300199
48. 2-methyl-5-chloroisothiazolin-3-one
49. 5-chloro-2-methyl-isothiazol-3-one
50. Anw-44440
51. Hs 818
52. Zinc02002061
53. Akos006230760
54. An-5810
55. 5-chloro-2-methyl-1,2-thiazol-3-one
56. Ncgc00181041-02
57. Ncgc00254127-01
58. 5-chloro-2-methyl-4-isothiazoline-3-one
59. A 33
60. Aj-32372
61. Ak-34411
62. Am806586
63. Bc221924
64. Cj-07312
65. Cj-30896
66. Ls-86318
67. Sc-16430
68. 5-chloro-2-methyl-isothiazol-3(2h)-one
69. Ab0011549
70. Db-007017
71. Kb-197365
72. St2406200
73. Tc-133185
74. 5-chloro-2-methyl-1,2-thiazol-3(2h)-one
75. Ft-0082495
76. Ft-0620267
77. X5928
78. 5-chloride-2-methyl-4-isothiazoline-3-ketone
79. Q-9256
80. 5-chloro-2-methyl-4-isothiazolin-3-one, Technical Grade
81. 5-chloro-2-methyl-3(2h)-isothiazolone; 5-chloro-2-methyl-isothiazolone; Kathon Wt; Mci/mi
82. 137086-87-4
83. 137662-59-0

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