Chloromethylisothiazolinone; CMIT; Substance identity: EC/List no:247-500-7; CAS no: 26172-55-4; Mol.formula:C4H4ClNOS; Methylchloroisothiazolinone; chloromethylisothiazolinone
CAS Number: 26172-55-4 ;IUPAC name: 5-Chloro-2-methyl-1,2-thiazol-3(2H)-one. Other names: 5-Chloro-2-methylisothiazol-3(2H)-one; 5-Chloro-2-methyl-4-isothiazolin-3-one; Chloromethylisothiazolinone;Chloromethylisothiazolone
Description: Isothiazolinone is a heterocyclic chemical compound related to isothiazole. Isothiazolinone is an antimicrobial preservative that is often used to control fungi, bacteria, and algae. Since water-containing solutions are the breeding grounds for bacteria, isothiazolinone can easily be used in such solutions.
Applications: Although isothiazolinones have no direct applications, their derivatives such as 5-chloro-2-methyl-4-isothiazolin-3-on and 2-methyl-4-isothiazolin-3 which are used together as preservatives in commercial households and cosmetics products, for instance, cleaners, shampoos, and washing materials.
Notably, various products that use isothiazolinones are in the market, including shampoo, hand sanitizer, and lotions. Isothiazolinones is used in these products as an inhibitor of microbial activity that could lead to the product spoiling before the expected expiration date.
Methylchloro-isothiazolinone (MCI) is contained, along with methylisothiazolinone (MI), in Kathon cosmetic grade (CG) and MCI/MI. It is irritant and sensitizer.
Isocil(R) MW-14 is a high performance biocide for preserving metal working fluids, hydraulic fluids, polymer emulsions, pigment dispersions. Suggested applications: preservative concentrate. Very low level.
Isocil(R) PC is a cost-effective antimicrobial for personal care formulations. Suggested applications: personal care preservative.
Isocil(R) RW is a high performance industrial microbiocide for use in recirculating water cooling towers, wood, mold and mildew control, pulp and paper mills, air washer systems. Suggested applications: Industrial water treatment. Very low use levels.
CAS No.26172-55-4. Chemical Name:Isothiazolinones.SynonymsCMI;MCI;CMIT;IDAS;mci/mi;CMI/MIT;KATHONFP;KATHONLX;CMIT/MIT;Danisol-K
Methylchloroisothiazolinone, also referred to as MCI, is a preservative with antibacterial and antifungal effects within the group of isothiazolinones. These compounds have an active sulphur moiety that is able to oxidize thiol-containing residues, thereby effectively killing most aerobic and anaerobic bacteria. Methylchloroisothiazolinone is effective against gram-positive and gram-negative bacteria, yeast, and fungi.
Methylchloroisothiazolinone is found in many water-based personal care products and cosmetics. Methylchloroisothiazolinone was first used in cosmetics in the 1970s. It is also used in glue production, detergents, paints, fuels, and other industrial processes. Methylchloroisothiazolinone is known by the registered tradename Kathon CG when used in combination with methylisothiazolinone.
Methylchloroisothiazolinone may be used in combination with other preservatives including ethylparaben, benzalkonium chloride, and bronopol.
Chloromethylisothiazolinone is a 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5.
It is a powerful biocide and preservative and is the major active ingredient in the commercial product Kathon(TM).
It has a role as an antimicrobial agent, a xenobiotic and an environmental contaminant.
It is a member of 1,2-thiazoles and an organochlorine compound. It derives from a methylisothiazolinone.
Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties.
It is found within many commercially available cosmetics, lotions, and makeup removers.
It is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area.
The American Contact Dermatitis Society named Methylchloroisothiazolinone the Contact Allergen of the Year for 2013.
Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.
Methylchloroisothiazolinone can cause allergic reactions in some people. The first publication of the preservative as a contact allergen was in 1988. Cases of photoaggravated allergic contact dermatitis, i.e. worsening of skin lesions after sun exposure, have also been reported.
In pure form or in high concentrations, methylchloroisothiazolinone is a skin and membrane irritant and causes chemical burns. In the United States, maximum authorized concentrations are 15 ppm in rinse-offs (of a mixture in the ratio 3:1 of 5-chloro-2-methylisothiazol 3(2H)-one and 2-methylisothiazol-3 (2H)-one). In Canada, methylchloroisothiazolinone may only be used in rinse-off products in combination with methylisothiazolinone, the total concentration of the combination may not exceed 15 ppm.
As of 2008, the International Agency for Research on Cancer (IARC), did not list methylchloroisothiazolinone as a known, probable, or possible human carcinogen, nor have in vivo tests found evidence of carcinogenic activity
Biocidal active substances
3(2H) -Isothiazolone, 5-chloro-2-methyl-
C&L Inventory, Other
Plant preservative mixture
Kathon CG 5243
A 33 (bactericide)
HS 818 (antiseptic)
5-Chloro-2-methyl-4-isothiazolin-3-one (>14% solution in water)
CMI + MI in mixture 3:1 (CAS 55965-84-9) ( section sign)
CMI (also as part of mixture with CAS no. 55965-84-9, entry #870)
5-Chloro-2-methyl-3(2H)-isothiazolone; 5-Chloro-2-methyl-Isothiazolone; Kathon WT; MCI/MI
5-Chloro-2-methyl-4-isothiazolin-3-one, tech grade, >14% in water. CMI/MI >2.0
5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE (ACTIVE INGREDIENT >14%, CMI/MI 2.5 - 4.0)
2-Methyl-1,2-thiazol-3(2H)-on --5-chlor-2-methyl-1,2-thiazol-3(2H)-on (1:1) [German] [ACD/IUPAC Name]
2-Methyl-1,2-thiazol-3(2H)-one - 5-chloro-2-methyl-1,2-thiazol-3(2H)-one (1:1) [ACD/IUPAC Name]
2-Méthyl-1,2-thiazol-3(2H)-one - 5-chloro-2-méthyl-1,2-thiazol-3(2H)-one (1:1) [French] [ACD/IUPAC Name]
3(2H)-Isothiazolone, 2-methyl-, compd. with 5-chloro-2-methyl-3(2H)-isothiazolone (1:1) [ACD/Index Name]
2-Methylisothiazol-3(2H)-one 5-chloro-2-methylisothiazol-3(2H)-one (1:1)
2-Methylisothiazol-3(2H)-one 5-chloro-2-methylisothiazol-3(2H)-one (1:1) 14% in water
2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one
2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one (1:1)
2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one(14%in H2O)
2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one(in H2O)
3(2H)-Isothiazolone, 5-chloro-2-methyl-, mixt. with 2-methyl-3(2H)-isothiazolone
5-CHLORO-2-METHYL-3(2H)-ISOTHIAZOLONE MIXT. WITH 2-METHYL-3(2H)-ISOTHIAZOLONE
5-Chloro-2-methyl-3(2H)-isothiazolone with 2-methyl-3(2H)-isothiazolone
compound with 2-methyl-isothiazol-3-one
Kathon 886 W
Kathon CG/ICP II
Kathon RH 886
MFCD01716911 [MDL number]
Tret-O-Lite XC 215
Euxyl K 100
Fennosan IT 21
GR 856 Izolin
Mitco CC 32 L
P3 Multan D
Parmetol DF 35, -DF 12, -A23, -K50, -K40, -DF 18
Special Mx 323
5-chloro-2-methyl-1,2-thiazol-3(2H)-one hydrochloride (1:1)
antimicrobial agent: A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
3. Kathon Cg 5243
6. 3(2h)-isothiazolone, 5-chloro-2-methyl-
13. 4-isothiazolin-3-one, 5-chloro-2-methyl-
14. Einecs 247-500-7
15. Brn 1210149
20. 5-chloro-2-methyl-4-isothiazolin-3-one Solution
26. Kathon Ixe
43. 26530-03-0 (hydrochloride)
51. Hs 818
59. A 33
80. 5-chloro-2-methyl-4-isothiazolin-3-one, Technical Grade
81. 5-chloro-2-methyl-3(2h)-isothiazolone; 5-chloro-2-methyl-isothiazolone; Kathon Wt; Mci/mi