CAS number: 123-99-9
Formula: C9H16O4
Molecular Weight: 188.22094
Emerox 1144 is a special acid obtained from natural and sustainable resources.
Emerox 1144 is an azelaic acid used as a base product for high-performance greases and esters.
Emerox 1144 enhances the properties of a product by:
-improving flexibility
-providing derivatives with lower melting points than derivatives based on even-carbon acids
-initiating reactions resulting in higher molecular weight compounds
-improving dye receptivity
-providing better solubility characteristics
Applications of Emerox 1144:
-Nylon Engineering Plastics and Fibers
-Polyester Fibers, Films and Adhesives
-Urethane Elastomers and Elastomeric Fibers
-Lubricant Basestocks
-Lithium Complex Greases
-Thermosetting Unsaturated Polyester Resins
-Epoxy Flexibilizers
-PVC Plasticizers
-Corrosion Inhibitors
Emerox 1144 is an azelaic acid used as a base product for high-performance greases and esters.
KEYWORDS:
123-99-9, Emerox, Anchoic acid, Azalaic Acid, Azelex, Emerox 1110, Emery's L-110, Finacea, Finevin, Heptanedicarboxylic acid
Uses of Emerox 1144:
Emerox 1144v is used as a raw material for the production of plasticizer dioctyl azelate and spices, lubricants, oils, and polyamide resins.
Emerox 1144 is widely used in medicine and cosmetics.
Emerox 1144 - General Information:
Emerox 1144 is a saturated dicarboxylic acid found naturally in wheat, rye, and barley.
Emerox 1144 is a natural substance that is produced (also known as Pityrosporum ovale), a yeast that lives on normal skin.
Emerox 1144 is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%.
Emerox 1144 works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.
Emerox 1144's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Emerox 1144 gel is used to treat the bumps, an area of abnormal tissue change (lesions), and swelling caused by rosacea (a skin disease that causes redness, flushing, and pimples on the face).
Emerox 1144 cream is used to treat pimples (acne).
EMEROX 1144 DESCRIPTION:
Emerox 1144 is a saturated dicarboxylic acid found naturally in wheat, rye, and barley.
Emerox 1144 is a natural substance (also known as Pityrosporum ovale), a yeast that lives on normal skin.
Emerox 1144 is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%.
Emerox 1144 works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.
Emerox 1144's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
APPEARANCE of Emerox 1144:
Emerox 1144 is a white to cream solid.
FUNCTION of Emerox 1144:
Emerox 1144 is used to treat mild to moderate acne.
Emerox 1144 works in part by stopping the growth of skin bacteria that can help cause acne.
Emerox 1144 also helps to lessen acne by keeping skin pores (tiny openings on the skin's surface) clear.
Also, Emerox 1144 may be useful as a hair growth stimulant
SYNONYMS:
Azelaic Acid Emerox 1114, Emerox 1114, 1,9-Nonanedioic Acid, Unelic AZ
STORAGE:
Store Emerox 1144 in a cool, dry place. Keep container closed when not in use.
WHAT IS EMEROX 1144?
Emerox 1144 is used to treat mild to moderate acne.
Emerox 1144 works in part by stopping the growth of skin bacteria that can help cause acne.
Emerox 1144 also helps to lessen acne by keeping skin pores (tiny openings on the skin's surface) clear.
Emerox 1144 may also be used to treat other conditions as determined by your doctor.
Emerox 1144 is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems.
Although this use is not included in product labeling, Emerox 1144 is used in certain patients with the following medical condition:
Tan discoloration of face, often in pregnant women or women taking birth control pills
EMEROX 1144 INDICATIONS:
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient.
For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains.
Now fever, headache and body pains are the indications of paracetamol.
A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
Emerox 1144 Gel, 15% is indicated for topical treatment of the inflammatory papules and pustules of mild to moderate rosacea.
Although some reduction of erythema which was present in patients with papules and pustules of rosacea occurred in clinical studies, efficacy for treatment of erythema in rosacea in the absence of papules and pustules has not been evaluated.
USES OF EMEROX 1144 IN DETAILS:
There are specific as well as general uses of a drug or medicine.
Emerox 1144 can be used to prevent a disease, treat a disease over a period or cure a disease.
Emerox 1144 can also be used to treat the particular symptom of the disease.
Emerox 1144 use depends on the form the patient takes it.
Emerox 1144 may be more useful in injection form or sometimes in tablet form.
Emerox 1144 can be used for a single troubling symptom or a life-threatening condition.
While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
HOW SHOULD I USE EMEROX 1144?
Use Emerox 1144 gel as directed by your doctor.
Check the label on the medicine for exact dosing instructions.
This kit includes a cleanser, lotion, and an Emerox 1144 gel.
Emerox 1144 gel is only to be used on the skin.
Before using Emerox 1144 gel, wash the affected area with lukewarm water and the provided cleanser, rinse thoroughly, and pat dry.
Cover the affected area with a thin film of medicine.
Gently rub the medicine into your skin.
Allow Emerox 1144 to dry, then apply the provided lotion to the entire face.
Wash your hands immediately before and after using Emerox 1144 gel.
Do not cover the affected area with gauze or a bandage unless your doctor tells you to do so.
Continue to use Emerox 1144 gel for the full course of treatment even if your condition improves.
Do not miss any doses.
If you miss a dose of Emerox 1144 gel, use it as soon as possible.
If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Do not use 2 doses at once.
Emerox 1144 for patients
Patients should be told:
To use Emerox 1144 for the full prescribed treatment period.
To avoid the use of occlusive dressings or wrappings.
To keep Emerox 1144 away from the mouth, eyes and other mucous membranes.
If it does come in contact with the eyes, they should wash their eyes with large amounts of water and consult a physician if eye irritation persists.
If they have dark complexions, to report abnormal changes in skin color to their physician.
Due in part to the low pH of azelaic acid, temporary skin irritation (pruritus, burning, or stinging) may occur when Emerox 1144 is applied to broken or inflamed skin, usually at the start of treatment.
However, this irritation commonly subsides if treatment is continued.
If it continues, Emerox 1144 should be applied only once-a-day, or the treatment should be stopped until these effects have subsided.
If troublesome irritation persists, use should be discontinued, and patients should consult their physician.
Emerox 1144 Interactions:
No information provided
Emerox 1144 Contraindications:
Emerox 1144 is contraindicated in individuals who have shown hypersensitivity to any of its components.
Additional information about Emerox 1144:
Emerox 1144 Indication:
For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
Mechanism Of Action:
The exact mechanism of action of azelaic acid is not known.
It is thought that azelaic acid manifests its antibacterial effects by inhibiting the synthesis of cellular protein in anaerobic and aerobic bacteria, especially Staphylococcus epidermidis and Propionibacterium acnes.
In aerobic bacteria, azelaic acid reversibly inhibits several oxidoreductive enzymes including tyrosinase, mitochondrial enzymes of the respiratory chain, thioredoxin reductase, 5-alpha-reductase, and DNA polymerases.
In anaerobic bacteria, azelaic acid impedes glycolysis.
Along with these actions, azelaic acid also improves acne vulgaris by normalizing the keratin process and decreasing microcomedo formation.
Azelaic acid may be effective against both inflamed and noninflamed lesions.
Specifically, azelaic acid reduces the thickness of the stratum corneum, shrinks keratohyalin granules by reducing the amount and distribution of filaggrin (a component of keratohyalin) in epidermal layers, and lowers the number of keratohyalin granules.
Drug Interactions:
Not Available
Food Interactions:
Not Available
Generic Name:
Azelaic Acid
Synonyms:
n-Nonanedioic acid; Nonanedioic acid; Lepargylic acid; Heptanedicarboxylic acid; Azalaic Acid; Anchoic acid; Azelainic acid
Drug Category:
Antineoplastic Agents; Dermatologic Agents
Drug Type:
Small Molecule; Approved
Pharmacology of Emerox 1144
Emerox 1144 is a saturated dicarboxylic acid found naturally in wheat, rye, and barley.
Emerox 1144 is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin.
Emerox 1144 is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%.
Emerox 1144 works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.
Emerox 1144's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Other Brand Names containing Azelaic Acid:
Azelex; Emerox 1110; Emerox 1144; Emery's L-110; Finacea; Finevin; Skinoren;
Absorption:
Approximately 4% of the topically applied azelaic acid is systemically absorbed.
Toxicity (Overdose):
Oral LD50 in rat: >5 g/kg
Protein Binding:
Not Available
Biotransformation:
Emerox 1144 ia mainly excreted unchanged in the urine but undergoes some b-oxidation to shorter chain dicarboxylic acids.
Half Life:
The observed half-lives in healthy subjects are approximately 45 minutes after oral dosing and 12 hours after topical dosing, indicating percutaneous absorption rate-limited kinetics.
Dosage Forms of Emerox 1144:
Cream Topical
Chemical IUPAC Name:
nonanedioic acid
Chemical Formula:
C9H16O4
Organisms Affected:
Various aerobic and anaerobic microorganisms
Physical Form:
POWDER FORM
Emerox 1144 Brand names, Emerox 1144 Analogs
Anchoic acid
Azalaic Acid
Azelaic acid, technical grade
Azelaicacidtech
Azelainic acid
Azelex
Emerox 1110
Emerox 1144
Emery's L-110
Finacea
Finevin
Heptanedicarboxylic acid
Lepargylic acid
Nonanedioic acid
Skinoren
n-Nonanedioic acid
anchoic acid
azalaic acid
azelaicacid
azelainic acid
emerox 1110
finacea
1,7-heptane dicarboxylic acid
heptanedicarboxylic acid
1,7-heptanedicarboxylic acid
lepargylic acid
nonane dioic acid
1,9-nonane dioic acid
nonanedioic acid
1,9-nonanedioic acid
N-nonanedioic acid
nonanedioicacid
skinorem