ISOPROPYL MYRISTATE

Isopropyl myristate= Ester of Isopropyl alcohol + Myristic acid
Chemical Description: Myristic acid isopropylester
Isopropyl myristate (IPM) is the ester of isopropyl alcohol and myristic acid. Isopropyl myristate is a texture enhancer, emollient and emulsifier in cosmetic formulations.


EC / List no.: 203-751-4
CAS no.: 110-27-0

Isopropyl myristate is among the commonly used fatty acid ester and is isopropyl ester of tetradecanoic acid. Isopropyl myristate is categorized mainly employed as synthetic oil and is produced by reaction of isopropyl alcohol and myristic acid. Isopropyl myristate is among the foremost available substitutes for natural oil in the cosmetics industry. Isopropyl myristate is also used as solvent in several trans-dermal pharmaceutical products and pharmaceuticals creams.

Major end user industries for isopropyl myristate include personal care, pharmaceuticals, food and lubricants among several others. 
Personal care is the largest application segment for isopropyl myristate and the trend is anticipated to continue for a foreseeable future. 
Isopropyl myristate is also used as a pesticide free product for killing lice. 
Isopropyl myristate helps in enhancing skin penetration properties of products owing to which, pharmaceutical is anticipated to be the fastest growing application segment for isopropyl myristate. 
Other applications of isopropyl myristate include solvents, plasticizer and bio diesel among others.

Isopropyl myristate is an emollient, it helps to strengthen the skin barrier, ensuring that moisture stays locked in. As an emollient, it also helps soften and smooth dry skin, which is why this is a great ingredient for those with dry or flaky skin. 

This fabulous ingredient can also acts as a lubricant, thickening agent or a moisturiser in your cosmetic product. It is used to give your product a slicker, smoother feel rather than an oily one.
Isopropyl myristate is an emollient. It nourishes the skin while preserving its hydration. Its main advantage is that it does not leave a greasy finish on the skin.


ISOPROPYL MYRISTATE is classified as :
Binding
Emollient
Skin conditioning
Solvent
Perfuming

CAS Number: 110-27-0
EINECS/ELINCS No: 203-751-4
INN Name:    isopropyl myristate
PHARMACEUTICAL EUROPEAN NAME: isopropylis myristas
Chem/IUPAC Name: Tetradecanoic acid, isopropyl ester

Recommendations
Aftershaves, Shampoos, Bath oils, Creams and Lotions.
INCI Name
Isopropyl Myristate

Dosage
1-10%


Isopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption. Isopropyl myristate has been largely studied and impulsed as a skin penetration enhancer. At the moment the primary usage for which isopropyl myristate is formally indicated is as the active ingredient in a non-prescription pediculicide rinse.
Isopropyl Myristate is an ester of isopropyl alcohol and myristic acid (a fatty acid that naturally occurs in coconut and palm oils).  It is a very lightweight emollient and can be used like a carrier oil in many applications.

Isopropyl myristate finds many applications in food, cosmetic and pharmaceutical industries as an emollient, thickening agent, or lubricant.
Isopropyl Myristate (IPM) is an emollient ester of low viscosity; light weight oil.
IPM is ester of isopropyl alcohol and myristic acid (vegetable-derived).

Isopropyl myristate is mainly used as a solubilizer, emulsifier and emollient in cosmetic and topical medicines. It is also used as a flavoring agent in the food industry

Isopropyl Myristate is a synthetic oil used as an emollient, thickening agent or lubricant in beauty products. Isopropyl Myristate is a popular cosmetic and pharmaceutical ingredient. 
Isopropyl Myristate is most often used as an additive in aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.

Isopropyl myristate IPM is the ester of myristic acid and isopropyl alcohol. It is manufactured from high quality palmkernel or coconut oil. Isopropyl Myristate is a thin fluid with high stability. It is easy to spread onto the skin, is easily absorbed and in addition smoothens the skin. IPM also helps bind certain cosmetic preparations (fine grain and powdery).

IPM is a multifunctional (emollient, solvent, spreading agent, penetrant) synthetically produced ester of vegetal myristic acid and petrochemical isopropyl alcohol

INCI Name: Isopropyl Myristate
IPM is commonly found in formulations to help reduce the greasiness of whipped butters and emulsions.

IPM is not soluble in water, but it is soluble in castor and several other oils.
Suggested Usage Rates: Lotions & Creams: 2-5% - Lipsticks & Lip Balms – 1-5% - Massage Oils 4-10%

INCI: Isopropyl Myristate
Appearance / Product characteristics: Clear, colorless, almost odorless oil
Use: Fast spreading emollient suitable for all cosmetic applications.

Application
After Sun Antiperspirants & Deodorants 
Baby Care and Cleansing 
Body Care 
Color Care
Conditioning Face Care 
Face Cleansing 
Personal Care Wipes 
Self Tanning 
Sun Protection
Product Groups: Emollients
Isopropyl myristate (IPM) is used as a substitute for natural oils in cosmetics and a co-solvent with skin penetration enhancement properties of active ingredients in many topical and transdermal preparations. Isopropyl myristate is a novel pediculicide rinse (50%) and a safe and effective therapy for the treatment of head lice in children and adults.
Isopropyl Myristate is a fast spreading emollient suitable for all cosmetic applications.

Isopropyl myristate is the synthetic oil widely used in the cosmetics as a lubricant and emollient. 
This emmolient is manufactured by condensing myristic acid with isopropyl alcohol. 
Isopropyl myristate is readily absorbed by the skin and lessens the greasy nature of cosmetics while lending them a sheer, slick feel. 
Generally Isopropyl myristate is considered to be safe

It is non-occlusive, spreads well and provides an elegant, non-oily skin feel. It may be used as a carrier for cosmetic and pharmaceutical additives, and is also an excellent solubilizer for lanolin. Hence it finds broad application in topically applied cosmetic and pharmaceutical liquid, cream, lotion, powder and spray products.


Isopropyl Myristate is included in formulas to dramatically reduce the greasy/oily feel; it’s brilliant in recipes with large amounts of butters that are famous for a heavier skin feel (like shea).
Isopropyl Myristate is also a great lightweight emollient; you can include it in recipes as an alternative to a liquid carrier oil to make for a lighter, faster-absorbing product.

At higher concentrations IPM can also be used in products like makeup removers.

Isopropyl Myristate should be included in the oil phase of your products; it can be hot or cold processed.

Isopropyl tetradecanoate is a fatty acid ester.

Isopropyl myristate is used as a thickening agent or as a moisturizer in common beauty products. It is a synthetic oil that actually lessens the "greasy" or oily feeling found in some lotions and creams, while aiding in absorption. While it is widely used in health items, isopropyl myristate is also used as a way to treat head lice and in a mouthwash that kills bacteria.


Isopropyl myristate is a synthetic oil widely used in the cosmetics and pharmaceutical industries as a lubricant, emollient, and as a non-toxic alternative for controlling head lice. The oil is manufactured by condensing myristic acid with isopropyl alcohol and is colorless and mild in odor.

Isopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption. Isopropyl myristate has been largely studied and impulsed as a skin penetration enhancer.

Isopropyl Myristate (IPM) in cosmetics has become universal. Its skin feel, its dry emollience, its skin penetration and clear miscibility with vegetable and mineral oils are just some of the sought after formulation properties.

Isopropyl Myristate is an ester of the fatty acid Myristic Acid.

Isopropyl Myristate has a silky feeling that makes skin (and hair) soft, smooth and supple.

It also reduces the greasy feel of other oils in the same product. Rather than an oily mess, the cream is now sleek and light to the touch.

Isopropyl Myristate is a polar emoliant and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired.

Isopropyl Myristate is being studied as a skin enhancer. It is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.

Isopropyl Myristate is used in the same way in flea and tick killing products for pets.

Isopropyl Myristate is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product "Dentyl pH".

Isopropyl Myristate is is also used as a solvent in perfume materials and in the removal process of prosthetic make-up.

Hydrolisis of the ester from Isopropyl Myristate is can liberate the acid and the alcohol. The acid could be responsible for the decreasing of the pH value of formulations

Chemical Formula: C17H3402

Molar Mass: 270.457 g-mol-1

Density: 0.85 g/cm3

Boiling Point: 167'C (333'F)

GENERAL DATA:


CAS Number 110-27-0
EINECS Number 203-751-4

Isopropyl Myristate 
 

Solubility: Oil Soluble
Benefits: Emollient, thickening agent, lubricant or moisturiser in beauty products. in cosmetic manufacturing this ingredient is used to give the finished product a slicker, smoother feel rather than an oily one.
INCI Name: Isopropyl Myristate
 

Applications: Most often used at between 1-10%. This all-natural ester is used to empart a dry yet moisturising feel to skin creams. 
In addition, Isopropyl Myristate is also used to help solubilise actives such as sunscreens, vitamins and perfumes into a base.

Origin: Vegetable - Palm or Coconut.
Solubility: Insoluble in glycerine and water. Soluble in alcohol.
Recommendations: Aftershaves, Shampoos, Bath oils, Anti-perspirants, Various creams and lotions

Isopropyl Myristate is used as an emollient in cosmetic and topical preparations when good absorption through the skin is desired.

Uses: 
Skin Care Products / Cosmetics
Aftershaves
Antiperspirants / Deodorants
Bath oil
Hair sprays, gels, tonics and lotions
Soaps / Cleansers
Shampoos / Conditioners
Moisturizers
Make-ups
Nail Polish Remover
Powders / Sprays
Sunscreens
Topical medications, possibly including tar products
Emulsifier and emollient / lubricant in topical OTC and prescription medications 
Fragrances


Other names for Isopropyl Myristate:
IPM
Isopropyl Tetradeconoate 
Tetradecanoic acid 1- methylethyl ester
Isopropylis Myristas
Isopropyl Myristas
1-Methylethyl Tetradecanoate 
Myristic acid Isopropyl ester
1-Methylethyl Ester Tetradecanoic acid 
1-Methylethyl Tetradecanoate
Isopropyl Ester Myristic acid
Isopropyl Tetradecanoate
Tetradecanoic acid
1-Methylethyl Ester
Tetradecanoic acid
1Methylethyl Ester 
1-Tridecanecarboxylic Acid 
Isopropyl Ester
Bisomel 
Crodacol IPM 

Benefits: Emollient, thickening agent, lubricant or moisturiser in beauty products. in cosmetic manufacturing this ingredient is used to give the finished product a slicker, smoother feel rather than an oily one.

INCI Name: Isopropyl Myristate

Applications: Most often used at between 1-10%. This all-natural ester is used to empart a dry yet moisturising feel to skin creams. In addition, it is also used to help solubilise actives such as sunscreens, vitamins and perfumes into a base.

Origin: Vegetable – Palm or Coconut.

Solubility: Insoluble in glycerine and water. Soluble in alcohol.

Recommendations:

Aftershaves
Shampoos
Bath oils
Anti-perspirants
Various creams and lotions

This multi-purpose oil is an ester of isopropyl alcohol and myristic acid. The isopropyl component is a propane derivative; mirystic acid is a fatty acid common in plant sources such as nutmeg and palm seeds. Isopropyl myristate possesses several unique characteristics which make it a valuable additive in many cosmetics and pharmaceutical products. Certainly one of the most significant of these is the oil's ease of absorption by the skin. Used as an emollient in creams and lotions, isopropyl myristate ensures deep, quick penetration for these preparations.

 

This deep penetrating characteristic does have a downside however; extensive use of products containing the oil may lead to pore clogging. It still remains a valuable absorption carrier, though, and is common component of moisturizers, bath oils, and lotions. Although itself an oil, isopropyl myristate also reduces greasiness in cosmetics. When added to lip products and creams, it lends the cosmetics a slick, sheer texture without any greasy feel.

 

Isopropyl myristate is also a common ingredient in pharmaceutical formulations. It is often used as a non-pesticide alternative for treating head lice infestations. The oil destroys the wax layer which insulates the lice and causes death by dehydration. It is also effective at controlling oral bacteria and is used in several mouthwash products.


The fatty acid esters have a broad range of applications in industries such as cosmetic industry, food industry, the pharmaceutical industry, the coating industry, lubricants, biodiesel etc.
The esters of fatty acids includes methyl esters, isopropyl esters, butyl esters, partial glycerides and wax esters (esters of fatty acids with long-chain fatty alcohols), and ester oils (esters of fatty acids with poly alcohols)
The commonly used fatty acid ester, isopropyl myristate (IPM), is the main focus of present research.

IPM, the isopropyl ester of myristic acid, is used in cosmetics as a substitute for natural oils because it has excellent spreading properties and is absorbed easily into the skin. 
In many topical and transdermal preparations, IPM is also used as a co-solvent with skin penetration enhancement properties of active ingredients.

Conventional methods for IPM synthesis involve the use of chemical catalyst at high temperatures. 
But this result in undesirable changes in a final product with respect to colour, odour, and stability, hence there is need for post refining steps which increases overall unit processes. 
Therefore, nowadays the use of an enzyme catalyzed reaction is in focus to replace the conventional methods. 
Recently, many lipase based catalysis for esters have been reported wherein the esterification reaction were enhanced by reaction/enzyme engineering.

In accompanying papers the lipase-catalyzed esterification of myristic acid and isopropyl alcohol to produce isopropyl myristate ester was studied. 
They have used organic solvents like heptanes, petroleum ether to carry out esterification reaction. 
However, use of such organic solvents creates two phase system, hence has downstream processing problems. 
Further theses conditions affect an enzyme activity adversely. Hence, there is need for medium engineering in order to develop the improved esterification reaction system. 
Additionally, lower rate of reaction and yield in enzymatic route needed to be addressed for an efficient isopropyl myristate synthesis reaction.

Description: Ester of isopropyl alcohol and myristic acid (vegetable-derived). Low viscosity fluid non-greasy emollient, tolerates wide pH range, compatible with most surfactants. Thanks to its low viscosity and density, it has a high spreadability. Colorless oil-like liquid. No or little odor. Water-insoluble, but soluble with silicones, and hydrocarbons. Specific gravity 0.85 (at 20°C).
CAS: 110-27-0
INCI Name: Isopropyl myristate

Benefits:
Superior emollient for non-greasy bath, body and baby oils
Lubricant and compression aid for pressed powders
Light & non-tacky emollient for creams and lotions. Readily adsorbed by the skin
When used at high concentrations it gently lifts makeup and surface dirt
Gives gloss and shine to hair
Resistant to oxidation (does not become rancid)
Widely used as diluent for fragrance oils.

Use: Can be added to formulas as is, add to oil phase. Typical use level 1-20%. Required HLB: 11.5. 

Storage: Stable when kept in a closed container at a cool & dry place. For external use only.

Applications: Creams, lotions, hand creams, shampoo, shower gels, makeup removers, powders and foundations.

Raw material source: Vegetable oils (myristic acid) and isopropanol
Manufacture: Isopropyl myristate is produced by distillation, which is preceded by the esterification of myristic acid and isopropanol, alkali refined to neutralize the catalyst.


IPM is fatty acid ester of isopropyl alcohol and myristic acid. 
It is used in personal care products to enhance their moisturising and skin conditioning properties.

Isopropyl Myristate is derived from Myristic Acid and isopropyl alcohol


IUPAC name: Propan-2-yl tetradecanoate
Other names: Tetradecanoic acid, 1-methylethyl ester, Isopropyl tetradecanoate
Myristic acid isopropyl ester

CAS Number: 110-27-0 

Properties
Chemical formula: C17H34O2
Molar mass: 270.457 g·mol−1
Density: 0.85 g/cm³
Boiling point: 167 °C (333 °F; 440 K) at 9 mmHg


Uses
Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. 
Isopropyl myristate is being studied as a skin enhancer. It is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.
It is used in the same way in flea and tick killing products for pets.

It is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product "Dentyl pH".

Isopropyl myristate is also used as a solvent in perfume materials, and in the removal process of prosthetic make-up.

Hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol. The acid could be responsible for decreasing of the pH value of formulations.


Isopropyl myristate works as an emollient, helping to maintain the skin’s natural barrier and retain moisture. Isopropyl myristate also helps to increase the penetration of key ingredients in your product.

ISOPROPYL MYRISTATE

TYPE OF INGREDIENT: Emollient, though it also acts as a thickening agent and lubricant in beauty products.

MAIN BENEFITS: Strengthens the skin's natural moisture barrier to lock in hydration, enhances the penetration of other ingredients, thickens formulas, and makes those with a high oil content feel silky rather than greasy.

WHO SHOULD USE IT: Isopropyl myristate is ideal for anyone with normal to dry skin looking for moisturization benefits, according to Palep.

HOW OFTEN CAN YOU USE IT: For the best results, follow the directions on the product it's found in, though daily or twice daily use is generally fine.

WORKS WELL WITH: Isopropyl myristate works well with an assortment of active ingredients, says Solomon, which is why it's found in so many different types of products and formulas.

DON'T USE WITH: Because it does enhance penetration, it’s important to assess the other ingredients in the formula and whether this increased penetration can cause unexpected side effects such as irritation, cautions Palep.

Benefits of Isopropyl Myristate For Skin
Strengthen's the skin barrier: Isopropyl myristate keeps the outermost layer of the skin strong and intact. Think of the skin barrier as being made up of bricks and mortar: the cells are the bricks and all of the lipids (fats) are the mortar. Isopropyl myristate is that mortar, filling in cracks in between the skin cells so that moisture can't escape.


Softens the skin: As an emollient, it also helps soften and smooth dry skin, which is why this is a choice ingredient for those with dry or flaky skin.


Enhances the penetration of other ingredients: The exact mechanism by which this works isn't fully clear, but it's thought that isopropyl myristate changes the structure of the stratum corneum, the most external layer of the skin, making it easier for active ingredients to absorb


isopropyl myristate
Categories: Texture Enhancer, Emollients
Texture enhancer and emollient as used in cosmetics. There is also research showing it can help enhance the absorption of ingredients in a cosmetic formula.

Isopropyl myristate is often called out as being a particularly bad pore-clogging ingredient; however, this assessment comes from dated research that doesn’t apply to how this ingredient is used in today’s cosmetics.


Isopropyl Myristate is so good at reducing the greasy feel of other ingredients that it is possible to make products that are primarily shea butter that don’t feel greasy.

Alternatives & Substitutions: It is tricky to substitute Isopropyl Myristate well. 
One could use a very absorbing carrier oil instead (something like camellia seed oil), but even the lightest carrier oils won’t dramatically reduce the greasy feeling of a heavier formula, meaning the end product will be much heavier/slower absorbing than originally intended.
You could try something like isododecane or cyclomethicone, but ingredients like that are very volatile, meaning they cannot be heated much and will evaporate out of the finished product over time if given the opportunity.

What Is Isopropyl Myristate?
Isopropyl myristate is an ingredient that you may have unknowingly used many times before. Isopropyl myristate is a synthetic oil made from two components. The first component is isopropyl alcohol, the antimicrobial agent used in some hand sanitizers, baby wipes, and antiseptic formulations. The second component is myristic acid, which is a naturally occurring fatty acid often found in coconut oil, nutmeg, and animal fats such as butter—the two elements when they are combined form an exceptional emollient. 

Emollients are thick, slightly waxy ingredients that help to maintain the skin’s natural barrier and provide the skin with that desired hydrated look. The skin’s natural barrier is the first few layers of skin and the protective oils that are produced, sebum. Disruption of the skin’s natural barrier has been linked to skin conditions such as eczema, so skin barrier health is vital to clear healthy-looking skin. 

Isopropyl myristate has the added benefit of also enhancing the penetration of ingredients into the skin. This means that key ingredients in your skincare can penetrate deeply into the skin, working to improve the appearance of the skin.

What Are The Benefits of Isopropyl Myristate?
Moisture retaining 
Working as an emollient isopropyl myristate helps to maintain the integrity of the skin’s natural barrier. Products with isopropyl myristate help to create a protective coating on the surface of the skin. This helps to prevent moisture loss and limit the skin’s exposure to allergens and bacteria. 

Absorption
Isopropyl myristate improves the absorption of other products into the skin. It is often used in medicated formulations so that the skin receives the medication effectively. This is an excellent characteristic when it comes to getting the most out of your skincare ingredients; however, it can be irritating to sensitive skin type or clogging to congested skin types. 

Texture
Isopropyl myristate can help to improve the texture of the products. It helps to thicken the product, which enhances the feeling of the product on the skin as it is applied. In formulation, it prevents oil-based ingredients from feeling too greasy or heavy but creating an even emulsion. 

Isopropyl myristate (IPM) Chemical Properties, Uses and Production

Chemical Properties
It is a colorless and odorless liquid, and miscible with vegetable oil. It is not easy to be either hydrolyzed or become rancid. The refractive index nD20 is 1.435~1.438, and the relative density (20°C) is 0.85~0.86.

Content Analysis
Weight 1.5 g sample. Then it is determined by the method ester assay (OT-18). The equivalent factor (e) in the calculation is 135.2. Or it is determined by a non-polar column method of gas chromatography (GT-10-4).

Applications
It is applied as a dispersant for lipstick, hair cream, lipstick, cleansing cream, fragrance powder and medical ointment and can be also used as perfume fixative.
It is applied as dispersant for cosmetics.
Carrier solvent. Allowed food flavor additive according GB 2760-96.
It is one of the important ingredients of high-end cosmetics, has excellent penetration into the skin, moisture and softening effect and is used as emulsifier and wetting agent for cosmetics.
Used for organic synthesis. As solvent. For the preparation of spices.
Oily raw materials of cosmetics, solvent for pesticide original drugs.
It is widely used as additives for high-end cosmetics, such as ointment, cream, and conditioner.

Production Method
It is a product of esterification of myristic acid derived from re-steamed coconut coil with isopropyl alcohol.
(1)  200 kg myristic acid and 450 kg isopropyl alcohol were added into the reaction vessel in turn. After mixing, 360 kg sulfuric acid (98%) was added. The reaction mixture was heated to reflux for 10 hours. Isopropyl alcohol was then recovered, washed with ice water, and neutralized with Na2CO3 aqueous solution (10%). Under normal pressure, isopropyl alcohol and water were distilled. While under reduced pressure, isopropyl myristate was distilled (185°C/1.0kPa~195°C/2.7kPa).
(2) 90 kg isopropyl alcohol was added into the reaction vessel and then sulfuric acid as catalyst, with 5% of the total amount, was added. During mixing, 228 kg myristic acid was added slowly. The mixture was heated to reflux and water was continuously separated. Until no water was separated, the reaction temperature was reduced and probe was obtained to measure the acid value. When the acid value reached 1.5 mg KOH/g, the reaction was completed. Alkali was then added for neutralization. After the removal of water under reduced pressure, the pressure was further reduced for dealcoholization until the acid value was 0.05~1.0 mg KOH/g. The final product is then isopropyl myristate.

Toxicity
ADI is not regulated (FAO/WHO, 2001).

Description
Isopropyl myristate is odorless when pure. May be synthesized by conventional esterification of isopropanol with myristic acid.

Chemical Properties
Pure isopropyl myristate is virtually odorless, very slightly fatty, but not rancid

Chemical Properties
colourless liquid of low viscosity

Chemical Properties
Isopropyl myristate is a clear, colorless, practically odorless liquid of low viscosity that congeals at about 5°C. It consists of esters of propan-2-ol and saturated high molecular weight fatty acids, principally myristic acid.

Occurrence
Reported found in kumquat peel oil, papaya, starfruit, plum brandy, coriander seed and loquat

Uses
Isopropyl myristate is an emollient in cosmetic and pharmaceutical bases.

Uses
In cosmetic and topical medicinal Preparations where good absorption through the skin is desired. A jellied isopropyl myristate was marketed as Estergel (Merck & Co.) .

Uses
isopropyl myristate is an emollient, moisturizer, binder, and skin softener that also assists in product penetration. An ester of myristic acid, it is naturally occurring in coconut oil and nutmeg. Although isopropyl myristate is generally considered comedogenic, some ingredient manufacturers clearly specify non-comedogenicity on their data sheets.

Production Methods
Isopropyl myristate may be prepared either by the esterification of myristic acid with propan-2-ol or by the reaction of myristoyl chloride and propan-2-ol with the aid of a suitable dehydrochlorinating agent. A high-purity material is also commercially available, produced by enzymatic esterification at low temperature.

Preparation
By conventional esterification of isopropanol with myristic acid


USES & APPLICATIONS
Pharmaceuticals: Thickening Agent, Emollient, Moisturizer in Topical Medicinal Preparations
Personal Care & Cosmetics: Emollient, Moisturizer, Thickening Agent in Creams and Lotions
Flavor and Fragrance: Solvent, Binder, Diluent


Isopropyl Myristate: Uses and Characteristics

Isopropyl myristate is notable for promoting the absorption of medicine and other products through the skin. It is commonly found in creams, lotions and topical medicines. It is also used as a thickening agent, emollient and moisturizer, as well as a solvent, binder and diluent in perfumes and food flavorings.


Pharmaceutical Applications
Isopropyl myristate is a nongreasy emollient that is absorbed readily by the skin. It is used as a component of semisolid bases and as a solvent for many substances applied topically. Applications in topical pharmaceutical and cosmetic formulations include bath oils; make-up; hair and nail care products; creams; lotions; lip products; shaving products; skin lubricants; deodorants; otic suspensions; and vaginal creams. For example, isopropyl myristate is a self-emulsifying component of a proposed cold cream formula, which is suitable for use as a vehicle for drugs or dermatological actives; it is also used cosmetically in stable mixtures of water and glycerol.
Isopropyl myristate is used as a penetration enhancer for transdermal formulations, and has been used in conjunction with therapeutic ultrasound and iontophoresis.It has been used in a water-oil gel prolonged-release emulsion and in various microemulsions. Such microemulsions may increase bioavailability in topical and transdermal applications. Isopropyl myristate has also been used in microspheres, and significantly increased the release of drug from etoposide-loaded microspheres.
Isopropyl myristate is used in soft adhesives for pressuresensitive adhesive tapes.

Contact allergens
Despite wide use in cosmetics, perfumes, and topical medicaments, isopropyl myristate is a very weak sen- sitizer and a mild irritant.

Pharmacology
Isopropyl myristate is used in pharmaceutical preparations because it improves solubility and increases absorption through the skin. External uses include a non-irritating iodine preparation for disinfecting the skin (Powers & Rieger, 1963) and aerosol bactericidal preparations for feminine hygiene use without irritation of the skin and mucous membranes (Geistlich, 1970; Watson. 1969). Preparations for internal use include oral steroid formulations (Hirata, 1970) and anaesthetic injection solutions (Davis, Pearce & Connor, 1972).
Veterinary medications containing isopropyl myristate include oral or parenteral compositions for lungworm infections (N. V. Philips' Gloielampenfabrieken, 1964) and a spray formulation for bovine udders to treat mastitis, combat infection and improve the general skin condition (Kraus, 1965). Isopropyl myristate has been found to be an effective repository vehicle for im injection of penicillin in rabbits and for sc administration of oestrogens in ovariectomized rats (Platcow & Voss, 1954).
In assays on human forearms, vasoconstrictor activity of ointment preparations containing 0025% betamethasone 17-benzoate in white soft paraffin was increased by the presence of isopropyl myristate (Pepler, Woodford & Morrison, 1971). Donovan, Ohmart & Stoklosa (1954) noted that the good solvent properties of isopropyl myristate might increase the therapeutic activity of formulations by the apparent alteration in particle size of the active ingredients, so that further evaluation and clinical study would be necessary before its use in extemporaneous compounding could be recommended. Studies in which the antifungal activity of paraben esters solubilized by surfactants was decreased by isopropyl myristate (Matsumoto & Aoki, 1962) indicate that the effectiveness of medicinal substances may be influenced by the presence of surfactants and oily ingredients such as isopropyl myristate.

Safety
Isopropyl myristate is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.
LD50 (mouse, oral): 49.7 g/kg
LD50 (rabbit, skin): 5 g/kg

Metabolism
Higher molecular weight aliphatic esters are thought to be readily hydrolysed to the corresponding alcohols and acids which are then metabolized; isopropyl myristate is undoubtedly hydrolysed to normal metabolic products (Fassett, 1963). When myristic acid (as the ethyl ester) was fed to dogs,

storage
Isopropyl myristate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container in a cool, dry place and protected from light.

Incompatibilities
When isopropyl myristate comes into contact with rubber, there is a drop in viscosity with concomitant swelling and partial dissolution of the rubber; contact with plastics, e.g. nylon and polyethylene, results in swelling. Isopropyl myristate is incompatible with hard paraffin, producing a granular mixture. It is also incompatible with strong oxidizing agents.

Regulatory Status
Included in the FDA Inactive Ingredients Database (otic, topical, transdermal, and vaginal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Isopropyl myristate Preparation Products And Raw materials

Raw materials:
Myristic acid 
Coconut oil


Is Isopropyl Myristate Safe?
According to research conducted by the Cosmetic Ingredient Review Expert Panel, it is safe for its indicated use. However, isopropyl myristate can cause some sensitivity issues. In a case study published in the journal, Contact Dermatitis examined the potential for irritation to occur in sensitive skin types using isopropyl myristate products. They were able to identify that there is some sensitivity associated with the ingredient in some people, about 2%. 

The other issue with isopropyl myristate is that it is considered to be comedogenic, meaning that it can create blockages of the pores. This can increase the visibility of pores and might contribute to the presence of blemishes. For this reason, it may be best to avoid products with high levels of isopropyl myristate if you have congested skin. There is a broad range of concentrations used in products with a range between 0.001-20%. Higher concentrations tend to be present in products such as foundations and heavy moisturizers; other products tend to utilize lower strength. 

Other Uses:
Isopropyl myristate is sometimes used as an artificial flavor in food. It is also used in some head lice treatments as the waxy ingredient coats the lice and prevents them from sourcing water or food. 

Other Names:
Isopropyl myristate can also be known as 1-methylethyl ester tetradecanoic acid, tetradecanoic acid, IPM, isopropyl ester myristic acid, isopropyl myristate, isopropyl tetradeconoate, myristic acid, isopropyl ester, 1-methylethyl tetradeconoate, 1-methylethyl ester, and tetradecanoic acid. 

ISOPROPYL MYRISTATE
110-27-0
Isopropyl tetradecanoate
Tetradecanoic acid, 1-methylethyl ester
Bisomel
Estergel
Isomyst
Promyr
Deltyl Extra
Kesscomir
Tegester
Wickenol 101
Sinnoester MIP
Crodamol IPM
Plymoutm IPM
Starfol IPM
Unimate IPM
Kessco IPM
Emcol-IM
Stepan D-50
Emerest 2314
1-Methylethyl tetradecanoate
Myristic acid isopropyl ester
JA-FA IPM
Kessco isopropyl myristate
Crodamol I.P.M.
Tetradecanoic acid, isopropyl
Myristic acid, isopropyl ester
Tetradecanoic acid, isopropyl ester
UNII-0RE8K4LNJS
1-Tridecanecarboxylic acid, isopropyl ester
MFCD00008982
Estergel (TN)
NSC 406280
methylethyl tetradecanoate
0RE8K4LNJS
iso-Propyl N-tetradecanoate
Isopropyl tetradecanoic acid
CHEBI:90027
tetradecanoic acid isopropyl ester
Tetradecanoic acid methyethyl ester
NCGC00164071-01
Deltylextra
WE(2:0(1Me)/14:0)
DSSTox_CID_6838
Isopropyl myristate, 96%
Isopropyl myristate, 98%
DSSTox_RID_78224
DSSTox_GSID_26838
propan-2-yl tetradecanoate
Caswell No. 511E
Isopropyl myristate [USAN]
CAS-110-27-0
FEMA No. 3556
HSDB 626
IPM-EX
IPM-R
EINECS 203-751-4
EPA Pesticide Chemical Code 000207
BRN 1781127
Tegosoft M
Isopropyl myristate [USAN:NF]
Liponate IPM
Crodamol 1PM
IPM 100
Lexol IPM
myristic acid isopropyl
PubChem19813
ACMC-1BVUK
Radia 7190
Isopropyl myristate (NF)
EC 203-751-4
SCHEMBL2442
component of Sardo Bath Oil
Myristic acid-isopropyl ester
Isopropyl myristate, >=98%
CHEMBL207602
IPM 90
DTXSID0026838
WLN: 13VOY1&1
FEMA 3556
ZINC8214588
Isopropyl myristate, >=90% (GC)
Tox21_112080
Tox21_202065
Tox21_303171
ANW-16142
LMFA07010677
NSC406280
s2428
AKOS015902296
Myristic acid, isopropyl ester (8CI)
Tox21_112080_1
DB13966
NSC-406280
component of Sardo Bath Oil (Salt/Mix)
NCGC00164071-02
NCGC00164071-03
NCGC00256937-01
NCGC00259614-01
R524
SC-19093
DB-040910
FT-0629053
M0481
D02296
Q416222
SR-01000944751
Isopropyl myristate, Vetec(TM) reagent grade, 98%
Q-201418
SR-01000944751-1
TERT-BUTYL[(1R)-1-CYANO-2-PHENYLETHYL]CARBAMATE
UNII-137MVX8C09 component AXISYYRBXTVTFY-UHFFFAOYSA-N
Isopropyl myristate, United States Pharmacopeia (USP) Reference Standard
TETRADECANOIC ACID,ISOPROPYL ESTER (MYRISTATE,ISOPROPYL ESTER)
Isopropyl myristate, Pharmaceutical Secondary Standard; Certified Reference Material


Pharmacodynamics
Isopropyl myristate is an emollient vehicle that is effective at enhancing the penetration of other medical agents that may be incorporated into the vehicle as active agents 7. In one study, a 50:50 isopropanol-isopropyl myristate binary enhancer synergistically increased the transport of estradiol across a two-layer human epidermis in vitro 2.

Mechanism of action
As a pediculicide, isopropyl myristate is capable of physically coating the exoskeleton bodies of lice
 This physical coating subsequently immobilizes the lice and works to dissolve the wax covering on the insect exoskeleton and blocks the insects' airways, leading to death by dehydration 8,9,3,4. Although this physical action of isopropyl myristate results in little lice resistance (given the lack of immunologic or chemical activity in this mechanism of action), the substance is also not ovicidal, which means any eggs that may have been laid by lice would not be affected 8,9,3,4. Moreover, isopropyl myristate is capable of eliciting its pediculicide action in a contact time of only 10 minutes per each necessary administration 8,9,3,4.

Absorption
Dermal absorption of isopropyl myristate is predicated to be 0.00020 mg/cm2/event, which is considered a very low absorption rate. 
In a study, topically applied isopropyl myristate was largely retained in the stratum corneum. It was not detected in the receptor fluid of flow-through diffusion cells in in-vitro skin permeation experiments using human epidermis (stratum corneum and viable epidermis) and dermis of varying thickness 2.

Volume of distribution
Readily available information regarding the pharmacokinetics of isopropyl myristate is not available.

Protein binding
Readily available information regarding the pharmacokinetics of isopropyl myristate is not available.

Metabolism
Any isopropyl myristate that is absorbed is likely to be hydrolyzed to its component compounds of isopropylalcohol and myristic acid.

Hover over products below to view reaction partners

Isopropyl myristate
Isopropyl alcohol + Myristic acid

Isopropyl myristate
isopropyl myristate

CAS names: Tetradecanoic acid, 1-methylethyl ester

IUPAC names
IPM
ISOPROPYL MYRISTATE
Isopropyl Myristate
Isopropyl myristate
isopropyl myristate
Isopropyl myristate
isopropyl myristate
Isopropyl Myristate (Tetradecanoic acid, 1-methylethyl ester) CAS 110-27-0
Isopropylmyristate
propan-2-yl tetradecanoate
Tetradecanoic acid, 1-methylethyl ester


Trade names
CHINT: FCE (i-Propyl)E C14
Crodamol IPM
DUB IPM
IPM-S
Isopropyl Palmitate
MMEster E1140
PALMESTER
Palmsurf IPM
Phase I REACH Kandidat
RADIA 7191
RADIA 7727
RADIA 7730
RADIA 7730K
RADIA 7730Q
WAGLINOL 6014
WAGLINOL 6014/95
WAGLINOL 6014/98
WAGLINOL 6014/N


Isopropyl myristate, also commonly known as IPM is a clear, light yellow liquid which is oily in appearance and virtually odourless. It is soluble in most solvents but considered insoluble in water. IPM is manufactured by the esterification of isopropyl alcohol with myristic acid, and increases the absorption of perfumes on the skin.  Uses include: reed diffusers, creams, lotions, bath oils, lip balms, and perfumes.  IPM is oil soluble and may make surfaces slippery.


APPLICATIONS:
An emollient in skin care cosmetics, preparations where good absorption is desired.
Isopropyl myristate is commonly used as a diluent in room diffusers and oil burners.
Blend with your chosen concentrated fragrance or essential oil (Typically between 10-30% depending on desired strength) to create your own room diffuser and oil burner
Diluent for essential oils,  fragrance oil or perfumes

TOXICITY PROFILE FOR ISOPROPYL MYRISTATE (2005)
Isopropyl myristate (IPM) has produced slight irritation of human skin, mild irritation of the rabbit eye and moderate irritation of rabbit skin. Other local effects have included nasal and lung irritation during inhalation of aerosols in monkeys and rats, acne development after application to rabbit skin, and increased permeability of human skin to certain other substances. Skin sensitization reactions have only rarely been reported, and no sensitizing potential has been detected in studies involving a large number of volunteers with normal skin. IPM was of low acute toxicity to laboratory animals by the oral and dermal routes. Repeated administration produced slight effects on the liver and blood in rats treated orally and in rabbits given skin applications


Other names: Tetradecanoic acid, 1-methylethyl ester; Myristic acid, isopropyl ester; Bisomel; Crodamol I.P.M.; Crodamol IPM; Deltyl Extra; Emcol-IM; Isomyst; Isopropyl tetradecanoate; Kessco IPM; Kesscomir; Promyr; Sinnoester MIP; Stepan D-50; Wickenol 101; Emerest 2314; Estergel; Ja-fa IPM; Kessco isopropyl myristate; Plymoutm IPM; Starfol IPM; Tegester; Tetradecanoic acid, isopropyl; Tetradecanoic acid, isopropyl ester; Unimate IPM; 1-Tridecanecarboxylic acid, isopropyl ester; D 50; 1-Methylethyl tetradecanoate; IPM; Lexol IPM; Liponate IPM; Radia 7190; Tegosoft M; iso-Propyl N-tetradecanoate; Methylethyl tetradecanoate; Tetradecanoic acid methyethyl ester; NSC 406280; component of Sardo Bath Oil; 1405-98-7


Isopropyl Myristate is a synthetic oil used as an emollient, thickening agent, or lubricant in beauty products. 
Composed of of Isopropyl Alcohol (a propane derivative) and Myristic Acid (a naturally-occurring fatty acid), Isopropyl Myristate is a popular cosmetic and pharmaceutical ingredient. 
Isopropyl Myristate is most often used an an additive in aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.

Isopropyl myristate (IPM) is the ester of isopropyl alcohol and myristic acid. Isopropyl myristate (IPM) is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired


Final Report on the Safety Assessment of Myristyl Myristate and Isopropyl Myristate
First Published July 1, 1982 Research Article
https://doi.org/10.3109/10915818209021261
Article information 
Free Access
Abstract
Acute oral and dermal toxicity tests indicated that Myristyl Myristate is nontoxic to rats. This cosmetic ingredient produced minimal to mild skin irritation, minimal eye irritation in rabbits, and no sensitization in guinea pigs. Studies with rabbits indicated that undiluted Isopropyl Myristate was a mild irritant after 24 h and moderate to severe when applied for three consecutive days. Isopropyl Myristate was minimally irritating to the rabbits' eye, and was not a skin sensitizer in studies with guinea pigs. In limited studies, Isopropyl Myristate was not carcinogenic on the skin of mice, but a mixture of Isopropyl Myristate and isopropyl alcohol significantly accelerated the carcinogenic activity of benzo(a)pyrene on the skin.

Human studies with Isopropyl Myristate indicated that it was not a human skin irritant or sensitizer when applied in a product formulation containing 15-58% of the ingredient. A product containing 43% Isopropyl Myristate produced no phototoxicity and no photo-contact allergenicity in human studies.

From the available information, it is concluded that Myristyl Myristate and Isopropyl Myristate are safe as cosmetic ingredients in the present practices of use.

Isopropyl Myristate, 96% 25GR
IPM 100
IPM-EX
IPM-R
Radia 7730 (IPM)
Isopropyl myristate Vetec(TM) reagent grade, 98%
MYRISTIC ACID ISOPROPYL ESTER MINIMU
ISO-PROPYL N-TETRADECANOATE
ISOPROPYL TETRADECANOATE
BISOMEL
ISOPROPYL MYRISTATE
ESTERGEL
FEMA 3556
MYRISTIC ACID ISOPROPYL ESTER
TETRADECANOIC ACID 1-METHYLETHYL ESTER
TETRADECANOIC ACID ISOPROPYL ESTER
kesscoipm
kesscoisopropylmyristate
Kesscomir
Lexol IPM-NF
Liponate IPM
Plymoutm IPM
plymoutmipm
Promyr
Propyl myristate
Radia 7190
Revenge
Sinnoester MIP
sinnoestermip
Starfol IPM
starfolipm
Stepan D-50
1-Methylethyl tetradecanoate
1-Methylethyltetradecanoate
1-Tridecanecarboxylic acid, isopropyl ester
ISOPROPYLMYRISTATE,NF
Isopropylmyristat
Myristic acid, isopropyl ester: (Tetradecanoic acid, isopropyl: Isopropyl myristate),
ISOPROPYL MYRISTATE pure
tetraclecyl isopropyl ester
Isoprooyl myristate
Isopropyl tetradecanoate, Myristic acid isopropyl ester
Propan-2-yl tetradecanoat
Isopropyl myristate,96%
Isopropyl Myristate (500 mg)
Isopropy1 myristate
Isopropyl Myristate 98% (IPM)
1-tridecanecarboxylicacid,isopropylester
component of Sardo Bath Oil
crodacolipm
Crodamol 1PM
Crodamol I.P.M.
Crodamol IPM
crodamolipm
D 50
Deltyl Extra
deltylextra
Emcol-IM


Isopropyl myristate (IPM) is used as a substitute for natural oils in cosmetics and a co-solvent with skin penetration enhancement properties of active ingredients in many topical and transdermal preparations. Isopropyl myristate is a novel pediculicide rinse (50%) and a safe and effective therapy for the treatment of head lice in children and adults.

Isopropyl myristate (Resultz) is available in Canada and Europe and received FDA approval for treatment of head lice in 2017, although it is not yet marketed in the United States. It is a non-insecticide–based drug that contains isopropyl myristate, an ingredient commonly used in cosmetics. Its mode of action is a mechanical process that weakens the waxy shell of lice, resulting in internal fluid loss and dehydration. [38] It requires only a 5-minute application time.

Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. 
Isopropyl myristate is being studied as a skin enhancer. 
Isopropyl myristate is also used as a solvent in perfume materials.


Isopropyl myristate (IPM) is the ester of isopropyl alcohol and myristic acid. Isopropyl myristate (IPM) is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired.


0RE8K4LNJS
110-27-0 [RN]
13VOY1&1 [WLN]
1-Methylethyl tetradecanoate
203-751-4 [EINECS]
3556
IPM
IPM 100
IPM-EX
IPM-R
Isopropyl myristate [ACD/IUPAC Name] [USAN]
isopropyl tetradecanoate
Isopropylmyristat [German] [ACD/IUPAC Name]
MFCD00008982 [MDL number]
Myristate d'isopropyle [French] [ACD/IUPAC Name]
myristic acid isopropyl ester
Myristic acid, isopropyl ester
Propan-2-yl tetradecanoate
Tetradecanoic acid 1-methylethyl ester
Tetradecanoic acid isopropyl ester
Tetradecanoic acid, 1-methylethyl ester [ACD/Index Name]
Tetradecanoic acid, isopropyl ester
XB8600000
1-Tridecanecarboxylic acid, isopropyl ester
4-02-00-01132 (Beilstein Handbook Reference) [Beilstein]
Bisomel
Crodamol 1PM
Crodamol IPM
DELTYL EXTRA
Deltylextra
EINECS 203-751-4
Emcol-IM
Emerest 2314
Estergel [Trade name]
Estergel (TN)
FEMA 3556
IPM 90
Isomyst
Isopropyl myristate (NF)
isopropyl myristate 96%
isopropyl myristate 98%
isopropyl myristate, ??? 95.0%
isopropyl myristate, 96%
iso-Propyl N-tetradecanoate
isopropyl tetradecanoate, 98%
isopropyl tetradecanoate,98%
Isopropyl tetradecanoic acid
Isopropylmyristate
Isopropylmyristate, Tetradecanoic acid isopropyl ester, Myristic acid isopropyl ester, Sterile IPM
Ja-fa IPM
Jsp000796
Kessco IPM
Kessco isopropyl myristate
Kesscomir
Lexol IPM
Liponate IPM
Methylethyl tetradecanoate
Myristic acid-isopropyl ester
NCGC00164071-01
Promyr
Radia 7190
Sinnoester MIP
Starfol IPM
Stepan D-50
Sterile Isopropyl Myristate (IPM)
Tegester
Tegosoft M
Tetradecanoic acid isopropyl ester, Myristic acid isopropyl ester
Tetradecanoic acid methyethyl ester
Tetradecanoic acid, isopropyl
UNII:0RE8K4LNJS
UNII-0RE8K4LNJS
Unimate IPM
Wickenol 101
WLN: 13VOY1&1


Isopropyl myristate is among the commonly used fatty acid ester and is isopropyl ester of tetradecanoic acid. 
Isopropyl myristate is categorized mainly employed as synthetic oil and is produced by reaction of isopropyl alcohol and myristic acid. 
Isopropyl myristate is among the foremost available substitutes for natural oil in the cosmetics industry. Isopropyl myristate is also used as solvent in several trans-dermal pharmaceutical products and pharmaceuticals creams.

Major end user industries for isopropyl myristate include personal care, pharmaceuticals, food and lubricants among several others. 
Personal care is the largest application segment for isopropyl myristate and the trend is anticipated to continue for a foreseeable future. 
Isopropyl myristate is also used as a pesticide free product for killing lice. Isopropyl myristate helps in enhancing skin penetration properties of products owing to which, pharmaceutical is anticipated to be the fastest growing application segment for isopropyl myristate. Other applications of isopropyl myristate include solvents, plasticizer and bio diesel among others.

Low production cost as compared to other available substitute is among the foremost driver for demand of isopropyl myristate. 
Moreover the apparatus employed in the production of isopropyl myristate can be used for production of several other products. 
Therefore low capital investment is among the major growth drivers for isopropyl myristate market. Isopropyl myristate is employed in several pharmaceutical products primarily creams. 
Therefore, high growth in pharmaceutical industry across the globe is a major factor fuelling demand for isopropyl myristate. 
Increasing disposable income leading to surge in demand for personal care products including oil and other skin products is anticipated to drive isopropyl myristate market growth during the forecast period.

Isopropyl myristate is used in combination with several other products including petroleum products. 
Isopropyl myristate is easily penetrated into the skin whereas the petrochemicals get clogged in pores leading to a decline in supply of oxygen to the skin resulting in several skin related issues. Isopropyl myristate when in contact with diethanolamine leads to production of carcinogenic compounds. 
Therefore intensive care has to be taken while using isopropyl myristate based products which has been a major restraint for isopropyl myristate market growth. 
Increasing research and development for increasing the application scope of isopropyl myristate is expected to offer huge growth opportunity in the market.


Specs of IPM for Guidance ONLY:

Acid Value, mgKOH/g: 1.0 max    ASTM D 1980-87
Saponification Value, mgKOH/g: 202 – 212    ASTM D 5558-95
Iodine Value, g/100g: 1.0 max    ASTM D 5554-95
Color APHA (Hazen): 30 max    ASTM D 1209-84
Dyn. Viscosity @ 20°C, mPas: 5 – 6    ASTM D 445-88
Moisture (m/m), %    : 0.1 max    ASTM D 1744-92
Specific Gravity @ 25°C: 0.846 – 0.854    ASTM D 1298-85
Residue on Ignition (m/m), %:     0.1 max    
Refractive Index @ 25°C: 1.432 – 1.436    ASTM D 1747-99
Residual Solvents: Passes Test    In-USP/NF Method
C14 Ester (m/m), %: 98.0 min    

Isopropyl Myristate is a highly refined and distilled ester obtained by the esterification of isopropyl alcohol with myristic acid. It is a waterclear, low viscous oily liquid with a very good spreading capacity on the skin. Isopropyl Myristate is mainly used in cosmetics as an oil
component for emulsions, bath oils and as a solvent for active substances. 


Low production cost as compared to other available substitute is among the foremost driver for demand of isopropyl myristate. Moreover the apparatus employed in the production of isopropyl myristate can be used for production of several other products. Therefore low capital investment is among the major growth drivers for isopropyl myristate market. Isopropyl myristate is employed in several pharmaceutical products primarily creams. Therefore, high growth in pharmaceutical industry across the globe is a major factor fuelling demand for isopropyl myristate. Increasing disposable income leading to surge in demand for personal care products including oil and other skin products is anticipated to drive isopropyl myristate market growth during the forecast period.

Isopropyl myristate is used in combination with several other products including petroleum products. Isopropyl myristate is easily penetrated into the skin whereas the petrochemicals get clogged in pores leading to a decline in supply of oxygen to the skin resulting in several skin related issues. Isopropyl myristate when in contact with diethanolamine leads to production of carcinogenic compounds. Therefore intensive care has to be taken while using isopropyl myristate based products which has been a major restraint for isopropyl myristate market growth. Increasing research and development for increasing the application scope of isopropyl myristate is expected to offer huge growth opportunity in the market.


Isopropyl Myristate (IPM) is a synthetic oil used as an emollient, thickening agent, or lubricant in beauty products such as aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.

A unique characteristic of Isopropyl Myristate is its ability to reduce the greasy feel caused by the high oil content of other ingredients in a product. This synthetic oil is often added to beauty products to give them a slicker, sheer feel rather than an oily one.

Isopropyl Myristate is easily absorbed by the skin, ensuring quick penetration of a formula's ingredients.  We use 2% in all of our lotions and creams which leaves us with a less greasy product but still slick enough to feel like a lotion.  

Usage rates:  2-5% in lotions and creams
                       30-40% in bath oils

INCI:  Isopropyl myristateIsopropyl Myristate (IPM) is a synthetic oil used as an emollient, thickening agent, or lubricant in beauty products such as aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.

A unique characteristic of Isopropyl Myristate is its ability to reduce the greasy feel caused by the high oil content of other ingredients in a product. This synthetic oil is often added to beauty products to give them a slicker, sheer feel rather than an oily one.

Isopropyl Myristate is easily absorbed by the skin, ensuring quick penetration of a formula's ingredients.  
Some of our customers prefer to us  2% in all of their lotion and cream formulations which leaves us with a less greasy product but still slick enough to feel like a lotion.  

Usage rates:  
2-5% in lotions and creams
30-40% in bath oils

INCI:  Isopropyl myristate

1. Isopropyl Tetradecanoate
2. 110-27-0
3. Tetradecanoic Acid, 1-methylethyl Ester
4. Estergel
5. Promyr
6. Bisomel
7. Isomyst
8. Kesscomir
9. Tegester
10. Deltyl Extra
11. Sinnoester Mip
12. Crodamol Ipm
13. Plymoutm Ipm
14. Starfol Ipm
15. Unimate Ipm
16. Kessco Ipm
17. Emcol-im
18. Wickenol 101
19. Myristic Acid Isopropyl Ester
20. Stepan D-50
21. Emerest 2314
22. Deltylextra
23. Ja-fa Ipm
24. Kessco Isopropyl Myristate
25. Tetradecanoic Acid, Isopropyl
26. Crodamol I.p.m.
27. Myristic Acid, Isopropyl Ester
28. Caswell No. 511e
29. Tetradecanoic Acid, Isopropyl Ester
30. Unii-0re8k4lnjs
31. Propan-2-yl Tetradecanoate
32. 1-methylethyl Tetradecanoate
33. 1-tridecanecarboxylic Acid, Isopropyl Ester
34. Fema No. 3556
35. Hsdb 626
36. Einecs 203-751-4
37. Epa Pesticide Chemical Code 000207
38. Nsc 406280
39. Brn 1781127
40. Ncgc00164071-01
41. Dsstox_cid_6838
42. Isopropyl Tetradecanoic Acid
43. Dsstox_rid_78224
44. Dsstox_gsid_26838
45. Isopropylmyristate
46. Cas-110-27-0
47. Crodamol I.p.m
48. Estergel (tn)
49. Pubchem19813
50. Ipm-ex
51. Acmc-1bvuk
52. Ipm-r
53. E(r)eaeaoi+/-uo Yen
54. Isopropyl Myristate (nf)
55. 0re8k4lnjs
56. Agn-pc-0jk8cm
57. Ac1l1q4r
58. Isopropyl Myristate [usan]
59. Component Of Sardo Bath Oil
60. Ksc174s6r
61. M0757_sigma
62. W355690_aldrich
63. 172472_aldrich
64. Chembl207602
65. M0757_sial
66. Isopropyl Myristate [usan:nf]
67. Jsp000796
68. Wln: 13voy1&1
69. Ctk0h4968
70. Ipm 100
71. Molport-003-927-101
72. E(r)eai(1/4)eaoi+/-uo Yen
73. Tox21_112080
74. Tox21_202065
75. Tox21_303171
76. Anw-16142
77. Lmfa07010677
78. Nsc406280
79. Akos015902296
80. Myristic Acid, Isopropyl Ester (8ci)
81. Tox21_112080_1
82. Ag-c-86237
83. Ag-d-27612
84. Ls-2869
85. Nsc-406280
86. Rl00430
87. Rtr-002139
88. Ncgc00164071-02
89. Ncgc00164071-03
90. Ncgc00256937-01
91. Ncgc00259614-01
92. Kb-77952
93. R524
94. We(2:0(1me)/14:0)
95. Db-040910
96. Tr-002139
97. Ft-0629053
98. M0481
99. D02296
100. I14-13725
101. 3b3-027120
102. Tetradecanoic Acid,isopropyl Ester (myristate,isopropyl Ester)
103. 1405-98-7
104. 852553-53-8


Isopropyl myristate is a flexible ingredient that can be used in creams, lip balms, perfumes, bath and body oils and even in room diffusers.

In creams, lotions and body butters it can be added for a sliky-soft feeling, sensuous glide when applying to skin.  Use at up to 5% in creams, lotions and body butters.

isopropylmyristate

Isopropylmyristate is a fatty acid found in cosmetics.

• Methylethyl tetradecanoate
• 1-Tridecanecarboxylic acid, isopropyl ester
• 4-02-00-01132 (Beilstein Handbook Reference)
• BRN 1781127
• Bisomel
• Caswell No. 511E
• Crodamol I.P.M.
• Crodamol IPM
• Deltyl Extra
• Deltylextra
• EINECS 203-751-4
• EPA Pesticide Chemical Code
• 000207
• Emcol-IM
• Emerest 2314
• Estergel
• FEMA No. 3556
• HSDB 626
• IPM
• Isomyst
• Isopropyl myristate
• Isopropyl tetradecanoate
• JA-FA IPM
• Kessco IPM
• Kessco isopropyl myristate
• Kesscomir
• Myristic acid, isopropyl ester
• NSC 406280
• Plymoutm IPM
• Promyr
• Sinnoester MIP
• Starfol IPM
• Stepan D-50
• Tegester
• Tetradecanoic acid, 1-methylethyl ester
• Tetradecanoic acid, isopropyl
• Tetradecanoic acid, isopropyl ester
• Unimate IPM
• Wickenol 101


bout: IsopropylMyristate (IPM) is an ester of isopropanol and myristic acid. IPM is a colorless liquid used in many applications including personal care and cosmetics, flavor, fragrance and pharmaceuticals. Isopropyl myristate is a vegetable based ester with a faint odor that has been manufactured to the highest standards of eco-friendly management.
 
Uses & Applications: IPM serves an emollient, moisturizer or thickening agent in the personal care and cosmetics industry, specifically in creams and lotions. It has proven uses as a solvent, binder and diluent in the flavor and fragrance industry. Additionally, its moisturizing and thickening properties make it suitable for topical medicinal preparations in pharmaceuticals.
 
Storage: Isopropylmyristate is not prone to causing irritation to the skin or eyes. The product is highly stable under normal conditions and should be stored in its original container.
 

CAS#: 110-27-0
Tetradecanoic Acid, Isopropyl Ester


Its functions (INCI)
Binding : Allows the cohesion of different cosmetic ingredients
Emollient : Softens and softens the skin
Masking : Reduces or inhibits the odor or basic taste of the product
Perfuming : Used for perfume and aromatic raw materials

Common Use: Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. Isopropyl myristate is being studied as a skin enhancer. It is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.

Isopropylmyristate is used as a solvent in perfume materials.

Isopropylmyristate is the non-aqueous component of the two-phase mouthwash, Dentyl pH, where it removes bacteria from the oral cavity.

Isopropylmyristate is also used in the removal process of prosthetic make-up.

Isopropylmyristate is also used in flea and tick products for pets.

The hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol. The acid could be responsible for decreasing of the pH value of formulations.

Recommended Storage: Store in a well ventilated, cool, dry area.

For external use only.


INCI Name: Isopropyl myristte Ester of isopropyl alcohol and myristic acid (derived from plants).Low viscosity non-greasy softener liquid, withstand wide pH range, compatible with most surfactants. It is used in cosmetics and topical pharmaceutical preparations where good absorption through the skin is desirable. It is used as a solvent in perfume materials as well as in animal formulations against fleas.

Myristic Acid Isopropyl Ester
Isopropyl myristate used in the solution spinning process of hollow fiber fabrication, isocyanates found in the potting compound, and nonendotoxin LAL-reactive material believed to be cellulose in nature and found during rinsing of cellulose hollow-fiber dialyzers have also been suspected to cause DR.

Isopropyl Myristate. IPM (Isopropyl Myristate) of ATAMAN CHEMICALS acts as an emulsifier, humectant, softening and wetting agent. It offers easy penetration. 
IPM (IsopropylMyristate) finds application mostly in formulating cosmetic products.

HLB – A guide to cream making.

If you are making creams there are three little words that you should know: H = Hydrophile, L = Lipophile and B = Balance. Anyone who has tried to wash a greasy pan without using detergent will know that oil and water don’t mix in fact they detest each other so much that they usually require chemical mediation. You may beg to differ and tell me that it is perfectly possible to get oil and water to mix and you would be right for a while but it doesn’t take long before they go their separate ways and spelling devastation for your formula.  
Without going into a detailed chemistry lesson water likes to bond with water and oils like to bond with other oils due to special internal forces. The strong bonds that exist within each separate phase can be broken if you put some energy into the system (for example by homogenizing or stirring at high speed for a while) but when you stop stirring the little balls of oil and water soon start to coalesce and grow and before too long you have your two phases again. This can be slowed down physically by adding something that acts as a barrier – a thickener or suspending agent may do this job nicely and may result in a product that is stable for months or more but this only tends to work where the difference between the phases is very large – say 95% water, 5% oil. So, what most people do is opt for an emulsifier and this is where chemical mediation comes in.

There are lots of different emulsifiers but the general principal remains the same. They have one end that likes water and another end that likes oil. This dual-personality means that they grab hold of water droplets with one arm and oil with the other helping to form the emulsion of your dreams!

The HLB scale (which goes from around 4-18) was originally established to help classify ethoxylated emulsifiers and is applied to non-ionic emulsifiers. Matching the HLB of your ingredients to the emulsifier via a few simple calculations gives you a good starting point for a formulation. While the system isn’t fool proof (it doesn’t always work) it is regularly used to help select a wide variety of different emulsification systems and remains a good starting point, especially for those new to formulating. The classifications run like this:

HLB ACTIVITY

4-6 Water in oil emulsifier.

6-9 Wetting agent to get powders into oils such as make-up.

8-16 Oil in water emulsifiers.

16-18 Generally used as solubilisers for fragrances or essential oils.

To work out which HLB you need to make an emulsion you need to do the following.

1) Find out the HLB of each of the main ingredients in your oil phase. For example: Beeswax HLB 12, Almond Oil HLB 6, Isopropyl Myristate HLB 11.5.

2) Work out each ingredients contribution to the total HLB for the oil phase. To do this you need to know how much oil is in your oil phase:

Percentage Ingredient HLB

5% Beeswax 12

10% Almond Oil 6

5% Isopropyl Myristate 11.5

So, the oil phase makes up 20% of the formulation so: HLB / TOTAL % OF OIL PHASE * % FOR THAT INGREDIENT.

Example – Beeswax: 12/20 * 5 = beeswax accounts for a HLB of 3 in this formulation.

Almond Oil 6/20 * 10 = Almond Oil accounts for a HLB of 3 in this formulation.

Isopropyl Myristate 11.5/20 * 5 = Isopropyl Myristate accounts for a HLB of 2.88.

The total HLB for this formulation works out at: 8.88 so you would choose emulsifiers with a HLB of between 8 and 9.

Now that you have identified your products HLB best practice takes two emulsifiers and blends them to form a stable emulsion. This is because it increases the complexity of the two phases and makes then just a little less likely to split. Different emulsifiers will have different sized ‘middles’ and this too can add to the stability – very long chain emulsifiers can tangle up in the formula providing a physical as well as chemical barrier between phases.

Finally you will be wondering what percentage of emulsifier is required. Unfortunately this is not covered in the HLB system so a general rule of thumb applies. Your emulsifier will generally make up between 2-7% of your formulation. Getting it right in your formula may take some development time but it is worth persisting with as once you crack the code you are on the road to riches with your own beautiful creams and lotions.


Crodamol IPM
Chemical Description
Isopropyl Myristate

Product Description
Pharmaceutical grade of isopropyl myristate. Solvent used in topical formulations to encourage rapid absorption into skin. Required HLB value of 10. Recommended topical usage levels of 0.5-5%. The version of this product manufactured in Brazil (BR) is not intended for pharmaceutical applications. For more information on product availability manufactured in other regions, please contact our sales office.

Pharmacopoeia Compliance
FDA-IID Listed
PhEur


Chemical Group
Ester
Fatty acid ester

Market Application
Dermatology
Human Pharmaceutical
Veterinary Health

Functions
Emollient
Solvent

Administration Route: Topical


Also called IPM - isopropylmyristate is a clear, thin but non-greasy feeling, synthetically produced cosmetic oil.  
Isopropylmyristate is created when isopropyl alcohol and naturally occuring myristic acid are combined together.  
Its a useful ingredient in formulations where the desired end result is a less greasy presentation. 
When used in combination with other natural oils, a small percentage of IPM helps improve the absorbency of the finished product and leaves a soft, smooth texture on the surface of the skin.


We recommend a ratio of 1 to 5% though the manufacture states it can be used up to 10%.

To use: Add to your oil phase. Isopropylmyristate is oil soluble and will not blend with water without an emulsifier.


IsopropylMyristate, also known as the abbreviated IPM is an emollient ester used in a variety of products from lotions, creams, to fragranced products, as an additive to help moisturize, and to  help reduce the greasiness of lotions and creams, especially those that are anhydrous. Another advantage to using IPM,. is that when added to lotions & creams it promotes a silky, smooth feel. In products made without water (anhydrous) like lotion bars, lip balms, etc. it is especially useful. Plus IPM has no strong odor. 

IPM is also used in cosmetic and topical medicinal preparations or where you need good, fast absorption through skin is desired.

It also is used as a nice moisturizing solvent in emulsions in  bath oils and many other bath products. 

IsopropylMyristate find uses as an excellent gentle make up remover too. IPM will remove many types of make-up

INCI: Isopropyl Myristate

Great for: Non-greasy emollient, skin penetration enhancer, and solvent for perfume

How it works: Isopropyl myristate is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. 
Isopropyl myristate is very popular in consumer products because it reduces the greasy feeling associated with products high in oils. 
Because it can clog pores, it is best used in products like foot creams and perfume oils.

Where does Isopropyl Myristate come from?
Isopropyl myristate is a synthetic emollient used to soften the skin.It is made from isopropyl alcohol (which many of us are familiar with as a disinfectant) and Myristic Acid (a naturally-occurring fatty acid found in palm and coconut oil),

Isopropylmyristate is manufactured by condensing myristic acid with isopropyl alcohol and is colorless and mild in odor. 
Isopropylmyristate is readily absorbed by the skin and lessens the greasy nature of cosmetics while lending them a sheer, slick feel. 
In addition, Isopropylmyristate is commonly used as an additive in oral hygiene products, such as mouthwash. 
Although generally considered to be safe, isopropylmyristate may cause mild allergic reactions and could aggravate skin conditions

Isopropyl Myristate is used as a binder and emollient for cosmetic products. 
Also as a lubrication enhancer Isopropyl Myristate is used as a skin conditioner in cosmetic products.
Some of our formulator customers use it in Styling and Hair Care products to enable sheen and lubrication to the hair. 
It's often used instead of oils to provide emollient properties (increasing softness, smoothness and moisturization)


Isopropyl Myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. Isopropyl myristate is being studied as a skin enhancer. It is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration. It is used in the same way in flea and tick killing products for pets.
It is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product “Dentyl pH”.
Isopropyl myristate is also used as a solvent in perfume materials, and in the removal process of prosthetic make-up.
Hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol. The acid could be responsible for decreasing of the pH value of formulations.


Use: Branched chain, low viscosity, non-occlusive emollient with good spreading properties. Good solvent for lipophilic actives and dyestuffs.

IPM is a multifunctional (emollient, solvent, spreading agent, penetrant) synthetically produced ester of vegetal Myristic Acid and petrochemical Isopropyl Alcohol that conforms to the requirements of the National Formulary monograph for Isopropyl Myristate. 

IsopropylMyristate is non-occlusive, spreads well and provides an elegant, non-oily skin feel. 

Isopropylmyristate may be used as a carrier for cosmetic and pharmaceutical additives, and is also an excellent solubilizer for lanolin. 
Hence it finds broad application in topically applied cosmetic and pharmaceutical liquid, cream, lotion, powder and spray products. 
IPM is best stored in sealed containers kept in a cool, dry place. 
Prolonged storage, at temperatures above 90°F (32°C) should be avoided.

Use: Cosmetic and pharmaceutical use : Oil base with low viscosity, good adaptation to skin. Colorless no odor. Suitable for cream-milk lotion, emollient and shampoo.

Use: Flavours and Fragrances, Cosmetics and Personal Care, Cleaning and Detergents, Industrial, Inks and Coatings, Pharmaceutical and Veterinary

Use: Very widely used solvent for low-polarity ingredients, mobile, non-flammable, non-sticky and and most unusual in that it has been demonstrated to be an effective fixative for many odourants: one of a very small number of odourless fixatives.

Isopropyl myristate is an ingredient that you may have unknowingly used many times before. Isopropyl myristate is a synthetic oil made from two components. The first component is isopropyl alcohol, the antimicrobial agent used in some hand sanitizers, baby wipes, and antiseptic formulations. The second component is myristic acid, which is a naturally occurring fatty acid often found in coconut oil, nutmeg, and animal fats such as butter—the two elements when they are combined form an exceptional emollient. 

Emollients are thick, slightly waxy ingredients that help to maintain the skin’s natural barrier and provide the skin with that desired hydrated look. 
The skin’s natural barrier is the first few layers of skin and the protective oils that are produced, sebum. 
Disruption of the skin’s natural barrier has been linked to skin conditions such as eczema, so skin barrier health is vital to clear healthy-looking skin. 

Isopropyl myristate has the added benefit of also enhancing the penetration of ingredients into the skin. 
This means that key ingredients in your skincare can penetrate deeply into the skin, working to improve the appearance of the skin.


What Are The Benefits of
Isopropyl Myristate?
Moisture retaining 
Working as an emollient isopropyl myristate helps to maintain the integrity of the skin’s natural barrier. Products with isopropyl myristate help to create a protective coating on the surface of the skin. This helps to prevent moisture loss and limit the skin’s exposure to allergens and bacteria. 

Absorption
Isopropyl myristate improves the absorption of other products into the skin. It is often used in medicated formulations so that the skin receives the medication effectively. This is an excellent characteristic when it comes to getting the most out of your skincare ingredients; however, it can be irritating to sensitive skin type or clogging to congested skin types. 

Texture
Isopropyl myristate can help to improve the texture of the products. It helps to thicken the product, which enhances the feeling of the product on the skin as it is applied. In formulation, it prevents oil-based ingredients from feeling too greasy or heavy but creating an even emulsion. 


Isopropyl Myristate, or IPM as is most commonly known, is a synthetic oil which is used for its moisturizing and emollient benefits. Although it is a synthetic product, its benefit in certain formulations is superior to other products. IPM has an amazing ability to penetrate and moisturize the skin, as well as helps to eliminate the greasy feeling in certain products with a lot of oil.

Solubility: Oil Soluble
Benefits: Emollient, thickening agent, lubricant or moisturiser in beauty products. in cosmetic manufacturing this ingredient is used to give the finished product a slicker, smoother feel rather than an oily one.
INCI Name: Isopropyl Myristate
 

Applications: Most often used at between 1-10%. This all-natural ester is used to empart a dry yet moisturising feel to skin creams. In addition, it is also used to help solubilise actives such as sunscreens, vitamins and perfumes into a base.
Origin: Vegetable - Palm or Coconut.
Solubility: Insoluble in glycerine and water. Soluble in alcohol.
Recommendations: Aftershaves, Shampoos, Bath oils, Anti-perspirants, Various creams and lotions


Isopropyl Myristate
Product Categories: Emollient
Product Applications: After Sun Care, AP/DEO, Baby Care, Body Care, Dry Shampoo, Face Care, Hair Care, Hand & Nail Care, Skin Care, Skin Cleansing, Sun Care

Isopropyl Myristate (IPM) is a polar emollient. In make up IPM is often used as a remover for prosthetic adhesives and Alcohol activated colours.


Benefits: Emollient, thickening agent, lubricant or moisturiser in beauty products. in cosmetic manufacturing this ingredient is used to give the finished product a slicker, smoother feel rather than an oily one.
INCI Name: Isopropyl Myristate 
Applications: Most often used at between 1-10%. Used to deliver a dry yet moisturising feel to skin creams. In addition, it is also used to help solubilise actives such as sunscreens, vitamins and perfumes into a base. Origin: Vegetable - Palm or Coconut. Solubility: Insoluble in glycerine and water. Soluble in alcohol. Recommendations: Aftershaves, Shampoos, Bath oils, Anti-per spirants, Various creams and lotions


Isopropyl Myristate (IPM) is a clear, colorless and nearly odorless synthetic oil that is widely used in the personal care and pharmaceutical industries. IPM is employed as an emollient, lubricant and non-toxic alternative for managing head lice. The oil possesses a number of unique characteristics that make it a valuable additive in numerous cosmetic and pharmaceutical products.

One of the most significant of these characteristics is IPM’s ease of absorption and high spreadability on the skin. This quality is a result of the oil’s low density and viscosity. 

METHOD OF MANUFACTURING IPM
Isopropyl myristate is commercially produced through the esterification of isopropyl alcohol (isopropanol) and myristic acid. The resultant compound is then distilled and further refined using an alkali to neutralize the catalyst. Additional distillation of this secondary compound produces isopropyl myristate.

APPLICATIONS OF ISOPROPYL MYRISTATE
There are numerous reasons why companies in the personal care industry include isopropyl myristate in their products. Perhaps the most important reason is its solubility. IPM is soluble in most organic solvents including ethanol, toluene, benzene, ether, castor oil, acetone, cottonseed oil, mineral oil, lanolin, chloroform and ethyl acetate. These solvents are widely utilized in many personal care products.

The oil has the ability to moisturize the skin in small doses. As an emollient, this oil helps in the strengthening of the skin’s natural moisture barrier. The overall result is a significant reduction in moisture loss through the day. This helps the skin stay hydrated for extended periods of time. Isopropyl myristate also has the ability to thicken formulations.

This property is essential in providing a denser texture to creams, lotions, and deodorants. While this property does not improve the skin directly, it offers a luxurious feel to skin care products thus improving consumer enjoyment or experience. In the case of deodorants, a denser texture allows for smoother application to the skin.

IPM plays a key role in solubilizing lanolin. The mixtures that contain upto 50 % lanolin in isopropyl myristate remains stable non-viscous liquids at a room temperature. As such, the oil is utilized as a solubilizing and penetrating agent in the anhydrous skin lotions with the high lanolin content.

Isopropyl myristate is also used to improve cosmetic products with high oil content. High oil content can make products feel greasy on the skin, which is a major problem with consumers. In addition, greasiness makes it impractical or difficult to use such products in a professional setting. Manufacturers include isopropyl myristate in such products to achieve a silky and smooth texture.

IPM is a crucial ingredient in hair and nail products, skin lotions, eye creams, bath preparations, make-up, shaving products, antiperspirants, and perfumes. It also serves as a plasticizer in hair sprays and lacquers.

IPM is employed in topical medicinal preparations where pharmaceutical effectiveness is dependent on proper absorption. Isopropyl myristate has strong dermal penetration properties. This is a valuable attribute, which helps other skin healing compounds penetrate deeper into the dermal layers for optimal results.

Companies that produce anti-aging serums and acne medications often incorporate isopropyl myristate into their formulas. One lesser-known property of isopropyl myristate is the ability to inhibit the growth of oral bacteria. A large number of oral hygiene product manufacturers such as mouthwash brands utilize this compound.

IPM is highly effective as a pesticide-free treatment option for head lice. It functions by dissolving the wax covering the exoskeleton of head lice, killing the insects by dehydration. It is considered safe for use in this regard on individuals above the age of four.

SIDE EFFECTS OF IPM
As evident in any product ingredient, isopropyl myristate has some side effects and indications. The most notable side effect is skin irritation. This may occur in people with very sensitive skin. The areas that are mostly affected are locations where the skin is very thin such as around the eyes and lips. In many cases, this happens due to IPM’s ability to increase the absorption of other ingredients that directly cause the irritation. IPM in itself does not cause irritation directly.

Overall, isopropyl myristate is considered safe for human consumption and has been widely adopted by the personal care and pharmaceutical industries. Several other cosmetic ingredients are similar to isopropyl myristate in regards to function. These include Isocetyl Stearate, Myristyl Myristate, Isopropyl Isostearate, Ethylhexyl Stearate and Tetrasodium EDTA.

Disclamer:
The information is website is for general information purposes only. Your use, reference or interpretation of any of the information published is at your own risk. We will provide Specifications & MSDS for our customers as each manufacturer may provide the same product with different specifications which may not apply to or may need to be adjusted to your formulations.


Isopropyl myristate is an ester derived from isopropyl alcohol and myristic acid. It is a low viscosity, fluid grade emollient. It is useful in a wide pH range and blends well with other surfactants. It comes as a colorless, no odor oil-like liquid. It’s low density and viscosity gives good spreadability. It is mainly a product of vegetable origin.

Use & Benefits: 
Isopropylmyristate is used in bath, baby and body oils since it is a superior emollient, it gives gloss and shines to hair. 
Moreover, it has a higher capacity to withstand oxidation, so it can provide a good shelf life. 
It can be used as a diluent i.e. to make up the volume up to certain limit that can be handled easily. 
Isopropylmyristate is also used in the fragrance oil. It can also be used as a lubricant, which can improve flow of powdery material. 
This helps uniform dispersion of dose in a particular formula. It is used as a compression aid for pressed powder, light and non-tacky for creams and lotions. 
Isopropylmyristate has a benefit of its smaller size that it penetrates readily into the skin. In higher concentration, can be used as a make up remover and cleanser.

Isopropylmyristate is used in shower gels, makeup removers, powders, and foundations, aftershaves, antiperspirants, hand creams, creams, and lotions.

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