OCTYLISOTHIAZOLINONE


OIT
OIT 45 %

Synonyms
Octylisothiazolinone, 2-Octylisothiazolinone, OIT, Octylisothiazolinone, NOIT, mildewcide OIT.
Octylisothiazolinone


Synonym:Octylisothiazolinone; 2-octyl-3(2h)-isothiazolon;2-octyl-3-isothiazolone;2-octyl-4-isothiazolin-3-on
2-n-Octyl-4-isothiazolin-3-one

CAS No.:26530-20-1

EINECS No.:247-761-7

Molecular Formula:C11H19NOS

Molecular Weight:213.3397


Octylisothiazolinone Biocide Metalworking Fluid Fungicide for Water-Based Cutting Fluids 
Soluble, synthetic, and semi-synthetic metalworking fluids or coolants provide an excellent environment for the growth of various microorganisms, including bacteria, mold, and yeast. 
If allowed to grow, these organisms can have detrimental effects on the fluids. 
For example, bacteria, which can grow very quickly, can destroy the integrity of the fluid by discoloration, destroying lubricity characteristics, and causing emulsions to split. 
Bacteria can also reduce the pH of the fluid, which can promote corrosion. 
Some forms of bacteria have objectionable odors. 

Fungi typically grow more slowly than bacteria, but can form large masses which clog filters and lines and in some cases lead to system shutATAMAN CHEMICALSn; fungi also generate foul odors and can cause corrosion. 
The increased use of synthetic fluids over the past few years has led to an even greater need for the enhanced fungal control that Octylisothiazolinone  can provide. 
For Tankside and Concentrate Octylisothiazolinone is a broad-spectrum fungicide that has been recommended and widely used for tankside control of fungi in metalworking central systems. 2-Octylisothiazolinone is also an effective fungicide for use in many metalworking fluid concentrates with the appropriate stabilizer package. 
Due to the wide variations in metalworking fluid formulations, laboratory or small-scale tests are recommended to evaluate Octylisothiazolinone in usedilution and concentrate metalworking fluids before they are commercialized.

Octylisothiazolinone is a highly effective, industrial fungicide that exhibits excellent fungistatic and fungicidal activity against fungi, including yeasts and mold, and Gram-Positive bacteria, and limited activity against Gram-Negative bacteria. 
Commonly known as octhilinone, 2-Octylisothiazolinone is the active ingredient of Octylisothiazolinone. 

It is supplied as a 45 percent active liquid in propylene glycol. 
The information in this brochure has been compiled to familiarize the reader with Octylisothiazolinone technology, to communicate the tremendous benefits of this product, and to provide directions for safe and efficient use of the product. 
By following the precautions outlined in this brochure, on the product label, and on the ATAMAN CHEMICALS Safety Data Sheet (SDS), Octylisothiazolinone can be safely handled. 
H O C3H8 -n C C N S C H 2-Octylisothiazolinone 45% minimum Propylene glycol (inert) 50% minimum 

The following are typical properties of Octylisothiazolinone Biocide; they are not to be considered product specifications. 
Appearance: Yellow to amber liquid 
Color (VCS):  8 max. 
Mildly sweet Specific gravity @ 24°C: 1.03 
Flash point, °C (Pensky Martens Closed Cup): 93 
Viscosity Brookfield @ 20°C, cps: 40 
Melting point, °C: -40 
Boiling point, °C: 188 
Vapor pressure, active ingredient @ 25°C: 3.7 x 10-5 torr 
Solubility The solubility data provided below were determined at ambient temperatures (20 to 25°C). 
The solubility and stability of the active ingredient may be affected when the temperature is lowered to 0°C or increased to 60°C. 

• Octylisothiazolinone Biocide is soluble in methanol, ethanol, propylene glycol, acetone, ethyl ether, ethyl acetate, chloroform, butyl Cellosolve, corn oil, and mineral oil. 

• The solubility of Octylisothiazolinone in toluene is 25% w/v. 

• The solubility of Octylisothiazolinone in water at 25°C is 480 ppm (active ingredient), although this may be increased by using suitable surfactants and emulsifiers. 
• Octylisothiazolinone is insoluble in heptane. 

Compatibility In concentrate and use-dilution metalworking fluids, the compatibility of Octylisothiazolinone Biocide is concentration-dependent and varies from formulation to formulation. 
It is compatible with most metalworking fluid additives, including surfactants and amines. 

Compatibility with amines may vary by the type, concentration and pH. 
Strong reducing agents, such as sulfides, mercaptans, bisulfites and metabisulfites, or strong oxidizing agents, such as hypochlorites, may affect the efficacy of Octylisothiazolinone.
Laboratory or small-scale tests are recommended in order to evaluate Octylisothiazolinone compatibility in use-dilution or concentrate metalworking fluids prior to commercialization. 2-Octylisothiazolinone is compatible with most other metalworking fluid biocides, including EXOCIDE 886 MW and EXOCIDE CC (methylchlorosiothiazolone), KORDEK LX5000 (methylisothiazolone), ROCIMA BT 2S biocides (benzisothiazolone), triazine and formaldehyde-releasers, IPBC (iodopropynylbutylcarbamate) and sodium Pyrithione. 
Stability In-Use Stability: Octylisothiazolinone Biocide has excellent stability in end use dilutions of metalworking fluids. 
It is stable over a wide pH range (4-10) in water and in metalworking fluid systems. 
Concentrate Stability: Octylisothiazolinone Biocide stability, in metalworking fluid concentrates, is variable. 

We recommend checking stability and performance before commercialization of products. 

ATAMAN CHEMICALS has several recommended stabilizers to improve stability and compatibility in many types of concentrates. 

Storage Stability: In general, the storage stability of the Octylisothiazolinone Biocide product is excellent. 
The shelf life of the product is nominally twelve years at 25°C. 

It is Physical Properties 
PS strongly recommended, however, that both the stability and compatibility of Octylisothiazolinone Biocide in metalworking fluid formulations or systems be thoroughly examined before commercialization. 

Table 1 
The many advantages of protecting your metalworking fluids with Octylisothiazolinone Biocide fungicide include: Features Benefits Highly effective microbicide Extends metalworking fluid life, reduces ATAMAN CHEMICALSntime, reduces makeup fluid use and reduces fluid disposal costs Broad spectrum activity Kills fungi and prevents the return of slime caused by fungal microorganisms, eliminates clogged lines and filters and musty odors caused by fungi Patented combinations of EXOCIDE 886 MW or KORDEK LX5000 biocides with Octylisothiazolinone Biocide Synergistic combinations that enhance the already wide spectrum of bioactivity. 
Enhanced activity present even if Octylisothiazolinone is added in the concentrate and Octylisothiazolinone added tankside Good temperature and pH stability 
Works well in a variety of metalworking conditions up to 60°C (140°F) and pH 10 
Highly soluble in water and does not foam 
Easy to dose 
Provides long lasting fungal control 
Cost effective versus competitive tankside treatments 
Fast acting 
Quickly controls growth and activity of odor-causing fungi 
Effective at low use rates and biodegradable 
Better for the environment 
Does not contain, release or generate formaldehyde 
Not subject to concern about formaldehyde, a known carcinogen 

Method of Addition Octylisothiazolinone should be directly dispensed into metalworking fluid concentrates or use-dilution metalworking fluids using a metering pump or other point-of-use device where possible and uniformLy dispersed throughout the fluid. 
Fluid Concentrate Octylisothiazolinone should be added to metalworking fluid concentrates at a level that ensures the final use-dilution fluid will contain 55 to 167 ppm of product (25 to 75 ppm active ingredient). 2-Octylisothiazolinone stability in a given concentrate should be determined prior to commercialization. 
Contact your local ATAMAN CHEMICALS representative for assistance in selecting one of several recommended stabilizers to enhance the performance and compatibility of Octylisothiazolinone in your metalworking fluid concentrate. 

Use-Dilution Fluid We highly recommend grossly contaminated systems be cleaned before treatment is begun. 
Initial Dose: For a noticeably fouled system, add 0.47 to 1.44 lbs (7 to 21 fl oz) of Octylisothiazolinone Biocide per 1,000 gallons of fluid. 
This will provide 25 to 75 ppm active ingredient. Repeat until control is achieved. 
Subsequent Dose: For maintenance of a non-fouled system, add 0.09 to 0.58 lbs (1.3 to 8.6 fl oz) of Octylisothiazolinone per 1,000 gallons of fluid every four weeks. 
This will provide 5 to 30 ppm active ingredient. 
A higher dose range and/or increased frequency of treatment may be required, depending upon the rate of dilution of the preservative with the makeup fluid, the nature and severity of contamination, level of control required, filtration effectiveness, system design, etc. 
Key Features & Benefits Applications/ Directions for Use 

General Practices When Using EXOCIDE Biocides 
• Know the size of your system and dose at the recommended use levels. 
• To improve performance and longevity, add Octylisothiazolinone on the clean side of the filters. 
It may be necessary to occasionally add Octylisothiazolinone to the dirty side of the filters if large populations of microorganisms are detected there. 
• Minimize contamination: – Eliminate or minimize dead spots – Disconnect unused portions of the system – Do not throw trash in sumps 
• Always remember to triple rinse (or equivalent) empty containers to avoid incidental contact. 
• Post placard with safety information and deactivation protocol near biocide handling area. 
Additional guidelines for maximizing the performance of Octylisothiazolinone are as follows: 
• Octylisothiazolinone stability and performance is improved with lower pH. 
Whenever possible, maintain the pH of system below pH 9.2. 
Lower pH also makes amines and amine-containing compounds less aggressive. 
• For systems with pH greater than 9.5, we strongly recommend determination of biological efficacy and chemical stability prior to use. 
• Avoid adding highly basic additives (alkaline materials with pH of 10-12) immediately prior to or after adding Octylisothiazolinone to your system. 
If a highly basic additive must be added, allow sufficient time (at least 30 minutes) between additions. 
Minimize levels of diethanolamine (DEA) in your system. If possible use 99% triethanolamine (TEA) or monoethanolamine (MEA) instead of DEA, and use these at as low a level as possible. 
• Always add Octylisothiazolinone directly to the metalworking fluid sump. Never use Octylisothiazolinone in a spray bottle. 
• Avoid charging Octylisothiazolinone in high temperature zones, since increasing temperatures accelerate other degradation effects. 
Ideally, add Octylisothiazolinone to the fluid below 60°C (140°F). 
• Avoid adding Octylisothiazolinone and incompatible corrosion inhibitors directly to the tank at the same time. 


How Does Octylisothiazolinone Biocide Work? 
Octylisothiazolinone Biocide utilizes a two-step mechanism involving rapid growth inhibition leading to a loss of cell viability. 
Growth inhibition is the result of rapid disruption of the central metabolic pathways of the cell by inhibition of several specific enzymes, including dehydrogenases. 
The critical enzymes which are affected are associated with the Krebs cycle, nutrient metabolism and energy generation. 
The key physiological activities that are rapidly inhibited in microbial cells are respiration (oxygen consumption), energy generation (ATP synthesis), and growth (assimilation). 
Many of these key enzymes are present in both aerobic and anaerobic microorganisms, which explains why Octylisothiazolinone is such a broad spectrum biocide. 
Inhibition of cellular activity and growth is rapid (within minutes), whereas cell death (cidal activity) is observed after several hours’ contact. 
In general, the higher the concentration of biocide, the shorter the contact time required for more complete kill. 
Cell death results from the progressive loss of protein thiols in the cell from one of multiple pathways. 
As cell metabolism is disrupted, free radicals are produced which also results in cell death. 
This unique mechanism results in the broad spectrum of activity of Octylisothiazolinone Biocide, low use levels for microbial control, and difficulty in attaining resistance by mutation. 
See technical bulletin (CS-632) for more detailed information. 

How Rapidly Does Octylisothiazolinone Biocide Work? Within minutes after addition of Octylisothiazolinone Biocide to a metalworking fluid sump, the metabolic activity of the microorganisms in the system shuts ATAMAN CHEMICALSn. 
This includes cellular respiration (oxygen uptake), growth, energy generation, and nutrient uptake. 
The microorganisms, although still alive, are no longer able to reproduce or metabolize metalworking fluid components. 
After 24 to 48 hours of contact with a lethal dose of the biocide, most of the microorganisms have been killed. 

How Long Does Octylisothiazolinone Biocide Last? 2-Octylisothiazolinone Biocide has excellent in-use stability and generally retains its antimicrobial efficacy in metalworking fluid systems for 2 to 4 weeks. 
Variables such as degree of fluid contamination, effectiveness of the filtration system, system turnover time, compatibility between the microbicide and the metalworking fluid components, and other system additives involved, can affect the life of the microbicide in a system. 


Is Octylisothiazolinone Biocide Effective in Reducing Fungal Biofilms? 
YES. 
2-Octylisothiazolinone Biocide has been shown to reduce microbial fouling and prevent biofilm development in metalworking fluid systems. 
The benefits of reduced fungal biofouling include improved system performance, reduced filter plugging, reduced biocorrosion, and improved microbial control. 

Is Octylisothiazolinone Biocide Effective When Used in Concentrates? 
YES. 
2-Octylisothiazolinone Biocide may be used in certain fluid concentrates to provide efficacy in the final use dilutions. 
Although Octylisothiazolinone stability may not be suitable for all concentrates, we have had success with the biocide alone or in combination with one of our recommended stabilizers. 

How Can I Improve Octylisothiazolinone Biocide Stability in Concentrates? 
We recommend testing Octylisothiazolinone Biocide in concentrates prior to commercialization. 

ATAMAN CHEMICALS technical staff can assist you in formulating products. 
We have years of experience and a range of recommended stabilizers to prolong the lifetime and improve compatibility of Octylisothiazolinone in concentrates. 
Contact your sales representative for assistance. 
Anti-Microbial Properties of Octylisothiazolinone Biocide Initial determinations of the efficacy of any biocidal product are made via minimum inhibitory concentration (MIC) measurements. 
The MIC test yields valuable information about the product’s inherent antimicrobial efficacy and spectrum of activity. 
The MIC for any product is the lowest level at which the active ingredient inhibits the growth of various microorganisms. 
This method is a useful tool for screening antimicrobial agents 

Efficacy Data Page under standardized laboratory conditions, in nutrient-rich growth conditions. 
In interpreting the data, remember that low values correspond to high activity. 
Table 2 indicates that Octylisothiazolinone Biocide possesses outstanding antimicrobial activity against a broad range of fungi (both yeasts and molds). 
Octylisothiazolinone has very low MIC values for most of the fungi tested and there is no gap in the spectrum of activity among the organisms tested. 

Table 2 
Fungistatic Activity of Octylisothiazolinone Biocide 
Organism ATCC Number (Strain) MIC* in PPM 
Active Ingredient Alternaria dianthicola 11782 1 
Aspergillus niger 9642 8 
Aspergillus oryzae 10196 2 
Aspergillus repens 9294 2 
Aureobasidium pullulans 9348 0.3 
Candida albicans (yeast) 11651 2 
Chaetomium globosum 6205 4 
Cladosporium resinae 11274 0.5 
Lenzites lepideus 12653 2 
Lenzites trabea 11539 2 
Penicillium funiculosum 9644 1 
Phoma glomerata 6735 120°F for extended periods of time can result in degradation of the active ingredient. 

Store away from direct sunlight. 

Decontamination and Spill Procedures Decontamination Solutions 2-Octylisothiazolinone Biocide can be decontaminated with a 5% solution of sodium hypochlorite (NaOCl) containing 2-5% sodium bicarbonate (NaHCO3 ). 
Solutions should be freshly prepared. 
Employees preparing or handling decontamination solutions should wear chemical splash goggles, an impervious apron or rain suit, and impervious rubber gloves. 

Note: Do not use decontamination solution to treat skin, eyes or clothing which have come in contact with Octylisothiazolinone. 
Decontamination of Equipment Equipment used in the handling of Octylisothiazolinone Biocide, such as mix tanks, lines, pumps, etc., must be decontaminated before carrying out maintenance or used for other service. 
To decontaminate this equipment, estimate the volume of Octylisothiazolinone remaining in the well-drained system. 
Prepare 10 volumes of decontamination solution per volume of Octylisothiazolinone (45%) and circulate the mixture throughout the equipment. 
Be certain that the Octylisothiazolinone and decontamination solution mix well. 
Wait at least 30 minutes to ensure complete reaction. 
Drain and rinse with clean water or detergent solution. Decontamination solution runoffs should be drained to a chemical sewer unless prohibited by state or local regulations. 
Drips, minor spills and exposed wet areas should be cleaned up promptly with the hypochlorite/bicarbonate mixture. 
Contaminated surfaces should be swabbed with decontamination solution and allowed to stand for 30 minutes before rinsing thoroughly with water. 
Decontaminated solutions should be drained to a chemical sewer unless prohibited by state or local regulations. 
Note: Because of the high level of activity of Octylisothiazolinone, a relatively small quantity could have a damaging impact on the effectiveness of waste treatment bio-systems. 
Laboratory or plant spills should be decontaminated with decontamination solution before being released to a biological waste treatment system. 

Cleanup of Spills Procedures provided in the Safe Handling Section should be followed when cleaning spills of Octylisothiazolinone Biocide. 
1. Wear impervious rubber gloves, chemical splash goggles, protective clothing and overshoes. 
2. Dike and adsorb the spilled material on an inert solid, such as clay or vermiculite or with spill control pillows. 
3. Transfer the adsorbent or pillows and surrounding surface soil into a pail or drum. This container should be no more than two-thirds full. 
4. Treat the contents of the container with 10 volumes of decontamination solution per estimated volume of spilled Octylisothiazolinone. 
5. Treat the surrounding spill area with excess decontamination solution. 
Flush after a minimum of 30 minutes into a chemical sewer. 
6. Do not discharge spills and cleaning runoffs into open bodies of water, because of a potential adverse impact on the environment. 
7. Carefully remove the contaminated gloves and place them in the container (peel off the gloves by pulling on the outside of the glove sleeve turning them inside out as they are removed). 
After 48 hours, seal the container and dispose of it by landfilling in accordance with local, state, and federal regulations. 

Safety Data Sheets ATAMAN CHEMICALS Technical Support Shipping Information Biocidal Product Directive Compliance Product Stewardship Bulletin CS-561, which is available on request, contains methods for determining the presence of Octylisothiazolinone Biocide’s active ingredient in use dilution metalworking fluids by high performance liquid chromatography (HPLC). 
This bulletin also contains HPLC procedures for determining EXOCIDE 886 MW active ingredients in use-dilution metalworking fluids. 
ATAMAN CHEMICALS maintains Safety Data Sheets (SDS) for all of its products. 
These sheets contain pertinent information that you may need to protect your employees and customers against any known health or safety hazards associated with our products.
We recommend that you obtain and review Safety Data Sheets (SDS) for our products from your distributor or ATAMAN CHEMICALS technical representative before using our products in your facility. 
We also suggest that you contact your supplier of other materials recommended for use with our product for appropriate health and safety precautions before using them. 
ATAMAN CHEMICALS Sales Service and Technical Service departments have over twenty-five years’ experience evaluating EXOCIDE biocides’ performance in a variety of applications. 
In the area of metalworking fluids we can advise on determining EXOCIDE biocide stability and efficacy in use-dilution as well as concentrate metalworking fluids, and we can make recommendations on how to evaluate the level and type of system contamination you may be experiencing. 
In addition, ATAMAN CHEMICALS personnel can assist you with questions on EXOCIDE biocides’ toxicology, environmental issues, safe storage, handling and use. 

Finally, ATAMAN CHEMICALS has available for your use a videotape on the safe use and handling of the family of EXOCIDE and KORDEK biocides for the metalworking industry, including Octylisothiazolinone, EXOCIDE 886 MW and KORDEK LX5000 biocides. 
For further information, contact your local ATAMAN CHEMICALS EXOCIDE biocide representative or contact ATAMAN CHEMICALS. 
2-Octylisothiazolinone Biocide 45% solution is available in 5-gallon pails (44 lbs), 30-gallon drums (44 lbs), and cartons (22 lbs) containing two 1-gallon jugs. 
To obtain samples, technical assistance, a Safety Data Sheet (SDS), or to have a technical representative call for an appointment, contact the nearest ATAMAN CHEMICALS office. 
2-Octylisothiazolinone Biocide is a biocidal product intended for use in accordance with Product Type 13 (Metalworking fluid preservatives) of the Biocidal Products Directive 98/8/ EC (BPD). 

ATAMAN CHEMICALS has a fundamental concern for all who make, distribute, and use its products, and for the environment in which we live. 
This concern is the basis for our product stewardship philosophy by which we assess the safety, health, and environmental information on our products and then take appropriate steps to protect employee and public health and our environment. 
The success of our product stewardship program rests with each and every individual involved with ATAMAN CHEMICALS products – from the initial concept and research, to manufacture, use, sale, disposal, and recycle of each product.

OIT
OIT 45 %
Octhilinone
2-n-Octyl-4-isothiazolin-3-one
26530-20-1

2-Octylisothiazolinone

2-Octyl-4-isothiazolin-3-one

2-octylisothiazol-3(2H)-one

2-Octyl-3-isothiazolone

Pancil

2-Octyl-2H-isothiazol-3-one

3(2H)-Isothiazolone, 2-octyl-

EXOCIDE OIT

2-Octyl-3(2H)-isothiazolone

Skane 8

Skane M-8

EXOCIDE OITF

Micro-chek skane

EXOCIDE LM

Microbicide M-8

2-octyl-1,2-thiazol-3-one

Micro-chek 11

Micro-chek 11D

EXOCIDE SP 70

EXOCIDE LP preservative

EXOCIDE 4200

4-Isothiazolin-3-one, 2-octyl-

UNII-4LFS24GD0V

Octyl-3(2H)-isothiazolone

RH OIT

2-Octyl-3-isothioazolone

2-Octyl-3-isothiazolinone

Octyl-4-isothiazol-3-one

2-n-Octyl-3-isothiazolone

4LFS24GD0V

MLS002415697

CHEBI:81936

SMR001370885

DSSTox_CID_5805

Pancil-T

DSSTox_RID_77928

DSSTox_GSID_25805

Skane M8

Caswell No. 613C

EXOCIDE

Vinylzene IT 3000DIDP

CAS-26530-20-1

Octhilinone [ANSI:BSI:ISO]

CCRIS 6082

EINECS 247-761-7

EPA Pesticide Chemical Code 099901

BRN 1211137

C11H19NOS

Pancil T

2-octyl-1,2-thiazol-3(2H)-one

Skane M 8

ACMC-1CDE4

Vinyzene IT 3000DIDP

SCHEMBL15648

cid_33528

KSC163A4D

SCHEMBL396433

CHEMBL1562104

DTXSID1025805

BDBM66023

HSDB 6713

KS-00000ZYZ

2-Octyl-4-Isothiazolin-3-Ketone

ZINC2012904

Tox21_201459

Tox21_300566

ANW-26014

MFCD00072473

RH-OIT

AKOS015897428

NCGC00091875-01

NCGC00091875-02

NCGC00091875-03

NCGC00091875-04

NCGC00091875-05

NCGC00254466-01

NCGC00259010-01

AS-11894

Octhilinone 10 microg/mL in Acetonitrile

2-Octyl-3(2H)-isothiazolone, Octhilinone

DB-028182

FT-0613248

O0343

O0378

C18752

K-6861

530O201

Q2013949

W-107168

2-Octyl-4-isothiazolin-3-one, PESTANAL(R), analytical standard

Octhilinone is a member of the class of 1,2-thiazole that is 1,2-thiazol-3-one substituted on the nitrogen (position 2) by an octyl group. 
A fungicide and antibacterial agent, it is used for treatment of canker and other fungal and bacterial diseases in fruit trees.

2-octyl-3-isothiazolone is a clear dark amber liquid. 
Used as a fungicide.

2-Octylisothiazolinone is a member of the chemically related isothiazolinone group of preservatives. 2-Octylisothiazolinone (OIT) is an antimicrobial agent that is mainly used in industrial settings.


Skin contact with 2-Octylisothiazolinone is required for it to cause a rash. 
Discontinuation of exposure to products containing 2-Octylisothiazolinone should result in improvement and/or resolution of your dermatitis. 
By law, all products made in the US for topical use have the ingredients listed either on the product package or the box that contains it, so check the labeling of you skin care products for this ingredient. 
If there is no information ask your pharmacist. 
At work, request a material safety data sheet (MSDS) to help identify potential sources of exposure.

Uses:
Preservative in leather
Paint manufacturing
Bactericide
Biocide
Fungicide in:
Adhesives
Decorative wood stains
Pulp
Water-based Paints
Sealants
Additive in refinery oil
Cutting oils
Wallpaper adhesive, etc.
Cosmetics
Shampoos
Wood
Wound protectant for pruning cuts

Other names for 2-Octylisothiazolinone:
Skane M-8
EXOCIDE OIT
2 Octyl-4 isothiazolin-3-one
2-Octyl-3 (2H)-isothiazolone
Octhilinone

Potential cross-reacting/co-reacting substances:
Benz-isothiazolinine
Methylchloroisothiazolinone/Methylisothiazolinone (MCI/MI)
OIT
2-octyl-2H-isothiazol-3-one
2-octylisothiazole-3(2H)-one
NOIT
2-Octyl-3(2H)-isothiazolone
2-octyl-3-isothiazolon
2-Octyl-4-isothiazolin-3-one
Isothiazolone, 2-octyl-
EXOCIDE
EXOCIDE OIT
EXOCIDE lp preservative
EXOCIDE sp 70
Microbicide M-8
Micro-chek 11
Micro-chek 11d
Micro-chek skane
Octhilinone
Octyl-3(2H)-isothiazolone
Pancil
pancil-t
RH OIT
Skane M-8
Skane hq
2-n-Octyl-4-isothiazolin-3-one

Synonyms:
     octhilinone
2-    octyl-1,2-thiazol-3(2H)-one
2-    octyl-1,2-thiazol-3-one
2-    octyl-3(2H)-isothiazolone
2-n-    octyl-4-isothiazolin-3-one
3(2H)-iso    thiazolone, 2-octyl-

2-Octyl-3-isothiazolinone
2-octyl-2H-isothiazol-3-one
2-Octyl-3-isothiazolone
Octyl-4-isothiazol-3-one
Octyl-3(2H)-isothiazolone
2-Octyl-3-isothioazolone
2-Octyl-4-isothiazolin-3-one
2-Octyl-3(2H)-isothiazolone
2-Octylisothiazolinone

Octhilinon
2-Octyl-2H-isothiazol-3-on

Other names: 4-Isothiazolin-3-one, 2-octyl-; KATHON LP Preservative; Octyl-4-isothiazol-3-one; Skane M 8; 2-n-Octyl-3-isothiazolone; 2-Octylisothiazolinone; 2-Octyl-3-isothiazolinone; 2-Octyl-3-isothiazolone; 2-Octyl-3-isothioazolone; 2-Octyl-3(2H)-isothiazolone; 2-Octyl-4-isothiazolin-3-one; EXOCIDE OIT; EXOCIDE sp 70; Micro-Chek 11; Micro-chek 11D; Micro-chek skane; Microbicide M-8; Octhilinone; Octyl-3(2H)-isothiazolone; Pancil; Pancil T; RH-OIT; Skane 8; EXOCIDE 4200; EXOCIDE OITF; EXOCIDE LM; Vinyzene IT 3000DIDP; 2-octyl-2H-isothiazol-3-one

Properties
The active content of the 2-Octyl-2H-Isothiazol-3-one (OIT) is 45% or 95%. 
The specific gravity of the OIT biocide is 1.03~1.04.

2-n-Octyl-4-isothiazolin-3-one is a low toxicity biocide. 
2-n-Octyl-4-isothiazolin-3-one is specifically developed for the complete microbiological protection of water-based and solvent-based products against bacterial and fungal spoilage in the wet state.

Applications
2-n-Octyl-4-isothiazolin-3-one is effective against mildew, bacteria, and fungi. 
2-n-Octyl-4-isothiazolin-3-one is widely used in a variety of industrial applications such as water treatment, paper pulp, coating & painting, metal cutting fluid, personal care products, cosmetics, etc.

Package and Storage
OIT biocide is packed in 25kg or 200kg plastic drum, or 1000kg IBC.

Synonyms
Octylisothiazolinone, 2-Octylisothiazolinone, OIT, Octylisothiazolinone, NOIT, mildewcide OIT.

Synonym:2-octyl-3(2h)-isothiazolon;2-octyl-3-isothiazolone;2-octyl-4-isothiazolin-3-on

CAS No.:26530-20-1

EINECS No.:247-761-7

Molecular Formula:C11H19NOS

Molecular Weight:213.3397

Properties: 2-n-Octyl-4-isothiazolin-3-one is a light yellow to amber transparent liquid. Soluble in organic solvents and slightly soluble in water. Boiling point: 120℃, Density: 1.04, Refractive index: 1.5500.

Uses: 2-n-Octyl-4-isothiazolin-3-one is a low toxicity, high efficiency, broad-spectrum antifungal agent, has a strong killing effect on mould, can achieve the ideal antifungal effect. 
2-n-Octyl-4-isothiazolin-3-one can be widely used in coatings, paints, lubricants, shoe oils, leather chemistry, wood products and cultural relics protection and many other products. 
2-n-Octyl-4-isothiazolin-3-one is VOC-free, stable under strong light and high temperature, broad-spectrum and efficient sterilization, can effectively prevent bacteria and fungi in plastics.

Storage:Sealed and stored in a cool, dry and ventilated place.

Packing:200kg plastic barrel

2-n-Octyl-4-isothiazolin-3-one
2-Octylisothiazolinone
OIT
OIT 45 %

Chemical name: n-octyl isothiazolin-one

Octylisothiazolinone is a low toxicity biocide specifically developed for the complete microbiological protection of water based and solvent based products against algal and fungal spoilage in the dry state. 
2-Octylisothiazolinone is a Glycol based liquid. 
Octylisothiazolinone is described chemically as a solution of 2-octyl-2H-isothiazoline-3-one. 
Octylisothiazolinone is recommended for a wide range of applications including paints, adhesives and sealants where protection is required in the dry state.

EC / List no.: 247-761-7
CAS no.: 26530-20-1

Description; 
2-Octylisothiazolinone is a clear glycolic solution, dry film fungicide, free from Carbendazim and diuron. 
2-Octylisothiazolinone has been developed for the complete dry film protection of water based coatings. 
2-Octylisothiazolinone is effective against a wide range of fungal and algal species, responsible for the discoloration and degradation of surface coatings. 

Dry –film degradation in paints and decorative coatings can be avoided by using the correct dry-film fungicides at the most cost effective use level. 
Ideal dry-film properties achieved by Octylisothiazolinone include: 
• High activity against a broad range of fungi and algae 
• Excellent activity at relatively low use concentrations 
• Carbendazim free 
• Diuron free 
• UV stable 
• Approved under the Biocidal Products Directive 
• Cost effective protection 

Applications; 
2-n-Octyl-4-isothiazolin-3-one is recommended for protection of a wide range of coating applications including water based decorative paints, wood stains and colours. 
2-n-Octyl-4-isothiazolin-3-one can also be used in solvent based applications. 
2-Octylisothiazolinone is effective against a wide range of spoilage moulds and yeasts. 

Use level; 
2-Octylisothiazolinone should be evaluated in finished products at levels between 0.20% and 1.0%. 
The level of protection will depend on many factors including the end destination of coating, relative humidity, sun strength and others and can be determined by evaluation by our team of microbiologists at the Clariant Microbiology facility

Microbiological data;
Even though 2-Octylisothiazolinone is designed for dry-film applications it also exhibits activity against a wide range of bacteria, fungi and yeast. 
This can be demonstrated by the following MIC data.
MIC Levels Organism MIC (ppm)
Bacteria
Pseudomonas aeruginosa 500
Proteus vulgaris 30
Escherichia coli 125
Staphylococcus aureus 10
Fungi
Aspergillus niger 8
Penicillium glaucum 3
Rhizopus nigricans 75
Chaetomium globosum 25
Yeast
Candida albicans 5
Rhodotorula rubra 5


Chemical compatibility;
2-Octylisothiazolinone is compatible with most raw materials used in the manufacture of industrial and decorative coatings. 
2-Octylisothiazolinone compatibility should always be checked and evaluated before use.

ATAMAN CHEMICALS Technical Service;
ATAMAN CHEMICALS technical service staff is available to assist customers in the determination of the optimum use level of biocide required to fully protect their product. 
A dedicated team of microbiologists are on hand at all time to assist customers with all technical enquiries relating to product protection. 
Full microbiological efficacy testing is available.

2-octyl-2H-isothiazol-3-one
2-octyl-2H-isothiazol-3-one
2-octyl-2H-isothiazol-3-one (OIT)
Octhilinone
octhilinone (ISO)
octhilinone (ISO); 2-octyl-2H-isothiazol-3-one
octhilinone (ISO); 2-octyl-2H-isothiazol-3-one; [OIT]
octhilinone (ISO);2-octyl-2H-isothiazol-3-one
octhilinone (ISO);2-octyl-2H-isothiazol-3-one; [OIT]
2-n-Octyl-4-isothiazolin-3-one


Translated names
2-Octil-2H-isotiazol-3-ona (OIT) (es)
2-Octil-2H-isotiazol-3-ona (OIT) (pt)
2-octil-2H-isotiazol-3-onă (OIT) (ro)
2-octyl-2H-isothiazol-3-on (OIT) (da)
2-Octyl-2H-isothiazol-3-on (OIT) (de)
2-octyl-2H-isothiazol-3-one (OIT) (mt)
2-octyl-2H-isothiazol-3-one (OIT) (no)
2-octyl-2H-isothiazole-3-one (OIT) (fr)
2-Octyl-2H-isothiazool-3-on (OIT) (nl)
2-oktil-2H-izotiazol-3-on (OIT) (hr)
2-oktil-2H-izotiazol-3-on (OIT) (hu)
2-oktil-2H-izotiazol-3-on (OIT) (sl)
2-oktil-2H-izotiazol-3-onas (OIT) (lt)
2-Oktil-2H-izotiazol-3-ons (OIT) (lv)
2-oktyl-2H-isotiazol-3-on (no)
2-oktyl-2H-isotiazol-3-on (OIT) (sv)
2-oktyl-2H-izotiazol-3-ón (OIT) (sk)
2-oktylo-2H-izotiazol-3-on (OIT) (pl)
2-oktyltetrahydroisothiazol-3-on (OIT) (cs)
2-oktyyli-2H-isotiatsol-3-oni (OIT) (fi)
2-oktüül-2H-isotiasool-3-oon (OIT) (et)
2-ottil-2H-isotiazol-3-one (OIT) (it)
2-οκτυλ-2H-ισοθειαζολόνη-3 (OIT) (el)
2-октил-2H-изотиазол-3-он (OIT) (bg)
octhilinon (ISO); 2-octyl-2H-isothiazol-3-on; [OIT] (da)
Octhilinon (ISO); 2-Octyl-2H-isothiazol-3-on; [OIT] (de)
octhilinone (ISO); 2-octyl-2H-isothiazol-3-one; [OIT] (fr)
octhilinone (ISO); 2-octyl-2H-isothiazool-3-on; [OIT] (nl)
octhilinone (οκθειλινόνη) (ISO)· 2-οκτυλ-2H-ισοθειαζολόνη-3 [OIT] (el)
Octilinona (ISO); 2-octil-2H-isotiazol-3-ona; [OIT] (es)
octilinona (ISO); 2-octil-2H-isotiazol-3-ona; [OIT] (pt)
octilinone (ISO); 2-ottil-2H-isotiazol-3-one; [OIT] (it)
octilinonă (ISO); 2-octil-2H-izotiazol-3-onă; [OIT] (ro)
okthilinon (ISO); 2-oktyl-2H-isothiazol-3-on; [OIT] (cs)
oktilinon (ISO); 2-oktil-2H-isotijażol-3-on; [OIT] (mt)
oktilinon (ISO); 2-oktil-2H-izotiazol-3-on; [OIT] (hr)
oktilinon (ISO); 2-oktil-2H-izotiazol-3-on; [OIT] (hu)
oktilinon (ISO); 2-oktil-2H-izotiazol-3-on; [OIT] (sl)
oktilinon (ISO); 2-oktyl-2H-isotiazol-3-on; [OIT] (sv)
oktilinonas (ISO); 2-oktil-2H-izotiazol-3-onas; [OIT] (lt)
oktilinoni (ISO); 2-oktyyli-2H-isotiatsol-3-oni; [OIT] (fi)
oktilinons (ISO); 2-oktil-2H-izotiazol-3-ons; [OIT] (lv)
Oktilinoon (ISO); 2-oktüül-2H-isotiasool-3-oon; [OIT] (et)
oktilinón (ISO); 2-oktyl-2H-izotiazol-3-ón; [OIT] (sk)
oktylinon (ISO); 2-oktylo-2H-izotiazol-3-on; [OIT] (pl)
октилинон (ISO); 2-октил-2H-изотиазол-3-он; [OIT] (bg)

CAS names
3(2H)-Isothiazolone, 2-octyl-

IUPAC names
2-N-Octyl-4-isothiazolin-3-on
2-Octylisothiazolinone
2-n-Octyl-4-isothiazolinone-3-one
2-octil-2H-isotiazol-3-ona
2-octyl-1,2-thiazol-3-one
2-octyl-2,3-dihydro-1,2-thiazol-3-one
2-octyl-2,3-dihydro-1,2-thiazol-3-one
2-Octyl-2H-isothiazol-3-one
2-octyl-2H-isothiazol-3-one
2-octyl-2h-isothiazol-3-one
2-octylisothiazol-3(2H)-one
octhilinone (ISO)
Octylisothiazolinone
2-n-Octyl-4-isothiazolin-3-one


Synonyms:
2-Octyl-4-isothiazolin-3-one; 2-Octyl-3(2H)-isothiazolone; Octhilinone; EXOCIDE OIT; RH OIT; Skane M-8; 2-octyl-3-isothiazolone; KATHON lp preservative; EXOCIDE sp 70; micro-chek 11; micro-chek 11d; micro-chek skane; pancil; pancil-t; skane hq; EXOCIDE OIT; Microbicide M-8; Isothiazolone, 2-octyl-; Octyl-3(2H)-isothiazolone.

Uses:
Octylisothiazolinone is used as a mildewcide, as a bactericide, as a fungicide, as a biocide in cooling-tower water, in paints, cutting oils, cosmetics and shampoos, and for leather preservation. 
2-n-Octyl-4-isothiazolin-3-one is also used as a wound protectant for pruning cuts.

Other identifiers
1135442-68-0

CAS number
1135442-68-0

Deleted CAS number
122667-23-6

CAS number
122667-23-6

Deleted CAS number
12673-72-2

CAS number
12673-72-2

Deleted CAS number
1617530-25-2

CAS number
1617530-25-2

Deleted CAS number
245125-70-6

CAS number
245125-70-6

Deleted CAS number
249757-59-3

CAS number
249757-59-3

Deleted CAS number
26530-20-1

2-Octylisothiazolinone
Octylisothiazolinone is a powerful fungicidal compound, which can be used as an additive in aqueous metalworking fluids. 2-Octylisothiazolinone offers excellent anti-fungal protection at use rates of 55 to 170 ppm on a post-addition basis. 2-Octylisothiazolinone is also compatible with EXOCIDE 886 MW.

STORAGE AND HANDLING OF 2-n-Octyl-4-isothiazolin-3-one
The expected shelf life for this product is 2 years under normal storage conditions. 
This product, like most chemicals, should be stored out of direct sun light in an area where the temperature is between 40ºF (4.4ºC) and 110ºF (43ºC).

SAFETY DATA
Octylisothiazolinone is very hazardous and proper handling and storage is critical. 
Avoid contact with skin and eyes. 
Prior to using this product, please consult the Material Safety Data Sheet for instructions regarding safe handling


ACTIVE INGREDIENT:
 2-Octylisothiazolinone 45.00%
OTHER INGREDIENTS: 55.00%
 Total: 100% 


EXOCIDE OIT Industrial Mildewcide is also sold for use in the formulation of industrial mildewcides in the following uses.
Formulators using this product are also responsible for providing data for the EPA registration for their formulated products.

COATINGS
For use as a mildewcide in coatings such as wood coatings, wood coating solutions, latex and solvent-based paints, semi-transparent stains, and solid stains.

BUILDING MATERIALS
For use as a mildewcide in building materials such as elastomeric roof and wall coatings and mastics, caulks, sealants, joint cements,spackling, stucco, and grouting.

WALLPAPER PASTES AND ADHESIVES
For use as a mildewcidal preservative to protect materials such as polyvinyl acetate, starch and dextrin-based pastes from fungal attack after they are applied.

AQUEOUS ADHESIVE AND TACKIFIER PRESERVATION
For use as a mildewcidal preservative in water-soluble and water-dispersed adhesives such as animal glues, vegetable glues, natural rubber latices, polyvinyl acetate, styrene-butadiene, polyurethane, epoxy, acrylic latices, and tackifiers derived from rosin and hydrocarbon resins.

LEATHER AND HIDE
For use in the prevention of mold, bacteria, and fungi in the storage and transport of wet leather stock such as pickled, chrome-tanned and vegetable-tanned leather and hides.

METALWORKING CUTTING FLUIDS
For use as a mildewcidal preservative in soluble and emulsifiable aqueous metalworking fluids. 


HYDRAULIC FLUIDS
For use as a preservative in the manufacture and use of high water-based hydraulic fluids and invert emulsion hydraulic fluids typically prepared by emulsifying 40% by volume water in 60% by volume of mineral oil using an oil soluble emulsifying agent.

VINYL AND PLASTICS
For use as a mildewcidal preservative in plastics and vinyl materials.

TEXTILES, LAUNDRY, FABRIC, FABRIC SURFACES, FABRIC MILDEWCIDE
For use to prevent mildew in laundered fabric, treated fabric, treated fabric surfaces, and textiles.

AIR WASHER WATER
For use as a mildewcidal preservative to prevent fouling in industrial air washer systems.

COOLING TOWER WATER
For use as a mildewcidal preservative to prevent fouling in water cooling systems when added to the reservoir, recirculating line or some other point to insure uniform mixing.

EMULSIONS, POLYMERS, AND POLYURETHANE
For use as a mildewcidal preservative in the manufacture and storage of synthetic and natural rubber polymer latices including: acrylic; styrene/butadiene; carboxylated styrene/butadiene; ethylene/vinyl acetate; polyurethane; and biopolymers intended for industrial use, such as xanthum gum, gum arabic, guar gum, protein derived polymers, starches, and casein derived polymers.


EXOCIDE OIT Industrial Mildewcide weighs 8.5 pounds per gallon 

2-Octylisothiazolinone is a highly effective industrial fungicide that exhibits excellent fungistatic and fungicidal activity in metalworking central systems and fluid concentrates.
• Appearance: Clear liquid
• Color: Pale yellow to amber
• Odor: Mildly sweet
• Specific Gravity @ 24°C: 1.03
• Flash Point, °C (Pensky Martens Closed Cup): 93
• Use rate of 16 oz. per 1000 gallons sump capacity

EXOCIDE OIT is a tank side additive used to control fungal growth in metalworking fluid systems.


Product Name
EXOCIDE OIT
Synonyms
2-Octyl-4-isothiazolin-3-one
3(2H)-Isothiazolone, 2-octyl-
EXOCIDE LP Preservative
Octhilinone
Ultrafresh DM 25
Vinyzene IT 3000DIDP

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