p-Chlorocresol is the organic compound with the formula ClC6H4OH. It is a monochlorinated m-cresol. It is a white or colorless solid that is only slightly soluble in water. As a solution in alcohol and in combination with other phenols, it is used as an antiseptic and preservative.
It is a moderate allergen for sensitive skin.
PCMC is a prill form chlorophenolic, low toxicity biocide developed for the complete in-can protection of water based products. PCMC is effective against a wide range of microorganisms including gram positive and gram negative bacteria, yeast and fungi. Microorganisms grow at a rapid rate and without use of the correct biocide, numbers can increase dramatically.
Chlorocresol appears as a pinkish to white crystalline solid with a phenolic odor. Melting point 64-66°C. Shipped as a solid or in a liquid carrier. Soluble in aqueous base. Toxic by ingestion, inhalation or skin absorption. Used as an external germicide. Used as a preservative in paints and inks.
p-Chlorocresol is prepared by chlorination of m-cresol.
Chlorocresol is a biocide used for its disinfectant and preservative properties, in topicals or cutting fluid.
For the preservation of adhesives, glues, polymer dispersions and emulsions, metalworking/cutting fluids, dyes, industrial lubricants, pigments and filler suspensions, materials in the building industry (e.g., concrete additives, joint cements), paint and coatings, paper, textile, photo, oil industries and leather at all stages of production.
It is recommended that the PCMC Preservative be pre-dissolved (e.g. in alcohol, glycol or caustic soda solution) to ensure the product is evenly distributed in the finished formulation.
PCMC Preservative can also be added in the form of an alkaline stock solution.
A stock solution containing 30% PCMC Preservative can be formulated by stirring 1 kg PCMC Preservative into 1.85 liters of water and 0.5kg 50% caustic soda solution until it dissolves.
Dissolving can be accelerated by gently heating the liquid.
The steam-volatility of PCMC Preservative must be taken in account in the case of certain applications (e.g. when drying glue slurries which contain PCMC Preservative)
Chemical Name : 4-CHLORO-M-CRESOL; PARA CHLORO META CRESOL; 4-Chloro-3-methylphenol; Other names: p-chloro-m-cresol; PCMC; Preventol; CMK; CAS Number: 59-50-7
CAS-59-50-7; 4-chloro-3-methyl-phenol; Clorocresol;para-Chloro-meta-cresol; PCMC; Preventol CMK; Raschit K; p-Chlor-m-cresol; 2-Chloro-5-hydroxytoluene; 6-Chloro-3-hydroxytoluene; 3-METHYL-4-CHLOROPHENOL;2-Chloro-hydroxytoluene;Chlorcresolum
;Chlorkresolum; Chlorocresolo; Chlorokresolum;Perol;m-Cresol, 4-chloro-; Chloro-3-cresol; Parachlorometacresol; 4-Chloro-3-methyl phenol; 4-chloro-meta-cresol;EINECS 200-431-6;4-Chloro-1-hydroxy-3-methylbenzene; 1-Chloro-2-methyl-4-hydroxybenzene
p-Chlorocresol is a chlorinated phenol which is used as an antiseptic and preservative. For use as a disinfectant such as a hand wash, it is commonly dissolved in alcohol in combination with other phenols. It is a moderate allergen for sensitive skin.
SYNONYMS: Chlorocresol; 3-Methyl-4-chlorophenol; 4-Chloro-3-methyl phenol;Parachlorometacresol; p-Chloro-m-cresol; 2-Chloro-5-hydroxytoluene; 2-Chloro-hydroxytoluene; 4-Chloro-1-hydroxy-3-methylbenzene; 4-Chloro-3-cresol; 4-Chloro-3-methylphenol; 4-Chloro-5-methylphenol; 4-Chloro-m-cresol; 6-Chloro-3-hydroxytoluene; 6-Chloro-m-cresol; Chlorkresolum; Chloro-3-cresol; Chlorocresol; Chlorocresolo; Chlorocresolum; Clorocresolo; PCMC; Parachlorometacresol; Parmetol; Parol; Peritonan; Perol; p-Chlor-m-cresol; p-Chloro-m-cresol; p-Chlorocresol;
Chemical formula: C7H7ClO
Molar mass: 142.58 g·mol−1
Appearance: White/pink solid
Density: 1.37 g/cm3 (20 °C)
Melting point: 55.55 °C (131.99 °F; 328.70 K)
Boiling point: 235 °C (455 °F; 508 K)
Solubility in water: 3.8 g/l at 20 °C (in water)
Technical Specification :
Appearance : White Crystalline Powder
Assay : 99.8 % Min.
Moisture : Less than 0.5% w/w
Melting Range : 64 0 C - 68 0 C
Boiling Point : 235 0 C
Solubility : Slightly soluble in water(4g/L), easily soluble in organic solvent such as alcohols(96 percent in ethanol), ethers, ketones, etc.
Appearance of Solution : The solution is clear and not more intensely coloured than reference solution BY6
Acidity : Not more than 0.2ml of 0.01M NaOH is required to produce a pure yellow colour
It is frequently used in--
Personal care products, antibacterial hand soap, soap, shampoo and healthy products.
Household & institutional disinfectant and cleansers, Public & hospital Hygiene.
Other fields such as leather, metal machining liquid, concrete, film, glue, textile, oiled, paper, etc.
MEDICATION (VET): In topical medicaments and in intrauterine lubricants as antiseptic and preservative (0.1-0.2% concentration).
Chlorocresol and chloracetamide are used in medications, glues, and cosmetics as preservatives.
The biocide 4-chloro-3-methylphenol (CMP, CAS number 59-50-7) is a common additive to metal-working fluids (MWF) and building materials.
4-chloro-m-cresol is a hydroxytoluene that is 3-methylphenol which is substituted by a chlorine at position 4. A ryanodine receptor agonist. It has a role as a ryanodine receptor agonist, an antimicrobial agent and a disinfectant. It is a hydroxytoluene and a member of monochlorobenzenes.
4-Chloro-3-methylphenol;Chlorocresol; 59-50-7; 4-Chloro-m-cresol; p-Chloro-m-cresol; Phenol, 4-chloro-3-methyl-; Parol; p-Chlorocresol;4-Chloro-3-cresol
Min. 99.8 % chlorocresol (p-chloro-m-cresol).
- For the preservation of thickener solutions, adhesives (including protein-based formulations), concrete additives, metalworking fluids, textile print thickeners, leather etc.
- For the formulation of disinfectants for use in hospitals, doctor’s offices, industry, institutions and sheds.
The product has a broad and very balanced spectrum of activity covering Gram-positive and Gram-negative bacteria, mould and yeast. Particularly effective against putrefactive bacteria and therefore suitable for use in products which are difficult to preserve (e.g. protein-based formulations).
Inter alia registered in Europe and USA.
Physical and Chemical Properties
1) PCMX is a security, efficient, anti-mould antiseptic, anti-mildew agent;
2) Solubility: 4g/L in water, freely soluble in organic solvent such as alcohols (96% in alcohols), ether, ketones and strong base aqueous solution, and completely soluble in oil.
3) Friendly to environment, formaldehyde-free, Non-toxic impurities, easily degradable;
4) Well compatibility with anionic surfactant, Non-ionic surfactant and emulgator. Good synergistic effect with other antiseptic and bactericide;
5) PH range of application: 4-12
1) Personal care products, Such as antibacterial soap, antibacterial shampoo and health care products;
2) Household & institutional disinfectant and cleansers, Public & hospital Hygiene product;
3) Other fields such as leather, metal machining liquid, concrete, film, glue, textile, oiled, paper, etc;
p-Chloro-m-cresol (PCMC) which is also known as chlorocresol is used as an external germicide and bactericide agent. It
has bactericidal activity against Gram positive and Gram negative organisms, along with yeasts, moulds and spores. It is also used as
preservative for various pharmaceutical preparations like cosmetics,lotions, tanning agents, and topical corticosteroids. Other than that, it is also used in glues, paints and varnishes, and leather goods. Moreover, it is used widely in eye drops, injections, shampoos
and emulsions due to its disinfectant and antifungal properties. Its antiseptic property makes it suitable for use in heparin solutions, andin various creams for skin care and dermatological care. Apart from that, it is reported as potent activator of Ca2+ release mediated
by ruthenium red/caffeine-sensitive Ca2+ release channel in skeletal muscle sarcoplasmic reticulum.
Other names: Chlorocresol; m-Cresol, 4-chloro-; p-Chlor-m-cresol; p-Chloro-m-cresol; p-Chlorocresol; Aptal; Baktol; Baktolan; Candaseptic; Ottafact; Parmetol; Parol; Peritonan; Preventol CMK; PCMC; Raschit; Raschit K; Rasen-Anicon; 2-Chloro-5-hydroxytoluene; 3-Methyl-4-chlorophenol; 4-Chloro-m-cresol; 4-Chloro-3-methylphenol; 4-Chloro-5-methylphenol; 6-Chloro-3-hydroxytoluene; CMK; 2-Chloro-hydroxytoluene; 4-Chloro-3-cresol; Rcra waste number U039; para-Chloro-meta-cresol; 1-Chloro-2-methyl-4-hydroxybenzene; Lysochlor; Phenol, 4-chloro-5-methyl-; NSC 4166
Chlorocresol, NF uses and applications include: External germicide; biocide; disinfectant; antimicrobial, preservative for paints, latex coatings, emulsions, adhesives, glues, gums, textiles, leather goods, pharmaceuticals, topicals, especially for starch and casein-based systems; antiseptic; defoamer in food-contact coatings and paperpaperboard; preservative in food-contact animal glues; in food packaging adhesives Use Level 0.1-0.15 (injectables), 0.075-0.12 (topicals)
Chlorocresol is a potent chlorinated phenolic disinfectant and antiseptic. It has bactericidal activity against Gram-positive and Gram-negative bacteria and is effective against fungi but has little activity against bacterial spores except at high temperatures. It is more active in acid than in alkaline solution. Chlorocresol is used in preparations for disinfection of the skin and wounds. It is also used as a preservative in cosmetics and in creams and other preparations for external use that contain water. Chlorocresol is used as a preservative in aqueous injections issued in multidose containers. It may also be added to aqueous preparations that cannot be sterilised in their final containers and have to be prepared using aseptic precautions. Concentrations of 0.1% have generally been used. Injections prepared with chlorocresol should not be injected into the CSF, the eye, or the heart. Also such injections should generally not be given in volumes greater than 15 mL. Sterilisation by heating with a bactericide such as chlorocresol is no longer a recommended practice.
As for Phenol. The antimicrobial activity of chlorocresol may be reduced by incompatibility (see above), adsorption, increasing pH, or through combination with organic matter (including oils and fats) or nonionic surfactants. Chlorocresol is less toxic than phenol. Sensitisation reactions may follow application to the skin and hypersensitivity has occurred after systemic use of injections containing chlorocresol as a preservative.
PCMC/Chlorocresol / 4-Chloro-3-methylphenol /p-chloro-m-cresol/para chloro meta cresol
Molecular Formula: C7H7ClO
CAS No: 59-50-7
Physical and Chemical Properties: This product is a security, efficient anti-mould antiseptic. Slightly soluble in water(4g/L), easy soluble in organic solvent such as alcohols(96 percent in ethanol), ethers, ketones, etc. Freely soluble in fatty oils, and dissolves in solutions of alkali hydroxides.
Caswell No. 185A
WLN: QR DG C
4-Chloro-3-methylphenol, technical grade
4-Chloro-3-methylphenol, analytical standard
4-Chloro-3-methylphenol, >=98.0% (HPLC)
4-Chloro-3-methylphenol 100 microg/mL in Methanol
Where is 4-chloro-3-cresol (pcmc) found?
4-chloro-3-cresol is used as a disinfectant and preservative found in creams, shampoos, antiseptics, disinfectants, and fungicides.
How can you avoid contact with 4-chloro-3-cresol (pcmc)?
Avoid products that list any of the following names in the ingredients:
• BRN 1237629
• CCRIS 1938
• Caswell No. 185A
• Chlorocresolum [INN-Latin]
• Chlorocresolum [Latin]
• Clorocresol [INN-Spanish]
• Clorocresol [Spanish]
• Clorocresolo [DCIT]
• EINECS 200-431-6
• EPA Pesticide Chemical Code
• HSDB 5198
• NSC 4166
• Phenol, 4-chloro-3-methyl-
• Preventol CMK
• RCRA waste number U039
• Raschit K
• 4-06-00-02064 (Beilstein Handbook Reference)
What are some products that may contain 4-chloro-3-cresol (pcmc)?
• Adhesives and glues
• Cooling fluids
• Corticosteroid creams
• Metalworking fluids
• Packing materials
• Textile finishes
Topical Antiseptics and Disinfectants
P-CHLORO-M-CRESOL, N° CAS : 59-50-7. Nom INCI : P-CHLORO-M-CRESOL. Nom chimique : 4-Chloro-3-methylphenol. chlorocresol . Synonymes : 4-chloro-m-cresol;p-Chloro-m-crésol;Chlorocrésol;4-Chloro-3-méthylphenol;2-Chloro-5-hydroxytoluene;2-CHLORO-HYDROXYTOLUENE;4-Chloro-1-hydroxy-3-methylbenzene;4-chloro-3-cresol;4-Chloro-3-hydroxytoluene;4-chloro-3-methyl phenol;4-CHLORO-META-CRESOL;6-CHLORO-3-HYDROXYTOLUENE;6-Chloro-m-cresol;AI3-00075;APTAL;BAKTOL;BAKTOLAN;CANDASEPTIC;Caswell No 185A;Chlorocresolo;Chlorocrésol;Chlorocresolo; Chlorocresolum (Latin); Chlorokresolum; Clorocresol (Spanish); EPA Pesticide Chemical Code 064206;m-Cresol, 4-chloro-; OTTAFACT; P-CHLOR-M-CRESOL; p-Chloro-m-crésol;P-CHLOROCRESOL;Parachlorometacresol;PARMETOL;PAROL;PCMC;PERITONAN;Phenol, 4-chloro-3-methyl-;PREVENTOL CMK;RASCHIT;RASCHIT K;RASEN-ANICON;RCRA waste number U039 ;N° EINECS/ELINCS : 200-431-6. Classification : Règlementé, Conservateur, Ses fonctions (INCI), Conservateur : Inhibe le développement des micro-organismes dans les produits cosmétiques.Noms français :
2-CHLORO-5-HYDROXYTOLUENE; 2-CHLORO-HYDROXYTOLUENE; 3-METHYL-4-CHLOROPHENOL; 4-CHLORO-3-METHYLPHENOL; 4-CHLORO-5-METHYLPHENOL
; 4-CHLORO-M-CRESOL; 4-CHLOROCRESOL; 4-CHLOROCRESOL (META-); 6-CHLORO-3-HYDROXYTOLUENE; 6-CHLORO-M-CRESOL; CHLORO-4 HYDROXY-3 TOLUENE; CHLORO-4 METHYL-3 PHENOL;Chloro-4 méthyl-3 phénol; M-CRESOL, 4-CHLORO; P-CHLOR-M-CRESOL; P-CHLORO-M-CRESOL; p-Chlorocresol; p-Chlorocrésol; PHENOL, 4-CHLORO-3-METHYL; PHENOL, 4-CHLORO-3-METHYL-. Noms anglais : p-Chlorocresol. Utilisation et sources d'émission : Agent désinfectant, agent antiseptique. 1237629 [Beilstein]; 200-431-6 [EINECS]; 441; 4-Chlor-3-methylphenol [German] ; 4-Chloro-3-methylphenol [ACD/IUPAC Name]; 4-Chloro-3-méthylphénol [French] [ACD/IUPAC Name]; 4-Chloro-m-cresol; 59-50-7 [RN]; chlorocresol; chlorocrésol [French] ; clorocresol [Spanish] ; GO7100000; p-Chlorocresol [Wiki]; p-Chloro-m-cresol; PCMC; Phenol, 4-chloro-3-methyl- [ACD/Index Name]; QR BG E1 [WLN]; хлорокрезол [Russian]; كلوروكريسول [Arabic]; 122307-41-9 [RN]; 1-Chloro-2-methyl-4-hydroxybenzene; 2-Chloro-5-hydroxytoluene; 2-Chloro-hydroxytoluene; 3-hydroxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one; 4-06-00-02064 (Beilstein Handbook Reference) [Beilstein]; 43M; 4-Chloro-1-hydroxy-3-methylbenzene; 4-Chloro-3-methoxy-2-methylpyridine-n-oxide; 4-chloro-3-methyl-phenol; 4-Chloro-3-Methylphenol (en); 4-Chloro-3-methylphenol 100 ?g/mL in Methanol; 4-Chloro-3-methylphenol 100 µg/mL in Methanol; 4-Chloro-3-methylphenol, BP, EP grade; 4-Chloro-3-methylphenol-2,6-d2; 4-Chloro-5-methylphenol; 4-Chloro-m-cresol;PCMC;Chlorocresol; 6-Chloro-3-hydroxytoluene; 6-Chloro-m-cresol; 93951-72-5 [RN]; Aptal; Baktol; Baktolan; C006984; Candaseptic; Chlorcresolum; Chlorkresolum; Chloro-3-cresol; Chlorocresol (4-Chloro-3-methylphenol); Chlorocresol (NF); Chlorocresol [USAN:INN]; Chlorocresolo; Chlorocresolum [INN-Latin]; Chlorocresolum [Latin]; Chlorokresolum; Clorocresol [INN-Spanish]; Clorocresol [Spanish]; Clorocresolo [DCIT]; CMK; EINECS 200-431-6; HSCI1_000352; DI1_000768; InChI=1/C7H7ClO/c1-5-4-6(9)2-3-7(5)8/h2-4,9H,1H Lysochlor; m-Cresol, 4-chloro-; NCGC00091338-02; Ottafact; para-Chloro-meta-cresol; Parachlorometacresol; parmatol; Parmetol; Parol [Wiki]; p-Chlor-m-cresol; Peritonan; Pharmakon1600-01500178; PHEN-2,6-D2-OL,4-CHLORO-3-METHYL- (9CI); Phenol, 4-chloro-5-methyl-; Preventol CMK; Raschit; Raschit K; 4-chloro-3-methylphenol; 4-chloro-m-cresol; chlorocresol; 4-chloro-m-cresol; 4-chloro-3-methylphenol; chlorocresol;4-chloro-m-cresol;4-chloro-3-methylphenol; Phenol, 4-chloro-3-methyl-. Translated names : 4-chlor-3-methylfenol (cs) ; 4-Chlor-3-methylphenol (de); 4-chlor-3-metilfenolis (lt); 4-Chlor-m-kresol (de); 4-chlor-m-krezolis, (lt); 4-chloro-3-metylofenol (pl); 4-chloro-3-méthylphénol (fr); 4-chloro-m-crésol (fr); 4-chloro-m-krezol (pl); 4-chlór-3-metylfenol (sk); 4-chlór-meta-krezol (sk); 4-clor-3-metilfenol (ro); 4-clor-m-cresol (ro); 4-cloro-3-metilfenol (es); 4-cloro-m-cresol (es); 4-hlor-3-metilfenols (lv); 4-hlor-m-krezols (lv); 4-kloori-3-metyylifenoli (fi); 4-klor-3-metylfenol (no); 4-klor-m-kresol (no); 4-kloro-3-metil-fenol (hr); 4-kloro-3-metilfenol (sl); 4-kloro-3-metüülfenool (et); 4-kloro-m-kresool (et); 4-kloro-m-krezol (hr); 4-klór-3-metilfenol (hu); 4-klór-m-krezol (hu); 4-хлоро-3-метилфенол (bg); 4-хлоро-m-крезол (bg); Chloorkresol (nl); chlorcresol (da); chlorkresol (cs); Chlorkrezolis (lt); chlorocresol (da); Chlorocrésol (fr); Chlorokresol (de); chlórkrezol (sk); clor crezol (ro); Clorocresol (es); Clorocresolo (it); Clorocrezol (ro); Hlorkrezols (lv); kloorikresoli (fi); klorkresol (no); Klorokresol (mt); Klorokresoli (fi); Klorokresool (et); Klorokrezol (hr); klórkrezol (hu); χλωροκρεζόλη (el); Χλωροκρεσόλη (el); Хлорокрезол (bg). : 4-Chlor- 3-methylphenol; 4-chloro-3-methyl phenol; 4-Chloro-m-cresol, PCMC, 2-Chloro-5-hydroxytoluene; p-chloro-m-cresol
6-chloro-3-hydroxytoluene; 2-chloro-5-hydroxytoluene; 3-methyl-4-chlorophenol; P-chloro-m-cresol; 4-chloro-m-cresol