PHMB 20%

PHMB 20% = Polyhexamethylene biguanidine = PHMB

Chemical Name: Polyhexamethylene biguanidine
CAS Number: 32289-58-0
Molecular Formula: C10H23N5
Molecular weight: 213.32

Polyhexamethylene biguanidine, also known as PHMB, polyhexanide or polihexanide, is a highly water soluble and hydrolytically stable polymeric material. 
The presence of multiple hydrogen bond and chelation sites within PHMB renders it of potential interest in the field of supramolecular chemistry. 
PHMB shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics. 
PHMB is available also as a solid.

Polyhexamethylene biguanide (PHMB) is a disinfectant used in swimming pools and hot tubs. 
The current study determined whether PHMB is an effective disinfectant against ocular adenovirus serotypes at a concentration used to disinfect swimming pools and hot tubs.

PHMB Application
PHMB 20% can be used as disinfectant, antibacterial, bactericide, mildew-proof, algae-inhibitor, flocculant, etc.
PHMB 20% is widely used in health care, chemicals, textiles, paper, wipes, livestock, aquaculture, fisheries, plastics, agriculture, water treatment and other fields.

PHMB 20% application:
Water treatment
- In swimming pools as an alternative to chlorine
- For industrial water(cooling tower, …)
Surface disinfecting
- Hospitals
- Algaecide for concrete surfaces
- All purpose surfaces disinfectant
Food industry
- Mink feed preservative
- Beet sugar disinfectant
- Precleanning of fresh vegetables
- Cleaning solution for food contact equipment
Leather industry
- Preservation of hides and skins
- Vet applications
- Teat dip mixtures, teat dip cloth, animal blood preservation
- Veterinary operations
- Preservative used for vet products
- Cited in the European Cosmetic directory
- Contact lens cleaner

PHMB 20% can be used directly after dilution with purified water or with other additive agent compounds. 
Reference amount 1:125~1:1000 (w/w).
Since the product in different areas of application, the product dosage are quite different, it is recommended to use under the guidance of our professional and technical persons.

Phmb 20% - Poly Hexamethylene Biguanide Phmb 
Available in colorless to pale yellow form, Polyhexamethylene biguanide, PHMB is accessible in liquid form. 
PHMB 20% tastes bitter and its purity level is 20%. 
PHMB 20% can be stored for 24 months. 
PHMB 20% is water soluble and PHMB 20% is cationic by nature. 
PHMB 20% is suitable for household, industrial and clinical application purpose. 
Ph level of this liquid substance ranges between 4 to 5. 
Polyhexamethylene biguanide, PHMB has been formulated under controlled temperature to preserve PHMB 20%s anti bacterial properties.
Standard of this liquid has been verified on the basis of PHMB 20%s composition, formulation method, effectiveness, shelf life, ph value, possible toxin content, etc.

Appearance: Colorless or Light yellow transparent liquid
Content of Active Substance (%): ≥20.0
PH value: 4.5-6.5
Density (@20℃g/cm3): 1.1+/-0.1
Viscosity (CP): 5
Boiling Point (℃): 102
Flash Point: Does not glow when boiling
Dispersibility in water: Compatible with water in any ratio

PHMB 20% usage:
PHMB 20% has the ability to kill bacteria, fungi, algae and yeast. 
PHMB 20% acts on the cell wall or cell membrane of bacteria, fungi, algae, Combine with phospholipid compounds, Rapid breakdown of their membrane system, making the Intracellular Substance outflow, And inhibit certain enzyme activities that attached in the cells, thereby achieving antibacterial and antifungal effects. 
PHMB 20% is low in toxicity and long-term use, Compared with polyhexamethylene monoterpene, This product has better antibacterial effect on fungi and yeast. 
The antibacterial effect of PHMB 20% is characterized by high efficiency, safety, stability, long-term effect, convenient use and environment friendly

PHMB 20% application:
-Water Treatment:
Swimming pool disinfection, as an alternative to chlorine;
PHMB 20% is non-irritating when used in swimming pool disinfection and is used in an amount of 10 to 50 ppm. 
PHMB 20% has a certain repair function on the skin.
For industrial water(cooling tower, …)
-Surface disinfecting:
algaecide for concrete surfaces
all purpose surfaces disinfectant

PHMB 20% is used as the main bactericidal ingredient in the compound hand sanitizer. 
When the content of PHMB 20% is 250-300 mg / l, PHMB 20% has a good killing effect on cell propagules and yeasts.

-Daily care products
PHMB 20% can be used for antibacterial preservation of disposable wet wipes, wet towels, napkins and antibacterial hand sanitizers; it is used for lens disinfectant.

Adding this product to the aquatic water system can inhibit bacteria in the water system and prevent aquatic diseases such as red legs, bad eyes and rotten plaque caused by bacteria. 
PHMB 20% also enhances water activity, reduces ammonia and phosphate in water, and controls algal growth. 
Naturally balance the ecosystem of the pond, which plays a good role in preventing and treating diseases. 
PHMB 20% is recommended to add 1 to 5 ppm to prevent and treat diseases. 
When the fish and shrimp are seriously ill, the dosage can be increased to 15 ppm.

Polyhexamethylene biguanide hydrochloride (English abbreviation PHMB) is a new generation of guanidine disinfectant, which has the advantages of broad-spectrum, long-lasting antibacterial, safe, non-toxic, and non-irritating. 
Polyhexamethylene biguanide hydrochloride (PHMB) has two forms, powder and aqueous solution, usually 20% aqueous solution. 
Polyhexamethylene biguanide hydrochloride (PHMB) has the functions of disinfection, sterilization and antiseptic. 
PHMB 20% can kill a variety of bacteria including Gram-positive bacteria, Gram-negative bacteria, fungi and yeasts. microorganism. 
Therefore, polyhexamethylene biguanide hydrochloride (PHMB) is often added to high-end products such as women’s lotions, disinfectant wipes, contact lens care solutions, etc., and is widely used in daily necessities, medical care, wet wipes, textiles and other fields.
CAS No.: 32289-58-0 (United States), 27083-27-8 (Europe), 91403-50-8 (INCI)
Molecular formula: C10H23N5
Molecular weight: 213.32

PHMB 20% can be used for antibacterial finishing of textiles. 
Due to PHMB 20%s good heat stability, PHMB 20% can be added to the melt spinning solution to make antibacterial synthetic fibers. 
PHMB 20% can also be used in antibacterial laundry liquid, PHMB 20% is non-irritating to the skin, and the washed clothes are harmless to the human body, and no odor is generated after use.

PHMB 20% should be stored in a dry, cool and sealed place, avoid light.
Storage: Store in a dry, cool and sealed place, avoid light.

Product Name: Poly(hexamethylenebiguanide) hydrochloride
Chemical Name: Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride
CAS No. : 32289-58-0
Molecular formula:(C7H16N3Cl)n=12-16
Appearance:  Colorless to yellowish liquid
Quality Standard:  Enterprise standard
Application: PHMB is used as a sanitizer or preservative to kill bacteria. 
PHMB 20% restrains the gram-positive bacterium,gram-negative bacterium, fungus and yeast  etc. 
As a preservative, PHMB 20% is used in cosmetics, personal care products, fabric softeners, contactlens solutions, hand washes, and more. 
PHMB 20% is also widely used in evironmental disinfection including hospitals, schools, hotels, and public places
Storage: Cool, drying, shading, and sealed storage.

PHMG is a new generation of disinfectant with a wide scope of applications in agriculture and food processing plants, logistics, kitchens, transport vehicles. 
PHMB is a disinfectant with a broad spectrum of activity against bacteria, viruses and fungi, inducing cell death by disrupting cell membrane integrity. 
and it is used as a preservative in cosmetics, personal care products, fabric softeners, contact lens solutions, hand washes, and more. 
In cosmetics, the preservation of fruit and vegetables. 
PHMB is also used to preserve wet wipes; to control odor in textiles; to prevent microbial contamination in wound irrigation, sterile dressings; to deodorize vacuums and toilets; to disinfect medical/dental utensil and trays, farm equipment, animal drinking water and hard surfaces for food handling institutions and hospitals. 

PHMB is used in antimicrobial hand washes and rubs and air filter treatments as an alternative to ozone. 
PHMB is also used as an active ingredient for recreational water treatment, as a chlorine free polymeric sanitizer, which is effective against a wide variety of microorganisms. 
PHMB 20% has been used in a wide range of applications from swimming pool sanitisers to preservatives in cosmetics and contact lens solutions. 
Clinical studies indicate it has a broad spectrum of activity, including against human immunodeficiency virus (HIV). 
PHMB appears to be available in presentations that provide clinicians with effective wound care modalities for most clinical scenarios and has also been used as a perioperative cleansing agent, in mouth wash, in ophthalmology. 
Petrou-Binder40 describes the germicidal effects of PHMB as eye drops prior to cataract surgery. 
PHMB can be found in swimming pool sanitizers, cosmetics, leather preservatives, contact lens disinfectants, cleanser in agriculture and food handling, in treatment of hatching eggs, fibers and textiles and technical fluids like cutting oils and glues

PHMB 20% is an environmental-friendly Cationic Polymer. 
PHMB 20% is water soluble and the aqueous solution is colorless and odorless, broad-spectrum, high-efficiency, low toxicity, good stability, non-flammable and non-explosive. 
Normally non-corrosive to stainless steel, stainless copper, carbon steel, wood, plastic, etc. 
PHMB is a high molecular polymer, which is not easily absorbed by tissues, has no corrosive effect, has good stability and is easy to rinse, good biocompatibility. 
Vitro studies have shown that PHMB 20% is non-toxic to human cells, and the in vivo irritation test results of rabbit and human hand skin show that it has no irritation to animal and human skin. 
PHMB 20% is widely used in textile printing and dyeing, animal husbandry, aquaculture, medical sterilization and daily disinfection.

Item: Specifications
Appearance: Clear colorless to light yellow odorless liquid
Assay (solid %): 19 to 21(w/w)
PH value (25℃): 4.0-5.0
Density (20℃): 1.039-1.046
Soluble in water: Totally soluble in water
Absorbance E 1% 1cm (by 237nm): Min.400
Ratio of absorbance (237nm/222nm): 1.0-1.2
Conclusion: The results conforms with enterprise standards

DESCRIPTION: PHMB (Polyhexamethylene -biguanide Hydrochloride) is a very widely used international antimicrobial agent, that can be widely used as antimicrobial and preservative of environment, skin, water disinfection, textiles, hygiene products, cosmetics. 
CAS No.: 32289-58-0 or 27086-27-8 or 133029-32-0
Functions: PHMB can be used as disinfectant, antibacterial, bactericide, mildew-proof, algae-inhibitor, flocculant ,etc.

Polyhexamethylene biguanide hydrochloride (PHMB) is a chemical biocide which is a polymer utilized in a wide variety of antimicrobial applications. 
This review provides a comprehensive literature of PHMB features from synthesis methods,mode of action, antimicrobial effects and safety considerations to both humans and environments.
Effectiveness against cellular organisms is due to the basic biguanide group attached to a flexible spacer, a hexamethylene group. 
PHMB is a disinfectant with a broad spectrum of inducing cell death by disrupting cell membrane integrity. 
PHMB 20% is an environmentally friendly product noncorrosive and nontoxic to both humans and animals. 
PHMB 20% is used as a preservative in cosmetics, personal care products, fabric softeners, contact lens solutions, hand washes, cosmetics, the preservation of fruit and vegetables. 
PHMB 20% is also used to preserve wet wipes; to control odor in textiles; to prevent microbial contamination in wound irrigation and sterile dressings; to disinfect medical/dental utensil and trays, farm equipment, animal drinking water, and hard surfaces for food handling institutions and hospitals; and to deodorize vacuums and toilets. 
PHMB 20% can work at low concentrations with very fast action with a broad spectrum of action in addition of its wide acceptance and exploitation for potential multi-purpose functional use. 
PHMB 20% will be promising for advanced environmental treatments including food disinfection, water disinfection, surface disinfection, and meet the criteria for an ideal antimicrobial agent.

PHMB 20% features:
Long lasting and broad-spectrum kill and inhibit various types of microbial; Not easy to produce antibiotic-resistant bacteria; Non-toxicto humans andhigher animals,no skin and mucous membrane irritation,no corrosion on the surface treatment.

PHMB 20% application:
Widely used in health care, chemicals, textiles, paper, wipes, livestock, aquaculture, fisheries, plastics, agriculture, water treatment and other fields.

PHMB 20% usage
PHMB can be used directly after dilution with purified water or with other additive agent compound. 
Reference amount 1:125~1:1000 (w/w). 
Since  PHMB 20% in different areas of application, the product dosage are quite different, it is recommended to use under the guidance of our professional and technical persons.

English name: Poly(hexamethylenebiguanide)hydrochloride
Chemical formula: (C8H17N5)n.xHCl
CAS No.: 32289-58-0
EINECS No.: 1308068-626-2

PHMB is recognized as the safest and the most efficient broad-spectrum antibacterial agent in the 21st century. 
PHMB 20% is colorless and tasteless, low bacterial inhibition concentration, broad spectrum, low toxicity.
PHMB 20% can form a layer of cations on the surface of article, which can inhibit bacteria for a long time. 
PHMB 20% also has no bacteria drug resistance.

PHMB 20 is one of a series of polydisperse biguanide molecules (PDBG). 
PHMB 20% is a 20% colloid containing poly (hexamethylene biguanide) hydrochloride, also known as polyaminopropyl biguanide.
PDBGs are cationic molecules composed of biguanide repeating units. 
PHMB 20 contains chloride anions and has a pKa that allows protonation (fully cationic).
PHMB 20% is an extremely versatile biocide that can be used alone or with other biocidal polymers in a wide variety of applications.

-Fast bactericide with excellent activity against gram-negative bacteria.
-Extremely effective against protozoa such as Acanthamoeba polypahga.
-By warning light smell

-Disinfection of hard surfaces (Food and Beverage, Biotechnology, Institutional Hygiene).
-Functional textiles (wound dressings, textiles).
-Water treatment (private pools, pasteurizers, hydrostatic oil testing and gas pipes, the simplest refrigeration units and refrigeration equipment).
-Personal care products (odor control and antibacterial properties of fabric care products).
-Wet wipes.
-Public places, toilet transport systems.

PHMB 20% Dosage
Based on the equipment, water quality when used with other water treatment chemicals. 
As disinfectant used alone, we advise 100mg/L~500mgL. 
Other application like aquaculture, animal husbandry, textile printing and dyeing.

Properties PHMB (polyhexamethylene biguanide) is a water-soluble cationic disinfectant with wide clinical, household, and industrial applications

Physical and chemical properties of PHMB 20%:
Polyhexamethylene biguanide hydrochloride is the chemical name with INCI Name:
Polyaminopropyl Biguanide 
IUPAC Name: Homopolymer of N-(3-Aminopropyl)- Imidodicarbonimidic Diamide. 
PHMB is a polymer which in is neat form represents a solid/powder of > 94.2 % purity, colourless, odourless, non-corrosive and non-irritating antimicrobial biocide. 
PHMB 20% has a good water solubility of around 40 %. 
PHMB 20% is also soluble in alcohol and being used as common solvents for paints and lacquers. 
Average molecular weights in the range between 2670 and 4216 Da. 
PHMB is a positively charged polymer having polymeric biguanide units in the backbone of its structure [−(CH2)6.NH.C(=NH). NH.C(=NH).NH-]n, where n ranges from 2 to 40 having an average value of 11. 
These properties make PHMB 20% as an interesting molecule to technological applications: It is as good a metal chelator as its parent molecule, biguanide; the five conjugated amines when binding to neighboring molecules with multiple hydrogen bonds, will be attractive for supra molecular chemistry. 
Films of PHMB are transparent and very adherent to metal, plastics and glass. 
PHMB 20% is a proton conductor, potentially applicable to proton exchange membrane fuel cells. 
Infrared absorption spectrum of PHMB showed that the most important are those located at 2,000–2,400 nm range, corresponding to nitrogen-related vibrations, including combination bands due to nitrogen-carbon bonds in the biguanide pseudo-aromatic ring. 
other bonds are due to methylene groups and residual hydration water

PHMB 20% Taste Bitter
Appearance WATER WHITE
Storage Room Temperature
Application Pharmaceutical
Structural Formula (C8H17N5)n

PHMB 20% Security
You must wear a gas mask and work clothes. If you may be exposed to dust, you must wear a dust mask (full face mask). 
In an emergency, you must wear an air ventilator.

PHMB 20% First-Aid
Inhalation: quickly leave the scene to a place with fresh air, keep the air unobstructed, if breathing is difficult, give oxygen. 
If breathing stops, give artificial respiration immediately and seek medical attention.
Skin contact: Take off contaminated clothes and rinse with plenty of water.
Eye contact: immediately lift the eyelid and rinse with plenty of water for 15 minutes, and seek medical attention immediately

PHMB 20% Packing & Storage
Store in a cool, dry, well-ventilated warehouse. 
Keep away from fire and heat sources. 
Prevent direct sunlight. 
The package is sealed and kept away from moisture. 
Store separately from oxidizers and flammable materials. 
Do not store them together. 
The storage area should be equipped with suitable materials to contain the leakage.

PHMB 20% Transportation
Airtight operation, local exhaust. 
Operators must undergo special training and strictly abide by operating procedures. 
PHMB 20% is recommended that operators wear masks, work clothes and rubber gloves. 
Lightly load and unload when handling to prevent damage to the packaging.
Equipped with leakage emergency treatment equipment, emptied containers may leave hazardous substances.

Product name: 20% Aqueous solution of Polyhexamethylene biguanide Hydrochloride (PHMB)

General Description
RCPC PHMB20% is a broad spectrum, fast acting bactericide. 
A 20% aqueous solution of Polyhexamethylene biguanide hydrochloride with the following structure, also known as PHMB, it is an effective preservative for make-up removers, moisturizing toners, facial cleansers, wet wipes, Water treatments application, Fermentation equipment and also offers antibacterial and deodorant properties.

PHMB 20% Applications
RCPC PHMB20% is an effective in wide range of industrial disinfection applications, primarily as a solid surface disinfectant.
Applications include:
-Veterinary establishments
-Poultry hatcheries
-Food processing plants
-Air conditioning units
-Beer glass cleaners

Background: Polyhexamethylene biguanide (PHMB) eye drops are a frequently used medication to treat Acanthamoeba keratitis. 
In the absence of marketed PHMB eye drops, pharmacy-compounding units are needed to prepare this much needed treatment, but the lack of validated PHMB stability data severely limits their conservation by imposing short expiration dates after preparation. 
In this study we aim to assess the physicochemical and microbiological stability of a 0.2 mg/mL PHMB eye drop formulation stored in two kinds of polyethylene bottles at two different temperatures.
Methods: A liquid chromatography coupled with diode array detector stabilityindicating method was validated to quantify PHMB, using a cyanopropyl bonded phase (Agilent Zorbax Eclipse XDB-CN column 4.6 75 mm with particle size of 3.5 mm) and isocratic elution consisting of acetonitrile/deionized water (3/97 v/v) at a flow rate of 1.3 mL/min. 
PHMB eye drops stability was assessed for 90 days of storage at 5 and 25 C in ethylene oxide sterilized low density polyethylene (EOS-LDPE) and gamma sterilized low density polyethylene (GS-LDPE) bottles.
The following analyses were performed: visual inspection, PHMB quantification and breakdown products (BPs) screening, osmolality and pH measurements, and sterility assessment. 
PHMB quantification and BP screening was also performed on the drops emitted from the multidose eyedroppers to simulate in-use condition.
Results: The analytical method developed meets all the qualitative and quantitative criteria for validation with an acceptable accuracy and good linearity, and is stability indicating. 
During 90 days of storage, no significant decrease of PHMB concentration was found compared to initial concentration in all stored PHMB eye drops. 
However, BP were found at day 30 and at day 90 of monitoring in both kind of bottles, stored at 5 and 25 C, respectively. 
Although no significant variation of osmolality was found and sterility was maintained during 90 days of monitoring, a significant decrease of pH in GS-LDPE PHMB eye drops was noticed reaching 4 and 4.6 at 25 C and 5 C respectively, compared to initial pH of 6.16.

PHMB 20% Specification:
Appearance: Colorless to pale yellow clear or almost clear liquid
Total solid: 19.0 - 21.0%
Purity: 99.0, % min.
Ash content: 0.2% max.
pH at 25℃: 3.0 - 5.5
Boiling Point: 102 - 103℃
Density at 25℃: 1.030 - 1.046
Absorbance ratio 237/222nm: 1.2 - 1.6

PHMB 20% usage:
PHMB Polyhexamethylene biguanide is a very widely used antimicrobial agent in the world. 
PHMB 20% is widely used in the environment, skin, water disinfection, and antibacterial antiseptic of textiles, hygiene products, cosmetics, used as disinfectant, antibacterial agent, sterilization Agent, mildew preservative, algaecide, flocculant.
Environmentally friendly polymer  – polyhexamethylene oxime, with broad spectrum of sterilization; low effective concentration; fast action; stable nature; excellent performance in water solubility; can be used at room temperature; Bacteria, no side effects; no corrosive; colorless, odorless; non-toxic; non-combustible, non-explosive, safe to use; moderate price; convenient transportation, can be said to be the best fungicide. 
In fact, PHMB 20% is an environmentally friendly, versatile new polymer that is used in a wide range of applications in industry, agriculture, medical and everyday life.
PHMB 20% is an antiseptic and bactericide. 
PHMB 20% is broad-spectrum antibacterial fugicide, take effective for kill gram-positive bacteria, gram-negative bacteria, fungus and yeast; usually used for swimming pool bactericide, universal detergent and disinfector as a fugicide.
Compare with PHMG, PHMB 20% has a better bacteriostasis effect for Aspartate bacillis, beer yeast and Aspergillus niger than PHMG.

PHMB 20% features
-Long-term broad-spectrum killing and inhibiting various microorganisms
-Non-toxic to human body and higher animals at the used concentration, non-irritating to skin and mucous membrane, and non-corrosive to the treated surface

PHMB 20% (Polyhexamethylene -biguanide Hydrochloride) is a very widely used international antimicrobial agent, that can be widely used as antimicrobial and preservative of environment, skin, water disinfection, textiles, hygiene products, cosmetics.
CAS No.: 32289-58-0 or 27086-27-8 or 133029-32-0

Typical Dosage:
Disinfection of pre-cleaned solid surface:  0.1 - 0.2
Water treatments applications: 0.01 - 0.1
Fermentation equipments:  0.3 - 0.5
Acid descales sanitizer: 0.4 - 0.7
Tunnel pasteurization: 0.05 - 0.01
Personal care: 0.05 - 2.0
Wet wipes: 0.2 - 1.0

PHMB was firstly synthesized by Rose and Swain (1954). 
PHMB 20% is a cationic biguanide polymer which is utilized in a wide variety of antibacterial applications. 
Several methods have been devised in order to prepare PHMB. 
For instance, one of the current methods is to obtain PHMB by polycondensation of sodium dicyanamide and hexamethylenediamine in two steps. 
Preparations of PHMB are polydisperse mixtures of polymeric biguanides, with a weighted average number (n) of 12 repeating hexamethylene biguanide units. 
The heterogeneity of the molecule is increased further by the presence of either amine, or cyanoguanidine or guanidine end-groups in any combination at the terminal positions of each chain. 
Equal amounts (in molar) of hexamethylenediamine and guanidine hydrochloride to be mixed in a round-bottomed three-necked flask, which is equipped with a mechanical stirrer and vacuum system. 
The mixture reacts at 100 °C for 60 min, and then at 170 °C for a certain time. 
During the reaction, by-product ammonia is neutralized by bubbling through aqueous HCl. 
At the end of reaction, the slightly yellow, viscous liquid solidifies upon cooling giving PHMG samples

CAS No:    32289-58-0
Synonyms: Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride;N,N'''-1,6-Hexanediylbis(N'-cyanoguanidine) hexamethylenediamine polymer hy drochloride;PHMB
Product Code: FP16108
MDL No:    MFCD00217750
Chemical Formula: (C8H17N5)n·x(HCl)
Appearance:  Colorless to yellowish transparent liquid & White power soild
Assay:20% & 99%

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