CAS Number: 25322-68-3
Composition of Polyethylene glycol (PEG) 6000:
Polyethylene glycol 6000
H(OCH2CH2)nOH
n = about 136
Product properties of Polyethylene glycol (PEG) 6000:
Polyethylene glycol (PEG) 6000 is a white waxy solid at room temperature.
Polyethylene glycol (PEG) 6000's two hydroxy end groups as well as its ether groups mainly control the physical and chemical properties of Polyglykol 6000.
Therefore Polyethylene glycol (PEG) 6000 is soluble in water and polar organic solvents like aceton or methanol.
Polyethylene glycol (PEG) 6000 is insoluble in pure hydrocarbons.
Polyethylene glycol (PEG) 6000 displays typical chemical reactions of alcohols/diols.
The solidification point of Polyethylene glycol (PEG) 6000 is about 58°C.
Polyethylene glycol (PEG) 6000, an inert and water-soluble liquid or solid substance, can be obtained through water and ethylene oxide.
Polyethylene glycol (PEG) 6000 is widely used as organic reaction intermediate, solvent, binder, raw materials for resin, polyol for urethane, dispersant, and emulsifier.
Polyethylene glycol (PEG) 6000 is a polymer of ethylene oxide with an average molecular weight of 6000.
Polyethylene glycol (PEG) 6000 is an excellent solubiliser.
Polyethylene glycol (PEG) 6000 can be used in a wide variety of home care and I&I applications.
Applications of Polyethylene glycol (PEG) 6000:
-Automatic & Hand Dishwash
-Fabric & Laundry Care
-Hard Surface Cleaning
-Industrial & Institutional Cleaning
-Waxes & Polishes
Composition of Polyethylene glycol (PEG) 6000:
Polyethylene glycol with 135 mol EO
Product properties of Polyethylene glycol (PEG) 6000:
Concentration [%]: approx. 100
Relative molar mass [Dalton]: 5600 - 6600
Appearance: white flakes
Hazen colour, 25% in water: max. 30
Solidification point [°C]: 55 - 60
Hydroxyl number [mg KOH/g]: 17 - 20
Viscosity, 20°C, 50% in water [mPas]: 210 - 262
Water (Karl Fischer method) [%]: max. 0.5
pH value, 5% in water: 5.0 – 7.0
Oxide ash [%]: max. 0.05
Solubility in water: dissolves to a clear solution
Application of Polyethylene glycol (PEG) 6000 includes washing powders and tabs, dissolving aids, tabletting and granulation auxiliaries, binding agents, toilet blocks.
Polyethylene glycol (PEG) 6000 is a slip, softener and mold-release agent.
Polyethylene glycol (PEG) 6000 is water-soluble carrier substance.
Polyethylene glycol (PEG) 6000 offers moisture-stabilizing effect in creams and leaves a pleasant feel on the skin.
Polyethylene glycol (PEG) 6000 can be used in transparent toothpastes.
Polyethylene glycol (PEG) 6000 exhibits good compatibility with cetyl alcohol, glycerol, stearic acid, polyvinyl pyrrolidone, casein, vegetable albumin.
Polyethylene glycol (PEG) 6000 has no emulsifying effect.
Chemical name: polyethylene glycol 6000
CAS Number: 25322-68-3
General description of Polyethylene glycol (PEG) 6000:
Polyethylene glycol (PEG) 6000 is a hydrophilic polymer.
Polyethylene glycol (PEG) 6000 can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups.
When crosslinked into networks PEG can have high water content, forming “hydrogels”.
Polyethylene glycol (PEG) 6000 is a suitable material for biological applications because it does not trigger an immune response
Polyethylene glycol (PEG) 6000 is high molecular weight Polyethylene Glycol that provides enhanced solvency, lubricity, hygroscopicity and other important functional properties in a wide range of formulations.
Uses of Polyethylene glycol (PEG) 6000:
-Fragrance carrier
-Binder and plasticizer for green-body formation in ceramics
-Wetting for after wash automotive sprays
-Household cleaners
-Dye carrier
-Lubricants
-Mining
-Mold release agent
-Plasticizer
-Wood treating
Polyethylene glycol (PEG) 6000 is widely used as organic reaction intermediate, solvent, binder, raw materials for resin, polyol for urethane, dispersant, and emulsifier.
KEYWORDS:
25322-68-3, Polyglykol 1000 SG VITA, Polyglykol 10000 S, Polyglykol 10000 SG, Polyglykol 12000 S, Polyglykol 1500 FL PU, Polyglykol 1500 S, Polyglykol 2000 PU, Polyglykol 2000 S, Polyglykol
Polyethylene glycol (PEG) 6000:
Polyethylene glycol (PEG) 6000 (CAS No. 25322-68-3) is a polyethylene glycol having white to off white color and available in solid flakes or powder form.
Polyethylene glycol (PEG) 6000 used as a base in the formulation of soap sticks.
Polyethylene glycol (PEG) 6000 has low glycol content and higher crystalinity.
Polyethylene glycol (PEG) 6000's high molecular weight mainly prompts its use in pharmaceutical formulations as solvent for oral, topical and parenteral preparations.
The high molecular weight Polyethylene glycol (PEG) 6000 is soluble in water and organic solvents such as alcohols.
Polyethylene glycol (PEG) 6000 can blend with other PEG molecular weights to achieve the desired viscosity properties.
Polyethylene glycol (PEG) 6000 is quite stable and does not support microbial growth, even in aqueous solutions.
Polyethylene glycol (PEG) 6000 is a high molecular polyethylene glycol (macrogol) mainly used as solvent for oral, topical and parenteral preparations.
Polyethylene glycol (PEG) 6000 has been used in pharmaceutical applications for over 50 years, giving this inactive ingredient a wide acceptance.
Polyethylene glycol (PEG) 6000 is a high molecular polyethylene glycol (macrogol) mainly used as solvent for oral, topical and parenteral preparations.
The high molecular weight Polyethylene glycol (PEG) 6000 is soluble in water and organic solvents such as alcohols.
Polyethylene glycol (PEG) 6000 can be blended with other PEG molecular weights to achieve the desired properties, i.e. viscosity.
Polyethylene glycol (PEG) 6000 will not become rancid and will not support microbial growth, even in aqueous solutions.
Polyethylene glycol (PEG) 6000 offers water solubility, nonvolatility, inertness and lubricity to the formulations
Polyethylene glycol (PEG) 6000 is an ideal choice for a variety of household product applications.
Polyethylene glycol (PEG) 6000 serves as an excellent laundry aid for powdered detergents in need of anti-caking properties, and acts as a carrier for starch.
Polyethylene glycol (PEG) 6000's binding properties make this PEG ideal for detergent cake applications and toilet bowl cleaners with added dissolution control to deliver the convenient and high-performing solutions consumers desire.
In ceramics applications, Polyethylene glycol (PEG) 6000 delivers the extra edge products need as a plasticizer, binder, and carrier with easy and smooth distribution, good lubricity for mold and die release, improved green-strength and easy burn-off without residue.
Polyethylene Glycols (PEGs), a family of water soluble linear polymers, are among the most versatile chemical ingredients available to formulators and manufacturers.
They are available in a wide range of viscosities, weights from 200 to 35000 and melting points for optimal formulation flexibility in applications including ceramics, lubricants, soaps and detergents, and toilet bowl cleaners.
By choosing a suitable product grade, you can achieve the desired balance of water solubility, hygroscopicity, vapor pressure, melting or freezing range, and viscosity.
Polyethylene glycol (PEG) 6000 is white or almost white solid with a waxy or paraffin-like appearance.
Polyethylene glycol (PEG) 6000 is very soluble in water and in methylene chloride, very slightly soluble in alcohol, practically insoluble in fatty oils and mineral oils
USP/NF: Polyethylene glycol 6000
Storage of Polyethylene glycol (PEG) 6000:
When stored in a cold, dry place in a closed container Polyethylene glycol (PEG) 6000 can be kept for at least two years.
Applications of Polyethylene glycol (PEG) 6000:
Based on their physical and chemical characteristics - Polyethylene glycol (PEG) 6000 is used for a wide variety of applications.
Fields of applications of Polyethylene glycol (PEG) 6000:
- Reactive diol/polyether component in polyester or polyurethene resins
- Component of auxiliaries for leather and textile processing
- Cosmetic / pharmaceutical formulations (e.g. humectant or plasticiser for creams, tablets, tooth paste)
- Lubricant and mould release agent for rubber, plastic and elastomer processing
- Plasticizer and binder for ceramic and concrete manufacturing
- Component of lubricant formulations
- Water soluble, lubricating component in metalworking fluids
- Humectant for paper, wood and cellulose films
- Solvent and humectant for dyes and inks
- Modifier for production of regenerated viscose
- Humectant and plasticizer for adhesives
Application of Polyethylene glycol (PEG) 6000 includes washing powders and tabs, dissolving aids, tabletting and granulation auxiliaries, binding agents, toilet blocks.
Polyethylene glycol (PEG) 6000 is a solid water soluble polymer with with excellent solvency for substances that do not readily dissolve in water.
Polyethylene glycol (PEG) 6000 also can help increase viscosity of a solution.
Polyethylene glycol (PEG) 6000 recommended for excipient applications, topical creams, lotions, personal care products, and solid oral dose. INCI Name: PEG-150
Uses of Polyethylene glycol (PEG) 6000:
-Pharmaceuticals - excipients
-Pharmaceuticals - actives
-Food contact
-Cosmetic
-Personal care
-Chemical intermediates
Benefits of Polyethylene glycol (PEG) 6000::
-Proven performance in a variety of excipient formulations
-Some products suitable for API Applications: laxative and lavage
-Compliance with USP/NF and Ph. Eur. monographs
-Solubilize / disperse wide variety of components
-Tune formulation to achieve desired form (solid, liquid with certain viscosities and melt-freeze points)
-Attract and retain moisture—ideal for ointments and lotions
Polyethylene glycols, also called macrogols in the European pharmaceutical industry, are manufactured by polymerization of ethylene oxide (EO) with either water, mono ethylene glycol or diethylene glycol as starting material, under alkaline catalysis.
After the desired molecular weight is reached (usually checked by viscosity measurements as in-process control) the reaction is terminated by neutralizing the catalyst with acid.
Normally lactic acid is used, but also acetic acid or others can also be used.
The result is a very simple chemical structure: HO-[CH2-CH2-O]n-H, where (n) is the number of EO-units.
X-ray structural analysis has shown that PEG chain may possess two different types of microstructure.
The shorter chains, with a degree of polymerization not exceeding 10, are said to have a zigzag structure, while longer chains form a so-called meandering structure.
The oxygen forms ether bridges at regular intervals in both types of chain which are responsible for many of the properties of PEGs (3-5).
The microstructure of PEG molecular chains is important in relation to the behaviour of PEGs towards various solvents and also to the formation of addition compounds which link with the “residual valencies” of the ether oxygen atoms.
Although technically these products should be called polyethylene oxides, for products with mean molecular weights of 200 to 35000, the term polyethylene glycols is normally used to indicate the significant influence of the hydroxyl end groups on the chemical and physical properties of these molecules.
Only products made by polymerization of ethylene oxide in solvents, with molecular weights up to several millions, are called polyethylene oxides.
As an abbreviation for polyglycols, the term “PEG” is used, in combination with a numerical value.
Within the pharmaceutical industry, the number indicates the mean molecular weight, whereas in the cosmetic industry the number refers to the number (n) of EO-units in the molecule.
Since the molecular weight of ethylene oxide is 44, the average molecular weight values of PEGs are given as round values of n*44.
Polyethylene glycol (PEG) 6000 have proved effective as antioxidants:
1. trimethyl dihydroquinoline polymer
2. diphenylamine derivatives
3. phenothiazine
4. phenyl-alpha-naphtylamine
5. 4,4‘-methylene-bis.2,6-di-tert.-butylphenol
6. butylated hydroxyanisole (BHA)
7. methoxy phenole (hydroxyanisole)
HYGROSCOPICITY:
The liquid PEG grades are hygroscopic,although not to the same extent as diethylene glycol or glycerol for example.
The ability to absorb water decreases with increasing molar mass.
A rule of thumb is: With a relative humidity of about 50% PEG 200 has about ¾ of the hygroscopicity of glycerol.
PEG 400 has about half, PEG 600 a third and PEG 1000 only a quarter.
PEG 2000 and higher grades are no longer hygroscopic.
PEGs take moisture from the air until an equilibrium is reached.
By plotting the water content of the substance in the equilibrium state as a function of the relative humidity, absorption isotherm is obtained.
The moisture absorption of lower glycols such as monoethylene glycol, diethylene glycol or 1,2-ropylene glycol corresponds roughly to that of glycerol.
An adaptable moderate hygroscopicity may be advantageous for a conditioning agent because products treated with it are less sensitive to climatic changes and have better storage stability.
SOLUBILITY PROPERTIES:
The excellent solubility characteristics of PEGs are of great importance in relation to their applications.
Two advantages are especially significant:
Firstly, the ability of PEGs to dissolve many substances and, secondly, their good solubility in numerous solvents.
In the preparation of aqueous solutions PEGs sometimes act as specifi c solubilizers.
The dissolving power and the solubility of PEGs decrease as the molar mass increases.
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