Povidone K30 is a homopolymer of vinylpyrrolidone in a white to milky white-colored powder form.
Povidone K30 has a K value of 27-33 and a total solids content of greater than 95%.
Povidone K30 is most commonly used as a suspending, dispersing, and emulsifying agent in paint, coating, adhesive, ink, and textile dyeing and printing applications.
CAS Number: 9003-39-8
EINECS: 1312995-182-4
Povidone K30 is a polymer that is stable in the presence of acids, bases, and many other chemical reagents.
Povidone K30 has been shown to form complexes with proteins, nucleic acids, and metals.
Povidone K30 has potential as a biomarker for diagnosing diseases such as cancer.
Povidone K30 can be used for surface methodology by adsorbing proteins on its surface.
The mechanism of the reaction is not yet known but it may involve steric interactions or transfer reactions.
Povidone K30 has been used in clinical trials as an implantable material for repairing damaged tissue or bone.
Povidone K30 is also used in electrochemical impedance spectroscopy to measure ion permeability through membranes by applying an alternating current across the membrane and measuring the resulting voltage change due to ion flow.
Povidone K30, also known as polyvinylpyrrolidone or polyvidone, is a polymer and used as a binder in pharmaceutical tablets.
Synonyms: Poly[1-(2-oxo-1-pyrrolidinyl)ethylene] ; Polyvinylpyrrolidone ; Povidone ; PVP
What is Povidone K30?
Povidone K30 is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.
Povidone K30 has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.
Povidone K30 has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder.
Povidone formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents.
The k number refers to the mean molecular weight of the povidone.
Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights.
The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body.
The best-known example of povidone formulations is povidone-iodine, an important disinfectant.
DESCRIPTION of Povidone K30:
Povidone K30 is a synthetic linear polymer consisting 1-vinyl-2-pyrrolidinone groups in different degrees of polymerisation and molecular weights.
Each grade is characterized by its viscosity in aqueous solution, relative to that of water, expressed as a K – value, typically in the 10 – 120 range.
Povidone K30 occurs as a fine, white to creamy white coloured, odourless hygroscopic powder.
Povidone with K- values equal to or lower than 30 are manufactured by spray–drying and occur as spheres.
Povidones with >K 90 are manufactured by drum drying and occur as plates.
Povidone is listed in the Ph.Eur, BP, JP and USP-NF.
Povidone K30 is generally regarded as essentially non-toxic material.
Povidone K30 is used as thickeners, dispersing agents, detoxicant, complexing agent, lubricants and binders.
Features and Benefits of Povidone K30:
-Highly versatile excipient
-Non-irritant, pH stable and temperature resistant
-Hygroscopic and freely soluble in water and hydro-alcoholic solutions
-Povidone K30 has a molecular weight of approx. 50000
Applications of Povidone K30:
-Binder and dissolution rate enhancer in solid dosage forms (wet granulation and direct compression)
-Solubiliser, suspending and viscosity increasing agent in oral formulations (suspensions and solutions)
-Tablet film coating polymer
Description of Povidone K30:
Povidone K30 (PVP K30) is a white to slightly creamy white, hygroscopic powder or flakes.
Povidone K30 is odorless or slightly odorous, tasteless; hygroscopic.
Povidone K30 is dissolved in water, ethanol, isopropanol or chloroform, and is insoluble in acetone or ether.
Applications of Povidone K30:
Povidone K30 (PVP K30) has a wide range of applications in medicine and is one of the three major medicinal excipients advocated by the international community.
Povidone K30 used as adhesives for tablets and granules.
Povidone K30 can also be used as a glidant for capsules, as an antidote and lubricant for eye drops, as a co-solvent for injections, as a dispersant for liquid preparations, as a stabilizer for enzymes and heat-sensitive drugs.
Povidone can also synthesize PVP-I disinfectant with iodine.
Povidone K30 can also be used as a cryopreservative in medicine.
Povidone K30 is divided into four levels according to its average molecular weight.
Povidone K30 is usually expressed by K value, and different K values represent the corresponding PVP average molecular weight range.
The K value is actually a characteristic value related to the relative viscosity of the PVP aqueous solution, and the viscosity is a physical quantity related to the molecular weight of the polymer, so the K value can be used to characterize the average molecular weight of PVP.
Generally, the greater the K value, the greater the viscosity and the stronger the adhesion.
Povidone K30 appearance is white or milky white powder or granules.
Applications of Povidone K30:
Dye-receptive resins
Film formers
Adhesives
Complexing agents
Binders and stabilizers
Protective colloid
Suspending agents
Pump sprays
Oral care products
Hair mousses and gels
Skin care products
Characteristics of Povidone K30:
Film former
Thickener
Adhesive
Provides high degree of clarity
Povidone K30 is a homopolymer of vinylpyrrolidone in a white to milky white-colored powder form.
KEYWORDS:
9003-39-8, 1312995-182-4, Povidone, PVP-K17, PVP-K25, Crospovidone, 2-Pyrrolidinone 1-ethenyl- homopolymer, 1-Ethenyl-2-pyrrolidinone homopolymer, n-Vinylpyrrolidinone polymer, Agent I133
Product description of Povidone K30:
Povidone K30 (Polyvinylpyrrolidone) are also called dye transfer inhibitors and are additives in laundry formulations that limit dye re-deposition onto the fabric during the wash cycle.
Storage of Povidone K30:
Keep Povidone K30 in a dry and cool place, away from direct sunlight, in a tightly closed container.
Applications of Povidone K30:
1.In Pharmaceutical Industry:
Povidone K30 is a kind of new excellent pharmaceutical excipient.
Povidone K30 is mainly used as binder for tablet and granule, dissolving assistant for injection, flow assistant for capsule, dispersant for liquid medicine and pigment, stabilizer for enzyme and heat-sensitive drug, coprecipitant for poorly soluble drugs, lubricator and antitoxic assistant for eye drug.
Povidone K30 has been used as excipient in more than one hundred drugs.
With excellent adhesive, film-forming, dispersing and thickening properties, Povidone K30 is widely used in the pharmaceutical industry.
Povidone K30 is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.
-Low molecular weight PVP-K, like PVP K12,K15,K17, are usually used as a solubilizing agent, crystallization inhibitor and suspension stabilizer in injection and ophthalmic formulations.
-Medium Molecular PVP-K, like PVP K25,K30, are often used as binder in tablets, capsules and granules, as a stabilizer for oral suspensions, film-forming agent, solubilizing agent, dispersant for pigments, as an enzyme stabilizer and to improve bioavailability.
-High molecular PVP-K, like PVP K90, work as highly effective binder. They are often used as stabilizer in oral and topical suspension, as a thickener, hydropylizing agent, etc.
2.In Cosmetic Industry
Povidone K30 is widely applied in a wide range in hair care, skin care & oral care products.
Povidone K30 is particularly suitable for formulations where viscosity modification and film forming properties are needed.
Povidone K30 is particularly suited to hair styling products.
-The medium molecular weights such as PVP K30 are preferred where viscosity is critical in applications, for example, spray.
-The higher molecular weight products such as PVP K90 are better choice where high viscosity are needed in applications.
Povidone K30 is widely used in cosmetics such as Hair Gels, Hair mousses, Liquid hair setting preparations, Pump Sprays.
3.Other Industrial Application of Povidone K30 include:
-Suspensant, disperser and emulsifier
-Glass fiber
-Detergent
-Plastics and resin
-Ink
-Paint and coating
-Textile dying and printing
-Film
-Adhesive
-TV tube
Important Note about Povidone K30:
Povidone K30 as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Povidone K30 toxicity and Hazards:
All products should be handled by qualified personnel only, trained in laboratory procedures.
Physico-chemical Properties of Povidone K30:
Molecular Formula: (C6H9NO)n
Molar Mass: 111.143
Density: 1,69 g/cm3
Melting Point: 130℃
Boling Point: 90-93 °C
Water Solubility: >=10 g/100 mL at 20 C
Appearance: White powder
Storage Condition: Room Temprature
Physical and Chemical Properties of Povidone K30:
Melting Point: 130°C
Use: Used as stationary liquid for gas chromatography
The aim of this study was to determine the effect of binder and disintegrant excipients toward tablet properties of levofloxacin as the latter tends to suffer brittle fracture upon compression.
The excipients used were povidone K-30 as the binder and sodium starch glycolate (SSG) as the disintegrant which the tablets were formulated according to factorial design 22 with two factors and two levels on each factor.
Four formulas were prepared by wet granulation method using 2 and 4% of each povidone K-30 and sodium starch glycolate in various compositions.
Tablet properties were evaluated for its hardness, friability, and disintegration time as well as dissolution profile.
The data obtained was statistically analyzed using Minitab 17 software to optimize the formulation and resulted in different impacts caused by each excipient.
Povidone K-30 exhibited an increment in hardness, friability, disintegration time but a decrease indissolution profile of levofloxacin tablet.
SSG decreased hardnessand disintegration time, but increased friability and dissolution profile of levofloxacin tablet.
Overlaid contour plot showed that the optimal formula regarding tablet properties of friability, disintegration time, and dissolution profile is in composition of 2.01% povidone K-30 and 2.01% sodium starch glycolate.
Keywords: levofloxacin tablet, povidone K-30, sodium starch glycolate, factorial design.
Specifications of Povidone K30:
Appearance: White to slightly creamy white, hygroscopic powder or flakes.
Identification A: An orange-yellow precipitate is formed.
Identification B: A pale blue precipitate is formed.
Identification C: A deep red color is produced.
pH (1 in 20): 3.0~7.0
Water: ≤5.0%
Residue on ignition : ≤0.1%
Lead: ≤10ppm
Aldehydes: ≤0.05%
Hydrazine: ≤1ppm
Vinylpyrrolidinone: ≤0.2%
2-pyrrolidone: ≤3.0%
Peroxides(as H2O2): ≤400ppm
K-value: 27.0~32.4
Assay(Nitrogen): 11.5~12.8%
TAMC: ≤1000cfu/g
TYMC: ≤100cfu/g
E. Coli: Negative in 1 g
Storage of Povidone K30:
Store Povidone K30 in tight container, in a dry and cool place.
Description of Povidone K30:
Povidone K30 is a water-soluble polymer made from the monomer N-vinylpyrrolidone.
Povidone K30 is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.
Features and advantages of Povidone K30:
-Precisely processed
-Safely packed
-Free from contaminants
Povidone K30 Physical properties:
Povidone K30 exists in white powder or aqueous solution.
Solubility of Povidone K30:
Povidone K30 readily dissolve in water, alcohol, amine and halohydrocarbon, but are not dissolved in acetone and aether etc..
Povidone K30 has good solubility, biocompatibility, and physiologically inert, film-forming character, colloid protect ability and compound ability to many organic or inorganic compounds.
Povidone K30 is also steady to acid, salt and heat, so it is widely used.
Povidone K30 exists as white or milk white powder or colorless or slight yellow transparent liquid.
Povidone K30 can dissolve in water and a variety of organic solvents.
Povidone K30 has good hygroscopicity, film-forming capability, complexing ability and physiological compatibility.
Poor solubility is a global issue of copious pharmaceutical industries as large number of drugs in development stage as well as already marketed products are poorly soluble which results in low dissolution and ultimately dosage increase.
Current study is aimed at developing a polyvinylpyrrolidone- (PVP-K30-) based nanogel delivery system for solubility enhancement of poorly soluble drug olanzapine (OLP), as solubilization enhancement is the most noteworthy application of nanosystems.
Crosslinking polymerization with subsequent condensation technique was used for the synthesis of nanogels, a highly responsive polymeric networks in drug’s solubility.
Developed nanogels were characterized by percent entrapment efficiency, sol-gel, percent swelling, percent drug loaded content (%DLC), percent porosity, stability, solubility, in vitro dissolution studies, FTIR, XRD, and SEM analysis.
Furthermore, cytotoxicity study was conducted on rabbits to check the biocompatibility of the system.
Particle size of nanogels was found with , and in vitro dissolution study exhibited that drug release properties were considerably enhanced as compared to the marketed formulation OLANZIA.
The solubility studies indicated that solubility of OLP was noticeably improved up to 36.7-fold in phosphate buffer of pH 6.8.
In vivo cytotoxicity study indicated that prepared PVP-K30-based formulation was biocompatible.
On the basis of results obtained, the developed PVP-K30-co-poly (AMPS) nanogel delivery system is expected to be safe, effective, and cost-effective for solubility improvement of poorly soluble drugs.
Is Povidone K30 safe to use when pregnant?
Yes
Is Povidone K30 safe while breastfeeding?
Yes
Is it safe to drive or operate heavy machinery when using Povidone K30?
If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Povidone K30 medicine then it may not be safe to drive a vehicle or operate heavy machinery.
One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively.
Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects.
Please check for these effects on your body when using Povidone K30.
Always consult with your doctor for recommendations specific to your body and health conditions.
Is PPovidone K30 addictive or habit forming?
Most medicines don't come with a potential for addiction or abuse.
Usually, the government's categorizes medicines that can be addictive as controlled substances.
Examples include schedule H or X in India and schedule II-V in the US.
Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines.
Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
Can i stop using Povidone K30 immediately or do I have to slowly wean off the use?
Some medicines need to be tapered or cannot be stopped immediately because of rebound effects.
Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.
Synonyms:
PVP
K-30
PVP-K
PVP-K30
PVP-K17
PVP-K25
PVP-K90
Povidone
PVP K 30
Crospovidone
Polyinylpyrrolidone
Polyvinylpyrrolidine
Polyvinylpyrrolidone
Polyvinglpyrrolidone
Polyvinyl pyrrolidone
poly vinyl pyrrolidone
Regulatory process names:
2-Pyrrolidinone, 1-ethenyl-, homopolymer
polyvinylpyrrolidone
Povidone
IUPAC names:
1-Ethenyl-2-pyrrolidinone homopolymer
1-Ethenyl-2-pyrrolidinone polymers
1-ethenylpyrrolidin-2-one
2-Pyrrolidinone, 1-ethenyl-, homopolymer
Agent I133
n-Vinylpyrrolidinone polymer
Poly(1-vinyl-2-pyrrolidinone)
Poly(N-vinyl-2-pyrrolidone)
Poly(vinylpolypyrrolidone)
Poly-1-vinyl-2-pyrrolidone
POLYVINYL PYRROLIDONE
Polyvinyl pyrrolidone
Polyvinylpyrrolidone
polyvinylpyrrolidone
Povidone
PVP
PVP K15
Trade names:
Agent I133
PVP
poly[1-(2-oxo-1-pyrrolidynyl)ethylene]
Polyvinylpyrrolidon
polyvinylpyrrolidone
PVP
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