PROXEL GXL


Proxel GXL by Lonza is a 20% aqueous dipropylene glycol solution of 1,2-benzisothiazolin-3-one. 
Proxel GXL is Used for the preservation of industrial water-based products against spoilage from bacteria, yeasts and fungi. 
Proxel GXL has a non-specific mode of action which means that bacterial resistance is very unlikely to occur. 
Proxel GXL boils without flashing and is stable in the presence of amines. 
The concentration of Proxel GXL required to adequately preserve your product depends on several factors. 
These include the susceptibility of the system to microbiological degradation, the extent to which micro-organisms can gain access, the species involved, pH, temperature, and length of time for which protection is required. 
Suitable for use in synthetic polymer emulsions, emulsion paints, printing inks, paper coating compositions. 

PROXEL GXL Preservative is effective in a wide range of industrial aqueous-based products such as emulsion paints, water-based adhesives, household products, printing inks, paper coating compositions, metal working fluids, agricultural pesticide dispersions.


Proxel GXL Preservative is a broad-spectrum biocide for the preservation of water-based products against spoilage from bacteria, yeasts and fungi. Proxel GXL is a 20% aqueous dipropylene glycol solution of 1,2-benzisothiazolin-3-one. The product is effective in aqueous-based household products.

Application:
Lattices
Oil-in-water emulsions
Emulsion paint and coatings
Adhesives
Paper coating compositions
Pesticide Formulations
Home Cleaning products
Laundry additives


INGREDIENTS:
Chemical Name CAS-No. Concentration (%)
1,2-Benzisothiazolin-3-one
CAS NO: 2634-33-5 
15.00 - 20.00 % 

Sodium hydroxide 
CAS NO: 1310-73-2 
5.00 - 10.00 % 

PROXEL GXL is a broad spectrum biocide for the preservation of industrial water-based products against spoilage from bacteria, yeasts and fungi.
PROXEL GXL is a 20% aqueous dipropylene glycol solution of 1,2-benzisothiazolin-3-one.

Applications
PROXEL GXL is effective in a wide range of industrial aqueous-based products. 
Application areas include:
• Synthetic polymer emulsions
• Emulsion paints
• Water-based adhesives
• Household products
• Printing inks
• Paper coating compositions
• Metal working fluids
• Agricultural pesticide dispersions
• Aqueous mineral and pigment slurries
• Tape joint compounds
• Leather processing solutions

Antimicrobial Properties
The levels of PROXEL GXL needed to prevent the growth of problem micro-organisms are listed in Table 1.
MICs do not represent effective use levels but do indicate the broad spectrum of activity of PROXEL GXL.
PROXEL GXL has a non-specific mode of action which means that bacterial resistance is very unlikely to occur.
Detailed information on the mode of action of PROXEL GXL is available on request.

Table 1: Minimum Inhibitory Concentrations (MIC)
Micro-organism PROXEL GXL (ppm)
Bacteria
Bacillus subtilis 40
Burkholderia cepacia 80
Enterobacter cloacae 80
Escherichia coli 40
Proteus vulgaris 125
Pseudomonas aeruginosa 250
Pseudomonas putida 250
Staphylococcus aureus 40
Streptococcus faecalis 40
Streptococcus lactis 15

Fungi
Alternaria alternata 700
Aspergillus niger 350
Aureobasidium pullulans 350
Chaetomium globosum 400
Cladosporium cladosporoides 400
Penicillium notatum 125

Yeasts
Candida albicans 200
Rhodotorula rubra 400
Saccharomyces cerevisiae (turbidans) 250

Table 2: Typical Physical Properties
Composition A solution of 1,2-benzisothiazolin3-one in dipropylene glycol and water.

Active agent 20% w/w
Physical form: Yellow-light brown solution
Viscosity at 10/25°C: 2000/400 mPa s (Newtonian)
pH at 25°C: 13.5
Boiling point: 100°C
Storage stability:  Stable under normal conditions of storage down to -10°C. If frozen, allow to thaw and stir well before use. 
Active agent is heat-stable and non-volatile.

Flash point: Boils without flashing
Density at 25°C: 1.14
Compatibility: Compatible and effective over pH range 4-12. 
Stable in the presence of amines. 
Incompatible with some oxidising and reducing agents e.g. persalts, sulphites

Amount to Use
PROXEL GXL should be added to the system as early in the process as possible. 
The concentration of PROXEL GXL required to adequately preserve your product depends on several factors. These include the susceptibility of the
system to microbiological degradation, the extent to which micro-organisms can gain access, the species involved, pH, temperature, and length of time for which protection is required.

A range of concentrations and applications is recommended in Table 3; however, it is recommended that a testing programme be undertaken to determine the most costeffective dose for your application.

Testing should take into account chemical compatibility/stability, plant hygiene conditions, susceptibility of the product to contamination, and the typical organisms involved.


Table 3: Applications
Product % PROXEL GXL (w/w)
Synthetic polymer emulsions: 0.05-0.15
Emulsion paints: 0.05-0.15
Water-based adhesives: 0.05-0.25
Household products: 0.05-0.15

Including Laundry detergents, Fabric softeners, Dish-washing liquids, Floor and wall cleaning solutions, Surface cleaning products, Window cleaners, Floor polishes and waxes, Shoe polishes
Tape joint compounds: 0.05-0.25
Printing inks: 0.05-0.15
Paper coating compositions: 0.05-0.15
Metal working fluids: 0.05-0.18
Agricultural pesticide products: 0.05-0.25
Aqueous mineral and pigment slurries: 0.05-0.15
Leather processing solutions: 0.05-0.25
For the short term preservation of freshly flayed skins & hides during processing


The PROXEL GXL Material Safety Data Sheet is provided with every sample and product shipment and is also supplied upon request. 
It should be read and understood by all supervisory personnel and employees before using this product. 


BIT, the primary active ingredient in Lonza's Proxel range, is widely-recognised as one of the most versatile, compatible and trusted broad spectrum preservatives available for the Home Care market.  Aside from single-active products based on BIT alone, the Proxel range also encompasses cost-effective and specialist blends with carefully-identified co-actives providing flexibility of choice for difficult-to-preserve systems.

Has been evaluated for its effect on the environment and human health.
Utilizes ingredients that are considered the safest in their class.
Is safer without sacrificing quality or performance.

Product Information
Proxel GXL is an anti-bacterial, 19.3% active content, Formaldehyde free glycol/alcohol solution suitable for all types of formulations. ProxelGXL Preservative, an aqueous solution of 1, 2- benzisothiazolin3-one, is an efficient microbiostat preservative for aqueous compositions such as oil in water emulsions. Proxel GXL Preservative is registered with the Environmental Protection Agency and has been granted EPA Registration No. 1258-1255.

Many aqueous dispersions and emulsions can be seriously impaired during storage and use due to the growth in them of bacteria and fungi. Proxel GXL Preservative is an effective preservative against growth of the above microbial agents in the aqueous systems listed and exhibits:

Effective control of a wide range of organisms at economic concentrations.
Long-term storage stability.
Ease of use due to its liquid form and good compatibility in most aqueous composition.


Summary
PROXEL GXL Preservative, an aqueous solution of 1, 2- benzisothiazolin3-one, is an efficient microbiostat preservative for aqueous compositions such as oil in water emulsions, latices, emulsion paints including varnishes, lacquers, and stains, water based adhesives, inks, casein and rosin dispersions, textile spin-finish solutions, pesticide formulations, aqueous slurries, titanium dioxide slurries, tape joint compounds, leather processing solutions, and for the preservation of fresh animal hides and skins.
PROXEL GXL Preservative is registered with the Environmental Protection Agency and has been granted EPA Registration No. 1258-1255.
Its components are also cleared by EPA for use under 40 CFR 180.920 for agricultural use.

General
Many aqueous dispersions and emulsions can be seriously impaired during storage and use due to the growth in them of bacteria and fungi.
PROXELGXL Preservative is an effective preservative against growth of the above microbial agents in the aqueous systems listed and exhibits:
a. Effective control of a wide range of organisms at economic concentrations.
b. Long-term storage stability.
c. Ease of use due to its liquid form and good compatibility in most aqueous composition.


Properties PROXELGXL
Composition A solution of 1, 2-benzisothiazolin-3-one at 19.3% in dipropylene glycol and water.
Physical Form and Appearance: Liquid
Viscosity (25°C) Brookfield: 500 centipoise (approx.)
Specific Gravity (25°C/25°C): 1.13 (approx.)
pH (25°C): 12 (approx.)
Density (25°C): 9.5 lb/gal (approx.)
Initial Boiling Point :100°C
Solubility: Soluble in water at use dilutions
Stability: Stable under all normal storage conditions. Maintain the pH above approximately 4. The active agent is heat stable and non-volatile. Protect from frost.


APPLICATIONS OF PROXEL GXL: 
Polymer latices based on acrylate, butadiene, PVA and styrene for various applications, e.g., wax, floor polishes, Synthetic/rubber latices

Oil-in-Water Emulsions: “Spin finish” solutions for use in the textile industry. Cutting/rolling oils. Soluble oils* (metal and engineering industries).

Emulsion Paint and Coatings: Including varnishes, lacquers and stains: For preservation in the can.

Adhesives: Carboxymethylcellulose (CMC)and derivatives, animal glues, adhesives based on gelatins and latex.

Paper Coating Compositions: Rosin dispersions. Starch and casein based products.

Pesticide Formulations: For product preservation For use – dilution

Preservation of Fresh Animal Hides and Skins
To preserve the integrity of fresh animal hides and skins prior to or during processing, use 13 fluid ounces to 2.5 gallons (1.0-24 lbs) of PROXEL GXL Preservative per 1000 pounds of hides or skins. 
Add the appropriate quantity of PROXELGXL Preservative to the brine solution during the curing operation or treat hides or skins with an appropriately diluted aqueous solution during other portions of the processing operation. 
The specific use rate and contact time needed to control microbial attack will depend upon the degree of decomposition of the hides or skins prior to treatment.

Leather Processing Solutions
Use PROXEL GXL Preservative at levels of 0.025-0.2% for the preservation of leather processing solutions.

General Recommendations
The concentration required to give protection depends on several factors. 
These include the susceptibility of the system to microbiological degradation, the extent to which microorganisms can gain access, the species involved, pH, temperature, and length of time for which protection is required.
For protection against bacterial attack, a concentration within the range 0.02-0.35% PROXEL GXL Preservative is almost invariably sufficient.
The control of mold growth, particularly on paste products of high solids content, may occasionally demand dosages above 0.25%.
In dilute fluid systems, spoilage is usually controlled with dosages not greater than 0.09%.

LATICES: Natural and synthetic latices based on acrylate, butadiene, PVA, styrene and other monomers, for use in various applications, e.g., wax, paint, floor polishes, synthetic rubber latices, add 0.05 - 0.15 % of this product (based on total weight of product).
EMULSION PAINTS AND STAINS: for in-can preservation, add 0.05 - 0.25% of this product (based on total weight of product).
OIL-IN-WATER EMULSIONS: "Spin finish" solutions for use in the textile industry. Cutting/rolling oils. Soluble oils* (metal and engineering industries). * We suggest that the addition to metal-working fluid concentrates of this product should be limited to 1.5% maximum. This will give a maximum recommended use level of 0.15% of this product in a 10:1 dilution of the concentrate and reduce the possibility of skin sensitization, add 0.05 - 0.18% of this product (based on total weight of product).
ADHESIVES: Carboxymethylcellulose (CMC) and derivatives, animal glues, adhesives based on gelatins and latex, add 0.05 - 0.25% of this product (based on total weight of product).
PAPER COATING COMPOSITIONS: Rosin dispersions. Starch and casein based products, add 0.05 - 0.15% of this product (based on total weight of product).
PESTICIDE FORMULATIONS: For product preservation. For ultimate use-dilution protection. This product is exempt from tolerance under 40CFR180.920, materials exempted from the requirements of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only. Based on the current 180.920 limit of 0.1% BIT in formulations, use levels of up to 0.5% (5000 ppm) of this product are allowed, add 0.05 - 0.25% of this product (based on total weight of product).
IN-CAN PRESERVATION OF SEED COATING MATERIALS (INCLUDES BUT NOT LIMITED TO
COLORANTS, DYES, SEED COATINGS, AND PESTICIDE FORMULATIONS, ETC.): add 0.05 - 0.5% of this product (based on total weight of product).
INKS: add 0.05 - 0.25% of this product (based on total weight of product).
AQUEOUS MINERAL SLURRIES: add 0.04 - 0.125% of this product (based on total weight of product).
CONSTRUCTION MATERIALS: Tape joint compounds, 1concrete admixtures, add 0.08 – 0.25% of this product (based on total weight of product)
SPECIALTY PRODUCTS AND HOUSEHOLD PRODUCTS: Home cleaning products, floor cleaners, floor waxes and polishes, surface cleaners, window cleaners, dish detergents, add 0.05 - 0.15% of this product (based on total weight of product).
LAUNDRY ADDITIVES: Liquid laundry detergents, fabric softeners, stain removers, add 0.05 - 0.15% of this product (based on total weight of product).
CAR CARE PRODUCTS: car washing products, car waxes, silicone emulsions, add 0.075 - 0.15% of this product (based on total weight of product).

PRESERVATION OF FRESH ANIMAL HIDES AND SKINS: To preserve the integrity of fresh animal hides and skins prior to or during processing, use 13 fluid ounces to 2.5 gallons (1.0–24 lbs) of this product per 1000 pounds of hides or skins. 
Add the appropriate quantity of this product to the brine solution during the curing operation or treat hides or skins with an appropriately diluted aqueous solution during other portions of the processing operation. 
The specific use rate and contact time needed to control microbial attack will depend upon the degree of decomposition of the hides or skins prior to treatment.
Leather Processing Solutions. Use this product at levels of 0.025 – 0.2% for the preservation of leather processing solutions.

SLIME CONTROL: There are two methods of adding slimicides to paper mill systems: shock dosing and continuous dosing. 
The preferred method of addition is by shock dosing since this ensures that a high concentration of this product is present in the system for several hours. 
When a slime control agent is added by continuous methods over periods of several hours, its concentration in the system at any time is low. This can lead to the development of resistant organisms, an effect that is less likely to occur when the shock dosing method is used.
It is not possible to give precise recommendations as to the quantity of this product to add to control slime formation, since the magnitude of the problem varies greatly from mill to mill, depending on the furnish employed, the cleanliness of the mill system, and the additional nutrients (for example, starch) that may be added to the stock.

The following quantities of this product are suggested for trial:

(a) Shock Dosing. Between 70 and 260 grams (2 ½ -9 oz. av.) of this product for each ton of paper produced per day should be added as a single daily shock dose, the actual quantity used depending on the severity of the slime problem. 
This addition may be made to any part of the stock preparation or backwater system. 
Alternatively, the addition may be made to those parts of the system where it is known that slime deposits accumulate.

(b) Continuous Addition. If this method is adopted, this product should be added continuously for either the single period of 8 hours during every 24 hours or for two separate periods of 4 hours during every 24 hours.
This product should be metered at the rate of 195–230 grams (7 – 8.3 oz. av.) for each ton of paper produced during the dosing period. 
Preferably, this addition should be made to the recirculated backwater.

BACTERIAL CONTROL FOR OIL RECOVERY SYSTEMS: this product is an effective preservative in most aqueous oil recovery products, and the suggested range of concentrations on which trials can be based are:
Drilling fluids, packer fluids, completion fluids: Polysaccharide fluid loss control agents and thickeners such as starch, guar, and xanthan gum– 0.05 – 0.15% on fluid weight or 1.5 – 4.5 on the dry polysaccharide weight.

SUBSURFACE INJECTION WATERS SUCH AS POLYMER AND MICELLAR/POLYMER WATERFLOODS: Thickeners such as xanthan gum and polyacrylamides – 0.015 – 0.15% on solution weight. 

GENERAL RECOMMENDATIONS: The concentration required to give protection depends on several factors. 
These include susceptibility of the system to microbiological degradation, the extent to which microorganism can gain access, the species involved, pH, temperature, and length of time for which protection is required.
For protection against bacterial attack, a concentration within the range of 0.02 - 0.35% of this product is almost invariably sufficient. 
The control of mold growth, particularly on paste products of high solids content, may occasionally demand dosages above 0.25%. 
In dilute fluid systems, spoilage is usually controlled with dosages not greater than 0.09%. 

PROXEL GXL Preservative is a broad spectrum biocide for the preservation of industrial water-based products against spoilage from bacteria, yeasts and fungi. 
It is a 20% aqueous dipropylene glycol solution of 1,2-benzisothiazolin-3-one. 


 

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