SPIRIT OF MINDERERUS

Spirit of Mindererus in aqueous solution, is a chemical compound with the formula NH4CH3CO2.
Spirit of Mindererus is a white, hygroscopic solid and can be derived from the reaction of ammonia and acetic acid.
Spirit of Mindererus is widely used in the chemical analysis, in the pharmaceutical industry, the food sector in preserving foods, and in various other industries too.

CAS Number: 631-61-8
EC Number: 211-162-9
Chemical Formula: C2H7NO2
Molar Mass: 77.083 g·mol−1

Spirit of Mindererus appears as a white crystalline solid.
The primary hazard is the threat to the environment.

Immediate steps should be taken to limit Spirit of Mindererus spread to the environment.
Spirit of Mindererus is used in chemical analysis, in pharmaceuticals, in preserving foods, and for other uses.

Spirit of Mindererus is an ammonium salt obtained by reaction of ammonia with acetic acid.
A deliquescent white crystalline solid, Spirit of Mindererus has a relatively low melting point (114℃) for a salt.

Spirit of Mindererus is used as a food acidity regulator, although no longer approved for this purpose in the EU.
Spirit of Mindererus has a role as a food acidity regulator and a buffer.
Spirit of Mindererus is an acetate salt and an ammonium salt.

Spirit of Mindererus is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.
Spirit of Mindererus is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Spirit of Mindererus is a white crystalline solid formed when ammonia reacts with acetic acid.
Spirit of Mindererus is widely used in the chemical analysis, in the pharmaceutical industry, the food sector in preserving foods, and in various other industries too.
Spirit of Mindererus is also used as a buffer in topical personal care and cosmetic products in manufacturing skin lotions, shampoos, conditioners and more.

Spirit of Mindererus or C2H7NO2 appears in the form of a crystalline white solid with a slight acetous odour.
This ammonium salt is derived from the reaction of ammonia and acetic acid.

The chemical name of this salt is spirit of Mindererus while it is even known as Azanium Acetate on the aqueous form.
The other names of Spirit of Mindererus include ammonium ethanoate and Azanium Acetate.

Spirit of Mindererus is extensively used in the preservation of foods; in pharmaceuticals and the chemical analysis procedure.
Spirit of Mindererus works most effectively when used in the form of a food acidity regulator.

However, Spirit of Mindererus is one of the major threats to the atmosphere or the living environment.
Instant measures need to be taken to restricting the spread of this hazardous sale in the environment.

Spirit of Mindererus is widely utilized as a catalyst in the Knoevenagel condensation.
Spirit of Mindererus is the primary source of ammonia in the Borch reaction in organic synthesis.

Spirit of Mindererus is used with distilled water to make a protein precipitating reagent.
Spirit of Mindererus acts as a buffer for electrospray ionization (ESI) mass spectrometry of proteins and other molecules and as mobile phases for high performance liquid chromatography (HPLC).
Sometimes, Spirit of Mindererus is used as a biodegradable de-icing agent and an acidity regulator in food additives.

Spirit of Mindererus is a salt that has interesting chemical properties and due to this reason, the pharmaceutical industry uses Spirit of Mindererus as an intermediary and raw material in various processes.
Spirit of Mindererus is a salt that forms from the reaction of ammonia and acetic acid.
Also, Spirit of Mindererus is useful for applications that require buffer solutions.

The Henry reactions are the most common reactions that use Spirit of Mindererus.
In an aqueous solution, spirit of Mindererus is a chemical compound that we know by the name Ammonium ethanoate or Azanium acetate, which is a white, hygroscopic solid we can derive from the reaction of ammonia and acetic acid.

Spirit of Mindererus has a variety of applications in molecular biology and chromatography.
Spirit of Mindererus is a useful reagent for the purification and precipitation of DNA and protein.
Spirit of Mindererus can be used in the HPLC and MS analysis of peptides, oligosaccharides, and proteins.

Spirit of Mindererus Uses:
Spirit of Mindererus is used in explosives, foam rubbers, vinyl plastics, and drugs.
Spirit of Mindererus is also used for preserving meats, dyeing and stripping, determining lead and iron, and separating lead sulfate from other sulfates.

There are large scale uses of Spirit of Mindererus.
Spirit of Mindererus is used in the form of a food acidity regulator.

Spirit of Mindererus is the food additive used for changing or controlling the alkalinity or acidity of foods.
Spirit of Mindererus is also widely used in the form of a catalyst in the Knoevenagel condensation procedure.

Spirit of Mindererus serves as one of the best sources of ammonia is the Borch reaction during organic synthesis.
Spirit of Mindererus is used in combination with wholly distilled water for making a kind of protein precipitating reagent.

Spirit of Mindererus even serves in the form of a buffer for ESI or electrospray ionization mass spectrometry of molecules and proteins and the form of a mobile phase for HPLC or high-performance liquid chromatography.
Quite rarely though, Spirit of Mindererus is even used in the form of a biodegradable de-icing agent.

Spirit of Mindererus even works best when used as a diuretic.
Spirit of Mindererus tends to be unstable at low pressure, and this is why Spirit of Mindererus is used for substituting cell buffers with different non-explosive salts in the preparation of mass spectrometry samples.

Other important uses of Spirit of Mindererus include:
Spirit of Mindererus is used in the manufacture of explosives.
Spirit of Mindererus is used for making foam rubber.

Spirit of Mindererus is used for preserving meat.Used for manufacturing vinyl plastics.
Spirit of Mindererus is used in different agricultural products.

In analytical chemistry, Spirit of Mindererus is used in the form of a reagent.
Spirit of Mindererus is used as a reagent in different dialysis procedures for the elimination of contaminants through diffusion.
In agricultural chemistry, Spirit of Mindererus, when used as a reagent, helps in determining soil CEC or cation exchange capacity along with the availability of potassium in the soil.

Spirit of Mindererus is the main precursor to acetamide:
NH4CH3CO2 → CH3C(O)NH2 + H2O

Spirit of Mindererus is also used as a diuretic.

Buffer:
As the salt of a weak acid and a weak base, Spirit of Mindererus is often used with acetic acid to create a buffer solution.
Spirit of Mindererus is volatile at low pressures.
Because of this, Spirit of Mindererus has been used to replace cell buffers that contain non-volatile salts in preparing samples for mass spectrometry.

Spirit of Mindererus is also popular as a buffer for mobile phases for HPLC with ELSD detection for this reason.
Other volatile salts that have been used for this include ammonium formate.

When dissolving Spirit of Mindererus in pure water, the resulting solution typically has a pH of 7, because the equal amounts of acetate and ammonium neutralize each other.
However, Spirit of Mindererus is a dual component buffer system, which buffers around pH 4.75 ± 1 (acetate) and pH 9.25 ± 1 (ammonium), but Spirit of Mindererus has no significant buffer capacity at pH 7, contrary to common misconception.

Other:
Spirit of Mindererus is a biodegradable de-icing agent.
Spirit of Mindererus is a catalyst in the Knoevenagel condensation and as a source of ammonia in the Borch reaction in organic synthesis.

Spirit of Mindererus is a protein precipitating reagent in dialysis to remove contaminants via diffusion.
Spirit of Mindererus is a reagent in agricultural chemistry for determination of soil CEC (cation exchange capacity) and determination of available potassium in soil wherein the ammonium ion acts as a replacement cation for potassium.
Spirit of Mindererus is part of Calley's method for lead artifact conservation

Food additive:
Spirit of Mindererus is also used as a food additive as an acidity regulator; INS number 264.
Spirit of Mindererus is approved for usage in Australia and New Zealand.[10]

Widespread uses by professional workers:
Spirit of Mindererus is used in the following products: pH regulators and water treatment products, laboratory chemicals and fertilisers.
Spirit of Mindererus is used in the following areas: health services, scientific research and development, agriculture, forestry and fishing and building & construction work.
Spirit of Mindererus is used for the manufacture of: food products and textile, leather or fur.

Release to the environment of Spirit of Mindererus can occur from industrial use: formulation of mixtures and formulation in materials.
Other release to the environment of Spirit of Mindererus is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use as processing aid, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

Uses at industrial sites:
Spirit of Mindererus is used in the following products: pH regulators and water treatment products, laboratory chemicals, leather treatment products and textile treatment products and dyes.
Spirit of Mindererus is used in the following areas: health services, scientific research and development and building & construction work.

Spirit of Mindererus is used for the manufacture of: chemicals, textile, leather or fur, food products and fabricated metal products.
Release to the environment of Spirit of Mindererus can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and in the production of articles.

Industry Uses:
Agricultural chemicals (non-pesticidal)
Catalyst
Intermediates
Not Known or Reasonably Ascertainable
Other (specify)
Solids separation (precipitating) agent, not otherwise specified
pH regulating agent

Consumer Uses:
Spirit of Mindererus is used in the following products: perfumes and fragrances and cosmetics and personal care products.
Other release to the environment of Spirit of Mindererus is likely to occur from: indoor use as processing aid.

Other Consumer Uses:
Agricultural chemicals (non-pesticidal)
Other (specify)
Photosensitive chemicals

Spirit of Mindererus Applications:
Spirit of Mindererus is widely utilized as a catalyst in the Knoevenagel condensation.
Spirit of Mindererus is the primary source of ammonia in the Borch reaction in organic synthesis.

Spirit of Mindererus Structural Formula:
As Spirit of Mindererus salt is constituted of a weak acid and a weak base and is often used with acetic acid to create a buffer solution.
Spirit of Mindererus chemical component is volatile at low pressures because Spirit of Mindererus has been used to replace cell buffers with non-volatile salts in preparing the chemical samples.

Spirit of Mindererus Production:
Spirit of Mindererus is produced by the neutralization of acetic acid with ammonium carbonate or by saturating glacial acetic acid with ammonia.
Obtaining crystalline Spirit of Mindererus is difficult on account of Spirit of Mindererus hygroscopic nature.

Two methods can be used for obtaining Spirit of Mindererus, and they are:
Through the saturation of glacial acetic acid or CH3COOH with NH3 or ammonia.
Through the neutralization of acetic acid with (NH4)2CO3 or ammonium carbonate.

These are the two basic methods used for obtaining Spirit of Mindererus, though some new methods have also surfaced in recent years.
Spirit of Mindererus functions in the form of an acetamide precursor.

This results in a reaction that follows like this:
NH4CH3CO2 → CH3C (O) NH2 + H2O

Spirit of Mindererus General Manufacturing Information:

Industry Processing Sectors:
Agriculture, Forestry, Fishing and Hunting
All Other Basic Inorganic Chemical Manufacturing
All Other Chemical Product and Preparation Manufacturing
Pharmaceutical and Medicine Manufacturing

Occurrence of Spirit of Mindererus:
In nature, Spirit of Mindererus is not present in a free compound state.
But, ammonium and acetate ions are present in many biochemical processes.

Spirit of Mindererus Properties:

Physical Properties:
Spirit of Mindererus is a hygroscopic white solid with a slightly acidic odor.
Furthermore, Spirit of Mindererus melting point is 113oC.
Also, Spirit of Mindererus is highly soluble in water and Spirit of Mindererus density in this liquid is 1.17 g/mL-1.

Chemical Properties:
Spirit of Mindererus is a slat of a weak acid (acetic acid) and a weak base (ammonia).
Use this salt with acetic acid to prepare a buffer solution that will regulate Spirit of Mindererus pH.
Nevertheless, Spirit of Mindererus use as a buffering agent is not very extensive because Spirit of Mindererus can be volatile in low pressures.

Spirit of Mindererus History:
The synonym Spirit of Mindererus is named after R. Minderer, a physician from Augsburg.

Spirit of Mindererus Handling and Storage

Precautions for safe handling:
Provide adequate ventilation.
When not in use, keep containers tightly closed.

Advice on general occupational hygiene:
Keep away from food, drink and animal feedingstuffs.

Conditions for safe storage, including any incompatibilities:
Store in a dry place.
Keep container tightly closed.
Hygroscopic solid.

Incompatible substances or mixtures:
Observe hints for combined storage.

Protect against external exposure, such as:
humidity

Consideration of other advice:
Specific designs for storage rooms or vessels

Recommended storage temperature: 15–25 °C

Specific end use(s):
No information available.

Spirit of Mindererus Stability and Reactivity:

Reactivity:
Spirit of Mindererus is not reactive under normal ambient conditions.

Chemical stability:
Moisture-sensitive.
Hygroscopic solid.

Possibility of hazardous reactions:

Violent reaction with:
Strong oxidiser, Hypochlorites, Gold compound.

Conditions to avoid:
Protect from moisture.

Incompatible materials:
There is no additional information.

Spirit of Mindererus First Aid Measures:

INHALATION:
Remove victim to fresh air; rinse nose and mouth with water.
If not breathing, give artificial respiration.
If breathing is difficult, give oxygen.

INGESTION:
Induce vomiting immediately. Give large amounts of water.

EYES:
Flush with water for at least 15 min.

SKIN:
Flush with soap and water.

General notes:
Take off contaminated clothing.

Following inhalation:
Provide fresh air.
In all cases of doubt, or when symptoms persist, seek medical advice.

Following skin contact:
Rinse skin with water/shower.

Following eye contact:
Rinse cautiously with water for several minutes.
In all cases of doubt, or when symptoms persist, seek medical advice.

Following ingestion:
Rinse mouth.
Call a doctor if you feel unwell.

Most important symptoms and effects, both acute and delayed:
Nausea, Vomiting, Spasms, Circulatory collapse.

Indication of any immediate medical attention and special treatment needed:
none.

Spirit of Mindererus Firefighting Measures:

Suitable extinguishing media:
co-ordinate firefighting measures to the fire surroundings water, foam, alcohol resistant foam, dry extinguishing powder, ABC-powder.

Unsuitable extinguishing media:
water jet

Special hazards arising from Spirit of Mindererus or mixture:
None.

Hazardous combustion products:

In case of fire may be liberated:
Nitrogen oxides (NOx), Carbon monoxide (CO), Carbon dioxide (CO₂)

Advice for firefighters:
In case of fire and/or explosion do not breathe fumes.
Fight fire with normal precautions from a reasonable distance.
Wear self-contained breathing apparatus.

Spirit of Mindererus Accidental Release Measures:

Personal precautions, protective equipment and emergency procedures:

For non-emergency personnel:
No special measures are necessary.

Environmental precautions:
Keep away from drains, surface and ground water.

Methods and material for containment and cleaning up:

Advice on how to contain a spill:
Covering of drains.
Take up mechanically.

Advice on how to clean up a spill:
Take up mechanically.

Other information relating to spills and releases:
Place in appropriate containers for disposal.
Ventilate affected area.

Spirit of Mindererus Preventive Measures:
The scientific literature for the use of contact lenses in industry is conflicting.
The benefit or detrimental effects of wearing contact lenses depend not only upon Spirit of Mindererus, but also on factors including the form of Spirit of Mindererus, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses.
However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye.

In those specific cases, contact lenses should not be worn.
In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Spirit of Mindererus Identifiers:
CAS Number: 631-61-8
ChEBI: CHEBI:62947
ChemSpider: 11925
ECHA InfoCard: 100.010.149
EC Number: 211-162-9
PubChem CID: 517165
RTECS number: AF3675000
UNII: RRE756S6Q2
UN number: 3077
CompTox Dashboard (EPA): DTXSID5023873
InChI: InChI=1S/C2H4O2.H3N/c1-2(3)4;/h1H3,(H,3,4);1H3
Key: USFZMSVCRYTOJT-UHFFFAOYSA-N
InChI=1/C2H4O2.H3N/c1-2(3)4;/h1H3,(H,3,4);1H3
Key: USFZMSVCRYTOJT-UHFFFAOYAY
SMILES: O=C([O-])C.[N+H4]

Synonyms: Spirit of Mindererus
Linear Formula: CH3CO2NH4
CAS Number: 631-61-8
Molecular Weight: 77.08
EC Number: 211-162-9

CAS number: 631-61-8
EC number: 211-162-9
Grade: ACS,Reag. Ph Eur
Hill Formula: C₂H₇NO₂
Chemical formula: CH₃COONH₄
Molar Mass: 77.08 g/mol
HS Code: 2915 29 00

Spirit of Mindererus Properties:
Chemical formula: C2H7NO2
Molar mass: 77.083 g·mol−1
Appearance: White solid crystals, deliquescent
Odor: Slightly acetic acid like
Density: 1.17 g/cm3 (20 °C)
1.073 g/cm3 (25 °C)
Melting point: 113 °C (235 °F; 386 K)
Solubility in water: 102 g/100 mL (0 °C)
148 g/100 mL (4 °C)
143 g/100 mL (20 °C)
533 g/100 mL (80 °C)
Solubility: Soluble in alcohol, SO2, acetone, liquid ammonia
Solubility in methanol: 7.89 g/100 mL (15 °C)
131.24 g/100 g (94.2 °C)
Solubility in dimethylformamide: 0.1 g/100 g
Acidity (pKa): 9.9
Basicity (pKb): 33
Magnetic susceptibility (χ): -41.1·10−6 cm3/mol
Viscosity: 21

Density: 1.17 g/cm3 (20 °C)
Melting Point: 114 °C
pH value: 6.7 - 7.3 (50 g/l, H₂O, 25 °C)
Vapor pressure: <0.001 hPa
Bulk density: 410 kg/m3
Solubility: 1480 g/l

Color: Colorless
Density: 1.170 g/cm3 (20 °C)
Form: Solid
Grade: Reagent Grade
Incompatible Materials: Strong oxidizing agents, Strong acids
Melting Point/Range: 113 °C
Purity Percentage: 99.99
Purity Details: ≥99.99%
Solubility in Water: 1.480 g/l (20 °C)
pH-Value: 6.7-7.3 (20 °C)
Storage Temperature: Ambient

Molecular Weight: 77.08 g/mol
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 0
Exact Mass: 77.047678466 g/mol
Monoisotopic Mass: 77.047678466 g/mol
Topological Polar Surface Area: 41.1Å²
Heavy Atom Count: 5
Complexity: 25.5
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Spirit of Mindererus Specifications:
Assay (acidimetric): ≥ 98.0 %
Insoluble matter: ≤ 0.005 %
pH-value (5 %; water, 25 °C): 6.7 - 7.3
Chloride (Cl): ≤ 0.0005 %
Nitrate (NO₃): ≤ 0.001 %
Sulfate (SO₄): ≤ 0.001 %
Heavy metals (as Pb): ≤ 0.0002 %
Ca (Calcium): ≤ 0.001 %
Fe (Iron): ≤ 0.0002 %
Substances reducing potassium permanganate (as formic acid): ≤ 0.005 %
Residue on ignition (as sulfate): ≤ 0.01 %
Water: ≤ 2.0 %

Appearance of Spirit of Mindererus: complying
Identity (IR): complying
Assay: Min. 97.0 %
pH (5 %, 25 °C): 6.7 - 7.3
Sulfated ash: Max. 0.01 %
Water insoluble matter: Max. 0.005 %
Metal trace analysis (ICP): Max. 100 ppm
Iron (Fe): Max. 5 ppm
Heavy metals (as Pb): Max. 5 ppm
Chloride (Cl): Max. 5 ppm
Nitrate (NO3): Max. 0.001 %
Sulfate (SO4): Max. 0.001 %

Spirit of Mindererus Structure:
Crystal structure: Orthorhombic

Spirit of Mindererus Thermochemistry:
Std enthalpy of formation (ΔfH⦵298): −615 kJ/mol

Spirit of Mindererus Related Products:
Diphenyltin Dichloride
Dipotassium Hydrogen Phosphite
1,1'-Diisooctyl Ester 2,2'-[(Dioctylstannylene)bis(thio)]bis-acetic Acid (Technical Grade)
Diphenylsilane-D2
4-ethynyl-α,α-diphenyl-Benzenemethanol

Spirit of Mindererus Names:

Regulatory process names:
Ammonium acetate
Ammonium acetate
ammonium acetate

IUPAC names:
acetic acid ammonium salt
Acetic acid, ammonium salt
Acetic Acid, Ammonium Salt, Ammonium ethanoate
Acetic acid; azane
acetic acid; azane
AMMONIUM ACETATE
Ammonium Acetate
Ammonium acetate
ammonium acetate
Ammonium Acetate
Ammonium acetate
Ammonium ethanoate
azanium acetate
azanium;acetate

Trade names:
AMMONIUM ACETATE
Ammonium Acetate

Other identifiers:
1066-32-6
631-61-8
8013-61-4
856326-79-9
858824-31-4
92206-38-7

Spirit of Mindererus Synonyms:
AMMONIUM ACETATE
631-61-8
Acetic acid, ammonium salt
Azanium Acetate
acetic acid ammonium salt
ammoniumacetate
azanium;acetate
ammonium ethanoate
AcONH4
Ammonium acetate-D3
CH3COONH4
CH3CO2NH4
UNII-RRE756S6Q2
HSDB 556
RRE756S6Q2
NH4OAc
AMMONIUM ACETICUM
EINECS 211-162-9
AI3-26540
INS No. 264
DTXSID5023873
CHEBI:62947
EC 211-162-9
ammonia acetate
MFCD00013066
E264
E 264
E-264
AMMONIUM ACETATE (II)
AMMONIUM ACETATE [II]
AMMONIUM ACETATE (MART.)
AMMONIUM ACETATE [MART.]
amoniumacetate
ammonium-acetate
acetic acid amine
ammonium acetate-
ammonia acetate salt
Ammonium Acetate ACS
AAT (CHRIS Code)
AMMONIUM ACETATE [MI]
Ammonium acetate solution, 5M
C2H4O2.H3N
DTXCID203873
AMMONIUM ACETATE [HSDB]
AMMONIUM ACETATE [INCI]
AMMONIUM ACETICUM [HPUS]
AMMONIUM ACETATE [WHO-DD]
USFZMSVCRYTOJT-UHFFFAOYSA-N
Acetic acid ammonium salt (1:1)
Ammonium acetate, biochemical grade
C2-H4-O2.H3-N
Acetic acid, ammonium salt (1:1)
NA9079
AKOS015904610
FT-0622306
EN300-31599
211-162-9 [EINECS]
631-61-8 [RN]
Acétate d'ammonium [French] [ACD/IUPAC Name]
Acetic acid, ammonium salt [ACD/Index Name]
Ammonium acetate [ACD/IUPAC Name] [Wiki]
ammonium ethanoate
Ammoniumacetat [German] [ACD/IUPAC Name]
MFCD00013066 [MDL number]
NH4OAc [Formula]
211-162-9MFCD00013066
acetic acid amine
acetic acid ammoniate
AcONH4
ammonia acetate
Ammonium acetatemissing
ammoniumacetate
azanium acetate
azanium and acetate
azanium ethanoate
buffers
E 264
E264
E-264
INS No. 264
OmniPur Ammonium Acetate - CAS 631-61-8 - Calbiochem
OmniPur(R) Ammonium Acetate