CAS Number: 112-60-7
Linear Formula: HO(CH2CH2O)3CH2CH2OH
Molecular Weight: 194.23
EC Number: 203-989-9
General description of Tetraethylene glycol:
An oligomer of polyethylene glycol, tetra (ethylene glycol) (TEG) is a transparent, colorless, odorless, low volatility, hygroscopic liquid soluble in ethyl alcohol and very soluble in water.
Applications of Tetraethylene glycol:
Tetraethylene glycol is used for the synthesis of tetraethylene glycol metha acrylate monomer.
Description of Tetraethylene glycol:
Tetraethylene glycol, also known as 2,2’-[oxybis(2,1-ethanediyloxy)]bisethanol or 3,6,9-trioxaundecan-1,11-diol, is classified as a member of the polyethylene glycols.
Tetraethylene glycol is an industrial solvent/chemical with a higher boiling point and lower volatility than the lower ethylene glycols.
Tetraethylene glycol is especially useful in polyester resins and as a plasticizer.
Tetraethylene glycol is also used as a chemical intermediate and as a solvent in the production of inks and dyes.
Tetraethylene glycol is often used as a process solvent in hydrocarbon purification processes and as a coupling agent in the production of textile lubricants and formulations.
Tetraethylene glycol is a non-carcinogenic (not listed by IARC) potentially toxic compound.
Description of Tetraethylene glycol:
Tetraethylene glycol is used as a solvent to dissolve water-insoluble compounds.
Tetraethylene glycol is employed as a nitrocellulose solvent, a plasticizer, a natural gas desiccant, a hydraulic fluid and in lacquers and coatings.
Furthermore, Tetraethylene glycol is used in the synthesis of tetraethylene glycol methacrylate monomer.
Tetraethylene glycol acts as a chemical intermediate and acts as a solvent for the manufacturing of inks and dyes.
In addition, Tetraethylene glycol serves as a coupling agent in the production of textile lubricants and formulations.
Tetraethylene glycol is a polymer consisting of ethylene glycol monomer units and two terminal hydroxyl groups.
The hydroxyl groups can react to further derivatize the compound.
Ethylene glycol compounds have hydrophilic characteristics.
The solubility of the polymer increases as the number of ethylene glycol groups increase.
Solubility of Tetraethylene glycol:
Tetraethylene glycol is miscible with water, ethanol, acetone, acetic acid, glycerin, pyridine, aldehydes, carbon tetrachloride and diethyl ether.
Tetraethylene glycol is immiscible with oil, benzene, toluene, fat and aliphatic hydrocarbons.
Tetraethylene glycol is a transparent, colorless, practically odorless, low-volatility, moderate-viscosity, hygroscopic liquid.
Tetraethylene glycol is completely miscible with water and many organic liquids.
Notes about Tetraethylene glycol:
Tetraethylene glycol is incompatible with strong oxidizing agents and strong bases.
Specifications of Tetraethylene glycol:
Density: 1.125
pH: 8.5
Melting Point: -4°C
Boiling Point: 313°C to 314°C
Flash Point: 193°C (379°F)
Odor: Odorless
Beilstein: 1634320
Refractive Index: 1.459
Solubility Information: Miscible with water,ethanol,acetone,acetic acid,glycerin,pyridine,aldehydes,carbon tetrachloride and diethyl ether. Immiscible with oil,benzene,toluene,fat and aliphatic hydrocarbons.
Formula Weight: 194.23
Percent Purity: 99%
Chemical Name or Material: Tetraethylene glycol
Tetraethylene glycol is employed as a nitrocellulose solvent, a plasticizer, a natural gas desiccant, a hydraulic fluid and in lacquers and coatings.
KEYWORDS:
112-60-7, 203-989-9, Tetraethylene, 2 2'-((Oxybis(ethane- 1-diyl))bis(oxy))diethanol, 3 6 9-Trioxaundecane-1 11-diol, Carbitol diethyl, PEG-4, Bis[2-(2-hydroxyethoxy)ethyl] ether, Tetra(ethylene glycol), NSC 1262
Tetraethylene glycol (TTEG) is a transparent, colorless, practically odorless, low-volatility, moderate-viscosity, hygroscopic liquid.
Tetraethylene glycol (TTEG) is completely miscible with water and many organic liquids.
Tetraethylene glycol (TTEG) has properties similar to diethylene and triethylene glycols and may be used preferentially in applications requiring a higher boiling point, higher molecular weight, or lower hygroscopicity.
The hydroxyl groups on tetraethylene glycol (TTEG) undergo the usual alcohol chemistry, giving a wide variety of possible derivatives.
Hydroxyls can be converted to aldehydes, alkyl halides, amines, azides, carboxylic acids, ethers, mercaptans, nitrate esters, nitriles, nitrite esters, organic esters, peroxides, phosphate esters, and sulfate esters.
Tetraethylene glycol (TTEG) may be used directly as a plasticizer or modified by esterification.
The solubility properties of tetraethylene glycol (TTEG) are important for many applications.
The end uses for tetraethylene glycol (TTEG) are numerous. See the following table.
Applications of Tetraethylene Glycol (TTEG):
-Hygroscopicity
-Dehydration of natural gas
-Moisturizing and plasticizing cork, adhesives
Plasticizer:
-Safety glass
-Separation membranes (silicone rubber, polyvinyl acetate, cellulose triacetate)
-Ceramic materials (resistant refractory plastics, molded ceramics)
BTX:
Separation of aromatic hydrocarbons from non-aromatic hydrocarbons (BTX extraction with tetraethylene glycol)
Low Volatility:
Gas Dehydration
Solvent:
-Resin impregnants and other additives
-Steam-set printing inks
-Aromatic and paraffinic hydrocarbons separations
-Cleaning compounds
-Polyethylene terephthalate production equipment cleaning
-Cyanoacrylate and polyacrylonitrile
Chemical Intermediate:
-Unsaturated Polyester resin
-Various resins of the alkyd type used as laminating agents in adhesives
-Esterificatiion products used in plasticizer intermediates for nitrocellulose lacquers and vinyl resins
-Polyester polyols for polyurethanes
-Thermoplastic polyurethanes
-Silicone compounds
-Emulsifiers
-Lubricants
The binary solubilities of tetraethylene glycol (TTEG) with benzene, toluene or p-xylene, were measured by the turbidity point method.
In TTEG the content of water ranged from 0 to 5% and the test temperature ranged from 20°C to 120°C.
Increasing the temperature resulted in greater solubility of the aromatics in TTEG, while increasing the content of water caused the aromatic solubility to decrease.
The benzene solubillity in TTEG was the greatest followed by toluene and xylene at the same water content and temperature.
The mutual solubility was predicted by correlating the paramaters of a new group for the UNIFAC model for the arorratics extraction system.
Synonym(s): Bis[2-(2-hydroxyethoxy)ethyl] ether, Tetraglycol, Tetra(ethylene glycol)
Linear Formula: HO(CH2CH2O)3CH2CH2OH
CAS Number: 112-60-7
Molecular Weight: 194.23
Beilstein: 1634320
EC Number: 203-989-9
MDL number: MFCD00002879
eCl@ss: 39020714
PubChem Substance ID: 24846965
NACRES: NA.23
Record Information of Tetraethylene glycol:
Version: 2.0
Creation Date: 2014-09-11 05:17:13 UTC
Update Date: 2014-12-24 20:26:57 UTC
Accession Number: T3D4801
Identification of Tetraethylene glycol:
Common Name: Tetraethylene Glycol
Class: Small Molecule
Description: Tetraethylene glycol is an industrial solvent/chemical with a higher boiling point and lower volatility than the lower ethylene glycols. It is especially useful in polyester resins and as a plasticizer. Tetraethylene glycol is also used as a chemical intermediate and as a solvent in the production of inks and dyes. Tetraethylene glycol is often used as a process solvent in hydrocarbon purification processes and as a coupling agent in the production of textile lubricants and formulations.
Compound Type:
-Dye
-Ether
-Household Toxin
-Industrial/Workplace Toxin
-Organic Compound
-Plasticizer
-Solvent
-Synthetic Compound
Synonyms: Not Available
Chemical Formula : C8H18O5
Average Molecular Mass : 194.226 g/mol
Monoisotopic Mass: 194.115 g/mol
CAS Registry Number: 112-60-7
IUPAC Name: 2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethan-1-ol
Traditional Name: tetraethylene glycol
SMILES: OCCOCCOCCOCCO
InChI Identifier: InChI=1S/C8H18O5/c9-1-3-11-5-7-13-8-6-12-4-2-10/h9-10H,1-8H2
InChI Key: InChIKey=UWHCKJMYHZGTIT-UHFFFAOYSA-N
Agent Name:
Tetraethylene glycol
CAS Number:
112-60-7
Formula:
C8-H18-O5
Major Category:
Other Classes
Synonyms:
3,6,9-Trioxaundecane-1,11-diol; Ethanol, 2,2'-(oxybis(2,1-ethanediyloxy))bis-; Ethanol, 2,2'-(oxybis(ethyleneoxy))di-; Hi-Dry; [ChemIDplus]
Category:
Ethylene Glycols
Description of Tetraethylene glycol:
Colorless hygroscopic liquid; [Hawley] Colorless to straw colored hygroscopic liquid; [HSDB]
Sources/Uses of Tetraethylene glycol:
Tetraethylene glycol is used as a solvent (nitrocellulose, coatings, adhesives, inks, lacquers, lubricants, metalworking fluids, and textile finishes); Also used to extract other solvents, to soften paper tissue, and to make other chemicals; [HSDB] Used as a solvent, extractant, plasticizer, humectant (natural gas), and lubricant (textiles); Also used in cement grinding and brake fluid manufacturing; [Reference #1]
Comments:
In rat studies, testicular abnormalities and congenital anomalies have been reported. [REPROTOX] In oral lethal dose studies, rats exhibited heavy breathing, tremors, and sluggishness; [Reference #1] An irritant; [MSDSonline] See "Ethylene glycol."
Physical Description of Tetraethylene glycol:
Tetraethylene glycol is a colorless to straw-colored liquid with a mild odor.
Tetraethylene glycol sinks and mixes with water.
CAS number: 112-60-7
EC number: 203-989-9
Hill Formula: C₈H₁₈O₅
Chemical formula: HO(CH₂CH₂O)₄H
Molar Mass: 194.23 g/mol
HS Code: 2909 49 80
Applications of Tetraethylene glycol:
Application Tetraethylene glycol for synthesis. CAS 112-60-7, EC Number 203-989-9, chemical formula HO(CH₂CH₂O)₄H.
Physicochemical Information of Tetraethylene glycol:
Boiling point: 327 - 328 °C (1013 hPa)
Density: 1.120 g/cm3 (25 °C)
Explosion limit: 0.5 - 3.4 %(V)
Flash point: 204 °C
Ignition temperature: 340 °C DIN 51794
Melting Point: -9.4 °C
pH value: 8.5 - 9.0 (500 g/l, H₂O, 20 °C)
Vapor pressure: <0.1 hPa (26 °C)
Viscosity kinematic: 50.13 mm2/s (20.65 °C)
Solubility: 1000 g/l
Chemical Formula: C8H18O5
Average Molecular Weight: 194.2255
Monoisotopic Molecular Weight: 194.115423686
IUPAC Name: 2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethan-1-ol
Traditional Name: tetraethylene glycol
CAS Registry Number: Not Available
SMILES:
OCCOCCOCCOCCO
InChI Identifier:
InChI=1S/C8H18O5/c9-1-3-11-5-7-13-8-6-12-4-2-10/h9-10H,1-8H2
InChI Key: UWHCKJMYHZGTIT-UHFFFAOYSA-N
Product Number: T0099
Purity / Analysis Method: >95.0%(GC)
Molecular Formula / Molecular Weight: C8H18O5 = 194.23
Physical State (20 deg.C): Liquid
CAS RN: 112-60-7
Reaxys Registry Number: 1634320
PubChem Substance ID: 87576111
SDBS (AIST Spectral DB): 760
MDL Number:
MFCD00002879
Specifications of Tetraethylene glycol:
Grade: Technical
Appearance: liquid
Auto Ignition Temperature: 358 °C (676 °F)
Boiling Point: > 329 °C (> 624 °F)
Color: colorless
Density: 1.126 g/cm3 @ 20 °C (68 °F)
Dynamic Viscosity: 58.3 cps @ 20 °C (68 °F)
Evaporation Rate: 0.01
Flash Point: 202 °C (396 °F)
Freezing Point: -4 °C (25 °F)
Odor: mild
Partition Coefficient: Pow: -2.3
pH: 8 @ 20 - 25 °C (68 - 77 °F)
Recommended Use: Industrial chemical
Relative Density: 1.1247 @ 20 °C (68 °F) Reference Material: (water = 1)
Relative Vapor Density: 6.7 @ 20 - 25 °C (68 - 77 °F)
Solubility in Water: completely soluble
Vapor Pressure: < 0.01 mmHg @ 20 °C (68 °F)
Chemical Taxonomy of Tetraethylene glycol:
Description: Belongs to the class of organic compounds known as polyethylene glycols. These are oligomers or polymers of ethylene oxide, with the general formula (C2H4O)n (with n>=3).
Kingdom: Organic compounds
Super Class: Organic oxygen compounds
Class: Organooxygen compounds
Sub Class: Ethers
Direct Parent: Polyethylene glycols
Alternative Parents:
-Primary alcohols
-Hydrocarbon derivatives
Substituents:
-Polyethylene glycol
-Hydrocarbon derivative
-Primary alcohol
-Alcohol
-Aliphatic acyclic compound
Molecular Framework: Aliphatic acyclic compounds
External Descriptors:
poly(ethylene glycol) (CHEBI:44920 )
Specifications of Tetraethylene glycol:
Colour (visual): colorless
Appearance of substance (visual): clear
Assay (GC, area%): ≥ 98.0 % (a/a)
Density (d 20 °C/ 4 °C): 1.121 - 1.124
Identity (IR): passes test
Water (K. F.): ≤ 0.3 %
Safety Information according to GHS
RTECS: XC2100000
Storage class: 10 - 13 Other liquids and solids
WGK: WGK 2 obviously hazardous to water
Quality Level:
200
vapor density:
6.7 (vs air)
vapor pressure:
<0.01 mmHg
assay:
99%
mol wt:
average Mn 200
refractive index:
n20/D 1.459 (lit.)
bp:
314 °C (lit.)
mp:
−5.6 °C (lit.)
density:
1.125 g/mL at 25 °C (lit.)
Ω-end:
hydroxyl
α-end:
hydroxyl
SMILES string:
OCCOCCOCCOCCO
InChI:
1S/C8H18O5/c9-1-3-11-5-7-13-8-6-12-4-2-10/h9-10H,1-8H2
InChI key:
UWHCKJMYHZGTIT-UHFFFAOYSA-N
Molecular Weight: 194.23
XLogP3-AA: -1.6
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 5
Rotatable Bond Count: 10
Exact Mass: 194.11542367
Monoisotopic Mass: 194.11542367
Topological Polar Surface Area: 68.2 Ų
Heavy Atom Count: 13
Formal Charge: 0
Complexity: 78.6
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
FIRST AID MEASURES of Tetraethylene glycol:
If inhaledIf breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contactWash off with soap and plenty of water.
In case of eye contactFlush eyes with water as a precaution.
If swallowedNever give anything by mouth to an unconscious person. Rinse mouth with water.
Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
Indication of any immediate medical attention and special treatment neededNo data available
FIRE FIGHTING MEASURES of Tetraethylene glycol:
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Further information
No data available
ACCIDENTAL RELEASE MEASURES of Tetraethylene glycol:
Personal precautions, protective equipment and emergency procedures
Avoid breathing vapours, mist or gas. For personal protection see section 8.
Environmental precautions
No special environmental precautions required.
Methods and materials for containment and cleaning up
Keep in suitable, closed containers for disposal.
Reference to other sections
HANDLING AND STORAGE of Tetraethylene glycol:
Precautions for safe handling
For precautions see section 2
Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place.
Store under inert gas.
Storage class (TRGS 510): Combustible liquids
Specific end use(s)
Apart from the uses mentioned in section 1 no other specific uses are stipulated
TETRAETHYLENE GLYCOL
112-60-7
Tetraglycol
2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol
3,6,9-Trioxaundecane-1,11-diol
HI-Dry
Carbitol, diethyl
PEG-4
Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-
Bis[2-(2-hydroxyethoxy)ethyl] ether
Tetra(ethylene glycol)
2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethanol
3,6,9-Trioxaundecan-1,11-diol
NSC 1262
2,2'-[oxybis(ethane-2,1-diyloxy)]diethanol
MFCD00002879
Ethanol, 2,2'-(oxybis(ethyleneoxy))di-
PROTAC Linker 18
2,2'-[oxybis(2,1-ethanediyloxy)]diethanol
Tetraethylene glycol, 99%
2,2'-((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethan-1-ol)
CHEBI:44920
2-(2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy)ethanol
Ethanol, 2,2'-(oxybis(2,1-ethanediyloxy))bis-
127821-00-5
DSSTox_CID_6922
2,2'-[oxybis(2,1-ethanediyloxy)]bisethanol
DSSTox_RID_78255
DSSTox_GSID_26922
125481-05-2
157299-02-0
1,3-Bis(1-isocyanato-1-methylethyl)benzene homopolymer
Tetraethyleneglycol
1,2,3-Propanetriol, polymer with 2,4-diisocyanato-1-methylbenzene, 2-ethyl-2-(hydroxymethyl)-1,3-pro
CAS-112-60-7
HSDB 843
C8H18O5
EINECS 203-989-9
BRN 1634320
AI3-01838
tetraethylenglycol
tetra-ethylene glycol
HO-PEG4-OH
OH-PEG4-OH
EC 203-989-9
SCHEMBL15101
WLN: Q2O2O2O2Q
UNII-R95B8J264J
2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethan-1-ol
CHEMBL1235254
DTXSID9026922
3,9-Trioxaundecane-1,11-diol
NSC1262
R95B8J264J
Tetraethylene Glycol Reagent Grade
NSC-1262
PREDNISOLONETEBUTATE(200MG)
ZINC1591820
Tox21_201629
Tox21_303245
STL268854
2,2'-(Oxybis(ethyleneoxy))diethanol
Ethanol,2'-[oxybis(ethyleneoxy)]di-
AKOS000119933
CS-W019531
HY-W018745
MCULE-9730823286
1,11-Dihydroxy-3,6,9-trioxaundecane
NCGC00164038-01
NCGC00164038-02
NCGC00257035-01
NCGC00259178-01
BP-20324
DS-17878
SY010865
FT-0645137
FT-0689175
FT-0763791
T0099
X4372
Ethanol,2'-[oxybis(2,1-ethanediyloxy)]bis-
W18472
2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-
2-(2-(2-(2-hydroxy-ethoxy)ethoxy)ethoxy)ethanol
J-519899
2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethanol
Q12430182
F8889-3081
2,2'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))diethanol
1,2,3-Propanetriol, polymer with 2,4-diisocyanato-1-methylbenzene, 2-ethyl-2-(hydroxymethyl)-1,3-propanediol, methyloxirane and oxirane
9004-76-6