TETRAMETHYLTHIURAM DISULFIDE

Tetramethylthiuram disulfide is called for short TMTD, is domestic widely used fine chemicals, is mainly used in tree elastomer, viton, reaches in the various latexes and do ultraaccelerator.
Tetramethylthiuram disulfide is an organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid.
Tetramethylthiuram disulfide is used in sulfur vulcanization of rubber as well as in the manufacture of pesticides and drugs.

CAS Number: 137-26-8
EC Number: 205-286-2
Molecular Formula: C6H12N2S4
Molecular Weight: 240.43

Tetramethylthiuram disulfide is a class of organosulfur compounds with the formula (R2NCSS)2.
Many examples are known, but popular ones include R = Me and R = Et.
They are disulfides obtained by oxidation of the dithiocarbamates.

Tetramethylthiuram disulfide is used in sulfur vulcanization of rubber as well as in the manufacture of pesticides and drugs.
They are typically white or pale yellow solids that are soluble in organic solvents.

Tetramethylthiuram disulfide can be used as a single accelerator, as a secondary accelerator or as a sulphur donor in most sulphur-cured elastomers.

Tetramethylthiuram disulfide is used as a fungicide, bacteriostat and pesticide.
Tetramethylthiuram disulfide is also used in the processing of rubber and in the blending of lubricant oils.

Tetramethylthiuram disulfide can be found in products such as seed disinfectants, antiseptic sprays, animal repellents, insecticides, wood preservatives, some soaps, rodent repellents and as a nut, fruit and mushroom disinfectant.
Further research may identify additional product or industrial usages of this chemical.

Tetramethylthiuram disulfide appears as a liquid solution of a white crystalline solid.
Primary hazard is to the environment.

Immediate steps should be taken to limit spread to the environment.
Tetramethylthiuram disulfide is easily penetrates the soil to contaminates groundwater and waterways.

Tetramethylthiuram disulfide is an organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid.
Tetramethylthiuram disulfide is widely used as a fungicidal seed treatment.

Tetramethylthiuram disulfide has a role as an antibacterial drug, an antiseptic drug and an antifungal agrochemical.
Tetramethylthiuram disulfide contains a dimethyldithiocarbamate.
Tetramethylthiuram disulfide is functionally related to a dimethyldithiocarbamic acid.

Tetramethylthiuram disulfide may be used in dermatology as a scabicide.
Tetramethylthiuram disulfide is mainly used as a fungicide for plants and treatment for seeds, however, this use is being investigated for safety in many markets including Canada.

Tetramethylthiuram disulfideis registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.
Tetramethylthiuram disulfideis used in formulation or re-packing, at industrial sites and in manufacturing.

Produce at present both at home and abroad Tetramethylthiuram disulfide mainly adopt Sodium Nitrite-air oxidation process, oxygen-air oxidation process, electrolytic oxidation, ydrogen peroxide 50 one-step oxidation process, etc. technology synthetic, China mainly adopts preceding two kinds of compound methods; But these two kinds of methods exist the production cost height, and technical process is complicated, and technical requirements is high, poor product quality, shortcomings such as contaminate environment.
Invention and created name is " one-step preparation method of thiofide Tetramethylthiuram disulfide ".

Publication number is the preparation method who has announced a kind of thiofide Tetramethylthiuram disulfide in the one Chinese patent application of CN1299814, is in reaction kettle, in alkaline environment by n n dimetylaniline and dithiocarbonic anhydride reaction; To react the clear liquid oxidation.
After the oxidizing reaction, rinsing, oven dry, comminuted solids thing get the Tetramethylthiuram disulfide finished product, though can single stage method prepare TMTD.
But this technology exists and produces a large amount of trade effluents, the weak point of constant product quality property difference.

Tetramethylthiuram disulfide can reduce the growth performance of chickens through decreasing liver index, whereas increasing kidney, cardiac, and spleen index, and induces tibial dyschondrolplasia (TD) by changing the expressions of VEGF, HIF-1α and WNT4.
Tetramethylthiuram disulfide is widely used in rubber processing as an ultra accelerator for low-temperature cures and in agriculture as an important pesticide.

Tetramethylthiuram disulfide is designed for the rubber industry.
Two grades are available: pdr; pdr-d.
All grades are white to off white.

Tetramethylthiuram disulfide offers fast vulcanization and gives an excellent vulcanization plateau with good heat aging and compression set resistance when used in sulfurless vulcanization systems and EV systems.
Tetramethylthiuram disulfide is a valuable secondary accelerator.

In mercaptan modified polychloroprene cured with ETU, Tetramethylthiuram disulfide acts as a scorch retarder without affecting the cure speed.

Tetramethylthiuram disulfide-pdr is recommended for use in soft compounds due to dispersability.
Tetramethylthiuram disulfide is non-staining and non-discoloring.
Excellent colors are obtained in non-black vulcanizates.

Tetramethylthiuram disulfide should be noted that in the application of Tetramethylthiuram disulfide N-nitrosodimethylamine can be formed by the reaction of dimethylamine, a decomposition product, with nitrosating agents (nitrogen oxides).

This standard substance is mainly used for measuring instrument calibration, analytical method evaluation and quality control, as well as the content determination and residue detection of corresponding components in related fields such as food, hygiene, environment and agriculture.
Tetramethylthiuram disulfide can also be used for value traceability or as a standard liquid reserve solution.

Tetramethylthiuram disulfide is diluted step by step and configured into various standard solutions for work.
1. Sample Preparation This standard substance is made of Tetramethylthiuram disulfide double pure product with accurate purity and fixed value as raw material, chromatographic methanol as solvent, and accurately configured by weight-volume method.

2. traceability and fixed value method This standard substance takes the configuration value as the standard value, and uses high performance liquid chromatography-diode array detector (HPLC-DAD) to compare this batch of standard substances and quality control control samples to verify the preparation value.
By using preparation methods, measurement methods and measuring instruments that meet the requirements of metrological characteristics, the traceability of the value of the standard substance is guaranteed.

3. characteristic value and uncertainty (see certificate) number name standard value (ug/mL) relative expansion uncertainty (%)(k = 2)BW10134 The uncertainty of the standard value of the two 1003 in methanol is mainly composed of raw material purity, weighing, constant volume and uniformity, stability and other uncertainty components.

4. uniformity test and stability inspection According to the JJF1343-2012, random sampling of sub-packed samples is carried out, uniformity test of solution concentration is carried out, and stability inspection is carried out.
The results show that the standard material has good uniformity and stability.
The standard substance is valid for 24 months from the date of setting the value.

The development unit will continue to monitor the stability of the standard substance.
If the value changes are found during the validity period, the user will be notified in time.

5. packaging, transportation and storage, use and precautions

1. Packaging:
This standard substance is packed in borosilicate glass ampoules, about 1.2 mL/branch.
When removing or diluting, the pipette quantity shall prevail.

2. Transportation and storage:
Ice bags should be transported, and extrusion and collision should be avoided during transportation; storage under freezing and dark conditions.

3. Use:
Balance at room temperature (20±3 ℃) before unsealing, and shake well.
Once the ampoule is opened, Tetramethylthiuram disulfide should be used immediately and cannot be used as a standard substance after being fused again.

Negatively Affects Plant Cell Walls, Infection Thread Walls, and Symbiosomes in Pea Symbiotic Nodules:
Tetramethylthiuram disulfide (TMTD) is a fungicide widely used in the cultivation of legumes, including the pea (Pisum sativum).
Application of Tetramethylthiuram disulfide can negatively affect nodulation; nevertheless, Tetramethylthiuram disulfide effect on the histological and ultrastructural organization of nodules has not previously been investigated.

In this study, the effect of Tetramethylthiuram disulfide at three concentrations (0.4, 4, and 8 g/kg) on nodule development in three pea genotypes (laboratory lines Sprint-2 and SGE, and cultivar ‘Finale’) was examined.
In SGE, Tetramethylthiuram disulfide at 0.4 g/kg reduced the nodule number and shoot and root fresh weights.

Treatment with Tetramethylthiuram disulfide at 8 g/kg changed the nodule color from pink to green, indicative of nodule senescence.
Light and transmission electron microscopy analyses revealed negative effects of Tetramethylthiuram disulfide on nodule structure in each genotype.

‘Finale’ was the most sensitive cultivar to Tetramethylthiuram disulfide and Sprint-2 was the most tolerant.
The negative effects of Tetramethylthiuram disulfide on nodules included the appearance of a senescence zone, starch accumulation, swelling of cell walls accompanied by a loss of electron density, thickening of the infection thread walls, symbiosome fusion, and bacteroid degradation.
These results demonstrate how Tetramethylthiuram disulfide adversely affects nodules in the pea and will be useful for developing strategies to optimize fungicide use on legume crops.

Applications of Tetramethylthiuram disulfide:
The tetramethyl derivative, known as thiram, is a widely used fungicide.
The tetraethyl derivative, known as disulfiram, is commonly used to treat chronic alcoholism.
Tetramethylthiuram disulfide produces an acute sensitivity to alcohol ingestion by blocking metabolism of acetaldehyde by acetaldehyde dehydrogenase, leading to a higher concentration of the aldehyde in the blood, which in turn produces symptoms of a severe hangover.

Tetramethylthiuram disulfide can be used as a single accelerator, as a secondary accelerator or as a sulphur donor in most sulphur-cured elastomers.
Tetramethylthiuram disulfide is scorchy and gives fast cure rates.

Tetramethylthiuram disulfide is produces an excellent vulcanisation plateau with good heat aging and compression set resistance in sulphurless and EV cure systems.
Good color retention is obtained in non-black vulcanisation.

Tetramethylthiuram disulfide is a valuable secondary accelerator for EPDM.
Tetramethylthiuram disulfide is may be used as a retarder in the vulcanisation of polychloroprene rubber with ETU and also be used as bactericide and pesticide.

Uses of Tetramethylthiuram disulfide:
Tetramethylthiuram disulfide is used as a crop fungicide and seed protectant.
Tetramethylthiuram disulfide is also used as an animal repellent to protect fruit trees and ornamentals.

Tetramethylthiuram disulfide is used as a fungicide applied to foliage.
Tetramethylthiuram disulfide is also used in seed treatment, as a rodent repellent, a vulcanizing agent, and additive to lubricating oil.

Tetramethylthiuram disulfide is fungicide for large brown patch snowmold and dollar spot on fine turfs.
Tetramethylthiuram disulfide is wood preservative, mushroom disinfectant.

Tetramethylthiuram disulfide is primary & secondary accelerator in compounding natural, isobutylene-isoprene, butadiene, styrene-butadiene, synthetic isoprene & nitrile-butadiene rubbers.
Tetramethylthiuram disulfide is a compound that is used as a pesticide.

Tetramethylthiuram disulfide belongs to protective fungicides of broad spectrum, with a residual effect period of up to 7d or so.
Tetramethylthiuram disulfide is mainly used for dealing with seeds and soil and preventing powdery mildew, smut and rice seedlings damping-off of cereal crops.

Tetramethylthiuram disulfide can also be used for some fruit trees and vegetable diseases.
For example, dressing seed with 500g of 50% wettable powder can control rice blast, rice leaf spot, barley and wheat smut.

As pesticides, Tetramethylthiuram disulfide is often referred to as Tetramethylthiuram disulfide and is mainly used for the treatment of seeds and soil and the prevention and controlling of cereal powdery mildew, smut and vegetable diseases.
Tetramethylthiuram disulfide, as the super accelerator of natural rubber, synthetic rubber and latex, is often referred to as accelerator Tetramethylthiuram disulfide and is the representative of thiuram vulcanization accelerator, accounting for 85% of the total amount of similar products.

Accelerator T is also the super accelerator of natural rubber, diene synthetic rubber, Ⅱ, R and EPDM, with the highest utilization rate of all.
The vulcanization promoting force of accelerator T is very strong, but, without the presence of zinc oxide, Tetramethylthiuram disulfide is not vulcanized at all.

Tetramethylthiuram disulfide is used for the manufacture of cables, wires, tires and other rubber products.
Tetramethylthiuram disulfide is used as the super accelerator of natural rubber, synthetic rubber and latex.

Tetramethylthiuram disulfide is used as the late effect promoter of natural rubber, butadiene rubber, styrene-butadiene rubber and polyisoprene rubber.
Tetramethylthiuram disulfide is used for the pest control of rice, wheat, tobacco, sugar beet, grapes and other crops, as well as for the seed dressing and soil treatment.

Tetramethylthiuram disulfide is suitable for the manufacture of natural rubber, synthetic rubber and latex, and can also be used as curing agent.
Tetramethylthiuram disulfide is the second accelerator of thiazole accelerators, which can be used with other accelerators as the continuous vulcanization accelerator.

In rubber industry, Tetramethylthiuram disulfide can be used as the super-vulcanization accelerator, and aften used with thiazole accelerator.
Tetramethylthiuram disulfide can also be used in combination with other accelerators as the continuous rubber accelerator.

For slowly decomposing out of free sulfur at more than 100 ℃, Tetramethylthiuram disulfide can be used as curing agent too.
Tetramethylthiuram disulfide products have excellent resistance to aging and heat, so Tetramethylthiuram disulfide is applicable to natural rubber, synthetic rubber and is mainly used in the manufacture of tires, tubes, shoes, cables and other industrial products.

In agriculture, Tetramethylthiuram disulfide can be used as fungicide and insecticide, and Tetramethylthiuram disulfide can also be used as lubricant additives.
Production methods from dimethylamine, carbon disulfide, ammonia condensation reaction was dimethyl dithiocarbamate, and then by the oxidation of hydrogen peroxide to the finished product.

Agricultural Uses:
Tetramethylthiuram disulfide is used as a fungicide to prevent crop damage in the field and to prevent crops from deterioration in storage or transport.
Tetramethylthiuram disulfide is also used as a seed, nut, fruit, and mushroom disinfectant from a variety of fungal diseases.

In addition, Tetramethylthiuram disulfide is used as an animal repellent to protect fruit trees and ornamentals from damage by rabbits, rodents, and deer.
Tetramethylthiuram disulfide has been used in the treatment of human scabies, as a sun screen, and as a bactericide applied directly to the skin or incorporated into soap.

Tetramethylthiuram disulfide is used as a rubber accelerator and vulcanizer and as a bacteriostat for edible oils and fats.
Tetramethylthiuram disulfide is also used as a rodent repellent, wood preservative, and may be used in the blending of lubricant oils.

Uses at industrial sites:
Tetramethylthiuram disulfideis used for the manufacture of: rubber products.
Release to the environment of Tetramethylthiuram disulfidecan occur from industrial use: as processing aid.

Industry Uses:
Chemical reaction regulator
Hardener
Not Known or Reasonably Ascertainable
Other
Polymerization promoter

Industrial Processes with risk of exposure:
Farming (Pesticides)

Tetramethylthiuram disulfide is called for short TMTD, is domestic widely used fine chemicals, is mainly used in tree elastomer, viton, reaches in the various latexes and do ultraaccelerator.

KEYWORDS:
137-26-8, 205-286-2, 1 1'-dithiobis(N N-dimethylthioformamide), Chipco Thiram 75, Bis((dimethylamino)carbon, NSC-1771, Orac TMTD, Thiotox, Disulfide bis(dimethylthiocarbamoyl), Fermide 850

Manufacturing Methods of Tetramethylthiuram disulfide:
Tetramethylthiuram disulfide is produced by careful oxidation of a N,N-dimethyl dithiocarbamate salt with hydrogen peroxide, chlorine, or air.

First prepared by oxidation of dimethylamine salt of dimethyldithiocarbamic acid with iodine in ethanolic solution.
Tetramethylthiuram disulfide is produced by in USA by passing chlorine gas through solution of sodium dimethyldithiocarbamate.
Tetramethylthiuram disulfide is produced by in Canada from iron oxide, hydrogen peroxide, sodium hydroxide, dimethylamine, and carbon disulfide.

Preparation of sodium fumarate Dimethylamine hydrochloride and carbon disulfide form sodium dimethylaminodithioformate (sodium fumarate) in the presence of sodium hydroxide.
The reaction temperature is 50-55°C and the pH is 8-9.

Preparation of Fomethine Fomethine (or Fomethine) and hydrogen peroxide in the presence of sulfuric acid to form Fomethion, the temperature is controlled below 10 ℃, the end point pH value is 3-4.
Chlorine gas can also be used instead of hydrogen peroxide and sulfuric acid.

The reaction is carried out in a sieve tray tower.
Chlorine gas enters from the bottom of the tower after dilution, and the top of the tower is sprayed with a 5% formaldehyde sodium solution.

This is called the chlorine-air oxidation method.
Sodium nitrite oxidation or electrolytic oxidation can also be used.

General Manufacturing Information of Tetramethylthiuram disulfide:

Industry Processing Sectors:
Rubber Product Manufacturing
Synthetic Rubber Manufacturing

Sampling Procedures of Tetramethylthiuram disulfide:
NIOSH 5005: Air samples containing Tetramethylthiuram disulfide are taken with a polytetrafluoroethylene membrane filter, connected to a sampling pump calibrated between 1 to 3 l/min for total sample size of 10 to 400 l.
This technique has an overall precision of 0.055 for a range of 3 to 12 mg/cu m for a 240 liter sample.
Sample stability: 1 week.

Analytic Laboratory Methods of Tetramethylthiuram disulfide:

Product analysis by hplc or by hydrolysis to dimethylamine, estimated by titration.
Residues determined by conversion to carbon disulfide, estimated by glc or colorimetry of a derivative.

Distillation method is described for Tetramethylthiuram disulfide in pesticide formulations. Sample is digested with acid, distilled under vacuum, and collected on a potassium hydroxide absorber.
Contents of absorber are washed with water, 1-2 drops of phenophthalein are added, neutralized with acetic acid and titrated immediately with 0.1 N iodine using 2% starch solution as indicator.

Tetramethylthiuram disulfide pesticide residues.
Spectrophotometric method: (applicable to corn, apples, tomatoes, strawberries, celery and similar fruits and vegetables).
Samples are extracted with chloroform, 10 mg copper iodide is added to filter extract and left to stand 1 hr with occasional mixing, then filtered and absorbance is read at 440 nm against chloroform as reference.
PPM Thiram= (ug thiram/ml) X ml chloroform used for extraction/g sample.

Method: EPA 630
Procedure: colorimetric
Analyte: thiram
Matrix: industrial and municipal discharges
Detection Limit: not provided.

Clinical Laboratory Methods of Tetramethylthiuram disulfide:
Methods for the isolation and detection of Tetramethylthiuram disulfide from autopsy tissues by thin layer chromatography are described.
Spots were viewed under UV light at 254 nm after spraying with an ethanolic solution of Fast Blue B and sodium hydroxide.
Detection limit using the Fast Blue B chromagen was approximately 0.5 mug with recovery rates of 90-95%.

Preparation, Structure, Reactions of Tetramethylthiuram disulfide:
Thiuram disulfides are prepared by oxidizing the salts of the corresponding dithiocarbamates (e.g. sodium diethyldithiocarbamate).

Typical oxidants employed include chlorine and hydrogen peroxide:
2 R2NCSSNa + Cl2 → (R2NCSS)2 + 2 NaCl

Thiuram disulfides react with Grignard reagents to give esters of dithiocarbamic acid, as in the preparation of methyl dimethyldithiocarbamate:
[Me2NC(S)S]2 + MeMgX → Me2NC(S)SMe + Me2NCS2MgX

Tetramethylthiuram disulfide feature planar dithiocarbamate subunits and are linked by an S−S bond of 2.00 Å.
The C(S)−N bond is short (1.33 Å), indicative of multiple bonding.
The dihedral angle between the two dithiocarbamate subunits approaches 90°.

Thiuram disulfides are weak oxidants.
They can be reduced to dithiocarbamates.

Treatment of a thiuram disulfide with triphenylphosphine, or with cyanide salts, yields the corresponding thiuram sulfide:
(R2NCSS)2 + PPh3 → (R2NCS)2S + SPPh3

Chlorination of thiuram disulfide affords the thiocarbamoyl chloride.

Properties of Tetramethylthiuram disulfide:
Tetramethylthiuram disulfide is color white, light gray powder or granular.
Tetramethylthiuram disulfide is density is 1.29.

Tetramethylthiuram disulfide is soluble in benzene, acetone, chloroform, CS2 partly soluble in alcohol, diethyl ether, CCI4 insoluble in water, gasoline and alkali with lower concentration.
Tetramethylthiuram disulfide is meeting hot water becomes to dimethylamine ammonium and CS2.

Action Mechanism of Tetramethylthiuram disulfide:
Inhibition of hepatic dehydrogenases results in an acetaldehyde reaction on exposure to ethanol.
Other effects may result from the known reactions of dithiocarbamates with metals, sulfhydryl-containing enzymes, or metabolism to reactive metabolites including carbon disulfide.

Ingestion of the fungicide Tetramethylthiuram disulfide (125 mg/kg) has been reported to evoke ovarian atrophy and cessation of egg laying in hens, presumably through inhibition of dopamine beta-hydroxylase.

Tetramethylthiuram disulfide was previously demonstrated that Disulfiram impairs the permeability of inner mitochondrial membrane (IMM).
In this report, the effect of Disulfiram and Tetramethylthiuram disulfide structural analogue Tetramethylthiuram disulfide on mitochondrial functions was studied in detail.

Tetramethylthiuram disulfide was found that mitochondria metabolize Tetramethylthiuram disulfide in a NAD(P)H- and GSH-dependent manner.
At the concentration above characteristic threshold, TDs induced irreversible oxidation of NAD(P)H and glutathione (GSH) pools, collapse of transmembrane potential, and inhibition of oxidative phosphorylation.

The presence of Ca(2+) and exhaustion of mitochondrial glutathione (GSH+GSSG) decreased the threshold concentration of TDs.
TDs induced the mitochondrial permeability transition (MPT).

Handling and Storage of Tetramethylthiuram disulfide:
Tetramethylthiuram disulfide should be stored in the dry and cooling place with good ventilation, avoiding exposure of the packaged product to direct sunlight.
The validity is 2 years.

Advice on safe handling:
Work under hood.
Do not inhale substance/mixture.

Hygiene measures:
Immediately change contaminated clothing.
Apply preventive skin protection.
Wash hands and face after working with substance.

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Tightly closed.
Dry.

Storage class:
Storage class (TRGS 510): 13: Non Combustible Solids

Stability and Reactivity of Tetramethylthiuram disulfide:

Reactivity
The following applies in general to flammable organic substances and mixtures:
In correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Chemical stability:
Tetramethylthiuram disulfide is chemically stable under standard ambient conditions (room temperature).

Possibility of hazardous reactions:

Violent reactions possible with:
Oxidizing agents
Reducing agents
acids

Caution! In contact with nitrites, nitrates, nitrous acid possible liberation of nitrosamines!

First Aid Measures of Tetramethylthiuram disulfide:

General advice:
Show Tetramethylthiuram disulfide safety data sheet to the doctor in attendance.

If inhaled:

After inhalation:
Fresh air.
Immediately call in physician.

If breathing stops:
Immediately apply artificial respiration, if necessary also oxygen.

In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.

In case of eye contact:

After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.

If swallowed:

After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.

Firefighting measures of Tetramethylthiuram disulfide:

Suitable extinguishing media:
Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from Tetramethylthiuram disulfideor mixture:
Carbon oxides
Nitrogen oxides (NOx)
Sulfur oxides
Combustible.

Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters:
Stay in danger area only with self-contained breathing apparatus.
Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system.

Fire Fighting Procedures of Tetramethylthiuram disulfide:

Fire Fighting:
Self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode.

If material involved in fire:
Extinguish fire using agent suitable for type of surrounding fire.(Material itself does not burn or burns with difficulty.)
Use foam, dry chemical, or carbon dioxide.

Use water in flooding quantities as fog.
Apply water from as far a distance as possible.
Keep run-off water out of sewers and water sources.

Accidental release measures of Tetramethylthiuram disulfide:

Personal precautions, protective equipment and emergency procedures:

Advice for non-emergency personnel:
Avoid inhalation of dusts.
Avoid substance contact.

Ensure adequate ventilation.
Evacuate the danger area, observe emergency procedures, consult an expert.

Environmental precautions:
Do not let product enter drains.

Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.

Observe possible material restrictions.
Take up dry.

Dispose of properly.
Clean up affected area.
Avoid generation of dusts.

Spillage Disposal of Tetramethylthiuram disulfide:

Personal protection:
Chemical protection suit including self-contained breathing apparatus.
Do NOT let this chemical enter the environment.

Sweep spilled substance into covered containers.
Carefully collect remainder.
Then store and dispose of according to local regulations.

Cleanup Methods of Tetramethylthiuram disulfide:

If Tetramethylthiuram disulfide is spilled, the following steps should be taken:
1. Ventilate area of spill.

2. For small quantities, sweep onto paper or other suitable material, place in an appropriate container.
Quantities may be reclaimed.

Environmental considerations:

Land spill:
Dig a pit, pond, lagoon, holding area to contain liquid or solid material.
If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner.

Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete.
Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.

Environmental considerations:

Water spill:
Use natural barriers or oil spill control booms to limit spill travel.
Remove trapped material with suction hoses.

Land spill:
Dig a pit, pond, lagoon, holding area to contain liquid or solid material.
Dike surface flow using soil, sand bags, foamed polyurethane,or foamed concrete.

Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.
Apply "universal" gelling agent to immobilize spill.
Apply appropriate foam to diminish vapor and fire hazard.

Identifiers of Tetramethylthiuram disulfide:
Linear Formula: (CH3)2NCSS2CSN(CH3)2
CAS Number: 137-26-8
Molecular Weight: 240.43
Beilstein: 1725821
EC Number: 205-286-2
MDL number: MFCD00008325
PubChem Substance ID: 24900038

Chemical Name: Tetramethyl thiuram disulfide
Molecular Formula: C6H12N2S4
Molecular Weight: 240.43
CAS NO. : 137-26-8

CAS: 137-26-8
Molecular Formula: C6H12N2S4
Molecular Weight (g/mol): 240.416
MDL Number: MFCD00008325
InChI Key: KUAZQDVKQLNFPE-UHFFFAOYSA-N
PubChem CID: 5455
ChEBI: CHEBI:9495
SMILES: CN(C)C(=S)SSC(=S)N(C)C

Product Number: B0486
Purity / Analysis Method: >98.0%(N)
Molecular Formula / Molecular Weight: C6H12N2S4 = 240.42
Physical State (20 deg.C): Solid
CAS RN: 137-26-8
Reaxys Registry Number: 1725821
PubChem Substance ID: 125308534
SDBS (AIST Spectral DB): 4777
Merck Index (14): 9371
MDL Number: MFCD00008325

Properties of Tetramethylthiuram disulfide:
Quality Level: 100
Assay: 97%
autoignition temp.: 316 °F
mp: 156-158 °C (lit.)
SMILES string: CN(C)C(=S)SSC(=S)N(C)C
InChI: 1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3
InChI key: KUAZQDVKQLNFPE-UHFFFAOYSA-N

Melting point: 156-158 °C(lit.)
Boiling point: 129 °C (20 mmHg)
Density: 1.43
vapor pressure: 8 x 10-6 mmHg at 20 °C (NIOSH, 1997)
refractive index: 1.5500 (estimate)
Flash point: 89°C
storage temp.: under inert gas (argon)
solubility: 0.0184g/l
form: solid
pka: 0.87±0.50(Predicted)
Odor: char. odor
Water Solubility: 16.5 mg/L (20 ºC)
Merck: 14,9371
BRN: 1725821
Exposure limits: NIOSH REL: TWA 0.5 mg/m3, IDLH 100 mg/m3; OSHA PEL: 0.5 mg/m3; ACGIH TLV: TWA 5 mg/m3.
InChIKey: KUAZQDVKQLNFPE-UHFFFAOYSA-N
LogP: 1.730
Indirect Additives used in Food Contact Substances: THIRAM
FDA 21 CFR: 175.105
CAS DataBase Reference: 137-26-8(CAS DataBase Reference)
EWG's Food Scores: 5-8
FDA UNII: 0D771IS0FH
ATC code: P03AA05
IARC: 3 (Vol. Sup 7, 53) 1991
NIST Chemistry Reference: Thiram(137-26-8)
EPA Substance Registry System: Thiram (137-26-8)

Molecular Weight: 240.4 g/mol
XLogP3-AA: 1.7
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 3
Exact Mass: 239.98833309 g/mol
Monoisotopic Mass: 239.98833309 g/mol
Topological Polar Surface Area: 121Å²
Heavy Atom Count: 12
Complexity: 158
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Specifications of Tetramethylthiuram disulfide:
Melting Point: >142°C
Color: White
Loss on Drying: 0.5% max.
Infrared Spectrum: Authentic
Assay Percent Range: 97%
Packaging: Glass bottle
Linear Formula: [(CH3)2NCS2]2
Quantity: 5 g
Beilstein: 04, 76
Merck Index: 15, 9525
Formula Weight: 240.41
Percent Purity: ≥96.0%
Physical Form: Powder
Chemical Name or Material: Tetramethylthiuram disulfide, 97%

Related Products of Tetramethylthiuram disulfide:
(2'S)-Nicotine 1-Oxide-d4
rac-Nicotine 1-Oxide-d4
1,7-Dimethyl-1H-imidazo[4,5-g]quinoxalin-2-amine
Disulfoton Sulfone
Disulfoton

Names of Tetramethylthiuram disulfide:

Regulatory process names:
Thiram
Thiram
thiram
thiram (ISO) tetramethylthiuram disulphide
thiram (ISO); tetramethylthiuram disulphide

Translated names:
thiram (cs)
thiram (da)
Thiram (it)
Thiram (nl)
Thiram (no)
thiram (ISO) bis(dimethylthiokarbamoyl)disulfid (cs)
Thiram (ISO) Bis-(dimethyl-thiocarbamoyl)-disulfid (de)
Thiram (Θιράμη) (el)
thiram tetramethylthiuram disulfide (nl)
thiram tetramethylthiuramdisulfid (da)
thiram δις (διμεθυλο-θειοκαρβαμοϋλ)-δισουλφίδιο (el)
Thirame (fr)
Thiuram (de)
Tiraam (et)
Tiraam tetrametüültiuraamdisulfiid (et)
Tiraami (fi)
Tiraami Tetrametyylitiuraamidisulfidi (fi)
Tiram (es)
Tiram (hr)
Tiram (hu)
Tiram (mt)
Tiram (ro)
Tiram (sl)
Tiram (sv)
tiram (bis dimetilcarbamoil) disolfuro disolfuro di tetrametiltiourame (it)
tiram (ISO) disulfura de tetrametiltiuram (ro)
tiram (ISO) tetrametiltiuram-diszulfid (hu)
tiram disulfuro de tetrametiltiuram disulfuro de bis (N,N-dimetiltiocarbamilo) (es)
tiram tetrametyltiuramdisulfid (no)
tiram tetrametyltiuramdisulfid (sv)
Tiramas (lt)
tiramas (ISO) tetrametiltiuramo disulfidas (lt)
Tirame (pt)
tirame dissulfureto de tetrametiltiurama (pt)
Tirams (lv)
tirám (sk)
tirám (ISO) bis(dimetyltiokarbamoyl)disulfán (sk)
tirāms (ISO) tetrametiltiurāma disulfīds (lv)
Tiuram (pl)
tiuram (ISO) disulfid tetrametylotiuramu (pl)
Тирам (bg)
тирам (ISO) тeтраметилтиурам дисулфид (bg)

IUPAC names:
[disulfanediylbis(carbonothioylnitrilo)]tetramethan
[disulfanediylbis(carbonothioylnitrilo)]tetramethane
Bis(dimethylthiocarbamoyl) disulfide
bis(dimethylthiocarbamoyl) disulfide
Bis(dimethylthiocarbamoyl)disulfide
dimethylcarbamothioylsulfanyl N,N-dimethylcarbamodithioate
N,N,N',N'-tetramethyl-Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2)
N,N-diethylcarbamodithioate
N,N-dimethyl[(dimethylcarbamothioyl)disulfanyl]carbothioamide
Tetramethylthiuram Disulfide
tetramethylthiuram disulfide
Tetramethylthiuram disulphide
tetramethylthiuram disulphide
Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetramethyl-
Thioperoxydicarbonic diamide, tetramethyl-
Thiram
thiram
Thiram
thiram (ISO)
UPV

Trade names:
MAT77 B
Thiram P

Other identifiers:
006-005-00-4
1135443-08-1
12680-07-8
12680-62-5
137-26-8
200889-05-0
2930 30 00
2930 30 00
2930.3
39456-80-9
56645-31-9
66173-72-6
92481-09-9
93196-73-7

Synonyms of Tetramethylthiuram disulfide:
1,1'-dithiobis(N,N-dimethylthioformamide)
Chipco Thiram 75
Spotrete
Tetrapom
Bis((dimethylamino)carbon
Fermide 850
SQ 1489
Thimer
Bis(dimethylthiocarbamyl)disulfide
Fernasan
Tersan
Thioknock
Tetramethylthioperoxydicarbonic diamide
Hexathir
Thiosan
Thiotex
Tetramethylthiuram disulfide
Mercuram
Thiurad
Thiramad
Tetramethylthiuram bisulfide
Nomersan
Thiuramyl
Thirasan
AAtack
Polyram-Ultra
Thylate
Thiuramin
Aceto tetd
Pomarsol
Tiuramyl
Tirampa
Arasan
Puralin
TMTD
TMTDS
Tripomol
Aules
Rezifilm
Tulisan
Vancide TM
thiram
Tetramethylthiuram disulfide
137-26-8
Thiuram
Rezifilm
TMTD
Pomarsol
Thirame
Arasan
Fernasan
Nobecutan
Thioscabin
Thirasan
Aapirol
Tersan
Tetrathiuram disulfide
Tetramethylthiuram
Falitiram
Formalsol
Hexathir
Kregasan
Mercuram
Normersan
Sadoplon
Spotrete
Tetrasipton
Thillate
Thiramad
Aatiram
Atiram
Fermide
Fernide
Hermal
Pomasol
Puralin
Thiosan
Thiotox
Thiulin
Thiulix
Heryl
Pomarsol forte
Methyl tuads
Accelerator T
Methyl Thiram
Fernasan A
Tetramethylthiuram disulphide
Nocceler TT
Arasan-M
Bis(dimethylthiocarbamoyl) disulfide
Thiram B
Arasan-SF
Cyuram DS
Ekagom TB
Hermat TMT
Tetramethylenethiuram disulfide
Accel TMT
Accelerator thiuram
Aceto TETD
Radothiram
Royal TMTD
Tetramethyl-thiram disulfid
Fernacol
Sadoplon 75
Tetramethylthiuram bisulfide
Tetrapom
Thioknock
Thirampa
Thiramum
Anles
Arasan-SF-X
Aules
Thimer
Panoram 75
Tetramethylthiouram disulfide
Tetramethylthiurane disulfide
Arasan 70
Arasan 75
Tersan 75
Thiram 75
Thiram 80
Spotrete-F
TMTDS
Arasan 70-S Red
Tetramethylthioperoxydicarbonic diamide
Methylthiuram disulfide
N,N-Tetramethylthiuram disulfide
Metiurac
Micropearls
Nomersan
Thianosan
Cunitex
Delsan
Metiur
Thimar
Teramethylthiuram disulfide
Tersantetramethyldiurane sulfide
Pol-Thiuram
Arasan 42-S
Tetramethylthiurum disulfide
Disulfure de tetramethylthiourame
Tetrathiuram disulphide
Sranan-sf-X
Hy-Vic
SQ 1489
Chipco thiram 75
Bis(dimethyl-thiocarbamoyl)-disulfid
Orac TMTD
Tetramethylthioramdisulfide
Tetramethyldiurane sulphite
Thiotox (fungicide)
Disulfide, bis(dimethylthiocarbamoyl)
Bis((dimethylamino)carbonothioyl) disulfide
Fermide 850
Tetramethyl thiuramdisulfide
Tetramethylthiocarbamoyldisulphide
Thiuramyl
Thylate
Attack
Methyl thiuramdisulfide
Bis(dimethylthiocarbamyl) disulfide
Tetramethyl thiurane disulfide
Bis(dimethyl thiocarbamoyl)disulfide
Thirame [INN-French]
Thiramum [INN-Latin]
Thiuram D
Disolfuro di tetrametiltiourame
Tetramethyl thiurane disulphide
Tetramethylenethiuram disulphide
N,N'-(Dithiodicarbonothioyl)bis(N-methylmethanamine)
RCRA waste number U244
Flo Pro T Seed Protectant
Tetramethylthiuram bisulphide
Tetramethylthiuran disulphide
Tetramethylthiurum disulphide
NSC-1771
Tetramethyl thiuram disulfide
Caswell No. 856
alpha,alpha'-Dithiobis(dimethylthio)formamide
Granuflo
Thiotex
Thiurad
Thiuramin
Tirampa
Tiuramyl
Trametan
Tridipam
Tripomol
Tyradin
Tuads
Tutan
Vulkacit mtic
N,N,N',N'-Tetramethylthiuram disulfide
C6H12N2S4
N,N-Tetramethylthiuram disulphide
Vulkacit thiuram
Thioperoxydicarbonic diamide, tetramethyl-
Thiuram M
Vulkacit TH
Tetramethylthioramdisulfide [Dutch]
Vulcafor TMT
Vulcafor TMTD
Bis((dimethylamino)carbonothioyl) disulphide
FMC 2070
Bis(dimethylthiocarbamoyl) disulphide
Tetramethyl-thiram disulfid [German]
Formamide, 1,1'-dithiobis(N,N-dimethylthio-
Zaprawa Nasienna T
[Me2NC(S)S]2
Vancida tm-95
Disulfuro di tetrametiltiourame
Arasan 42S
Thiram [ISO]
Attack [Antifungal]
TUEX
CCRIS 1282
HSDB 863
Disolfuro di tetrametiltiourame [Italian]
Disulfuro di tetrametiltiourame [Italian]
DTXSID5021332
Disulfure de tetramethylthiourame [French]
ENT 987
NSC1771
Thiram [USAN:INN]
dimethylcarbamothioylsulfanyl N,N-dimethylcarbamodithioate
Bis(dimethyl-thiocarbamoyl)-disulfid [German]
NSC 1771
VUAgT-I-4
EINECS 205-286-2
NSC 49512
NSC 59637
NSC-49512
Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetramethyl-
RCRA waste no. U244
EPA Pesticide Chemical Code 079801
NSC 622696
NSC-622696
[disulfanediylbis(carbonothioylnitrilo)]tetramethane
BRN 1725821
rhenogran
Thiuram M rubber accelerator
UNII-0D771IS0FH
AI3-00987
MLS000069752
MLS002702972
0D771IS0FH
CHEBI:9495
Thiuram disulfide, tetramethyl-
Thiuram-M
Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetramethyl-
NSC49512
CCG-35460
NSC-59637
NSC622696
TNTD
SQ-1489
NCGC00091563-01
SMR000059023
Thioperoxydicarbonic diamide ((H2N)C(S))2S2, tetramethyl-
[dithiobis(carbonothioylnitrilo)]tetramethane
EC 205-286-2
.alpha.,.alpha.'-Dithiobis(dimethylthio)formamide
4-04-00-00242 (Beilstein Handbook Reference)
DTXCID401332
69193-86-8
N,N-dimethyl[(dimethylcarbamothioyl)disulfanyl]carbothioamide
N,N',N'-Tetramethylthiuram disulfide
TMT Disulfide
Thioperoxydicarbonic diamide (((H2N)C(S))2S2), N,N,N',N'-tetramethyl-
CAS-137-26-8
Formamide,1'-dithiobis(N,N-dimethylthio-
Bis[(dimethylamino)carbonothioyl] disulfide
NSC59637
WLN: 1N1 & YUS & SSYUS & N1 & 1
tiramo
Thioperoxydicarbonic diamide [(H2N)C(S)]2S2, tetramethyl-
Basultra
Betoxin
Tiradin
Tiram
Accelerant T
Ziram metabolite
Arasan m
Vulkazam S
Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetramethyl-
Vanguard GF
Vancide TM
Akrochem TMTD
Perkacit TMTD
Vulkacit DTMT
Robac TMT
Rezifilm (TN)
Arasan 50 red
Spotrete WP 75
MFCD00008325
Vancide TM-95
Naftocit thiuram 16
Thiram [BSI:ISO]
Spectrum_001687
Thiram (USAN/INN)
Agrichem flowable thiram
THR (CHRIS Code)
THIRAM [HSDB]
THIRAM [IARC]
THIRAM [INCI]
THIRAM [USAN]
THIRAM [INN]
Spectrum2_001554
Spectrum3_001592
Spectrum4_000860
Spectrum5_001653
THIRAM [WHO-DD]
THIRAM [MI]
THIRAM [MART.]
bmse000928
D02UVS
NCIMech_000272
cid_5455
NCIOpen2_007854
SCHEMBL21144
BSPBio_003184
KBioGR_001499
KBioSS_002167
BIDD:ER0359
DivK1c_000741
SPECTRUM1503322
SPBio_001428
CHEMBL120563
Thiram [USAN:INN:BSI:ISO]
Thiram [USAN:INN:ISO:BSI]
BDBM43362
HMS502F03
KBio1_000741
KBio2_002167
KBio2_004735
KBio2_007303
KBio3_002684
KUAZQDVKQLNFPE-UHFFFAOYSA-
ENT-987
NINDS_000741
HMS1922A12
HMS2093E03
HMS2234B08
HMS3374C05
Pharmakon1600-01503322
Tetramethylthiuram disulfide, 97%
Tox21_111150
Tox21_201569
Tox21_301102
LS-803
NSC758454
s2431
STL264104
(dimethylamino){[(dimethylamino)thioxomethyl]disulfanyl}methane-1-thione
AKOS000120200
bis (dimethyl thiocarbamoyl) disulfide
Bis(dimethylaminothiocarbonyl)disulfide
Disulfide, bis(dimethylthiocarbamoyl)-
Tox21_111150_1
bis(dimethylaminothiocarbonyl) disulfide
DB13245
KS-5354
NSC-758454
Tetramethylthioperoxydicar-bonic diamide
IDI1_000741
QTL1_000082
NCGC00091563-02
NCGC00091563-03
NCGC00091563-04
NCGC00091563-05
NCGC00091563-06
NCGC00091563-07
NCGC00091563-08
NCGC00091563-09
NCGC00091563-10
NCGC00091563-12
NCGC00255002-01
NCGC00259118-01
NCI60_001477
NCI60_006736
SBI-0051813.P002
Thiram, PESTANAL(R), analytical standard
B0486
CS-0012858
FT-0631799
EN300-16677
D06114
D97716
AB00052345_10
Thiram; (Tetramethylthioperoxydicarbonic diamide)
Q416572
SR-01000736911
J-006992
J-524968
SR-01000736911-2
Thiram, certified reference material, TraceCERT(R)
BRD-K29254801-001-06-3
Z56754480
F0001-0468
TETRAMETHYLTHIOPEROXYDICARBONIC ACID [(H2N)C(S)]2S2
N,N-Dimethyl[(dimethylcarbamothioyl)-disulfanyl]carbothioamide
1-(dimethylthiocarbamoyldisulfanyl)-N,N-dimethyl-methanethioamide
N,N-dimethylcarbamodithioic acid (dimethylthiocarbamoylthio) ester
Diamida Tioperoxidicarbonica ([(H2N) C (S)] 2S2), N,N,N',N'-tetrametil-
InChI=1/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3
N(1),N(1),N(3),N(3)-tetramethyl-2-dithioperoxy-1,3-dithiodicarbonic diamide
N,N-dimethylcarbamodithioic acid [[dimethylamino(sulfanylidene)methyl]thio] ester
TETRAMETHYLTHIOPEROXYDICARBONIC DIAMIDE ((((CH(SUB 3))(SUB 2)N)C(S))(SUB 2)S(SUB 2))