Triton X-100 (C14H22O(C2H4O)n) is a nonionic surfactant that has a hydrophilic polyethylene oxide chain (on average it has 9.5 ethylene oxide units) and an aromatic hydrocarbon lipophilic or hydrophobic group.
The hydrocarbon group is a 4-(1,1,3,3-tetramethylbutyl)-phenyl group.
Triton X-100 is closely related to IGEPAL CA-630 or former Nonidet P-40, which might differ from it mainly in having slightly shorter ethylene oxide chains.
Thus Triton X-100 is slightly more hydrophilic than Igepal CA-630; these two detergents may not be considered to be functionally interchangeable for most applications.
Physical properties of Triton X-100:
Undiluted Triton X-100 is a clear viscous fluid (less viscous than undiluted glycerol).
Undiluted Triton X-100 has a viscosity of about 270 centipoise at 25 °C which comes down to about 80 centipoise at 50 °C.
Triton X-100 is soluble at 25 °C in water, toluene, xylene, trichloroethylene, ethylene glycol, ethyl ether, ethyl alcohol, isopropyl alcohol, and ethylene dichloride.
Triton X-100 is insoluble in kerosene, mineral spirits, and naphtha, unless a coupling agent like oleic acid is used.
Uses of Triton X-100:
Triton X-100 is a commonly used detergent in laboratories.
Triton X-100 is widely used to lyse cells to extract protein or organelles, or to permeabilize the membranes of living cells.
Some applications of Triton X-100 include:
-Inactivation of lipid-enveloped viruses (e.g. HIV, HBV, HCV) in manufacturing of biopharmaceuticals
-Industrial purpose (plating of metal)
-Ingredient in influenza vaccines, including Fluarix, Flublok, and Fluzone
-Permeabilizing unfixed (or lightly fixed) eukaryotic cell membranes[6]
-Solubilizing membrane proteins in their native state in conjunction with zwitterionic detergents such as CHAPS
-Part of the lysis buffer (usually in a 5% solution in alkaline lysis buffer) in DNA extraction
-Reducing surface tension of aqueous solutions during immunostaining (usually at a concentration of 0.1-0.5% in TBS or PBS Buffer)
-Dispersion of carbon materials for soft composite materials
-Restricting colony expansion in Aspergillus nidulans in microbiology
-Decellularization of animal-derived tissues
-Removing SDS from SDS-PAGE gels prior to renaturing the proteins within the gel
-Disruption of cell monolayers as a positive control for TEER measurements
-Micellar catalyst
-Reducing surface tension in etching such as undercutting fine features (micron size openings) in MEMS device processing
-Triton X-100 is an ingredient in Photo-Flo, a solution used in photographic processing to prevent minerals from water being deposited of the film after drying.
Apart from laboratory use, Triton X-100 can be found in several types of cleaning compounds, ranging from heavy-duty industrial products to gentle detergents.
Triton X-100 is also a popular ingredient in homemade vinyl record cleaning fluids together with distilled water and isopropyl alcohol.
General description of Triton X-100:
Triton X-100 is a common non-ionic surfactant and emulsifier which is often used in biochemical applications to solubilize proteins.
Triton X-100 is considered a comparatively mild detergent, non-denaturing, and is reported in numerous references as a routinely added reagent.
Triton X-100 is utilized for lysing cells to extract protein and cellular organelles.
Triton X-100 can also permeabilize the living cell membrane for transfection.
Triton X-100 has hemolytic property and is used for DNA extraction.
Biochem/physiol Actions of Triton X-100:
Triton X-100 is widely used non-ionic surfactant for recovery of membrane components under mild non-denaturing conditions.
Applications of Triton X-100:
Triton X-100 is used in the permeabilization of cells for immunofluorescence staining
Triton X-100 is used as a component of lysis buffer in western blot analysis
Triton X-100 is used as a component of Tris-buffered saline for the preparation of cell sections in Immunogold labelling for electron microscope
Triton X-100 is a nonionic surfactant for use in household and industrial cleaners, paints and coatings, and pulp and paper processing.
Uses of Triton X-100:
-Agrochemicals
-Paints and coatings dispersions
-Iodophors
-Emulsion polymerization
-Fiber lubricants
Benefits of Triton X-100:
-Excellent steric and freeze/thaw stabilizer
-Effective pigment and carbon black dispersant
-Excellent for aromatic, chlorinated and other difficult-to-emulsify compounds
-Good solubility in the presence of salts or electrolytes
-Provides lubricity
CAS NUMBER: 9002-93-1
NAMES: X-100; Triton X-100; octylphenol ethylene oxide condensate; Octoxynol-9; toctylphenoxypolyethoxyethanol.
GENERAL INFORMATION of Triton X-100:
X-100 is a nonionic detergent, 100% active ingredient, which is often used in biochemical applications to solubilize proteins.
Triton X-100 has no antimicrobial properties.
Triton X-100 is considered a comparatively mild detergent, non-denaturing, and is reported in numerous references as a routinely added reagent.
Triton X-100 does absorb in the ultraviolet region of the spectrum, however, so can interfere with protein quantitation.
A number of polymeric resins have been used to remove X-100 from solution, including Amberlite hydrophobic XAD resins and Rezorian A161 cartridges.
The "X" series of Triton detergents are produced from octylphenol polymerized with ethylene oxide.
The number ("-100") relates only indirectly to the number of ethylene oxide units in the structure.
X100 has an "average of 9.5" ethylene oxide units per molecule, with an average molecular weight of 625.
In addition, lower and higher mole adducts will be present in lesser amounts, varying slightly within supplier's standard manufacturing conditions.
No antioxidants are added but commercial preparations of Triton X-100 have been found to contain peroxides up to 0.22% hydrogen peroxide (H2O2) equivalents.
These impurities may interfere with biological reactions.
Ataman offers X-100-PC and X-100R-PC as biological grade alternatives.
STRUCTURE:
N = approx. 9.5
Triton X-100tm has a structure very similar to those of Igepal CA-630 [Sigma I3021] and of Nonidet P-40 (no longer commercially available), and the names are sometimes reported as synonyms.
However, Triton X-100 is slightly more hydrophilic than Igepal CA-630; these two detergents are NOT considered to be functionally interchangeable in most applications.
PHYSICAL PROPERTIES of Triton X-100:
Triton X-100 is a very stable material, assumed to be stable for years if stored sealed.
Triton X-100 is a clear to slightly hazy, colorless to light yellow liquid (color by APHA = 100).
1. Specific gravity: 1.065 at 25°C (Approx. 1.07 g/mL)
2. Approximate molecular weight = 625, giving effective molarity = 1.7 M for the neat liquid.
3. UV absorption: lambda max = 275 nm and 283 nm in methanol
4. Viscosity (Brookfield): 240 cps at 25°C
5. pH (5% aqueous solution): 6.0 to 8.0
6. Critical micelle concentration (CMC): 0.22 to 0.24 mM
SOLUBILITY / STABILITY of Triton X-100:
Triton X-100 is soluble in all proportions at 25°C in water, benzene, toluene, xylene, trichloroethylene, ethylene glycol, ethyl ether, ethanol, isopropanol, and ethylene dichloride.
Solutions are stable to autoclaving.
At certain concentrations the solutions may be cloudy but dispersible above the cloud point; they should clear with stirring upon cooling.
However, any ethylene oxide polymer can form trace peroxides on exposure to oxygen.
These impurities may interfere with biological reactions.
SPECIFIC USAGE NOTES:
For lysing cells, typically about 0.1% X-100 solution in water will be sufficient, and even up to 0.5% concentrations will usually not harm most enzymes being isolated.
Many enzymes remain active in the presence of X-100; for example, a commonly used protease, Proteinase K, remains active in 1% (w/w) solutions of X-100.
Triton X-100 is a nonionic surfactant that has been used most often to stabilize proteins in aqueous solution, X-100; 4-(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol; t-Octylphenoxypolyethoxyethanol; Polyethylene glycol tert-octylphenyl ether.
IUPAC name:
2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol
Triton X-100 (TX-100) is a non-ionic surfactant with various uses in the pharmaceutical industry, including for cleaning and as an ingredient in some medicinal products.
Other names:
Polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-phenyl ether
Octyl phenol ethoxylate
Polyoxyethylene octyl phenyl ether
4-Octylphenol polyethoxylate
Mono 30
TX-100
t-Octylphenoxypolyethoxyethanol
Octoxynol-9
Description of Triton X-100:
Detergent, equivalent to Nonidet P-40.
Triton X-100 is used as a non-ionic detergent, emulsifier and dispersing agent.
Triton X-100 is useful for isolation of membrane proteins.
Triton X-100 is also used in electrophoresis.
Triton X-100 is an active ingredient in influenza vaccine (Fluzone).
Triton X-100 finds applications in the dispersion of carbon materials for soft composite materials and restricting colony expansion in Aspergillus nidulans in microbiology.
Further, Triton X-100 is an active ingredient in homemade vinyl record cleaning fluids together with distilled water and isopropyl alcohol.
Solubility:
Triton X-100 is miscible with water.
Notes:
Store Triton X-100 in a cool place.
Triton X-100 is incompatible with strong acids, strong bases and strong oxidizing agents.
Identification of Triton X-100:
Product form : Substance
Substance name : Triton X-100
CAS-No. : 9036-19-5
Product code : LC26280
Formula : (C2H4O)n.C14H22O
Synonyms : 2-methyl-2-propenoic acid, polymer with 2-propenoic acid and N-octy-2-propenamide /
alpha((1,1,3,3-tetramethylbutyl)phenyl)omega-hydroxypoly(oxy-1,2-ethanediyl) / ethoxylated octylphenol /
octylphenoxypoly(ethoxyethanol) / poly(ethylene oxide)octylphenyl ether / Triton X 100
Physicochemical Information of Triton X-100:
Boiling point: >200 °C (1013 hPa)
Density: 1.07 g/cm3 (20 °C)
Flash point: 251 °C
pH value: 5.0 - 8.0 (10 g/l, H₂O, 20 °C)
Vapor pressure: <0.01 hPa (20 °C)
Specifications of Triton X-100:
Identity (IR-spectrum): passes test
pH-value (10 g/l): 6.0 - 8.0
Density (d 20/4): 1.064 - 1.067
Cloud point: 63 - 69 °C
Ethylene oxide (GC): ≤ 30 ppm
Dioxane (GC): ≤ 20 ppm
Sulfated ash (600 °C): ≤ 0.2
Water (according to Karl Fischer): ≤ 0.2
Triton X-100 is a nonionic surfactant that has a hydrophilic polyethylene oxide chain (on average it has 9.5 ethylene oxide units) and an aromatic hydrocarbon lipophilic or hydrophobic group.
KEYWORDS:
2315-67-5, 9002-93-1, Octoxinol, 4-tert-Octylphenol Monoethoxylate, UNII-20CAX7IO75, Poly(oxyethylene)-p-tert-octylphenyl ether, 20CAX7IO75, Polyoxyethylene mono(octylphenyl) ether, Triton, Triton X
Five-branched gold nanostars are obtained using Triton X-100 in a seed-growth synthesis.
They have the uncommon feature of two intense localized surface plasmon resonances (LSPRs) in the 600–900 and 1100–1600 nm ranges.
Both LSPRs convert laser radiation into heat, offering two photothermally active channels in the NIR and SWIR ranges.
Synonym(s):
t-Octylphenoxypolyethoxyethanol, Polyethylene glycol tert-octylphenyl ether
Linear Formula:
t-Oct-C6H4-(OCH2CH2)xOH, x= 9-10
CAS Number:
9036-19-5
Beilstein:
2315025
MDL number:
MFCD00128254
PubChem Substance ID:
329830772
NACRES:
NA.21
Triton X-100 is a non-ionic, mild, non-denaturing detergent, used for solubilizing cell membrane, without denaturing proteins.
Triton X-100 is often used in immunochemistry (immunocytochemistry and immunohistochemistry) analysis to permeabilize cell membrane that helps antibodies to enter and reach internal cell structure.
Triton X-100 is a highly viscous liquid.
Accurately transferring a right volume of Triton X-100 is difficult due to its viscous nature, therefore, a 20% solution of Triton X-100 can be prepared.
REQUIREMENTS:
Reagents and solution
Triton X-100
Deionized water
COMPOSITION:
20% Triton x-100 in water
Nonionic surfactant.
Triton X-100 is used as detergent & wetting agent for hard surface cleaners, metal cleaners, paper production, and textile processing, wetting agent and dispersant for paint & coating systems, emulsifier & process aid for metalworking fluids, agrochemicals, and oilfield applications.
Triton X-100 possesses good wetting agent.
OBJECTIVE:
Preparation of 100 ml of 20% Triton X-100 in water
Application Notes of Triton X-100:
The principal uses of Triton X-100 is in industrial and household detergent applications and in emulsifying agents.
Triton X-100 is employed in almost every type of liquid, paste, and powdered cleaning compound, ranging from heavy-duty industrial products to gentle detergents for fine fabrics.
Triton X-100 is also an important ingredient of primary emulsifier mixtures used in the manufacture of emulsion polymers, stabilizers in latex polymers, and emulsifiers for agricultural emulsion concentrates, and wettable powders.
Quality Level:
200
grade:
laboratory grade
description:
non-ionic
form:
liquid
TRITON X-100 is a nonionic, octylphenol ethoxylate surfactant with excellent detergency used in multiple applications including textiles and agrochemicals.
Triton is specially processed to eliminate quenching and phosphorescence impurities.
Triton X-100 is specifically intended for use in liquid scintillation counting applications.
Specifications of Triton X-100:
Appearance (Clarity): Clear
Appearance (Colour): Colourless to pale yellow
Appearance (Form): Liquid
Miscibility:
1:30 in water is clear
1:30 in ethanol is clear
1:30 in edible oil is clear
Colour (APHA): max. 30
Density (g/ml) @ 20°C: 1.060 - 1.070 g/ml
Refractive Index (20°C): 1.490 - 1.491
Sulphated Ash: max 0.1%
Chloride (CI): max 0.005%
Sulphate (SO4): max 0.005%
Iron (Fe): max 0.0005%
Heavy Metals (Pb): max 0.0005%
Water (KF): max 0.5%
Turbidity Point: 63 - 69°C
DNase, RNase, Protease: Not detected
mol wt:
micellar avg mol wt 80,000
average mol wt 625
aggregation number:
100-155
CMC:
0.2-0.9 mM (20-25°C)
transition temp:
cloud point 65 °C
pour point ~7 °C
solubility:
water: 0.1 mL/mL, clear to slightly hazy, colorless to faintly yellow
Applications of Triton X-100:
Triton X-100 has been used:
• In the permeabilization of cells for immunofluorescence staining
• As a component of lysis buffer in western blot analysis
• As a component of Tris-buffered saline for the preparation of cell sections in Immunogold labelling for electron microscope
Description of Triton X-100:
Triton X-100 is a nonionic surfactant, it can also be used as a detergent and it is considered 100% "active" and biodegradable in liquid form.
Triton X-100 has numerous general uses as a wetting agent, emulsifier or even as a mild detergent.
Triton X-100 is an effective desizing agent and assists oxalic acid in the removal of rust.
Triton X-100 is compatible with certain bleaches.
Safe for cotton, rayon, nylon acetate, polyester and blends.
Test on wool and linens.
Use a 2-3% solution to remove grime from paintings and to clean masonry.
Soluble in water, ethyl & isopropyl alcohol, toluene, xylene and most chlorinated solvents.
Chemical formula: C14H22O(C2H4O)n
Biochem/physiol Actions of Triton X-100:
Triton X-100 is widely used non-ionic surfactant for recovery of membrane components under mild non-denaturing conditions.
General description of Triton X-100:
Triton X-100 has hemolytic property and is used for DNA extraction.
Triton X-100 is a common non-ionic surfactant and emulsifier which is often used in biochemical applications to solubilize proteins.
Triton X-100 is considered a comparatively mild detergent, non-denaturing, and is reported in numerous references as a routinely added reagent.
Triton X-100 is utilized for lysing cells to extract protein and cellular organelles.
Triton X-100 can also permeabilize the living cell membrane for transfection.
HLB:
13.5
SMILES string:
CC(C)(C)CC(C)(C)c1ccc(OCCOCCOCCOCCOCCOCCOCCO)cc1
InChI:
1S/C28H50O8/c1-27(2,3)24-28(4,5)25-6-8-26(9-7-25)36-23-22-35-21-20-34-19-18-33-17-16-32-15-14-31-13-12-30-11-10-29/h6-9,29H,10-24H2,1-5H3
InChI key:
HNLXNOZHXNSSPN-UHFFFAOYSA-N
Product Description of Triton X-100:
Catalogue Number: T886800
Chemical Name: Triton X-100
Synonyms: Polyethyleneglycols Mono[p-(1,1,3,3-tetramethylbutyl)phenyl] Ether; p-(1,1,3,3-Tetramethylbutyl)phenol Monoether with Polyethylene Glycol; (p-t-Octylphenoxy)polyethoxyethanol; Anapoe X 100; Anapoe X 114; Antarox A 200; Coulter Dispersant IA; Criton X 100; Hydrol SW; Iconol OP; Intra-Cell; Koromex II; Lutensol OP 10; NOP 90; Nonidel P 40; OPE 30; Octoxynol 5; Ortho-Gynol; Photo-Flow 200; Poly(oxyethylene) p-tert-Octylphenyl Ether; Polyethylene Gllycol Mono(4-octylphenyl) Ether; Polyethylene Glycol Mono(4-tert-octylphenyl) Ether; Polyoxyethylene Glycol-p-tert-octylphenyl Ether; Polyoxyethylene Mono(octylphenyl) Ether; Preceptin; Surfac OP 30; Surfac OP 5; Surfonic OP 120; TOP 10; TX 100; TX 102; TX 305; TX 35; TX 405; Texofor FP 300; Octoxynol 9;
CAS Number: 9002-93-1
Molecular Formula: C14H22O•(OCH2CH2)n
Appearance: Colourless Oil to Thick Oil
Molecular Weight: N/A
Storage: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly)
Category: Standards; Miscellaneous;
Applications of Triton X-100:
Triton-X 100 is a non-ionic surfactant.
Triton X-100 is used in the enhancement of film porosity in conducting polymers.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
Description of Triton X-100:
Catalogue Number: 108603
Replaces: 8603-30; 8603
Synonyms: Octoxynol, (p-tert-Octylphenoxy)polyethoxyethanol, O-[4-(1,1,3,3-Tetramethylbutyl)phenoxy]polyethoxyethanol, Polyethyleneglycol-[4-(1,1,3,3-tetramethylbutyl)phenyl]-ether
Viscosity of Aqueous Solutions:
For the water-soluble members of the series in the 7-13 polyglycol range, the viscosity of the aqueous solutions increases to a maximum on approaching a concentration of 50 percent from either a lower or higher concentration.
At room temperature in tap or distilled water, gels may be formed in the concentration range of 40- to 70-percent surfactant; the exact concentration range for gel formation varies with the individual nonionic.
Triton X-100 does not form a gel at 50°C in fresh water or at 25°C in 1 molar (approximately 5.8% by weight) sodium chloride (NaCl) solution.
In making up dilute aqueous solutions of the Triton Nonionics, gel formation can usually be prevented by adding the surfactant to warm water with agitation.
If it is necessary to go through the critical gel concentration via the reverse order of addition, the solution should be warmed to decrease the viscosity and the possibility of gelation.
Viscosity at elevated temperature of the higher members is sometimes needed for product transfer.
The Table below shows the viscosity of Triton X-405 (70% solution) at different temperatures.
CAS Number: 9002-93-1
ECHA InfoCard: 100.123.919
PubChem CID: 5590
UNII: 3E2NC94VPF
CompTox Dashboard (EPA): DTXSID8034085
Triton X-100 is a nonionic detergent, 100% active ingredient, which is often used in biochemical applications to solubilize proteins.
Triton X-100 has no antimicrobial properties.
Triton X-100 is a nonionic surfactant which has a hydrophilic polyethylene oxide group (on average it has 9.5 ethylene oxide units) and a hydrocarbon lipophilic or hydrophobic group.
The hydrocarbon group is a 4-(1,1,3,3-tetramethylbutyl)-phenyl group.
The pluronics are triblock copolymers of ethylene oxide and propylene oxide.
The part formed from ethylene oxide is more hydrophilic than the part from propylene oxide.
Triton X-100 is very viscous at room temperature and is thus easiest to use after being gently warmed.
Triton X Series surfactants are versatile nonionic surfactants recognized for their wetting, detergency, superior hard surface, metal cleaning and excellent emulsification performance.
TRITON X Series surfactants are used in almost every type of liquid, paste, and powdered cleaning compound, ranging from heavy-duty industrial products to gentle detergents.
They are important ingredients of primary emulsifier mixtures used in the manufacture of emulsion polymers and stabilizers in latex polymers.
TRITON X Series surfactants are recognized for pigment wetting and stabilization in coatings, and are offered in a range of HLB to match specific wetting and dispersing requirements.
Description of first aid measures of Triton X-100:
First-aid measures general :
Check the vital functions.
Unconscious: maintain adequate airway and respiration.
Respiratory arrest: artificial respiration or oxygen.
Cardiac arrest: perform resuscitation.
Victim conscious with labored breathing: half-seated.
Victim in shock: on his back with legs slightly raised.
Vomiting:
prevent asphyxia/aspiration pneumonia.
Prevent cooling by covering the victim (no warming up).
Keep watching the victim.
Give psychological aid.
Keep the victim calm, avoid physical strain.
Depending on the victim's condition: doctor/hospital.
First-aid measures after inhalation :
Remove the victim into fresh air.
Respiratory problems: consult a doctor/medical service.
First-aid measures after skin contact :
Wash immediately with lots of water.
Soap may be used.
Take victim to a doctor if irritation persists.
First-aid measures after eye contact :
Rinse immediately with plenty of water.
Remove contact lenses, if present and easy to do.
Continue rinsing.
Do not apply neutralizing agents.
Take victim to an ophthalmologist if irritation persists.
First-aid measures after ingestion :
Rinse mouth with water.
Immediately after ingestion: give lots of water to drink.
Give activated charcoal.
Consult a doctor/medical service if you feel unwell.
Ingestion of large quantities: immediately to hospital.
Chemical formula C14H22O(C2H4O)n (n = 9-10)
Molar mass: 647 g mol−1
Appearance : viscous colourless liquid
Density: 1.07 g/cm3
Melting point: 6 °C (43 °F; 279 K)
Boiling point: 270 °C (518 °F; 543 K)
Solubility in water: Soluble
Surface tension:
CMC 0.22 mM
Vapor pressure: < 1 mmHg (130 Pa) at 20 °C
Refractive index (nD): 1.490-1.494
Molecular Weight: 250.38
XLogP3-AA: 4.6
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 6
Exact Mass: 250.193280068
Monoisotopic Mass: 250.193280068
Topological Polar Surface Area: 29.5 Ų
Heavy Atom Count: 18
Formal Charge: 0
Complexity: 232
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count : 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Triton X-100(TX-100) and Triton N(TN) are scarcely adsorbed to the surface of HAP in the absence of SDS.
This is because their affinity for a raw surface of HAP is weak. However, it was found that these nonionic surfactants were adsorbed to the HAP in the presence of SDS.
This fact suggests that the SDS adsorbed on HAP offers the adsorption site for TX-100 and TN, as expected above.
Alternatives for viral inactivation:
Since the inclusion of Triton X-100 in the candidate list of substances of very high concern for authorization, pharmaceutical companies, as well as bioprocessing research groups, are in need of an alternative detergent which must at the same time be eco-friendly and effective.
Ideally, a Triton X-100 replacement should generate minimal manufacturing process change, because only then the necessary updates of regulatory filings for medicines could be realized without additional animal experiments or even clinical studies.
Therefore, an alternative virus-inactivating detergent should have physico-chemical properties similar to Triton X-100, be soluble, easy to remove, and eco-friendly, and not degrade to toxic metabolites.
In a recent study, two alternatives for antiviral treatment in biopharmaceutical manufacturing have been identified: Triton X-100 reduced, as well as a novel compound which was named Nereid (after the mermaids in Greek mythology).
As reflected by the name, Nereid can be seen as just another relative of the Triton X-100 family, however, due to a small molecular difference, it does not degrade into phenolic compounds the way that Triton X-100 does.
The virus inactivation studies comprised experiments with several relevant viruses under various conditions.
It turned out that at room temperature, where most virus inactivation steps in biopharmaceutical manufacturing are conducted, both Triton X-100 reduced and Nereid showed similar virus inactivating performances as Triton X-100.
In contrast, for some processes that are conducted at cold temperatures, Nereid and Triton X-100 gave better results than Triton X-100 reduced.
Triton X-100
2315-67-5
9002-93-1
Octoxinol
Octoxynol-1
Octoxynol-3
Triton X
4-tert-Octylphenol Monoethoxylate
2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol
Ethanol, 2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]-
Octoxynol 1
UNII-20CAX7IO75
Poly(oxyethylene)-p-tert-octylphenyl ether
Polyethylene glycol mono(p-tert-octylphenyl) ether
20CAX7IO75
2-[4-(1,1,3,3-Tetramethylbutyl)phenoxy]ethanol
Polyoxyethylene mono(octylphenyl) ether
Triton,(-)
NCGC00091012-01
4-tert-Octylphenol monoethoxylate solution
Triton X 45
Triton X 305
DSSTox_CID_14085
DSSTox_RID_79110
DSSTox_GSID_34085
2-(4-(1,1,3,3-Tetramethylbutyl)phenoxy)ethanol
Marlophen 820
Neutronyx 605
2-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)ethanol
Ethanol, 2-(4-(1,1,3,3-tetramethylbutyl)phenoxy)-
Hyonic pe-250
Triton X 35
Octoxinolum
Triton X 165
Triton X 405
Triton X 705
Triton X-102
MFCD00132505
Peg 4-isooctylphenyl ether
Peg 4-tert-octylphenyl ether
CAS-9002-93-1
Ethanol, octylphenoxy-
Triton X 102
p-tert-(Octylphenoxypolyethoxy)ethanol
Polyoxyethylene (9) octylphenyl ether
2-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)ethan-1-ol
2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethan-1-ol
Polyoxyethylene (13) octylphenyl ether
Polyethylene glycol 450 octyl phenyl ether
Octoxinol (INN)
NSC 5259
Peg (P-(1,1,3,3-tetramethylbutyl)phenyl) ether
Octyl phenol condensed with l2-l3 moles ethylene oxide
Octoxynol 9 (NF)
Octylphenol Ethoxylate
Triton,(+)
Igepal CA 630
Triton X-405
Polyethylene glycol mono(p-(1,1,3,3-tetramethylbutyl)phenyl) ether
Triton X-100 (TN)
alpha-(4-(1,1,3,3-Tetramethylbutyl)phenyl)-omega-hydroxypoly(oxy-1,2-ethanediyl)
SCHEMBL33822
CHEMBL39763
octylphenoxy polyethoxy ethanol
2-[4-(2,4,4-Trimethyl-2-pentanyl)phenoxy]ethanol
alpha-(P-(1,1,3,3-Tetramethylbutyl)phenoxy)ethanol
CHEBI:9750
DTXSID1058680
DTXSID8034085
BDBM81480
NSC5259
4-iso-Octylphenol-mono-ethoxylate
CHEBI:177811
Bio1_000474
Bio1_000963
Bio1_001452
ETHANOL, 2-(P-(1,1,3,3-TETRAMETHYLBUTYL)PHENOXY)-
CAS_5590
NSC-5259
NSC_5590
ZINC1532311
EINECS 264-520-1
Tox21_111055
Tox21_202544
PDSP1_001087
PDSP2_001071
STL451484
AT25387
MCULE-7119685362
NSC-406472
Polyethylene glycol p-octylphenyl ether
NCGC00260093-01
AS-68067
CAS_118-96-7
4-tert-Octylphenol Monoethoxylate-[13C6]
Ethanol,1,3,3-tetramethylbutyl)phenoxy]-
CS-0449852
FT-0673247
FT-0689215
Polyethylene glycol 4-tert-octylphenyl ether
D05229
J-015013
4-tert-Octylphenol-monoethoxylate-ring-13C6 solution
Q27253450
4-(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol
4-iso-Octylphenol-mono-ethoxylate 10 microg/mL in Acetone
Glycols, mono[p-(1,1,3,3-tetramethylbutyl)phenyl] ether
Polyethylene glycol p-(1,3,3-tetramethylbutyl)phenyl ether
Phenol,1,3,3-tetramethylbutyl)-, monoether with polyethylene glycol
POLYETHYLENE GLYCOL MONO-4-OCTYLPHENYL ETHER (N=APPROX. 10)
Polyethylene glycol mono[p-(1,3,3-tetramethylbutyl)phenyl] ether
4-tert-Octylphenol monoethoxylate solution, 1 mug/mL in acetone, analytical standard
4-tert-Octylphenol monoethoxylate solution, 10 mug/mL in acetone, analytical standard
Poly(oxy-1, .alpha.-[4-(1,1,3,3-tetramethylbutyl)phenyl]-.omega.-hydroxy-
3,9,12,15,18,21,24,27,30-Decaoxatriacontan-1-ol, 30-[p-(1,1,3,3-tetramethylbutyl)phenyl]-
63869-93-2