TURPINAL SL

CAS number: 2809-21-4 

Etidronic acid. 

Turpinal SL provides hair damage control in bleaching/ coloring process. 
Turpinal SL acts as chelating agent. 

Turpinal SL has been developed for the personal care industry in order to answer the need for high purity chemicals with strong chelation properties. 
Turpinal SL uses range from peroxide stabilization to bar soap oxidation prevention.

Description of Turpinal SL:
Turpinal SL etidronic acid high purity cosmetics grade produced and tested to ensure quality and consistency. 
Turpinal SL is ideally suited for personal care and cosmetic applications. 

WHAT IS TURPINAL SL?
Turpinal SL belongs to a group of medicines called bisphosphonates. 
Turpinal SL alters the cycle of bone formation and breakdown in the body.

Turpinal SL is used to treat Paget's disease, and to treat conditions of irregular bone growth due to hip fracture or spinal cord injury.
Turpinal SL may also be used for purposes not listed in this medication guide.

Incorporate Turpinal SL at low levels in bar soap and hair care preparations. 
Turpinal SL is an excellent chelating agent for transition metals such as iron, copper, manganese and zinc. 
Turpinal SL is stable in oxygen bleaching conditions.

Turpinal SL is a personal care products additive. 
Turpinal SL is an excellent complexing agent for transition metals such as iron, copper, manganese and zinc. 
Turpinal SL is produced and tested to meet the consistent high quality requirements encountered. 

Turpinal SL is stable under oxygen bleach conditions. 
Turpinal SL type is preferred for formulations based on neutral pH. 
Turpinal SL is miscible with water in all proportions and has a strong complexing capacity with polyvalent cations.

Recommended uses of Turpinal SL: 
Turpinal SL ideally suited for use in personal care and cosmetic applications. 

Turpinal SL is added to bar soap and hair care preparations at low levels. 
Turpinal SL has a shelf life of at least 1 year in its original sealed packaging at 5-30 oC. 
Turpinal SL is recommended to add Turpinal at concentrations between 0.1-2% with reference to the finished product during production. 

Turpinal SL usage areas:
- Stabilization of peroxide bonds, especially in alkaline environments,
- As a complexing agent in hair cosmetics containing mercaptan groups (such as thioglycolic acid, thiolactic acid)
- Limiting hair damage caused by bleaching and coloring,
- Turpinal SL is used in the stabilization of soap bars, especially under the influence of daylight, where Turpinal is used as an antioxidant and protects it from discoloration and molding (sour, smell).

Chemical Properties of Turpinal SL:
Chemical Composition: Etidronic Acid

Turpinal SL - General Information:
Turpinal SL is a diphosphonate which affects calcium metabolism. 
Turpinal SL inhibits ectopic calcification and slows down bone resorption and bone turnover.

Pharmacology of Turpinal SL:
Turpinal SL is a first generation (non-nitrogenous) bisphosphonate in the same family as clodronate and tiludronate. 
Turpinal SL affects calcium metabolism and inhibits bone resorption and soft tissue calcification. 

Turpinal SL is a high purity etidronic acid solution. 
The TURPINAL series has been developed for the personal care industry in order to answer the need for high purity chemicals with strong chelation properties. 
The microbiological and trace metal content in TURPINAL SL is carefully monitored in order to provide a high purity product that meets the stricter standards of the personal care product industry.

Of the etidronic acid that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. 
The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. 
Turpinal SL has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.

Turpinal SL Interactions:
There have been isolated reports of patients experiencing increases in their prothrombin times when etidronate was added to warfarin therapy. 
The majority of these reports concerned variable elevations in prothrombin times without clinically significant sequelae. 
Although the relevance of these reports and any mechanism of coagulation alterations is unclear, patients on warfarin should have their prothrombin time monitored.

Turpinal SL Contraindications:
Didronel tablets are contraindicated in patients with known hypersensitivity to etidronate disodium or in patients with clinically overt osteomalacia.
Turpinal SL disodium tablets, USP are indicated for the treatment of symptomatic Paget’s disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury. 
Turpinal SL disodium tablets are not approved for the treatment of osteoporosis.

Paget’s Disease:
Turpinal SL disodium tablets are indicated for the treatment of symptomatic Paget’s disease of bone. 

Turpinal SL disodium therapy usually arrests or significantly impedes the disease process as evidenced by:
-Symptomatic relief, including decreased pain and/or increased mobility (experienced by 3 out of 5 patients).
-Reductions in serum alkaline phosphatase and urinary hydroxyproline levels (30% or more in 4 out of 5 patients).
-Histomorphometry showing reduced numbers of osteoclasts and osteoblasts, and more lamellar bone formation.
-Bone scans showing reduced radionuclide uptake at pagetic lesions.

In addition, reductions in pagetically elevated cardiac output and skin temperature have been observed in some patients.
In many patients, the disease process will be suppressed for a period of at least one year following cessation of therapy. 
The upper limit of this period has not been determined.

The effects of the Turpinal SL disodium treatment in patients with asymptomatic Paget’s disease have not been studied. 
However, Turpinal SL disodium treatment of such patients may be warranted if extensive involvement threatens irreversible neurologic damage, major joints, or major weight-bearing bones.

Heterotopic Ossification:
Turpinal SL disodium tablets are indicated in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury.

Turpinal SL disodium tablets reduce the incidence of clinically important heterotopic bone by about two-thirds. 
Among those patients who form heterotopic bone, Turpinal SL disodium tablets retard the progression of immature lesions and reduces the severity by at least half. 
Follow-up data (at least 9 months post-therapy) suggests these benefits persist.

In total hip replacement patients, Turpinal SL disodium tablets do not promote loosening of the prosthesis or impede trochanteric reattachment.
In spinal cord injury patients, Turpinal SL disodium tablets do not inhibit fracture healing or stabilization of the spine.

HOW SHOULD I USE TURPINAL SL?
Use Turpinal SL as directed by your doctor. 
Check the label on the medicine for exact dosing instructions.

Take Turpinal SL with 6 to 8 ounces (180 to 240 mL) of plain water first thing in the morning, at least 30 minutes before eating, drinking, or taking any other medicine. 
Turpinal SL works best if taken 60 minutes before eating, drinking, or taking any other medicine. 

Taking Turpinal SL with orange juice, coffee, or mineral water may decrease its effectiveness.
Do not break, crush, suck, or chew the tablet before swallowing.

Do not lie down for at least 30 minutes after taking Turpinal SL and until after you have had your first meal or snack of the day.
Do not take Turpinal SL at bedtime or before getting out of bed.

Calcium or iron supplements, vitamins, or antacids containing calcium, magnesium, or aluminum may interfere with the absorption of Turpinal SL. 
These medicines must be taken at least 2 hours after taking Turpinal SL.

If you miss a dose of Turpinal SL, skip the missed dose and go back to your regular dosing schedule. 
Do not take 2 doses at once.

Additional information about Turpinal SL:
Turpinal SL Indication: 
For the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury.

Mechanism Of Action: 
Bisphosphonates, when attached to bone tissue, are absorbed by osteoclasts, the bone cells that breaks down bone tissue. 
Although the mechanism of action of non-nitrogenous bisphosphonates has not been fully elucidated, available data suggest that they bind strongly to hydroxyapatite crystals in the bone matrix, preferentially at the sites of increased bone turnover and inhibit the formation and dissolution of the crystals. 

Other actions may include direct inhibition of mature osteoclast function, promotion of osteoclast apoptosis, and interference with osteoblast-mediated osteoclast activation. 
Turpinal SL does not interfere with bone mineralization. 
In malignancy-related hypercalcemia, etidronic acid decreases serum calcium by inhibiting tumour-induced bone resorption and reducing calcium flow from the resorbing bone into the blood. 

Turpinal SL also reduces morbidity of osteolytic bone metastases by inhibiting tumour-induced bone resorption. 
Turpinal SL may promote osteoclast apoptosis by competing with adenosine triphosphate (ATP) in the cellular energy metabolism. 
The osteoclast initiates apoptosis and dies, leading to an overall decrease in the breakdown of bone.

Turpinal SL has been developed for the personal care industry in order to answer the need for high purity chemicals with strong chelation properties. 

KEYWORDS:
2809-21-4, Etidronic acid, Acetodiphosphonic acid, EHDP, Etidronate Disodium, Etidronsaeure, HEDP, Hydroxyethanediphosphonic acid, Oxyethylidenediphosphonic acid, Etidronate

Drug Interactions: 
-Aluminium Formation of non-absorbable complexes
-Bismuth Formation of non-absorbable complexes
-Calcium Formation of non-absorbable complexes
-Iron Formation of non-absorbable complexes
-Magnesium oxide Formation of non-absorbable complexes
-Magnesium Formation of non-absorbable complexes
-Sucralfate Formation of non-absorbable complexes

Food Interactions: 
Take on an empty stomach.
Avoid aluminium, calcium, iron and magnesium.

Generic Name: 
Etidronic acid

Synonyms: 
Acetodiphosphonic acid
Acide etidronique [INN-French]
Acido etidronico [INN-Spanish]
Acidum etidronicum [INN-Latin]
EHDP
Etidronate Disodium
Etidronsaeure
HEDP
Hydroxyethanediphosphonic acid
Oxyethylidenediphosphonic acid
Etidronate

Drug Category: 
Antihypocalcemic Agents
Antineoplastic Agents
Bisphosphonates
Osteoporosis Prophylactic

Drug Type: 
Small Molecule
Approved

Turpinal products are high purity grades of etidronic acid and sodium etidronate which are suitable for use in cosmetics and Personal Care or any applications requiring a very low metal content. 
The high purity of these products is guaranteed by thorough quality control procedures (including testing for microbiological contamination). 
Moreover, the certificate of analysis accompanying each batch contains detailed information covering chemical purity and trace metal content. 

Their chelating properties make them outstanding candidates for the chelation of metal ions, in particular the transition metals (Fe, Cu, Mn, Zn) and the water hardness ions (Ca, Mg). 
Thanks to the chelating properties and threshold effect, and added to its chemical stability in oxidizing environment, Turpinal can bring substantial benefits in many application fields and more specifically in the cosmetics industry. 

These products are ideal chelants or additives in the following applications: 
-In the stabilization of peroxide bonds, in alkaline media specifically 
-As a chelant in hair cosmetics containing mercaptan groups, i.e. thioglycolic acid, thiolactic acid 
-As a means of limiting hair damage caused by bleaching or colouring 
-In the stabilization of bar soaps, where Turpinal® is used as antioxidant and prevents discolouration and rancidity, in particular under the influence of day light 
-In the stabilization of fragrances, which would otherwise lose their strength over time during storage of cosmetic formulations. 

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