CAS Number: 9005-64-5
EC Number: 500-018-3
Molecular Formula: C26H50O10
Molecular weight: 522.7
Tween 20 is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid.
Tween 20's stability and relative nontoxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.
As the name implies the ethoxylation process leaves the molecule with 20 repeat units of polyethylene glycol; in practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species.
Tween 20 is used as a wetting agent in flavored mouth drops, helping to provide a spreading feeling to other ingredients like SD alcohol and mint flavor.
Tween 20 is also used as wetting agent in rubber balers in the elastomer industry.
Tween 20 has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies
Tween 20 is a polyoxyethylene sorbitol ester that belongs to the polysorbate family.
Tween 20 is a nonionic detergent having a molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, 1 sorbitol, and 1 lauric acid as the primary fatty acid.
Tween 20 is a nonionic detergent widely used in biochemical applications.
Tween 20 has been used as an emulsifying agent for the preparation of stable oil-in-water emulsions.
Tween 20 has been used in pre-extraction of membranes to remove peripheral proteins (used at 2% for extraction of membrane-bound proteins).
Tween 20 has been used as a blocking agent for membrane based immunoassays at a typical concentration of 0.05%.
Tween 20 can be used for lysing mammalian cells at a concentration of 0.005 to 0.5%.
Tween 20 lubricates the skin and has a soothing effect.
Tween 20 is used in oil-in-water emulsions (lotions, conditioners, cream rinses, shampoos, liquid soaps, body polishes or scrubs, etc.).
Tween 20 is widely used for body mist and linen sprays.
TWEEN 20 has been used as a blocking agent for membrane based immunoassays at a typical concentration of 0.05%.
TWEEN 20 is suitable for use as a solubilizing agent of membrane proteins and as a blocking agent in Western blotting.
TWEEN 20 can be used for lysing mammalian cells at a concentration of 0.05 to 0.5%.
Precautions and Disclaimer:
For Laboratory Use Only.
Not for drug, household or other uses.
Preparation Instructions
TWEEN 20 is miscible in water (100 mg/ml), yielding a clear, yellow solution.
TWEEN 20 is also miscible with alcohol, dioxane, and ethyl acetate; and is practically insoluble in liquid paraffin and fixed oils.
Storage/Stability of TWEEN 20:
Aqueous solutions of polysorbates undergo autoxidation during storage, with changes being catalyzed by light, increased temperature, and copper sulfate.
Autoclaving is not recommended without testing for changes in properties.
TWEEN 20 may not be stable to autoclaving, particularly with metal cations in buffer solutions.
TWEEN 20 is heat sensitive and will darken when exposed to elevated temperatures.
Polysorbates have been reported to be incompatible with alkalis, heavy metal salts, phenols, and tannic acid.
Polysorbates may reduce the activity of many preservatives.
Tween 20 is found as an ingredient in most body care products, cosmetics, and wet wipes.
Tween 20 is often used in combination with other emulsifiers such as mono- and diglycerides or sorbitan monostearates for a variety of purposes, such as dispersing flavors and colors, solubilizing essential oils and vitamins, and improving volume and texture in baked goods.
Tween 20 is a highly hydrophilic surfactant
Tween 20 is approved as food additives.
Tween 20 is a useful emulsifier, dispersant and solvent for aroma chemicals and oils.
Tween 20 is a nonionic solubilizing agent used in the textile industry.
Tween 20 is a polysorbate type nonionic surfactant formed by ethoxylation of sorbitan prior to the addition of lauric acid.
Tween 20 is used as a detergent and emulsifier in pharmacological practice.
Biotechnical Applications of Tween 20:
In biological techniques and sciences, Tween 20 has a broad range of applications.
For example, Tween 20 is used as a washing agent in immunoassays.
Tween 20 helps to prevent non-specific antibody binding.
In this major application, Tween 20 is dissolved in Tris-buffered saline or phosphate buffered saline at dilutions of 0.05% to 0.5% v/v.
These buffers are used for washes between each immunoreaction, to remove unbound immunologicals, and eventually for incubating solutions of immunoreagents (labeled antibodies) to reduce nonspecific background.
Tween 20 is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.
Industrial and Domestic Applications of Tween 20:
Tween 20 is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.
Tween 20 is also used as wetting agent in rubber balers in the elastomer industry.
Tween 20 has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies
Tween 20 is a polyoxyethylene sorbitol ester that belongs to the polysorbate family.
Tween 20 is a nonionic detergent having a molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, 1 sorbitol, and 1 lauric acid as the primary fatty acid.
Tween 20 is responsible for the hydrophilic nature of the surfactant, while the hydrocarbon chains provide the hydrophobic environment.
Tween 20 is a nonionic detergent widely used in biochemical applications.
Tween 20 has been used as an emulsifying agent for the preparation of stable oil-in-water emulsions.
Tween 20 has been used in pre-extraction of membranes to remove peripheral proteins (used at 2% for extraction of membrane-bound proteins).
Tween 20 has been used as a blocking agent for membrane based immunoassays at a typical concentration of 0.05%.
Tween 20 can be used for lysing mammalian cells at a concentration of 0.005 to 0.5%.
Tween 20 has been used as a component of:
-washing buffer and blocking buffer in Western blotting
-blocking buffer in immunohistochemistry
-washing buffer in ELISA (enzyme linked immunosorbent assay)
-reaction mixture in PCR (polymerase chain reaction)
Tween 20 is derived from coconut oil.
Tween 20 is non-toxic.
APPLICATIONS OF TWEEN 20:
-detergent production
-Emulsifiers
-mouth droppers
-Biotechnological Techniques
-immunoassays
-biochemistry laboratories
-suspension stabilizers
-Pharmacological Applications
-Elastomer Industry
-Peripheral Protein Synthesis
-Immunological Tests
-Surfactants
-Deodorizing Products
-Shampoo production
-Liquid soap manufacture
-body lotions
-Wet Wipes production
-cosmetics industry
-Skin care products
-textile industry
Tween 20 is a nonionic detergent having a molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, 1 sorbitol, and 1 lauric acid as the primary fatty acid.
KEYWORDS:
9005-64-5, 500-018-3, Tween, POLYOXYETHYLENE SORBITAN MONOLAURATE, Polyoxyethylene (20) sorbitan monolaurate, Polyoxyethylenesorbitan monolaurate, 2-[2-[34-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl, dodecanoate, Polysorbate (INN), Sorbimacrogol laurate 300
Tween 20 is a nonionic surfactant
Tween 20 is used as an emulsifier and a dispersing agent that allows oil and water to mix without the use of alcohol.
Tween 20 is a water-soluble yellowish liquid.
Tween 20 is an odor remover and stabilizer.
Tween 20 lubricates the skin and has a soothing effect.
Tween 20 is used in oil-in-water emulsions (lotions, conditioners, cream rinses, shampoos, liquid soaps, body polishes or scrubs, etc.).
In addition, Tween 20 is widely used for body mist and linen sprays.
Tween 20 is found as an ingredient in most body care products, cosmetics, and wet wipes.
PHYSICAL PROPERTIES OF TWEEN 20:
Molecular Weight: 522.7
XLogP3-AA: 2.5
Exact Mass: 522.34039779
Monoisotopic Mass: 522.34039779
Topological Polar Surface Area: 133 Ų
Physical Description: It is a lemon to amber-coloured oily liquid
Color: Lemon- to amber-colored
Form: liquid
Odor: Characteristic odor
Taste: Bitter
Melting Point: 110 °C
Solubility: Soluble in water, ethanol, methanol, ethyl acetate and dioxane. Insoluble in mineral oil and petroleum ether
Density: 1.095 g/mL
Tween 20 is a nonionic surfactant
Tween 20 is used as an emulsifier and a dispersing agent that allows oil and water to mix without the use of alcohol.
Tween 20 is a water-soluble yellowish liquid.
Tween 20 is an odor remover and stabilizer.
Tween 20 is derived from coconut oil.
Tween 20 is non-toxic.
Tween 20 is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.
Tween 20 is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid.
Tween 20's stability and relative nontoxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.
Tween 20 is often used in combination with other emulsifiers such as mono- and diglycerides or sorbitan monostearates for a variety of purposes, such as dispersing flavors and colors, solubilizing essential oils and vitamins, and improving volume and texture in baked goods.
Tween 20 is a highly hydrophilic surfactant
Tween 20 is approved as food additives.
Tween 20 is a useful emulsifier, dispersant and solvent for aroma chemicals and oils.
Tween 20 is a nonionic solubilizing agent used in the textile industry.
Tween 20 is a polysorbate type nonionic surfactant formed by ethoxylation of sorbitan prior to the addition of lauric acid.
Tween 20 is used as a detergent and emulsifier in pharmacological practice.
CHEMICAL PROPERTIES OF TWEEN 20:
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 10
Rotatable Bond Count: 26
Heavy Atom Count: 36
Complexity: 507
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 4
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
SYNONYMS:
Tween 20
9005-64-5
POLYOXYETHYLENE SORBITAN MONOLAURATE
Polyoxyethylene (20) sorbitan monolaurate
Polyoxyethylenesorbitan monolaurate
2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
Polysorbate (INN)
9005-66-7
Sorbimacrogol laurate 300
2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate
2-(2-(3,4-Bis(2-hydroxyethoxy)tetrahydrofuran-2-yl)-2-(2-hydroxyethoxy)ethoxy)ethyl dodecanoate
2-[2-[3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
Alkest TW 20
Polyoxyethylene Sorbitan Monolaurate Kosher
FT-0645136
Polyoxyethylene Sorbitan Monolaurate 20 NF
D05565
D05566
D05567
3,6-Anhydro-1-O-[2-(dodecanoyloxy)ethyl]-2,4,5-tris-O-(2-hydroxyethyl)hexitol
Polysorbate 20 (NF)
Polysorbate 40 (NF)
Polysorbate 60 (NF)
Tween(R) 20
tween (R) 20
Tween 20 (TN)
Tween 40 (TN)
Tween 60 (TN)
SCHEMBL118527
POE (6) sorbitol monolaurate
POE(20) sorbitan monolaurate
CHEMBL371631
Ethoxylated Sorbitan monolaurate
POE (20) sorbitan monolaurate
DTXSID60922815
MFCD00165986
E432