VITAMIN B3 (NIACINAMIDE)

CAS NUMBER: 98-92-0
EC NUMBER: 202-713-4
MOLECULAR WEIGHT: 122.12
MOLECULAR FORMULA: C6H6N2O

Vitamin B3 (Niacinamide), also known as nicotinic acid, is one of the types of acid that is beneficial for the skin.
Vitamin B3 (Niacinamide), which we have been hearing about recently, is actually a form of vitamin. 

Vitamin B3 (Niacinamide) is frequently used in skin care applications with Vitamin B3 (Niacinamide)s anti-acne, anti-blemish and remover, skin lightening and moisturizing effects.
Vitamin B3 (Niacinamide) is available as a dietary supplement. 
Vitamin B3 (Niacinamide) is generally considered safe with few side effects at appropriate doses. 

Vitamin B3 (Niacinamide) is also a very common ingredient in the personal care and cosmetics industry. 
As always, Vitamin B3 (Niacinamide)'s best to consult a doctor before taking any supplements.
Vitamin B3 (Niacinamide) is actually the name given to the niacin and Vitamin B3 (Niacinamide) forms of vitamin B3. 
Vitamin B3 (Niacinamide), a water-soluble form of B vitamin, is also known as nicotinic acid in skin care ingredients.

BENEFITS OF Vitamin B3 (Niacinamide):
The molecular structure of Vitamin B3 (Niacinamide) has the feature of solving many skin problems, especially hyperpigmentation. 
We can list the benefits of Vitamin B3 (Niacinamide) as follows:
Vitamin B3 (Niacinamide) plays an important role in keeping your skin healthy. 
For this reason, Vitamin B3 (Niacinamide) is a popular additive in the cosmetics and skincare industry.

Vitamin B3 (Niacinamide) and Nicotinic acid also provide vitamin B3 activity. 
But they differ in their chemical makeup and how they affect your health.
In this article, we will talk about what Vitamin B3 (Niacinamide) is, one of the most frequently used products in the cosmetic industry, Vitamin B3 (Niacinamide)s benefits, uses and possible side effects.

Vitamin B3 (Niacinamide) is a form of vitamin B3 (Niacin), one of the eight B vitamins your body needs for good health. 
Vitamin B3 (Niacinamide) plays a vital role in converting the food you eat into usable energy. 
Vitamin B3 (Niacinamide) helps body cells perform important chemical reactions.

Since Vitamin B3 (Niacinamide) is water soluble, your body does not store Vitamin B3 (Niacinamide), so foods containing Nicotinic acid or Vitamin B3 (Niacinamide) are consumed daily.
Vitamin B3 (Niacinamide) is often found as Vitamin B3 (Niacinamide) in animal-based products such as meat and poultry, and as Nicotinic acid in plant-based foods such as nuts and green vegetables.
Vitamin B3 (Niacinamide) is a form of vitamin B3 (Niacin) that plays an important role in energy metabolism and cell health. 

Vitamin B3 (Niacinamide) has tremendous effects that bring out the natural beauty of the skin.
Vitamin B3 (Niacinamide) is the name given to the niacin and Vitamin B3 (Niacinamide) forms of vitamin B3. 

Vitamin B3 (Niacinamide) is an important compound functioning as a component of the coenzyme NAD. 
Vitamin B3 (Niacinamide)s primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. 
Most animals cannot manufacture Vitamin B3 (Niacinamide) in amounts sufficient to prevent nutritional deficiency and Vitamin B3 (Niacinamide) therefore must be supplemented through dietary intake.

And Vitamin B3 (Niacinamide) is water soluble.
Vitamin B3 (Niacinamide), which is in vitamin B3, of course enters the body through food. 
Vitamin B3 (Niacinamide) can also be applied externally. 

Vitamin B3 (Niacinamide), which is found in serum, care cream and make-up materials that gives shine to the skin, creates a visible youth effect on the skin.
Vitamin B3 (Niacinamide) is one of the two forms of vitamin B3, the other being Nicotinic acid. 
Vitamin B3 (Niacinamide) is also known as Niacin.

Vitamin B3 (Niacinamide) is a powder of good water solubility, having a solubility of 1 g in 1 ml of water. 
Unlike niacin, Vitamin B3 (Niacinamide) has a bitter taste; the taste is masked in the encapsulated form. 
Used in fortification of cereals, snack foods, and powdered beverages.

-Immunity: 
Vitamin B3 (Niacinamide) helps create a type of protein for keratin that keeps your skin tight and healthy.

-Lipid Barrier:
Vitamin B3 (Niacinamide) can help your skin develop a ceramide (lipid) barrier, which can help retain moisture. 
Vitamin B3 (Niacinamide) is especially beneficial for those with eczema or dry skin and all other skin types.

-Minimizes Redness and Blemishes: 
Vitamin B3 (Niacinamide) can help alleviate redness caused by eczema, acne and other inflammatory skin conditions.

-Minimizes Pore Appearance: 
Has a secondary benefit in keeping skin smooth and hydrated. 
Provides a natural reduction in pore size over time.

-Regulates Oil: 
The benefits of retaining moisture are not just for those with dry skin types. 
Vitamin B3 (Niacinamide) also helps regulate the amount of production of the sebaceous glands and prevent the sebaceous glands from working excessively.

-Protects Against Sun Damage: 
Vitamin B3 (Niacinamide) also supports the regeneration of healthy skin cells. 
Vitamin B3 (Niacinamide) also protects them from damage caused by ultraviolet rays.

-Effects Against Hyperpigmentation: 
Some research shows that Vitamin B3 (Niacinamide) concentrations are helpful in lightening dark spots.

-Minimizes Fine Lines and Wrinkles: 
Research also shows that Vitamin B3 (Niacinamide) concentrations are helpful in reducing some of the signs of sun damage that come with aging. 
This includes fine lines and wrinkles.

-Protects Against Oxidative Stress: 
Vitamin B3 (Niacinamide) helps form cells in the skin while protecting them from environmental stressors such as sunlight, air pollution and toxins.

-Anti-Acne Effects: 
Vitamin B3 (Niacinamide) can be helpful in severe acne, especially in inflammatory forms such as papules and pustules. 
Over time, you may see fewer lesions and improved skin tissue.

OTHER USES OF Vitamin B3 (Niacinamide):
-Vitamin B3 (Niacinamide) reduces the redness caused by acne and pimples.
-Vitamin B3 (Niacinamide) eliminates problems such as redness and irritation that occur in sensitive skin.
-Vitamin B3 (Niacinamide) makes the skin look brighter and livelier.
-Vitamin B3 (Niacinamide) has an anti-aging effect by supporting the production of collagen.
-Vitamin B3 (Niacinamide) eliminates the blemished appearance and eliminates the tone differences in the skin.

Vitamin B3 (Niacinamide) is a widely used vitamin in skin care.
-prevent premature aging lines
-To reduce fine lines on the skin
-Equalize skin tone
-Making the skin look brighter and brighter
-Calming acne skin and removing redness
-Removing dark spots
-Purify the skin and create a detox effect
-Strengthening the skin barrier
-To prevent the formation of new spots by repairing the skin
-moisturizing the skin
-reduce sensitivity

Vitamin B3 (Niacinamide), a water-soluble form of B vitamin, is also known as nicotinic acid in skin care ingredients.

KEYWORDS:
98-92-0, 202-713-4, 3-Pyridinecarboxamide, Nicotinic acid amide, pyridine-3-carboxamide, vitamin PP, Papulex, Aminicotin, Nicobion, Savacotyl

CHEMICAL PROPERTIES OF Vitamin B3 (Niacinamide):
Vitamin B3 (Niacinamide) is white needle crystal or crystalline powder, no smell or odor slightly, slightly bitter taste. 
The relative density is 1.4, melting point is 131-132 ℃.1 g of the above the product is soluble in 1 ml of water, 1.5 ml ethanol or 10 ml glycerin, insoluble in ether. 

The pH of 10% aqueous solution is 6.5-7.5. in dry air to light and heat stability, in alkaline or acidic solution, heating generation to nicotinic acid. 
Rats by oral LD502.5-3.5g/kg ADI value does not make special provisions.

ACTION OF Vitamin B3 (Niacinamide):
Vitamin B3 (Niacinamide) is an amide derivative of vitamin B3 and a PARP inhibitor
The coenzymes NAD and NADP take part in energy yielding metabolism and mediate several oxidation-reduction reactions. 
NAD hydrolyses to form Vitamin B3 (Niacinamide), which is then transported to other tissues. 
Hydrolysis of Vitamin B3 (Niacinamide) yields nicotinic acid through salvage pathway.
Vitamin B3 (Niacinamide) (Vitamin B3 (Niacinamide)) (Nam) is a building block (active component) of coenzymes Vitamin B3 (Niacinamide) adenine dinucleotide (NAD) and Vitamin B3 (Niacinamide) adenine dinucleotide phopshate (NADP). 
Vitamin B3 (Niacinamide) may be used as a substrate of Vitamin B3 (Niacinamide) phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule.

HOW DOES Vitamin B3 (Niacinamide) WORK:
Vitamin B3 (Niacinamide) can be made from niacin in the body. 
Niacin is converted to Vitamin B3 (Niacinamide) when Vitamin B3 (Niacinamide) is taken in amounts greater than what is needed by the body. 
Vitamin B3 (Niacinamide) is easily dissolved in water and is well-absorbed when taken by mouth.
Vitamin B3 (Niacinamide) is required for the proper function of fats and sugars in the body and to maintain healthy cells.
Unlike niacin, Vitamin B3 (Niacinamide) has no beneficial effects on fats and should not be used for treating high cholesterol or high fat levels in the blood.

Vitamin B3 (Niacinamide) vitamin can be obtained from natural foods or applied externally to your skin with creams and serums. 
Vitamin B3 (Niacinamide), which is in anti-aging creams and brightening care creams, is one of the ingredients that you must use for a radiant appearance. 

Consuming foods containing Vitamin B3 (Niacinamide) vitamin and using care creams containing Vitamin B3 (Niacinamide) will begin to create a visible youthful effect on your skin.
Vitamin B3 (Niacinamide), which is also called Vitamin B3 (Niacinamide), is one of two major forms of vitamin B3 (niacin) found in supplements (the other is nicotinic acid). 

Vitamin B3 (Niacinamide)’s often touted to help manage acne, rosacea, pigmentation issues, and wrinkles. 
But is there any science behind those claims?
Scientists theorize that niacin (and therefore Vitamin B3 (Niacinamide)/Vitamin B3 (Niacinamide)) may be effective because Vitamin B3 (Niacinamide)’s a precursor to two super-important biochemical cofactors: Vitamin B3 (Niacinamide) adenine dinucleotide (NAD+/NADH) and Vitamin B3 (Niacinamide) adenine dinucleotide phosphate (NADP+). 

Both of these molecules are central to the chemical reactions that your cells—including skin cells—need to repair damage, propagate, and function normally. 
Many of these essential reactions can’t occur at all without NAD+, which your cells can’t make without Vitamin B3 (Niacinamide).

Vitamin B3 (Niacinamide) is one of the two forms of vitamin B3 the other being nicotinic acid. 
Vitamin B3 (Niacinamide) is also known as niacin.

Vitamin B3 (Niacinamide) and nicotinic acid both provide vitamin B3 activity, but they differ in chemical structure and how they affect your health.
Vitamin B3 (Niacinamide) is a form of vitamin B3 (niacin) one of the eight B vitamins your body needs for good health.

Vitamin B3 (Niacinamide) plays a vital role in converting the food you eat into usable energy and helps your body’s cells carry out important chemical reactions (1Trusted Source).
Since Vitamin B3 (Niacinamide)’s water-soluble, your body doesn’t store this vitamin, which is why you need to eat nicotinic acid or Vitamin B3 (Niacinamide) daily.Vitamin B3 is generally found as Vitamin B3 (Niacinamide) in animal-based products, such as meat and poultry, and as nicotinic acid in plant-based foods like nuts, seeds and green vegetables (2Trusted Source).
Many refined grain products, including cereals, are also fortified with Vitamin B3 (Niacinamide) (2Trusted Source).

Your body can also make Vitamin B3 (Niacinamide) from tryptophan, an amino acid present in most protein foods.
However, the conversion of tryptophan to vitamin B3 is inefficient, as Vitamin B3 (Niacinamide) takes 60 mg of tryptophan to make just 1 mg of vitamin B3.

Historically, vitamin B3 was called vitamin PP, an acronym for pellagra-preventive.
That’s because a deficiency of Vitamin B3 (Niacinamide) or tryptophan leads to a disease called pellagra, which is characterized by the four D’s — diarrhea, dermatitis, dementia and, if left untreated, death (3Trusted Source).

Nicotinic acid and Vitamin B3 (Niacinamide) can both treat pellagra, but Vitamin B3 (Niacinamide) is preferred since Vitamin B3 (Niacinamide)’s associated with fewer side effects, such as flushing of the skin.
Vitamin B3 (Niacinamide) (Vitamin B3) is indicated to reduce the appearance of skin blemishes and congestion. 
A high 10% concentration of this vitamin is supported in the formula by zinc salt of pyrrolidone carboxylic acid to balance visible aspects of sebum activity.

Vitamin B3 (Niacinamide) or Vitamin B3 (Niacinamide) (NAM) is a form of vitamin B3 found in food and used as a dietary supplement and medication. 
As a supplement, Vitamin B3 (Niacinamide) is used by mouth to prevent and treat pellagra.

Vitamin B3 (Niacinamide) is a water soluble vitamin.
Side effects are minimal.
At high doses liver problems may occur.
Normal amounts are safe for use during pregnancy. 

Vitamin B3 (Niacinamide) is in the vitamin B family of medications, specifically the vitamin B3 complex. 
Vitamin B3 (Niacinamide) is an amide of nicotinic acid. 
Foods that contain Vitamin B3 (Niacinamide) include yeast, meat, milk, and green vegetables.

Vitamin B3 (Niacinamide) was discovered between 1935 and 1937.
Vitamin B3 (Niacinamide) is on the World Health Organization's List of Essential Medicines. 

Vitamin B3 (Niacinamide) is available as a generic medication and over the counter.
Commercially, Vitamin B3 (Niacinamide) is made from either nicotinic acid (niacin) or nicotinonitrile.
In a number of countries grains have Vitamin B3 (Niacinamide) added to them.

Vitamin B3 (Niacinamide), also known as Vitamin B3 (Niacinamide), is a non-flushing form of vitamin B3. 
Vitamin B3 (Niacinamide) has multiple positive functions in the body, including supporting restful sleep and healthy joint and skin.
Vitamin B3 (Niacinamide) also acts as an antioxidant, inhibiting free radical formation, and Vitamin B3 (Niacinamide) has been shown to promote the regeneration of beta cells in the pancreas.

Vitamin B3 (Niacinamide) has been found to stimulate neurotransmitter receptors in the brain, without binding to the receptor sites, which creates a calming, sedative-like effect.
High amounts of Vitamin B3 (Niacinamide) have been documented as being beneficial in protecting joint cartilage cells.
Vitamin B3 (Niacinamide) has also been used in support of several dermatological conditions.

Vitamin B3 (Niacinamide) is not derived from yeast
Vitamin B3 (Niacinamide) is a water-soluble form of Vitamin B3, which works as an anti-inflammatory to help brighten, repair and firm skin, while slowing the signs of aging. 

Vitamin B3 (Niacinamide) is most often used to address concerns around fine lines, dullness, and loss of collagen and elastin. 
Vitamin B3 (Niacinamide) works better in teams, so try to layer products with these ingredients for even better results.
Vitamin B3 (Niacinamide) is an active form of Vitamin B3, which has long been used for Vitamin B3 (Niacinamide)s brightening effects on pigmentations. 

Vitamin B3 (Niacinamide)'s known to be a stable ingredient not affected by light, damp surroundings or oxidation. 
Vitamin B3 (Niacinamide) is a cell-communicative skincare ingredient that can have an effect on enlarged pores, fine lines and uneven skin tone.
Vitamin B3 (Niacinamide) is also called vitamin B3 or vitamin PP, is a kind of water-soluble vitamin, belong to B vitamin, as NAD (Vitamin B3 (Niacinamide) adenine dinucleotide, NAD) and NADP (Vitamin B3 (Niacinamide) adenine dinucleotide phosphate, NADP) composition, hydrogenation and dehydrogenation properties of Vitamin B3 (Niacinamide) in the body part of this two kinds of structure of coenzyme the reversible, play a role of hydrogen delivery in biological oxidation, can promote tissue respiration, biological oxidation process and the new supersedes the old, having a great significance in maintaining normal tissue, especially the integrity of the skin digestive tract and the nervous system. 

When the lack of B vitamins, due to respiration and metabolism of cells affected by pellagra, so this product is mainly used for the prevention and treatment of pellagra, stomatitis, glossitis and so on.
In addition, this product has prevention of heart block and improving the sinoatrial node and anti-fast experimental arrhythmia function, can significantly improve Vera Pammy induced bradycardia and atrioventricular block. 
The clinical for coronary heart disease, viral myocarditis, rheumatic heart disease and a handful of digitalis poisoning associated with arrhythmia (mostly applied only when other medications fail), generally the degree atrioventricular block has obvious curative effect, basically after the treatment, all block can disappear, has obvious curative effect in sick sinus syndrome, right bundle branch block effect is poor.

After the stomach intestinal absorption by the oral, intramuscular absorption faster, then absorption distribution to the body tissues, t1/2 is 45 min. 
The liver metabolism, most metabolize N-n-methylVitamin B3 (Niacinamide), only a small amount of treatment as the prototype from the urine was more than necessary. 
If the daily urinary excretion of N-methyl Vitamin B3 (Niacinamide) is lower than 4mg, suggesting that Vitamin B3 (Niacinamide) deficiency.
Vitamin B3 (Niacinamide) and nicotinic acid are collectively referred to vitamin PP, nicotinic acid in the animal body is involved in metabolic processes in the form of Vitamin B3 (Niacinamide), both have a common vitamin activity. 
Vitamin B3 (Niacinamide) is white crystalline powder, odorless or almost odorless, bitter taste, easily soluble in water or ethanol, soluble in glycerol. 

Hygroscopic weak stable., acid, alkali and high temperature. 
The nature mainly exists in cereal skin, yeast, peanuts, meat, animal organs, milk and green leafy vegetables, in the body Vitamin B3 (Niacinamide) is from tryptophan synthesis, but the efficiency is very low. 
Prevention and treatment of pellagra, exposed parts of symmetric dermatitis, stomatitis, glossitis, anorexia, dermatitis, liver disease, coronary heart disease, atrioventricular block, sick sinus syndrome, diarrhea, neuritis and dementia.
Occasionally dizziness, nausea, abdominal discomfort, loss of appetite, disappear on their own, in early pregnancy overdose possible teratogenic intramuscular injection can cause pain, so less.

Molecular Weight: 123.11     
XLogP3: 0.4     
Hydrogen Bond Donor Count: 1     
Hydrogen Bond Acceptor Count: 3     
Rotatable Bond Count: 1     
Exact Mass: 123.032028402     
Monoisotopic Mass: 123.032028402     
Topological Polar Surface Area: 50.2 Ų     
Heavy Atom Count: 9     
Formal Charge: 0     
Complexity: 114     
Isotope Atom Count: 0 
Defined Atom Stereocenter Count: 0     
Undefined Atom Stereocenter Count: 0     
Defined Bond Stereocenter Count: 0     
Undefined Bond Stereocenter Count: 0     
Covalently-Bonded Unit Count: 1     
Compound Is Canonicalized: Yes 

USES OF Vitamin B3 (Niacinamide):
Vitamin B3 (Niacinamide) can help form a protein and (lipid) barrier in the skin and lock in moisture to prevent environmental damage. 
In general, the benefits to the body include:
Aside from being the preferred form of niacin for treating pellagra, Vitamin B3 (Niacinamide) has several other health benefits and uses.

Vitamin B3 (Niacinamide) plays an important role in keeping your skin healthy.
For this reason, Vitamin B3 (Niacinamide)’s a popular additive in the cosmetic and skincare industry.

When applied topically or taken orally as a supplement, Vitamin B3 (Niacinamide) has been shown to have anti-inflammatory effects on the skin.
Vitamin B3 (Niacinamide) has been used to treat skin conditions like acne and rosacea, a facial skin disorder characterized by redness.
This makes Vitamin B3 (Niacinamide) a popular alternative to oral or topical antibiotics for treating acne or rosacea.

Vitamin B3 (Niacinamide) is the preferred treatment for pellagra, caused by niacin deficiency.
While niacin may be used, Vitamin B3 (Niacinamide) has the benefit of not causing skin flushing.
Vitamin B3 (Niacinamide) cream is used as a treatment for acne.
Vitamin B3 (Niacinamide) has anti-inflammatory actions, which may benefit people with inflammatory skin conditions.

Vitamin B3 (Niacinamide) increases the biosynthesis of ceramides in human keratinocytes in vitro and improves the epidermal permeability barrier in vivo.
The application of 2% topical Vitamin B3 (Niacinamide) for 2 and 4 weeks has been found to be effective in lowering the sebum excretion rate.
Vitamin B3 (Niacinamide) has been shown to prevent Cutibacterium acnes-induced activation of toll-like receptor 2, which ultimately results in the down-regulation of pro-inflammatory interleukin-8 production.

Other skin benefits from topical Vitamin B3 (Niacinamide) may include relief to a stripped moisture barrier in the skin, reduced irritation, increase of collagen production, and the lessening of hyperpigmentation in one's skin.
Same as nicotinic acid. Water soluble is better than niacin acid, easy to generate complex agglomerate with vitamin C. 
The dosage is 30-80 mg/kg. Vitamin B3 (Niacinamide) and nicotinic acid are in common use generally and nicotinic acid can transform into Vitamin B3 (Niacinamide) in animals. 

The production capacity is more than 30000 tons in the world. 
In Japan, Vitamin B3 (Niacinamide) used in medicine (40%), feed additives (50%) and food additives (10%). 
Vitamin B3 (Niacinamide) and Vitamin B3 (Niacinamide) are non-toxic, naturally contains in liver, kidney, yeast and honey. 
The Vitamin B3 (Niacinamide) LD50 of subcutaneous injection for rat is 1.7 g/kg.

Vitamin B3 (Niacinamide) is of Vitamin drugs, and involved in metabolic process. 
Can be used in skin care products, to prevent coarse skin, maintain healthy skin cells, and promote skin whitening. 
In addition, Vitamin B3 (Niacinamide) can also be used in hair care products, to promote scalp blood circulation, healthy hair follicles, promotes hair growth and prevent alopecia.

Vitamin B3 (Niacinamide) is used in biochemical research, to prepare tissue culture medium. 
The pharmaceutical industry.
Vitamin B3 (Niacinamide) is a nutrient and dietary supplement that is an available form of niacin. 
Nicotinic acid is pyridine beta-carboxylic acid and Vitamin B3 (Niacinamide), which is another term for Vitamin B3 (Niacinamide), is the corresponding amide. 

When applied topically or taken orally as a supplement, Vitamin B3 (Niacinamide) has been shown to have anti-inflammatory effects on the skin. 
Vitamin B3 (Niacinamide) has been used to care for skin conditions such as Acne and Rosacea, a facial skin condition characterized by redness.
Thanks to this, products containing Vitamin B3 (Niacinamide) have become a popular alternative for ailments such as Acne or Rosacea.

-Vitamin B3 (Niacinamide) prevents the formation of fine lines and wrinkles and fights the signs of premature aging.
-Evens out skin tone.
-Vitamin B3 (Niacinamide) has a healing effect on acne.
-Vitamin B3 (Niacinamide) soothes the skin by reducing its sensitivity.
-Vitamin B3 (Niacinamide) makes the skin more lively and bright.
-Vitamin B3 (Niacinamide) lightens the color of dark spots and whitens the skin.
-Vitamin B3 (Niacinamide) reduces the appearance of redness.
-Vitamin B3 (Niacinamide) repairs the structure of the skin and prevents the formation of new spots.
-Vitamin B3 (Niacinamide) nourishes the skin and strengthens its structure.
-Vitamin B3 (Niacinamide) applies intensive moisture therapy.

PROPERTIES OF Vitamin B3 (Niacinamide):
-Quality Level: 200,
-biological source: synthetic
-assay: ≥99.5% (HPLC)
-form: powder or crystals
-application(s): cell analysis: suitable
-ign. residue: ≤0.2%
-loss: ≤0.2% loss on drying, 20 °C (HV)
-color: colorless to white
-melting point: 128-131 °C (lit.) 128-131 °C
-anion traces: chloride (Cl-): ≤50 mg/kg sulfate (SO42-): ≤150 mg/kg

About Vitamin B3 (Niacinamide) Helpful information:
Vitamin B3 (Niacinamide) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
Vitamin B3 (Niacinamide) is used by consumers, by professional workers (widespread uses), in formulation or re-packing and at industrial sites.

Consumer Uses of Vitamin B3 (Niacinamide):
Vitamin B3 (Niacinamide) is used in the following products: cosmetics and personal care products.
Other release to the environment of Vitamin B3 (Niacinamide) is likely to occur from: indoor use as processing aid.

Article service life of Vitamin B3 (Niacinamide):
ECHA has no public registered data on the routes by which Vitamin B3 (Niacinamide) is most likely to be released to the environment. 
ECHA has no public registered data indicating whether or into which articles Vitamin B3 (Niacinamide) might have been processed.

Widespread uses by professional workers of Vitamin B3 (Niacinamide):
ECHA has no public registered data indicating whether or in which chemical products Vitamin B3 (Niacinamide) might be used. 
ECHA has no public registered data on the types of manufacture using Vitamin B3 (Niacinamide). 
Other release to the environment of Vitamin B3 (Niacinamide) is likely to occur from: indoor use as processing aid.

Formulation or re-packing of Vitamin B3 (Niacinamide):
ECHA has no public registered data indicating whether or in which chemical products Vitamin B3 (Niacinamide) might be used. 
Release to the environment of Vitamin B3 (Niacinamide) can occur from industrial use: formulation of mixtures.

Uses at industrial sites of Vitamin B3 (Niacinamide):
ECHA has no public registered data indicating whether or in which chemical products Vitamin B3 (Niacinamide) might be used. 
Vitamin B3 (Niacinamide) is used for the manufacture of: chemicals.
Release to the environment of Vitamin B3 (Niacinamide) can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and of substances in closed systems with minimal release.

Manufacture of Vitamin B3 (Niacinamide):
ECHA has no public registered data on the routes by which Vitamin B3 (Niacinamide) is most likely to be released to the environment.

98-92-0
3-Pyridinecarboxamide
Nicotinic acid amide
pyridine-3-carboxamide
vitamin PP
Papulex
Aminicotin
Amixicotyn
Nicobion
Nicotylamide
Nikotinamid
Savacotyl
Benicot
Dipegyl
Endobion
Hansamid
Vitamin B3 (Niacinamide), TMS derivative
Vitamin B3 (Niacinamide), N-trimethylsilyl-
N-trimethylsilylpyridine-3-carboxamide
ZINC230613149
nicotinic acid
niacin
59-67-6
Pyridine-3-carboxylic acid
3-pyridinecarboxylic acid
3-Carboxypyridine
wampocap
Niaspan
Acidum nicotinicum
Apelagrin
Pellagrin
Akotin
Daskil
Efacin
Pelonin
Linic
vitamin B3
nicamin
nicobid
nicocap
nicolar
Enduracin
Nicodelmine
Niconacid
Nicotinipca
Pellagramin
Direktan
Nicacid
Nicangin
Peviton
Bionic
Diacin
Nicyl
Nyclin
Niac
Vitaplex N
Davitamon PP
Nico-Span
Tega-Span
Nicocidin
Nicocrisina
Niconazid
Nicoside
Nicotamin
Nicotene
Nicovasan
Nicovasen
Nipellen
SK-Niacin
Naotin
Nicodan
Nicodon
Niconat
Nicosan 3
Nicosyl
Nicotil
Tinic
3-Carboxylpyridine
Nicotine acid
Niacor
nicotinate
Slo-niacin
NICO
3-Picolinic acid
Nicotinsaure
Nico-400
Acide nicotinique
Pyridine-beta-carboxylic acid
Nicagin
anti-Pellagra vitamin
Caswell No. 598
PP Factor
Kyselina nikotinova
P.P. factor
Pellagra preventive factor
S115
Nicotinsaure [German]
Acido nicotinico
3-Pyridylcarboxylic acid
m-Pyridinecarboxylic acid
Kyselina nikotinova [Czech]
MFCD00006391
niacine
CCRIS 1902
Pyridine-carboxylique-3
EPA Pesticide Chemical Code 056701
Acide nicotinique [INN-French]
Acido nicotinico [INN-Spanish]
Acidum nicotinicum [INN-Latin]
HSDB 3134
Pyridine-carboxylique-3 [French]
AI3-18994
Pyridinecarboxylic acid, 3-
Niacin [USP]
SR 4390
BRN 0109591
UNII-2679MF687A
NAH
CHEMBL573
beta-pyridinecarboxylic acid
MLS000069603
Pyridine-.beta.-carboxylic acid
CHEBI:15940
Niacin (USP)
2679MF687A
NSC-169454
P.P. factor-pellagra preventive factor
CAS-59-67-6
NCGC00016268-02
SMR000059024
DSSTox_CID_932
[5, 6-3H]-niacin
DSSTox_RID_75875
DSSTox_GSID_20932
Niacin [USAN]
Nicotinicacid
Niacin (nicotinic acid)
SR-01000722017
EINECS 200-441-0
NIASPAN TITRATION STARTER PACK
NSC 169454
pellagra
Nikotinsaeure
Ncotnc acd
preventative factor
antipellagra vitamin
Niaspan (TN)
3PyrCOOH
[3H]nicotinic acid
Niacor (TN)
Nicotinic Acid,(S)
[3H]-Nicotinic acid
Niacin extended release
Nicotinic acid [INN]
Spectrum_001063
3-Pyridinecarboxylicacid
Nicotinic acid, Ph Eur
5-pyridinecarboxylic acid
Opera_ID_1346
Prestwick0_000881
Prestwick1_000881
Prestwick2_000881
Prestwick3_000881
Pyridine-3-carbonic acid
Spectrum2_000006
Spectrum3_000515
Spectrum4_000965
Spectrum5_001287
3-Pyridyl carboxylic acid
Nicotinic acid-d3(major)
WLN: T6NJ CVQ
3-pyridine carboxylic acid
bmse000104
Nicotinic acid, >=98%
Nicotinic acid, USP grade
EC 200-441-0
SCHEMBL1433
Oprea1_514398
BSPBio_000662
BSPBio_002069
KBioGR_001309
KBioSS_001543
5-22-02-00057 (Beilstein Handbook Reference)
BIDD:GT0644
DivK1c_000695
Nicotinic acid (JP17/INN)
SPECTRUM1500430
.beta.-Pyridinecarboxylic acid
SPBio_000011
SPBio_002881
BPBio1_000730
GTPL1588
GTPL1594
ZINC1795
DTXSID1020932
BDBM23515
HMS502C17
KBio1_000695
KBio2_001543
KBio2_004111
KBio2_006679
KBio3_001569
ABT-919
NINDS_000695
HMS1570B04
HMS1920P17
HMS2091H22
HMS2097B04
HMS2236A05
HMS3259K21
HMS3371E07
HMS3655K08
HMS3714B04
Pharmakon1600-01500430
Nicotinic acid, analytical standard
BCP16301
HY-B0143
STR00112
Tox21_110337
Tox21_201420
Tox21_302904
AC8691
BBL037343
CCG-38340
Nicotinic acid, for synthesis, 99%
NSC169454
NSC757241
s1744
STK301803
Nicotinic acid (Vitamin B3) solution
AKOS000118980
Nicotinic acid, >=99.5% (HPLC)
Tox21_110337_1
AM81316
CS-1946
DB00627
MCULE-3788394698
NC00524
Nicotinic Acid 1.0 mg/ml in Methanol
NSC-757241
PS-4255
SDCCGMLS-0066610.P001
IDI1_000695
NCGC00016268-01
NCGC00016268-03
NCGC00016268-04
NCGC00016268-05
NCGC00016268-08
NCGC00016268-09
NCGC00094734-01
NCGC00094734-02
NCGC00256537-01
NCGC00258971-01
AC-22484
BP-21419
NCI60_001041
Nicotinic acid, NIST(R) SRM(R) 148
Nicotinic acid, plant cell culture tested
SY011111
SBI-0051456.P003
DB-007765
Nicotinic Acid [Matrix for MALDI-TOF/MS]
AB00052050
FT-0600004
FT-0672715
FT-0672716
FT-0672717
FT-0672718
FT-0773496
N0082
N1103
Nicotinic acid 10 microg/mL in Acetonitrile
Nicotinic acid, purum, >=99.0% (HPLC)
SW197229-3
C00253
D00049
Nicotinic acid, SAJ special grade, >=99.5%
AB00052050-13
AB00052050_14
AB00052050_15
Nicotinic acid, meets USP testing specifications
AC-907/25014105
L001199
Nicotinic acid, Vetec(TM) reagent grade, >=98%
Q134658
J-523605
SR-01000722017-2
SR-01000722017-3
SR-01000722017-4
Z56755709
3DDB011E-F3A6-45B6-A2D2-77B2A6E8936E
F2191-0082
Niacin, United States Pharmacopeia (USP) Reference Standard
Nicotinic acid, certified reference material, TraceCERT(R)
Nicotinic acid, European Pharmacopoeia (EP) Reference Standard
Nicotinic acid, matrix substance for MALDI-MS, >=99.5% (HPLC)
Nicotinic acid, for inorganic trace analysis, >=99.999% (metals basis)
Niacin (Nicotinic Acid), Pharmaceutical Secondary Standard; Certified Reference Material
101113-41-1
Nicotinic acid (Vitamin B3) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material
Nicotinic acid, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, >=98%

Regulatory process names:
Nicotinic acid
nicotinic acid

CAS names:
3-Pyridinecarboxylic acid

IUPAC names:
3-PYRIDINECARBOXYLIC ACID
3-Pyridinecarboxylic acid
Niacin
Nicotinic Acid
Nicotinic acid
nicotinic acid
Nicotinic acid
Pyridin-3-carbonsäure
Pyridine 3 carboxylic acid
Pyridine-3-carboxilic acid
pyridine-3-carboxylate
Pyridine-3-carboxylic acid
pyridine-3-carboxylic acid

Trade names:
ACIDO NICOTINICO USP POLVERE
CMS177 Nicotinic acid

Other identifiers:
123574-58-3
1580002-26-1
59-67-6

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