CAS Number: 108-91-8
EC Number: 203-629-0
Chemical formula: C6H13N
Molar mass: 99.17
Cyclohexanamine is an organic compound, belonging to the aliphatic amine class.
Cyclohexanamine is a colorless liquid, although, like many amines, samples are often colored due to contaminants.
Cyclohexanamine has a fishy odor and is miscible with water.
Like other amines, Cyclohexanamine is a weak base, compared to strong bases such as NaOH, but it is a stronger base than its aromatic analog, aniline.
Cyclohexanamine is a useful intermediate in the production of many other organic compounds.
Cyclohexanamine is a food contaminant arising from its use as a boiler water additive Cyclohexylamine, also called hexahydroaniline, 1-aminocyclohexane, or aminohexahydrobenzene, is an organic chemical, an amine derived from cyclohexane.
Cyclohexanamine is a clear to yellowish liquid with fishy odor, with melting point of 17.7 °C and boiling point 134.5 °C, miscible with water.
Like other amines, Cyclohexanamine is of mildly alkaline nature, compared to strong bases such as NaOH, but it is a stronger base than its aromatic sister compound aniline, which differs only in that its ring is aromatic.
Cyclohexanamine is flammable, with flash point at 28.6 °C.
Explosive mixtures of Cyclohexanamine with air can be formed above 26 °C.
Cyclohexanamine is toxic by both ingestion and inhalation; the inhalation itself may be fatal.
Cyclohexanamine readily absorbs through skin, which it irritates.
Cyclohexanamine is corrosive.
Cyclohexanamine is listed as an extremely hazardous substance as defined by Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act
Applications of Cyclohexanamine:
Cyclohexanamine is used as an intermediate in synthesis of other organic compounds.
Cyclohexanamine is the precursor to sulfenamide-based reagents used as accelerators for vulcanization.
Cyclohexanamine is a building block for pharmaceuticals (e.g., mucolytics, analgesics, and bronchodilators).
The amine itself is an effective corrosion inhibitor.
The herbicide hexazinone and the anesthetic hexylcaine are derived from Cyclohexanamine.
Cyclohexanamine has been used as a flushing aid in the printing ink industry.
Description of Cyclohexanamine:
A primary aliphatic amine consisting of Cyclohexanamine carrying an amino substituent.
Preferred IUPAC name:
Cyclohexanamine
Other names:
Aminocyclohexane
Aminohexahydrobenzene
Hexahydroaniline
Hexahydrobenzenamine
CAS Number: 108-91-8
CHEBI: 15773
ChEMBL: ChEMBL1794762
ChemSpider: 7677
ECHA InfoCard: 100.003.300
EC Number: 203-629-0
IUPHAR/BPS: 5507
KEGG: C00571
PubChem CID: 7965
RTECS number: GX0700000
UNII: I6GH4W7AEG
CompTox Dashboard (EPA): DTXSID1023996
Preparation of Cyclohexanamine:
Cyclohexanamine is produced by two routes, the main one being the complete hydrogenation of aniline using some cobalt- or nickel-based catalysts:
C6H5NH2 + 3 H2 → C6H11NH2
Cyclohexanamine is also prepared by alkylation of ammonia using cyclohexanol.
Cyclohexanamine appears as a clear colorless to yellow liquid with an odor of ammonia.
Flash point of Cyclohexanamine is 90°F.
Cyclohexanamine irritates the eyes and respiratory system.
Skin contact of Cyclohexanamine may cause burns.
Cyclohexanamine is less dense than water.
Cyclohexanamine vapors heavier than air.
Toxic oxides of nitrogen produced during combustion.
About Cyclohexanamine Helpful information
Cyclohexanamine is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.
Cyclohexanamine is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Consumer Uses of Cyclohexanamine:
Cyclohexanamine is used in the following products: polymers.
Release to the environment of Cyclohexanamine can occur from industrial use: formulation in materials and in the production of articles.
Other release to the environment of Cyclohexanamine is likely to occur from: outdoor use, indoor use, outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Article service life of Cyclohexanamine:
Release to the environment of Cyclohexanamine can occur from industrial use: of articles where the substances are not intended to be released and where the conditions of use do not promote release, formulation in materials and in the production of articles.
Other release to the environment of Cyclohexanamine is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use and indoor use.
Cyclohexanamine can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).
Widespread uses by professional workers of Cyclohexanamine:
Cyclohexanamine is used in the following products: polymers, adhesives and sealants, coating products and fillers, putties, plasters, modelling clay.
Cyclohexanamine is used in the following areas: formulation of mixtures and/or re-packaging, mining and building & construction work.
Cyclohexanamine is used for the manufacture of: plastic products and machinery and vehicles.
Release to the environment of Cyclohexanamine can occur from industrial use: formulation in materials, in the production of articles and formulation of mixtures.
Other release to the environment of Cyclohexanamine is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Formulation or re-packing of Cyclohexanamine:
Cyclohexanamine is used in the following products: polymers, adhesives and sealants, coating products and fillers, putties, plasters, modelling clay.
Release to the environment of Cyclohexanamine can occur from industrial use: formulation in materials, in the production of articles and formulation of mixtures.
Other release to the environment of Cyclohexanamine is likely to occur from: indoor use, outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Uses of Cyclohexanamine at industrial sites:
Cyclohexanamine is used in the following products: polymers.
Cyclohexanamine is used in the following areas: mining and building & construction work.
Cyclohexanamine is used for the manufacture of: plastic products, machinery and vehicles and furniture.
Release to the environment of Cyclohexanamine can occur from industrial use: in the production of articles, formulation in materials and in processing aids at industrial sites.
Other release to the environment of Cyclohexanamine is likely to occur from: outdoor use, indoor use, outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Manufacture of Cyclohexanamine:
Release to the environment of Cyclohexanamine can occur from industrial use: manufacturing of the substance.
Chemical formula: C6H13N
Molar mass: 99.17
Appearance: clear to yellowish liquid
Odor strong, fishy, amine odor
Density: 0.8647 g/cm3
Melting point: −17.7 °C (0.1 °F; 255.5 K)
Boiling point: 134.5 °C (274.1 °F; 407.6 K)
Solubility in water: Miscible
Solubility:
very soluble in ethanol, oil
miscible in ethers, acetone, esters, alcohol, ketones
Vapor pressure: 11 mmHg (20° C)
Acidity (pKa): 10.64
Refractive index (nD): 1.4565
Alternative Parents of Cyclohexanamine:
-Organopnictogen compounds
-Monoalkylamines
-Hydrocarbon derivatives
Substituents of Cyclohexanamine
-Cyclohexylamine
-Organopnictogen compound
-Hydrocarbon derivative
-Primary amine
-Primary aliphatic amine
-Amine
-Aliphatic homomonocyclic compound
Phosphoramide mustard Cyclohexanamine is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy.
Phosphoramide mustard Cyclohexanamine induces DNA damage.
2-Methyl-1-cyclohexanamine exists in four stereoisomeric forms.
Although Cyclohexanamine is a simple compound, none of the stereoisomers is readily available in its pure form.
We herein described a crystallization method identified by a salt screen (diastereomeric salt formation) allowing the isolation of a single trans enantiomer from a readily available commercial source consisting of a mixture of all four stereoisomers.
Assay of Cyclohexanamine as related impurity in glipizide (as active ingredient or in its pharmaceutical formulations) has been achieved through pre-column derivatization with o-phtaldialdehyde (OPA) followed by the HPLC/DAD assay.
Derivatization reaction was found to be fast, quantitative, and produces required sensitivity under UV detection at 245 nm.
The absolute limit of quantitation is placed around 0.05 μg/mL, meaning less than 0.001% with respect to the amount of glipizide used in the test solution and 1/10 from the maximum threshold imposed for Cyclohexanamine in glipizide through the European Pharmacopoeia compendial monograph.
No interferences from the derivatization reagent or its related by-products and from the other impurities of glipizide were observed.
The assay was validated according to guidances in force.
The precision of the method is placed within the 10% interval (expressed as relative standard deviation) while accuracy is placed in the ±10% range (expressed as % bias).
This method can successfully replace the gas chromatographic/flame ionization detection (GC-FID) method recommended by the compendial European Pharmacopoeia monograph.
Toxicity of Cyclohexanamine:
Cyclohexanamine has a low acute toxicity with LD50 (rat; p.o.) = 0.71 ml/kg Like other amines, it is corrosive.
Cyclohexanamine is listed as an extremely hazardous substance as defined by Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act.
The National Institute for Occupational Safety and Health has suggested workers not be exposed to a recommended exposure limit of over 10 ppm (40 mg/m3) over an eight-hour workshift.
Formula: C12H23N
Molecular weight: 181.3177
IUPAC Standard InChI: InChI=1S/C12H23N/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h11-13H,1-10H2 Copy
InChI version 1.06
IUPAC Standard InChIKey: XBPCUCUWBYBCDP-UHFFFAOYSA-N Copy
CAS Registry Number: 101-83-7
Other names: Dicyclohexylamine; Dodecahydrodiphenylamine; N-Cyclohexylcyclohexanamine; N,N-Dicyclohexylamine; Cyclohexylcyclohexanamine; Dicyklohexylamin; DCH; N-Cyclohexyl-cyclohexylamine; DCHA; Dicha; N,N-Diclohexylamine; UN 2565; Aminodicyclohexane; Bis(cyclohexyl)amine; NSC 3399
Use: corrosion inhibitors; dye intermediate; emulsifying agent; organic syntheses; paint film solvent; petroleum additive
Density: 0.865 g/mL
Molar volume: 114.7 mL/mol
Refractive index: 1.459
Molecular refractive power: 31.35 mL/mol
Dielectric constant: 4.43
Dipole moment: 1.31 D
Melting point: -18 °C
Boiling point: 134 °C
Vapour pressure: 1 Torr
Surface tension: 31.54 dyn/cm
Critical pressure: 4.2 atm
Solubility in water: 100 % w/w
Solubility of water: 100 % w/w
Log10 partition octanol / water: 1.49
Hildebrant solubility parameter (δ): 9.2
Molecular Weight: 99.17
XLogP3: 1.5
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 0
Exact Mass: 99.104799419
Monoisotopic Mass: 99.104799419
Topological Polar Surface Area: 26 Ų
Heavy Atom Count: 7
Complexity: 46.1
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
CYCLOHEXYLAMINE
Cyclohexanamine
108-91-8
Aminocyclohexane
Hexahydroaniline
Hexahydrobenzenamine
Aminohexahydrobenzene
Cyclohexyl amine
1-Cyclohexylamine
1-Aminocyclohexane
Aniline, hexahydro-
Benzenamine, hexahydro-
Aminocylcohexane
Cyclohexylamines
cyclohexyl-amine
UNII-I6GH4W7AEG
1-AMINO-CYCLOHEXANE
CCRIS 3645
HSDB 918
cyclohexaneamine
Cyclohexylamine.HCl
I6GH4W7AEG
Cyclohexylamin
CHEBI:15773
MFCD00001486
157973-60-9
Cyclohexylamine [UN2357] [Corrosive]
DSSTox_CID_3996
DSSTox_RID_77250
DSSTox_GSID_23996
CAS-108-91-8
HAI
EINECS 203-629-0
UN2357
BRN 0471175
cylohexylamine
cyclohexylarnine
cyclo-hexylamine
AI3-15323
cyclohexane-amine
n-cyclohexylamine
cyclohexanyl amine
Hexahydro-Aniline
monocyclohexylamine
4-Cyclohexylamine
Cyclohexylamine,(S)
Hexahydro-Benzenamine
Cyclohexanamine, 9CI
CyNH2
Cyclohexylamine [UN2357] [Corrosive]
Cyclohexylamine, 99.5%
bmse000451
EC 203-629-0
4-12-00-00008 (Beilstein Handbook Reference)
BIDD:ER0290
GTPL5507
CHEMBL1794762
DTXSID1023996
BDBM81970
BCP30928
Tox21_202380
Tox21_300038
STK387114
ZINC12358775
AKOS000119083
Cyclohexylamine, ReagentPlus(R), 99%
MCULE-7654331405
UN 2357
VS-0326
Aminocyclohexane pound>>Hexahydroaniline
NCGC00247889-01
NCGC00247889-02
NCGC00253922-01
NCGC00259929-01
AM802905
BP-21278
CAS_108-91-8
NCI60_004907
Cyclohexylamine 1000 microg/mL in Methanol
Cyclohexylamine, ReagentPlus(R), >=99.9%
FT-0624217
X6008
C00571
46880-EP2272837A1
46880-EP2277848A1
46880-EP2277862A2
46880-EP2281563A1
46880-EP2284159A1
46880-EP2284174A1
46880-EP2287141A1
46880-EP2292228A1
46880-EP2292621A1
46880-EP2295406A1
46880-EP2295418A1
46880-EP2298731A1
46880-EP2298746A1
46880-EP2298778A1
46880-EP2305219A1
46880-EP2305651A1
46880-EP2308812A2
46880-EP2308833A2
46880-EP2308854A1
46880-EP2311804A2
46880-EP2311810A1
46880-EP2380874A2
56751-EP2284166A1
56751-EP2298769A1
56751-EP2308878A2
J-002206
J-520164
Q1147539
F2190-0381
Cyclohexyldimethylamine
Cyclohexyldimethylamine
cyclohexyldimethylamine
N,N-DIMETHYL-CYCLOHEXYLAMINE
N,N-DIMETHYLCYCLOHEXYLAMINE
Cyclohexanamine, N,N-dimethyl-
Ciclohexildimetilamina
Cyclohexanamine, N,N- dimethyl
Cyclohexanamine, N,N-dimethyl-
Cyclohexyldimethylamine
cyclohexyldimethylamine
Cyclohexyldimethylamine
cyklohexyldimethylamin
Dimethylcyclohexylamine
DIMETHYLCYCLOHEXYLAMINE (DMCHA)
DMCHA
N,N-Dimethyl cyclohexyl amine
N,N-Dimethylcyclohexanamine
N,N-dimethylcyclohexanamine
N,N-Dimethylcyclohexylamine
N,N-dimethylcyclohexylamine
N,N-dimethylcyclohexylamine
130254-81-8
130254-81-8
1304117-32-5
1304117-32-5
1639015-74-9
1639015-74-9
205657-42-7
205657-42-7
389120-80-3
389120-80-3
75496-03-6
75496-03-6
98-94-2