CAS number: 142-84-7
EC Number: 205-565-9
Chemical formula: C6H15N
Molar mass: 101.193 g·mol−1
IUPAC Name: N-propylpropan-1-amine
Dipropylamine is a flammable, highly toxic, corrosive amine.
Dipropylamine occurs naturally in tobacco leaves and artificially in industrial wastes.
Dipropylamine exposure can cause excitement followed by depression, internal bleeding, dystrophy, and severe irritation.
Dipropylamine (DPA; also called Di-N-Propylamine DNPA) is a secondary amine which belongs to the class of dialkylamines.
Dipropylamine is a versatile intermediate with a variety of applications.
Chemical Properties of Dipropylamine:
Dipropylamine is a colourless liquid.
Chemical Properties of Dipropylamine:
Dipropylamine, like the other short chain aliphatic amines, is a very strong base, its reactivity being governed by the unshared electron pair on the nitrogen atom.
Dipropylamine forms a hydrate with water.
The amine also can react with inorganic or organic nitrites under acidic conditions and possibly by reaction with nitrogen oxides from the air to form the highly mutagenic and carcinogenic N-nitrosodipropylamine.
Production Methods of Dipropylamine:
Dipropylamine is manufactured by reaction of propanol and ammonia over a dehydration catalyst at high temperature and pressure.
Alternatively, propanol and ammonia can be combined with hydrogen over a dehydrogenation catalyst.
In each instance, the resulting mixture of primary, secondary, and tertiary amines can be separated by continuous distillation and extraction.
Dipropylamine is a natural component of vegetables, fish, fruits, and other foods and of tobacco products.
Dipropylamine also is found in human urine, waste water lagoons and in workplace air.
The toxic compound, Dipropylamine, can be produced inadvertently by nitrosation of n-dipropylamine during various manufacturing processes that use the diamine.
Dipropylamine, therefore, occurs as an impurity in some dinitroaniline pesticides and rubber products.
Dipropylamine also is found in various foodstuffs including cheese, cured meats, cooked fish and alcoholic beverages, apparently by reaction of n-dipropylamine with the preservative sodium nitrite.
General Description of Dipropylamine:
Dipropylamine is a clear colorless liquid with an ammonia-like odor.
Dipropylamine' flash point is 30°F.
Dipropylamine is less dense than water.
Dipropylamine vapors heavier than air.
Toxic oxides of nitrogen produced during combustion.
Applications, intermediate used in the production of: crop protection agents, herbicides, pharmaceuticals. Packaging, available in bulk and drums.
Air & Water Reactions of Dipropylamine:
Dipropylamine is highly flammable.
Dipropylamine is soluble in water.
Product Description:
General:
Synonyms: di-n-propylamine, N,N-dipropylamine, N-propyl-1-
propanamine, N-dipropylamine
Use: synthetic intermediate
Molecular formula: C6H15N
CAS No: 142-84-7
EINECS No: 205-565-9
Annex I Index no: 612-048-00-5
Dipropylamine is used in the rubber industry and as a chemical intermediate in themanufacture of the herbicides S-ethyl-di-n-propylthiocarbamate and S-propyldi-n-propylthiocarbamate.
KEYWORDS:
142-84-7, 205-565-9, 1-Propanamine N-propyl-, DI-N-PROPYLAMINE, Dipropylamine, JL9200000, MFCD00009362, N-Propylpropan-1-amine, (n-C3H7)2NH, 33'-IMINODIPROPIONITRILE
Dipropylamine is used in the rubber industry and as a chemical intermediate in themanufacture of the herbicides S-ethyl-di-n-propylthiocarbamate and S-propyldi-n-propylthiocarbamate.
Dipropylamine also is employed in thepurification of perfluoro compounds to convert the incompletely fluorinatedimpurities to solids which are then removed by filtration.
Description of Dipropylamine:
Dipropylamine is a flammable, highly toxic, corrosive amine.
Dipropylamine occurs naturally in tobacco leaves and artificially in industrial wastes.
Exposure can cause excitement followed by depression, internal bleeding, dystrophy, and severe irritation.
Chemical Name: Dipropylamine
Synonyms: DPA;DNPA;ai3-24037;(n-C3H7)2NH;Di-n-propyL;DIPROPYLAMINE;Dipropanamine;AURORA KA-7671;N-Dipropylamine;Di-n-propylamin
CBNumber: CB1713802
Molecular Formula: C6H15N
IDENTIFICATION of Dipropylamine:
Dipropylamine is a colorless liquid with a strong ammonialike odor.
Dipropylamine is used as a chemical intermediate in the manufacture of herbicides.
Physical data:
Appearance: colorless liquid
Melting point: -40 C
Boiling point: 108 - 110 C
Vapor density:
Vapor pressure:
Density (g cm-3): 0.74
Flash point: 7 C (closed cup)
Explosion limits:
Autoignition temperature:
Water solubility: soluble, forming hydrates
Stability: Stable
Highly flammable. Incompatible with strong oxidizing agents.
Reactivity Profile of Dipropylamine:
Dipropylamine neutralizes acids in exothermic reactions to form salts plus water.
Dipropylamine may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard of Dipropylamine:
Dipropylamine inhalation causes severe coughing and chest pain due to irritation of air passages; can-cause lung edema; may also cause headache, nausea, faintness, and anxiety.
Dipropylamine ingestion causes irritation and burning of mouth and stomach.
Dipropylamine contact with eyes causes severe irritation and edema of the cornea.
Dipropylamine contact with skin causes severe irritation.
Health Hazard of Dipropylamine:
Inhalation of dipropylamine vapors can result in severe coughing and chest pain due to irritation of airways.
Transient symptoms of exposure may include headache, nausea, faintness, and anxiety.
Prolonged breathing of vapors may result in lung edema.
Dipropylamine also can cause severe irritation and edema of the cornea.
A review of the toxicity of dipropylamine has been prepared.
Fire Hazard of Dipropylamine:
Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires.
Preferred IUPAC name:
N-Propylpropan-1-amine
CAS Number: 142-84-7
Beilstein Reference: 505974
ChemSpider: 8562
ECHA InfoCard: 100.005.060
EC Number: 205-565-9
PubChem CID: 8902
RTECS number: JL9200000
UNII: 60P318IIRY
UN number: 2383
CompTox Dashboard (EPA): DTXSID2025185
The 2D chemical structure image of DIPROPYLAMINE is also called skeletal formula, which is the standard notation for organic molecules.
The carbon atoms in the chemical structure of DIPROPYLAMINE are implied to be located at the corner(s) and hydrogen atoms attached to carbon atoms are not indicated – each carbon atom is considered to be associated with enough hydrogen atoms to provide the carbon atom with four bonds.
The 3D chemical structure image of DIPROPYLAMINE is based on the ball-and-stick model which displays both the three-dimensional position of the atoms and the bonds between them.
The radius of the spheres is therefore smaller than the rod lengths in order to provide a clearer view of the atoms and bonds throughout the chemical structure model of DIPROPYLAMINE.
Chemical formula: C6H15N
Molar mass: 101.193 g·mol−1
Appearance : Colorless liquid
Odor: Ichtyal, ammoniacal
Density: 738 mg mL−1
Melting point: −63.00 °C; −81.40 °F; 210.15 K
Boiling point: 109 to 111 °C; 228 to 232 °F; 382 to 384 K
Solubility in diethyl ether: Miscible
Henry's law constant (kH): 190 μmol Pa−1 kg−1
Refractive index (nD): 1.4049
Other names:
(Dipropyl)amine
Industrial uses of Dipropylamine:
Dipropylamine is used in the rubber industry and as a chemical intermediate in the manufacture of the herbicides S-ethyl-di-n-propylthiocarbamate and S-propyl di-n-propylthiocarbamate.
Dipropylamine also is employed in the purification of perfluoro compounds to convert the incompletely fluorinated impurities to solids which are then removed by filtration.
In 1984, U.S. production of Dipropylamine was 41 million pounds.
Safety Profile:
Dipropylamine is moderately toxic by shin contact and inhalation.
Dipropylamine is a skin irritant.
Dipropylamine is a very dangerous fire hazard, when exposed to heat or flame.
Dipropylamine can react with oxidizers.
Dipropylamine explosion hazard is unknown.
Keep Dipropylamine away from heat and open flame.
Metabolism of Dipropylamine:
There is little information available on the metabolism and disposition of dipropylamine in biological systems.
The available evidence suggests that dipropylamine is not a substrate for monoamine oxidase, but rather is inhibitory.
Valiev administered dipropylamine intraperitoneally to rats and reported it to be moderately inhibitory to liver monoamine oxidase.
Previous work by this author demonstrated that lethal doses of dipropylamine and other secondary and tertiary amines significantly inhibited rat liver monoamine oxidase activity.
The carcinogenic N-nitrosodipropylamine has been detected in the stomach when dipropylamine (present in fish, vegetables and fruit juices) comes in contact with nitrite, which is often used as a food additive in meats and smoked fish.
Further metabolism of the carcinogen N-nitrosodipropylamine product formed upon nitrosation of dipropylamine is required to form a highly electrophilic carbonium ion capable of alkylating DNA, etc.
Di-n-propylamine is a member of the class of compounds known as dialkylamines.
Dialkylamines are organic compounds containing a dialkylamine group, characterized by two alkyl groups bonded to the amino nitrogen.
Di-n-propylamine is soluble (in water) and a very strong basic compound (based on its pKa).
Di-n-propylamine can be found in a number of food items such as wild celery, orange bell pepper, yellow bell pepper, and pepper (c. annuum), which makes di-n-propylamine a potential biomarker for the consumption of these food products.
Dipropylamine hydrochloride is the hydrochloride salt of Dipropylamine (D492150).
Dipropylamine hydrochloride is also used as a reagent to prepare derivatives of 4-(2-N,N-di-n-propylaminoethyl)-5-hydroxyindole, some of which are potent, active dopaminergic agonists.
Air & Water Reactions of Dipropylamine:
Dipropylamine is highly flammable.
Dipropylamine is soluble in water.
Propylamine, dipropylamine and triplopylamine were adsorbed on sepiolite specimens under reflux, at their normal boiling points.
The infrared spectra of the original and the amine adsorbed specimens were recorded before and after heat treatments between 50-400"C.
The examination of the spectra revealed that the adsorption of amines took place by the replacement of the zeolitic water in the pores of the sepiolite by the amines.
Fire Hazard:
Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires.
The relative density was 0.7401.
Boiling point 109~110 deg C.
Melting Point -63.6 °c.
Flash point 7 ℃.
Refractive index 4042.
The vapor pressure at 20 °c was 2.80 kPa.
Slightly soluble in water, soluble in ethanol and ether, etc.
Hydrate formation with water.
Dipropylamine - Preparation Method:
The N-propanol amination method is obtained by catalytic dehydrogenation, amination, dehydration and hydrogenation of propanol as a raw material (see tripropylamine).
Acrylonitrile hydrogenation method using acrylonitrile as a raw material and a copper-nickel compound as a catalyst, the catalytic hydrogenation is carried out at a temperature of 40-250 ° C.
And a pressure of 0-4.9 MPa to obtain dipropylamine.
Density: 0.7±0.1 g/cm3
Boiling Point: 108.8±0.0 °C at 760 mmHg
Melting Point: -63 °C
Molecular Formula: C6H15N
Molecular Weight: 101.190
Flash Point: 3.9±0.0 °C
Exact Mass: 101.120445
PSA: 12.03000
LogP: 1.70
Vapour Pressure: 25.5±0.2 mmHg at 25°C
Index of Refraction: 1.405
Stability: Stable. Highly flammable. Incompatible with strong oxidizing agents.
Water Solubility: soluble
Use and emission sources:
Manufacture of organic products, manufacture of pesticides
In this work, a comprehensive study of the hydrothermal synthesis and catalytic performance of SAPO-34 templated by the isomeric dipropylamine (DPA) and diisopropylamine (DIPA) was carried out.
SAPO-34 with a faster crystallization rate and lower Si content could be obtained with DIPA as the template, suggesting the better templating efficacy of DIPA than DPA.
Theoretical calculations reveal that DIPA possesses more favourable non-bonding interactions with the CHA framework and the electronic configuration is of vital importance in determining the template efficacy.
SAPO-34-DIPA with low silicon contents exhibits excellent performance, over which a maximum selectivity of ethylene plus propylene (87.2%) is observed.
This value should be among the top ever reported.
The surface Si enrichment on the crystals, which is both template- and condition-dependent, is revealed to be of significant influence in the catalytic performance.
The relatively homogenous Si distribution in the crystals, lower acid concentration and weaker acid strength corporately make SAPO-34-DIPA an excellent MTO catalyst.
Reactivity Profile of Dipropylamine:
DIPROPYLAMINE neutralizes acids in exothermic reactions to form salts plus water.
Dipropylamine may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Dipropylamine is flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Synonyms: N-propylpropan-1-amine, dipropylamine, N-dipropylamine, N-propyl-1-propanamine, N-propyl-propylamine
Molecular Weight: 101.19
XLogP3: 1.7
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 4
Exact Mass: 101.120449483
Monoisotopic Mass: 101.120449483
Topological Polar Surface Area: 12 Ų
Heavy Atom Count: 7
Formal Charge: 0
Complexity: 23.4
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
REASON FOR CITATION:
* Dipropylamine is on the Hazardous Substance List because it is cited by DOT, NFPA and EPA.
* Dipropylamine is on the Special Health Hazard Substance List because it is FLAMMABLE.
HAZARD SUMMARY:
-Dipropylamine can affect you when breathed in.
-Dipropylamine can severely irritate and burn the skin and eyes on contact.
-Breathing Dipropylamine can irritate the nose and throat causing coughing and wheezing.
-Breathing Dipropylamine can irritate the lungs causing coughing and/or shortness of breath. Higher exposures can cause a build-up of fluid in the lungs (pulmonary edema), a medical emergency, with severe shortness of breath.
-Exposure to Dipropylamine can cause headache, nausea, fainting, and anxiety.
-Dipropylamine is a FLAMMABLE LIQUID and a DANGEROUS FIRE HAZARD.
Density: 0.7400g/mL
Color: Undesignated
Melting Point: -63.0°C
Boiling Point: 105.0°C to 110.0°C
Flash Point: 7°C
Assay Percent Range: 98.5% min. (GC)
Infrared Spectrum: Authentic
Linear Formula: (CH3CH2CH2)2NH
Packaging: Glass bottle
Beilstein: 04, 138
Merck Index: 15, 3383
Refractive Index: 1.4030 to 1.4050
Quantity: 250mL
Solubility Information: Solubility in water: 46g/L (20°C). Other solubilities: freely soluble in alcohol
Specific Gravity: 0.74
Formula Weight: 101.19
Physical Form: Liquid
Percent Purity: 99%
Viscosity: 0.5 mPa.s (20°C)
Water : 0.2% max.
Chemical Name or Material: Dipropylamine, 99%
142-84-7 [RN]
1-Propanamine, N-propyl- [ACD/Index Name]
205-565-9 [EINECS]
DI-N-PROPYLAMINE
Dipropylamine [Wiki]
Dipropyl-amine
JL9200000
MFCD00009362 [MDL number]
n-Dipropylamine
n-propyl-1-propanamin [ACD/IUPAC Name]
N-Propyl-1-propanamin [German] [ACD/IUPAC Name]
N-Propyl-1-propanamine [ACD/IUPAC Name]
N-Propyl-1-propanamine [French] [ACD/IUPAC Name]
N-Propylpropan-1-amine
(n-C3H7)2NH [Formula]
3,3'-IMINODIPROPIONITRILE
345909-05-9 [RN]
63220-61-1 [RN]
92517-02-7 [RN]
DI(N-PROPYL)AMINE
DI(PROPYL-3,3,3-D3)AMINE
DI-N-PROPYL-1,1,2,2,3,3,3-D7-AMINE (MONO-PROPYL-D7)
Di-n-propylamin
Di-n-propyl-d14-amine
dipropilamina [Portuguese]
dipropyl amine
DiPropylamine Reagent Grade
dipropylammonium
EINECS 205-565-9
InChI=1/C6H15N/c1-3-5-7-6-4-2/h7H,3-6H2,1-2H
N,N-dipropylamine
N-Propyl-propylamine
STR03559
UN 2383
DIPROPYLAMINE
Di-n-propylamine
142-84-7
1-Propanamine, N-propyl-
N-propylpropan-1-amine
n-Dipropylamine
N-Propyl-1-propanamine
RCRA waste number U110
dipropyl amine
di(n-propyl)amine
UNII-60P318IIRY
DIPROPYL-AMINE
di-n-propylamin
60P318IIRY
RCRA waste no. U110
CCRIS 4805
HSDB 2644
EINECS 205-565-9
UN2383
BRN 0505974
di-propylamine
AI3-24037
di-n-propyl amine
N,N-Dipropylamine
N-propyl propylamine
N-propyl-propylamine
MFCD00009362
Dipropylamine, 99%
N,N-Dipropylamine #
N,N-di-n-propylamine
DSSTox_CID_5185
DiPropylamine Reagent Grade
EC 205-565-9
DSSTox_RID_77699
DSSTox_GSID_25185
SCHEMBL15445
(n-C3H7)2NH
CHEMBL3185961
DTXSID2025185
STR03559
ZINC1672989
Tox21_202085
BBL027756
STL194269
AKOS000118843
MCULE-6223802621
UN 2383
NCGC00249163-01
NCGC00259634-01
CAS-142-84-7
D0930
FT-0614098
FT-0625300
Dipropylamine [UN2383] [Flammable liquid]
104486-EP2292597A1
104486-EP2298761A1
104486-EP2301627A1
125304-EP2295424A1
Q410621
J-007705
J-520390
F2190-0303
Trade name
1-Propanamine, N-propyl- (9CI)
Di-n-propylamin
Di-n-propylamine
Di-n-propylamine (DnPA)
Dipropylamin
Dipropylamine
Dipropylamine (8CI)
N-Propyl-1-propanamine
n-Dipropylamine
sek. Alkylamin
Alternate Name(s)
N,N-Dipropylamine
(N-C3H7)2NH
Di-n-propyl amine
N-Dipropylamine
N-Propyl-1-propanamine
N-Propyl-propylamine
N-propylpropan-1-amine
AI3-24037
BRN 0505974
CCRIS 4805
EINECS 205-565-9
HSDB 2644
RCRA WASTE NO. U110
UN2383
Synonyms
N,N-Dipropylamine
N-Propyl-1-propanamine
Di-n-propylamine
2 propylamine
N-propylpropan-1-amine
N-propylpropan-1-aminium