HEXANEDIOIC ACID

Hexanedioic acid = Adipic Acid = AA

CAS Number: 124-04-9
EC Number: 204-673-3
Chemical formula: C6H10O4
Molar mass: 146.142 g·mol−1

Hexanedioic acid or Adipic acid is the organic compound with the formula (CH2)4(COOH)2.
Hexanedioic acid otherwise rarely occurs in nature.
Hexanedioic acid is known as manufactured E number food additive E355.

Hexanedioic acid is a white crystalline, solid that occurs naturally in beet juice.
Hexanedioic acid is prepared synthetically from cyclohexanol.
Hexanedioic acid is primarily used in the production of Nylon and Polyurethane foams.

Hexanedioic acid is mainly used as a monomer for the production of polyamide 6.6 pellets and other polyamides or polymers in the field of Engineering Plastics, Textile Fibers and Industrial Yarns as well as Polyurethane for flexible and semi-rigid foams.
Hexanedioic acid is also used as an intermediate for organic synthesis in the field of lubricants, plasticizers, wet strength resins, coatings, adhesives, sealants and elastomers, perfumes and cosmetics.
In addition, Hexanedioic acid is used in formulation in the field of pH regulator and buffer and used as laboratory chemicals.

Hexanedioic acid is a white crystalline solid.
Hexanedioic acid is insoluble in water.

The primary hazard is the threat to the environment.
Immediate steps should be taken to limit Hexanedioic acids spread to the environment.
Hexanedioic acid is used to make plastics and foams and for other uses.

Hexanedioic acid is an alpha,omega-dicarboxylic acid that is the 1,4-dicarboxy derivative of butane.
Hexanedioic acid has a role as a food acidity regulator and a human xenobiotic metabolite.

Hexanedioic acid is an alpha,omega-dicarboxylic acid and a dicarboxylic fatty acid.
Hexanedioic acid is a conjugate acid of an adipate(1-).

Hexanedioic acid is a straight-chain aliphatic dicarboxylic acid, commonly used in the manufacturing of nylon-6,6 and plasticizers.
Conventionally Hexanedioic acid was manufactured from petrochemicals but in recent days Hexanedioic acid can be synthesized from renewable substrates by means of biological methods.

Hexanedioic acid otherwise rarely occurs in nature.
Other major applications of Hexanedioic acid also involve polymers.
Hexanedioic acid is a monomer for production of polyurethane and Hexanedioic acids esters are plasticizers.

Hexanedioic acid also known as Hexane-1,6-dioic acid is a dibasic acid with the molecular formula C3H8O4, CAS 124-04-9.
Hexanedioic acid is slightly soluble in water and soluble in alcohol and acetone.

Hexanedioic acid (hexanedioic acid) and pimelic acid (heptanedioic acid) pyrolyze differently from the acids with a smaller number of carbon atoms.
Belongs to the class of organic compounds known as medium-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.

Hexanedioic acid, or more formally hexanedioic acid, is a white crystalline solid that melts at 152 ºC.
Hexanedioic acid is one of the most important monomers in the polymer industry.
Today, the most common manufacturing process is the nitric acid (HNO3) oxidation of a cyclohexanol–cyclohexanone mixture called KA (for ketone–alcohol) oil.

Almost all Hexanedioic acid is used as a comonomer with hexamethylenediamine to produce nylon 6-6.
Hexanedioic acid is also used to manufacture other polymers such as polyurethanes.
Using HNO3 to produce Hexanedioic acid has Hexanedioic acids downside: Copious amounts of nitrous oxide (N2O), a greenhouse gas, are coproduced and released into the atmosphere.
This method eliminates the production of N2O; but before the process can be used commercially, problems associated with the formation of organic peroxides from ozone and the difficulty of using UV light on a large scale must be overcome.

Hexanedioic acid is used mainly in the production of nylon.
Hexanedioic acid occurs relatively rarely in nature.
Hexanedioic acid has a tart taste and is also used as an additive and gelling agent in jello or gelatins.

Hexanedioic acid is also used in some calcium carbonate antacids to make them tart.
Hexanedioic acid has also been incorporated into controlled-release formulation matrix tablets to obtain pH-independent release for both weakly basic and weakly acidic drugs.
Hexanedioic acid in the urine and in the blood is typically exogenous in origin and is a good biomarker of jello consumption.

In fact, a condition known as Hexanedioic aciduria is actually an artifact of jello consumption (PMID: 1779643 ).
However, certain disorders (such as diabetes and glutaric aciduria type I.) can lead to elevated levels of Hexanedioic acid snd other dicarboxcylic acids (such as suberic acid) in urine (PMID: 17520433 ; PMID: 6778884 ).
Moreover, Hexanedioic acid is also found to be associated with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.
Hexanedioic acid is also microbial metabolite found in Escherichia.

Hexanedioic acid is a mildly toxic, white, crystalline compound.
The C6 straight-chain dicarboxylic acid is slightly soluble in water and soluble in alcohol and acetone.
Nearly all commercial Hexanedioic acid is produced from cyclohexane.

This carbonic acid is frequently used in fluxes as an activator.
Hexanedioic acids characteristic lies in the (-COOH) group(s).
Hexanedioic acid reacts in the presence of temperature with metal oxides and converts these into metall.
With this reaction, oxides resting on the surface of the areas to be soldered are removed and the liquid solder can react with the pure metall.

Production of Hexanedioic acid and Derivatives from Carbohydrate-Containing Materials
The present invention generally relates to processes for the chemocatalytic conversion of a glucose source to an Hexanedioic acid product.
The present invention includes processes for the conversion of glucose to an Hexanedioic acid product via glucaric acid or derivatives thereof.

The present invention also includes processes comprising catalytic oxidation of glucose to glucaric acid or derivative thereof and processes comprising the catalytic hydrodeoxygenation of glucaric acid or derivatives thereof to an Hexanedioic acid product.
The present invention also includes products produced from Hexanedioic acid product and processes for the production thereof from such Hexanedioic acid product.

Our high purity Hexanedioic acid (AA) is an important intermediate in the production of Nylon 6.6 but also used for a wide range of applications: resins, adhesives, coatings, plastics, paper, plasticizers, and detergency.
We offer Hexanedioic acid in the form of powder (density of untamped powder: 0.63 - 0.65 g/cm³).

Mom, dad, racecar, kayak, radar, sagas - can you guess what these words have in common? They are palindromes.
Palindromes are words that can be read the same way backward as forward.
What these words have in common with Hexanedioic acid is simple - the structural formula of Hexanedioic acid is like a palindrome.

Hexanedioic acid is composed of carbon, hydrogen and oxygen.
Hexanedioic acids basic formula is C6H10O4.
This means Hexanedioic acid has a total of 6 carbons, 10 hydrogens and 4 oxygens.

If you write Hexanedioic acid as a basic formula, Hexanedioic acid doesn't look much like a palindrome, but how about if Hexanedioic acid was written like this: HOOCHCHHCHHCHHCHCOOH.
You'll notice at the beginning and the end there is a HOOC.
This group is known as a called a carboxyl

When attached to other groups in chemistry Hexanedioic acid is referred to as a carboxylic acid.
A carboxyl group makes up both ends of Hexanedioic acid, and since there are two of them, Hexanedioic acid is categorized as a dicarboxylic acid (di meaning 2).
Hexanedioic acid isn't Hexanedioic acids only name, but Hexanedioic acid's the one most commonly used.

Stuck in the middle of the two carboxylic acids is a group of four carbons with two hydrogens that is often abbreviated (CH2).
Thus the structure of Hexanedioic acid is a 6 carbon chain with two carboxylic acid groups at each end.

Hexanedioic acid has been incorporated into controlled-release formulation matrix tablets to obtain a pH-independent release for both weakly basic and weakly acidic drugs.
Hexanedioic acid has also been incorporated into the polymeric coating of hydrophilic monolithic systems to modulate the intragel pH, resulting in zero-order release of hydrophilic drugs.
The disintegration at intestinal pH of the enteric polymer shellac has been reported to improve when Hexanedioic acid was used as a pore-forming agent without affecting release in the acidic media.
Hexanedioic acid is used to make bisobrin an antifibrinolytic.

Hexanedioic acid, FCC is used as a food ingredient as a flavorant and gelling aid and as an acidulant in baking powders.
Spectrum Chemical offers over 300 Food Grade (FCC) chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Hexanedioic acid (hexanedioic acid or 1,4-butanedicarboxylic acid) is a white crystalline solid.
Hexanedioic acid is used in the manufacturing of nylon and of polyurethane foams.
Hexanedioic acid is also commonly used in food preparations during the Easter holiday as plasticizers and lubricants or as a food additive, in baking powders and adhesives.

Synthesis of Hexanedioic acid:
A simple, straightforward, and environmentally benign protocol for the synthesis of Hexanedioic acid from oxidation of cyclohexanone with Oxone in the presence of 0.5 mol% RuCl3 · nH2O is reported.
The reaction completes within a very short time even at room temperature.
The generality of the method is shown successfully for synthesis of other C-5 to C-8 dicarboxylic acids.

Solubility of Hexanedioic acid in Organic Solvents and Water:
The solubility of Hexanedioic acid in methanol, ethanol, propanol, isopropanol, n-butanol, tert-butanol, acetone, 1,4-dioxane, acetic acid, and water was measured within the 0–60°C temperature range.
A sampler for determination of the temperature dependence of the solubility of solids in liquids by the isothermal method was suggested.
The thermodynamic parameters of solution of Hexanedioic acid in the above solvents were calculated.
The dependence of the solubility on the solvent and temperature was considered.

Hexanedioic acid, also known as hexanedioic acid, is produced from a mixture of cyclohexanol and cyclohexanone with air or nitric acid.
Hexanedioic acid is naturally found in beets and sugar cane.

Hexanedioic acid is commonly added as the main acid in bottled drinks, giving them a bubbly fizz.
Hexanedioic acid is also adds a tart flavor to fruit juice and gelatin.

The organic acid is used in many powdered food and drink mixes to provide a sweet flavor.
Along with adding tartness, Hexanedioic acid allows jam, gelatin and jelly to jiggle but still hold their shape.
Hexanedioic acid adds texture to some types of cheese and can serve as a leavening agent in baking powder, cake mixes and baked goods.
Food oil manufacturers add Hexanedioic acid to their edible oils in order to prolong the time Hexanedioic acid takes for bottled oils to become rancid.
When used as a food acidulant in products, acidic acid is clearly identified in the ingredient list by Hexanedioic acids name or food additive number 355.

These corrosion data are mainly based on results of general corrosion laboratory tests, carried out with pure chemicals and water solutions nearly saturated with air (the corrosion rate can be quite different if the solution is free from oxygen).
All concentrations are given in weight-% and the solvent is water if nothing else is shown.
The corrosion data apply to annealed materials with normal microstructure and clean surfaces, throughout.

Hexanedioic acid is also used as a Plasticizer, Lubricant, and a food additive in baking powder (in place of Cream of tartar) and in beverages (in place of Citric acid).
Hexanedioic acid is not Hygroscopic.
Prior to 1940, Hexanedioic acid was also used for bronzing metals, preparing photographic paper, textile dyeing, and as a component in synthetic wax sizes mixed with Glycerol, Stearic acid, and Palmitic acid.

Ascend is the only large-scale producer of food-grade Hexanedioic acid in the world.
Ascend ships Hexanedioic acid in a variety of package sizes, including rail cars, tank trucks, super sacks and 50-pound bags, via our established, efficient global distribution network.

What Foods Contain Hexanedioic acid?
Providing tart taste, gel-like shape, firm texture and fizzy flavors, Hexanedioic acid is a rather flexible food additive.
Although Hexanedioic acid’s found naturally in a few foods, most of the Hexanedioic acid found in the food supply is synthetic.
Although Hexanedioic acid has been approved for safe consumption since 1965, some people try to avoid this and other food additives altogether.
In that case, Hexanedioic acid’s important to know which foods contain synthetic Hexanedioic acid.

Identification of Hexanedioic acid:
Hexanedioic acid’s used in a variety of industrial and textile applications, such as to manufacture lubricants and nylon production.
Hexanedioic acid can be found in carpet, automobile tires and clothing.
The Chemical Company website explains that a majority of Hexanedioic acid production is used in these industrial applications.
The other 10 percent is made specifically for use in foods and beverages.

Hexanedioic acid for Flavor:
Hexanedioic acid is naturally found in beets and sugar cane.
The synthetic version of Hexanedioic acid is commonly added as the main acid in bottled drinks, giving them a bubbly fizz.

Hexanedioic acid also adds a tart flavor to fruit juice and gelatin.
The organic acid is used in many powdered food and drink mixes to provide a sweet flavor.
Hexanedioic acid might also be found in imitation flavor extracts, dairy products, tart condiments like pickles and relish and throat lozenges.

Hexanedioic acid for Texture:
Along with adding tartness, Hexanedioic acid allows jam, gelatin and jelly to hold their jiggly shapes.
It gives a firm texture to some types of cheese and serves as a leavening agent in baking powder, cake mixes and baked goods.
Hexanedioic acid is also frequently added to edible oils, prolonging the time Hexanedioic acid takes for them to become rancid.

Production of Apidic Acid:
Hexanedioic acid is isolated as odorless, colorless crystals with an acidic taste.
Hexanedioic acid undergoes the reactions of carboxylic acids, reacting at one or both carboxylic acid groups to form salts, esters, amides, nitriles and so on.

Because of the bifunctional nature of this acid (Figure 1), Hexanedioic acid is used in a number of industrial polymerization processes.
Hexanedioic acid is an industrially important 6-carbon dicarboxylic acid[/caption] Most Hexanedioic acid is used captively by the producer in the manufacture of nylon-6,6 polyamide, prepared by reaction of Hexanedioic acid with 1,6-hexanediamine.
Hexanedioic acid is also used for a wide range of applications, including: conversion to esters; in placticizers, lubricants and polyurethane resins; as an acidulant for gelatins and jams; as a food additive for buffering or neutralizing; to make insect repellent; as a starch crosslinking agent; and as an intermediate for paints.
Commercial production of Hexanedioic acid has been predominantly based on cyclohexane and, to a lesser extent, phenol.
In light of shifts in hydrocarbon pricing, alternative Hexanedioic acid production.

Hexanedioic acid is a white crystalline, solid that occurs naturally in beet juice.

KEYWORDS:
124-04-9, 204-673-3, Adipic Acid, AA, Adilactetten, 1 6-Hexanedioic acid, Molten Hexanedioic acid, Hexanedioate, FEMA No. 2011, UNII-76A0JE0FKJ

Identifiers of Hexanedioic acid:
CAS Number:124-04-9
Beilstein Reference: 1209788
ChEBI: CHEBI:30832
ChEMBL: ChEMBL1157
ChemSpider: 191
ECHA InfoCard: 100.004.250
EC Number: 204-673-3
E number: E355 (antioxidants, ...)
Gmelin Reference: 3166
KEGG: D08839
RTECS number: AU8400000
UNII: 76A0JE0FKJ
UN number: 3077
CompTox Dashboard (EPA): DTXSID7021605
InChI: InChI=1S/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10) check
Key: WNLRTRBMVRJNCN-UHFFFAOYSA-N check
InChI=1/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10)
Key: WNLRTRBMVRJNCN-UHFFFAOYAY
SMILES: O=C(O)CCCCC(=O)O
C(CCC(=O)O)CC(=O)O

The nylon (polyamide) is further processed into fibers for applications in carpeting, automobile tire cord, and clothing.
Hexanedioic acid is also used to manufacture plasticizers and lubricant components.
Food grade Hexanedioic acid is used as a gelling aid, an acidulant, and as a leavening and buffering agent.
Molecular Formula: C6H10O4

Hexanedioic acid Market Overview:
Hexanedioic acid is one of the most commercially important type of aliphatic dicarboxylic acids, especially due to Hexanedioic acids significant usage as a feedstock for the production of industrial fibers.
Hexanedioic acid is produced from the oxidation of a mixture of cyclohexanol and cyclohexanone with nitric acid.
Alternatively, Hexanedioic acid can also be produced from butadiene carbonylation.

There has been a significant demand for chemically resilient, strong and durable fibers for the manufacture of automotive parts.
This has initiated a strong demand for Hexanedioic acid, since Hexanedioic acid is one of the key ingredients for the production of composite materials.
The major consumption of Hexanedioic acid is as the feedstock for the production for nylon 6,6 resin and engineering fibers.

The non-nylon applications of Hexanedioic acid include Hexanedioic acids usage in the manufacture of polyurethanes, plasticizers, food additives and pharmaceuticals.
The escalating demand for Hexanedioic acid from automotive, electrical & electronics, consumer goods and appliances industry is one of the chief drivers for the Hexanedioic acid market.
The extensive research and development in the textile production technology is also one of the key factors influencing the Hexanedioic acid market.
The companies are focusing on developing high quality, durable, lightweight and high absorption capacity fibers which are capable of enduring extreme conditions such as high temperatures and are chemically inert as well.

The Hexanedioic acid market has witnessed a significant growth in the recent decade and the trend is anticipated to continue for the forecast period.
However, the presence of stringent environmental regulations in different regions and the rise of hybrid fibers is expected to restrain the Hexanedioic acid market.
The Hexanedioic acid market can be segmented on the basis of the regions as North America, Latin America, APEJ, Japan, Eastern Europe, Western Europe and Middle East & Africa.

In terms of production and consumption APEJ is the biggest market for the Hexanedioic acid.
The chief markets in APEJ region include India and China, which are forecasted to exhibit double digit CAGR owing to relatively relaxed regulation and high demand from the automotive manufacturers markets Followed by APEJ the next most promising region is Middle East and Africa, which will be a chief participant in the Hexanedioic acid market in the coming years.
Although North America is one of the largest market for Hexanedioic acid in terms of consumption.
However, the demand in this regions is modest and is anticipated to exhibit modest growth over the forecast period.
Europe is anticipated to exhibit a modest growth in imminent years for Hexanedioic acid owing to Hexanedioic acids high demand in the automotive industry, but the market in this region is limited due to the presence of strict regulations.

Molecular Weight Description of Hexanedioic acid:
The Hexanedioic acid molecule consists of 10 Hydrogen atom(s), 6 Carbon atom(s) and 4 Oxygen atom(s) - a total of 20 atom(s).
The molecular weight of Hexanedioic acid is determined by the sum of the atomic weights of each constituent element multiplied by the number of atoms, which is calculated to be:
146.1412⋅g/mol

The exact term of the above molecular weight is “molar mass”, which is based on the atomic mass of each element.
Molecular weight is actually an older term of “relative molar mass” or “molecular mass”, which is a dimensionless quantity equal to the molar mass divided by the molar mass constant defined by 1 g/mol.
Molecular masses are calculated from the standard atomic weights of each nuclide, while molar masses are calculated from the atomic mass of each element.
The atomic mass takes into account the isotopic distribution of the element in a given sample.

Hexanedioic acid is commonly known as “fat acid” with the formula C6H10O4, molecular weight is 146.14, which is an importantdibasic acidin aliphaticsdibasic acid.
Hexanedioic acid is a kind of white crystalline solid, and odorless.

Hexanedioic acid has common features with aliphaticsdibasic acid, including salt forming reaction, esterification reaction, amidation, etc.
Meanwhile, Hexanedioic acid can form polymer with diamine through polycondensation reaction.

Hexanedioic acid is mainly used in producing nylon fiber and engineering plastics, and polyurethane in quantity.
Most of parts are used to produce PU, liquid for sole, polyurethane foam, etc.
A small number of them are used for high quality lubricating oil.
High quality ester of Hexanedioic acid can be used as PVC and Hexanedioic acids copolymer, plasticizer of natural synthetic rubber.
A large number of Hexanedioic acid ester is used to produce food packaging, thin film and PVC for insulation.

Hexanedioic acid is also used for sour agent of food and drink.
Hexanedioic acid is not easy to deliquesce, so Hexanedioic acid is used in dry food, and can be kept in a long time.

The Hexanedioic acid products adopt cyclohexene method to make cyclohexanol, then nitric acid oxidation.
The products have obvious advantages, such as high purity, good quality, and large output.
The production technology has obvious advantages of low raw material consumption, low energy consumption, low three wastes discharge, high automaticity, safety and environmental protection.

We have: pure Hexanedioic acid, cyclohexane, cyclohexanol,diacid, cyclohexene, dilute nitric acid(65%), etc.
Safety, storage and transportation: Hexanedioic acid is stable, non-toxic, and not easy to deliquesce.
Be careful of water-proof, rain-proof when transportation.
When the content is higher than 14%, Hexanedioic acid is easy to have static to cause fire, so please use carefully.
The upper explosive limit of Hexanedioic acid dust mixed with air blending is 7.9%, the lower limit is 3.94%.

Hexanedioic acid, also known as fatty acid, is an important organic diacid with the molecular formula C6H10O4.
HS code for Hexanedioic acid is 29171200.
Widely used in applications of sole raw liquor, PU coating, TPU, nylon 66, plasticizer, adhesives, and so on.

Manufacture of Hexanedioic acid:
Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Origin of Hexanedioic acid:
Natural sources of Hexanedioic acid include beet and sugar cane, pork fat, guava fruit, papaya and raspberry which are economically feasible.
Commercially-available Hexanedioic acid crystalline powder is obtained via a synthetic process which was developed in 1906 for industrial applications and is still used today.

Regulatory approval for using this acid in foods was granted in 1965.

Article No. : 00710
Grade: Extra Pure
Purity: 99%
Molecular Formula: C6H10O4
Molecular Weight: 146.14
H.S. Code: 2917.1200
Shelf Life: 60 Months

Physicochemical Information of Hexanedioic acid:
Density: 1.36 g/cm3 (25 °C)
Flash point: 196 °C
Ignition temperature: 405 °C
Melting Point: 150.85 °C
pH value: 2.7 (23 g/l, H₂O, 25 °C)
Vapor pressure: 0.097 hPa (18.5 °C)
Bulk density: 700 kg/m3
Solubility: 15 g/l

Function of Hexanedioic acid:
Hexanedioic acid serves several functions in baked goods:
Leavening acidulant along with baking powder

pH regulator mainly in confections, jellies and jams
Buffering agent mainly for systems in the pH 2.5-3.0 range
Unique flavor enhancement and desirable smooth tartness

Sequestrant in edible oil and fats
Whipping ability enhancer in egg whites
Gelling aid in gelatin-based desserts
Ascorbic acid and cream of tartar substitute with improved results

Nutrition of Hexanedioic acid:
Hexanedioic acid is safe for consumption under the set conditional daily intake of 0 – 5 mg/kg of body weight.

Almost 90 percent of Hexanedioic acid produced is used in the production of nylon 66.
The nylon, which has a protein-like structure, is further processed into fibers for applications in carpeting, automobile tire cord, and clothing.
Hexanedioic acid is also used to manufacture plasticizers and lubricant components.
Food grade Hexanedioic acid is used as a gelling aid, an acidulant, and as a leavening and buffering agent.

Hexanedioic acid is an organic compound with the formula (CH2)4(COOH)2.
Hexanedioic acid is the most important of the dicarboxylic acids from the industrial perspective.

Hexanedioic acid rarely occurs in nature.
Historically, Hexanedioic acid was prepared from various fats by oxidation.
Currently, Hexanedioic acid is made from a mixture of cyclohexanone and cyclohexanol called “KA oil,” the abbreviation of “ketone-alcohol oil.”

The KA oil is oxidized using nitric acid to produce Hexanedioic acid, via a multistep pathway.
Early in the reaction, cyclohexane is converted to the ketone, which releases the nitrous acid.
Several methods have been developed by carbonylation of butadiene.

For example, the hydrocarboxylation proceeds as follows:
CH2=CHCH=CH2 2CO 2H2O —> HOOC(CH2)4COOH

A method has been reported that uses principles of green chemistry where water is the only by-product.
Cyclohexene is oxidized with hydrogen peroxide using a tungstate-based catalyst and a phase transfer catalyst.
Again, the only waste product is water.

90% of Hexanedioic acid is consumed in the industry for the production of nylon by poly-condensation with hexamethylenediamine.
Hexanedioic acid is mainly used for the production of nylon 6,6 polymer for fibers and plastics.
Nylon has a protein-like structure.
Hexanedioic acid can be further processed into the fibers for applications in carpets (felts), automobile tire cords and clothing.

Hexanedioic acid can be used in the production of Hexanedioic acid plasticizer and lubricant components.
Hexanedioic acid can be used in the production of polyester polyols for polyurethane systems.

Technical grade Hexanedioic acid can be used to produce plasticizers, to add flexibility and to give flexibility to unsaturated polyesters.
Hexanedioic acid can be used in the production of rigid and flexible foams, in the production of wire coaters, elastomers and adhesives, to increase the flexibility of alkyd resins, in the production of wet strong resins and in the production of synthetic lubricants and oils for the paper chemical industry.

Acetic Acid is an organic compound with the chemical formula CH3COOH (also written as CH3CO2H or C2H4O2).
Hexanedioic acid is a colorless liquid that when undiluted is also called glacial acetic acid.
Vinegar is roughly 4%-8% acetic acid by volume, making acetic acid the main component of vinegar apart from water.

Acetic acid has a distinctive sour taste and pungent smell.
Besides Hexanedioic acids production as household vinegar, Hexanedioic acid is mainly produced as a precursor to polyvinylacetate and cellulose acetate.

Hexanedioic acid is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 000 tonnes per annum.
Hexanedioic acid is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment)

Hexanedioic acid formation from cyclohexanediol using platinum and vanadium catalysts:
Vanadium compounds have shown great potential alongside Pt/C for the oxidation of cyclohexanediol to Hexanedioic acid.
However, the low stability of these materials often leads to ambiguity when considering the homogeneous or heterogeneous nature of the active species.
In this article we describe our attempts to synthesise stable vanadium catalysts through the utilisation of vanadium bronze structures.

By the addition of sodium, copper or silver into these structures, leaching could be decreased to 5% for AgVO3, compared to 88.4% with V2O5.
These reactions were run in aqueous conditions under 3 bar O2.
However, despite significant stabilisation of vanadium in the bronze structures, we show that as little as 7.6 ppm of a homogeneous vanadium species in the reaction solution can cause the selective oxidation of 2-hydroxycyclohexanone to Hexanedioic acid.
Analysis of the speciation by 51V NMR and UV-vis has revealed the active species to be in the +5 oxidation state in the form of a decavanadate compound with the presence of small amounts of monovanadate.

Hexanedioic acid is one of the most important feedstocks for producing resins, nylons, lubricants, plasticizers.
Current industrial petrochemical process, producing Hexanedioic acid from KA oil, catalyzed by nitric acid, has a serious pollution to the environment, due to the formation of waste nitrous oxide.
Hence, developing cleaner methods to prouce Hexanedioic acid has attracted much attention of both industry and academia.
Hexanedioic acid is an intermediate monomer used for the production of polyamides (Nylon), polyester polyols for polyurethanes, lubricants, plasticizers, wet strength resins, coatings, adhesives, sealants and elastomers as well as pharmaceutical products, perfumes and cosmetics.

Aipic acid, hexanedioic acid, 1,4-butanedicarboxylic acid, mol wt 146.14, HOOCCH2CH2CH,CH2COOH, is a white crystalline solid with a melting point of about 152°C.
Little of this dicarboxylic acid occurs naturally, but Hexanedioic acid is produced on a very large scale at several locations around the world.
The majority of this material is used in the manufacture of Nylon-6,6 polyamide, which is prepared by reaction with 1,6-hexanediamine.
Hexanedioic acid is a colorless, odorless, sour-tasting crystalline solid that undergoes reactions including esterification, amidation, reduction, halogenation, salt formation, and dehydration.

Hexanedioic acid also undergoes several industrially significant polymerization reactions.
Hexanedioic acid historically has been manufactured predominantly from cyclohexane.
However, much research continues to be directed to alternative feedstocks, especially butadiene and cyclohexene, as dictated by shifts in hydrocarbon pricing.
Air quality regulations may exert further pressure for alternative routes as manufacturers seek to avoid NOx abatement costs.

When dispersed as a dust, Hexanedioic acid is subject to normal dust explosion hazards.
The material is an irritant, especially upon contact with the mucous membranes.
Protective goggles or face shields should be worn when handling the material.
The material should be stored in corrosion-resistant containers, away from alkaline or strong oxidizing materials.

Hexanedioic acid is a very large-volume organic chemical and is one of the top 50 chemicals produced in the United States in terms of volume, although demand is highly cyclic.
Hexanedioic acid for nylon takes ∼60% of U.S. cyclohexane production.
Hexanedioic acid is relatively nontoxic.

Hexanedioic acid is a white crystalline solid.
Hexanedioic acid is insoluble in water.
The primary hazard is the threat to the environment.

Immediate steps should be taken to limit Hexanedioic acids spread to the environment.
Hexanedioic acid is used to make plastics and foams and for other uses.

The researchers are struggling to establish more reliable, renewable and affordable Hexanedioic acid synthesis methods, and among which, biological synthesis of Hexanedioic acid is attracting the most attention.
There are two biological routes for adipate synthesis: (1) biological accumulations of precursors of Hexanedioic acid such as d-glucaric acid and cis,cis-muconic acid, which can be further catalyzed to adipate; (2) synthesis of adipate directly from carbon source.
With the emergence of metabolic engineering and synthetic biology, biological synthesis of Hexanedioic acid from renewable substrates is now feasible.
Here, we review the new approaches and technologies to produce Hexanedioic acid biologically, with the direct synthesis of Hexanedioic acid from the renewable substrates of special interes

Hexanedioic acid is a dicarboxylic acid with the lowest acidity of commonly used food acids.
Hexanedioic acid is a food additive which serves several functions in jams, beverages and baked goods.
Hexanedioic acid’s used as an acidulant, pH regulator, flavoring, buffering and leavening agent.
In baking, this acid is typically used as: Leavening agent with baking soda Substitute for cream of tartar and ascorbic acid Texture firmer

Commercial production of Hexanedioic acid:
Hexanedioic acid is produced commercially by the following process:
Oxidation of cyclohexane in the presence of air to form a mixture of cyclohexanone and cyclohexanol.
Oxidation of the cyclohexanone and cyclohexanol mixture with nitric acid to produce the Hexanedioic acid.
The process has a theoretical yield of 92-96% when high purity cyclohexanone and cyclohexanol mixture is used.

Preparation and reactivity of Hexanedioic acid:
Hexanedioic acid is produced from a mixture of cyclohexanone and cyclohexanol called KA oil, the abbreviation of ketone-alcohol oil.
The KA oil is oxidized with nitric acid to give Hexanedioic acid, via a multistep pathway.
Early in the reaction, the cyclohexanol is converted to the ketone, releasing nitrous acid:
HOC6H11 + HNO3 → OC(CH2)5 + HNO2 + H2O

Among Hexanedioic acids many reactions, the cyclohexanone is nitrosated, setting the stage for the scission of the C-C bond:
HNO2 + HNO3 → NO+NO3− + H2O
OC6H10 + NO+ → OC6H9-2-NO + H
Side products of the method include glutaric and succinic acids.
Nitrous oxide is produced in about one to one mole ratio to the Hexanedioic acid,[5] as well, via the intermediacy of a nitrolic acid.
Related processes start from cyclohexanol, which is obtained from the hydrogenation of phenol.

Alternative methods of production of Hexanedioic acid:
Several methods have been developed by carbonylation of butadiene.
For example, the hydrocarboxylation proceeds as follows:
CH2=CH−CH=CH2 + 2 CO + 2 H2O → HO2C(CH2)4CO2H

Another method is oxidative cleavage of cyclohexene using hydrogen peroxide.
The waste product is water.
Historically, Hexanedioic acid was prepared by oxidation of various fats, thus the name (ultimately from Latin adeps, adipis – "animal fat"; cf. adipose tissue).

Reactions of Hexanedioic acid:
Hexanedioic acid is a dibasic acid (Hexanedioic acid has two acidic groups).
The pKa values for their successive deprotonations are 4.41 and 5.41.
With the carboxylate groups separated by four methylene groups, Hexanedioic acid is suited for intramolecular condensation reactions.
Upon treatment with barium hydroxide at elevated temperatures, Hexanedioic acid undergoes ketonization to give cyclopentanone.

Hexanedioic acid is a carboxylic acid.
Carboxylic acids donate hydrogen ions if a base is present to accept them.
They react in this way with all bases, both organic (for example, the amines) and inorganic.
Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat.

Neutralization between an acid and a base produces water plus a salt.
Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water.
Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions.
The pH of solutions of carboxylic acids is therefore less than 7.0.
Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt.

Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt.
Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry.
Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Hexanedioic acid to corrode or dissolve iron, steel, and aluminum parts and containers.

Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide.
The reaction is slower for dry, solid carboxylic acids.
Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide.

Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides.
Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat.
Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat.

Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents.
These reactions generate heat.
A wide variety of products is possible.
Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.
Behavior in Fire: Melts and may decompose to give volatile acidic vapors of valeric acid and other substances.

Uses of Hexanedioic acid:
All that being said, Hexanedioic acid has a wide variety of uses and over 4.4 billion pounds of Hexanedioic acid has been produced worldwide.
So what kind of uses does Hexanedioic acid have?
Hexanedioic acid can be combined with other molecules or some chemical groups can be added to the four middle carbons to make a useful product.

Hexanedioic acid is used to make Nylon 6,6.
Nylon 6,6 formation
Nylon 6,6 is used in carpeting, clothing, cords and mechanical parts.

In addition, Hexanedioic acid is useful for making plastics or polyesters.
In particular, Hexanedioic acid has been used in food wrap and blood bags.
Forms and derivatives of Hexanedioic acid are also used as a vehicle for pharmaceutical drugs - this means Hexanedioic acid helps the drug get into your body when you're sick.

More than 92% of the production of Hexanedioic acid is dedicated for the production of nylon 6,6 by a reaction with HMD Hexamethylene diamine.
Nylon is utilized in fibbers, clothing, plastics, filaments, food packaging,
Hexanedioic acid is also used in polyurethane resins, foam, shoe soles, and as food additive.
Esters of Hexanedioic acid are used as plasticizers for PVC (Polyvinyl Chloride) resins and lubricant component.

Arpadis is one of the largest chemical distributor in Europe.
Arpadis is handling the storage, transport, export & import formalities of Hexanedioic acid globally.
Other major applications also involve polymers; Hexanedioic acid is a monomer for production of polyurethane and Hexanedioic acids esters are plasticizers, especially in PVC.

Hexanedioic acid is used in the following products: washing & cleaning products.
Other release to the environment of Hexanedioic acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

Nylon 6,6 and specialty nylons
Polyester polyols for polyurethanes
Wet-strength resins for paper products

Plasticizers for PVC
Unsaturated polyester resins
Glass interleaving powders
Ingredient in foods and medications

Widespread uses by professional workers of Hexanedioic acid:
Hexanedioic acid is used in the following products: laboratory chemicals and washing & cleaning products.

Hexanedioic acid is used in the following areas: municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and printing and recorded media reproduction.
Hexanedioic acid is used for the manufacture of: machinery and vehicles.
Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

In medicine of Hexanedioic acid:
Hexanedioic acid has been incorporated into controlled-release formulation matrix tablets to obtain pH-independent release for both weakly basic and weakly acidic drugs.
Hexanedioic acid has also been incorporated into the polymeric coating of hydrophilic monolithic systems to modulate the intragel pH, resulting in zero-order release of a hydrophilic drug.
The disintegration at intestinal pH of the enteric polymer shellac has been reported to improve when Hexanedioic acid was used as a pore-forming agent without affecting release in the acidic media.
Other controlled-release formulations have included Hexanedioic acid with the intention of obtaining a late-burst release profile.

In foods of Hexanedioic acid:
Small but significant amounts of Hexanedioic acid are used as a food ingredient as a flavorant and gelling aid.
Hexanedioic acid is used in some calcium carbonate antacids to make them tart.
As an acidulant in baking powders, Hexanedioic acid avoids the undesirable hygroscopic properties of tartaric acid.
Hexanedioic acid, rare in nature, does occur naturally in beets, but this is not an economical source for commerce compared to industrial synthesis.

Safety and Handling of Hexanedioic acid:
Product Identifier: Hexanedioic acid
Signal Word: Danger

Precautionary Statement of Hexanedioic acid:
P280-Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do.
P310-Immediately call a POISON CENTER/doctor/.

Safety of Hexanedioic acid:
Hexanedioic acid, like most carboxylic acids, is a mild skin irritant.
Hexanedioic acid is mildly toxic, with a median lethal dose of 3600 mg/kg for oral ingestion by rats.

Hand protection of Hexanedioic acid:
Wear suitable gloves.
Chemical protection gloves are suitable, which are tested according to EN 374.
For special purposes, Hexanedioic acid is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.
The times are approximate values from measurements at 22 ° C and permanent contact.

Increased temperatures due to heated substances, body heat etc. and a reduction of the effective layer thickness by stretching can lead to a considerable reduction of the breakthrough time.
If in doubt, contact manufacturer.
At an approx. 1.5 times larger / smaller layer thickness, the respective breakthrough time is doubled / halved.
The data apply only to the pure substance.
When transferred to substance mixtures, they may only be considered as a guide.

Environmental of Hexanedioic acid:
The production of Hexanedioic acid is linked to emissions of N2O, a potent greenhouse gas and cause of stratospheric ozone depletion.
At Hexanedioic acid producers DuPont and Rhodia (now Invista and Solvay, respectively), processes have been implemented to catalytically convert the nitrous oxide to innocuous products:

Stability of Hexanedioic acid:
Hexanedioic acid to be avoided include ammonia, strong oxidizing agents
Hexanedioic acid

Appearance:
Pure white, solid and odorless crystal
White crystals or crystalline powder; practically odourless; aqueous phase has a pleasant sour taste Food and Agriculture Organization of the United Nations Hexanedioic acid.

Production of Hexanedioic acid:
Hexanedioic acid is white, crystalline compound mainly obtained by oxidation of cyclohexanol and cyclohexanone with nitric acid.
An alternative method of production of Hexanedioic acid is the hydrocarbonylation of butadiene, oxidation cleavage of cyclohexene.

Application of Hexanedioic acid:
Hexanedioic acid for synthesis.
CAS 124-04-9, pH 2.7 (24.9 g/l, H₂O, 25 °C).

Hexanedioic acid is used in a variety of ways in baked goods.
Most commonly, in chemically leavened bakery products as a leavening agent, and in pie filling as gelling aid and buffering agent.
Hexanedioic acid can substitute for tartaric acid and cream of tartar, due to Hexanedioic acids non-hygroscopicity.
Hexanedioic acid has a neutralization value (NV) of 115, implying that 115 grams of bicarbonate are required to neutralize 100 grams of Hexanedioic acid.

Hexanedioic acid can be used as a starting material in the preparation of:
Aliphatic polyesters by reacting with ethyleneglycol/1,3 propyleneglycol/1,4-butanediol using inorganic acid as a catalyst.
Cyclopentanone using a weak base such as Na2CO3.
Linear polybutylene adipate (PBA) having carboxylic acids at the terminals by reacting with 1,4-butanediol.

Hexanedioic acid is used as a monomer for:
Polyamide 6.6 and other polyamides in the field of Engineering Plastics, Textile Fibers and Industrial Yarn;
Polyurethane for flexible and semi-rigid foams;
Other polymers.

Hexanedioic acid is used as an intermediate for organic synthesis in the field of:
Lubricants;
Plasticizers;
Wet strength resins;
Coatings / Adhesives / Sealants and Elastomers;
Pharmaceutical products, perfumes and cosmetics;
Hexanedioic acid is used in formulation in the field of:
pH regulator;
Buffer;
RHODIACID™ AA - Hexanedioic acid is used as laboratory chemicals

Uses at industrial sites of Hexanedioic acid:
Hexanedioic acid is used in the following products: pH regulators and water treatment products, polymers, leather treatment products and washing & cleaning products.
Hexanedioic acid has an industrial use resulting in manufacture of another substance (use of intermediates).

Hexanedioic acid is used in the following areas: municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and formulation of mixtures and/or re-packaging.
Hexanedioic acid is used for the manufacture of: chemicals, plastic products and textile, leather or fur.
Release to the environment of this substance can occur from industrial use: as processing aid, for thermoplastic manufacture, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, formulation of mixtures and in the production of articles.
Other release to the environment of Hexanedioic acid is likely to occur from: outdoor use as reactive substance.

Formulation or re-packing of Hexanedioic acid:
Hexanedioic acid is used in the following products: pH regulators and water treatment products, leather treatment products and washing & cleaning products.
Release to the environment of this substance can occur from industrial use: formulation of mixtures and as processing aid.

Naylon 6,6
Polyurethane
Paper Industry Chemicals
Alkyde production
Polyester Production
DOA

Adhesives & Sealants
Alkyd resins
Beamhouse
Carrier for fragances
Coal
Crop Protection
Environment protection
Gas desulphurization
Hardener and crosslinking agents for polymeres
Manufacturing of coating
Manufacturing of dyestuffs
Manufacturing of fibres
Manufacturing of herbicides
Manufacturing of pharmaceutical agents
Manufacturing of photochemicals
Manufacturing of plastics
Manufacturing of tensides
Manufacturing of textile dyestuffs
Paper Manufacture
Plasticizers for polymeres
Polyester
Polyester resins
Polymer auxiliaries
Soaking
Synthetic lubricants
Textile dyestuffs

Properties of Hexanedioic acid:
So now we know the formula and structure Hexanedioic acid, what are some of Hexanedioic acids properties?
What does Hexanedioic acid look like? What is known about Hexanedioic acid?

Well, for one Hexanedioic acid is a white crystalline solid at room temperature - this means Hexanedioic acid kinda looks like salt or white sand.
Hexanedioic acid's also slightly flammable.
This means if you add a little heat you might get a fire.
If you add extremely high heat you may even get a little bit of an explosion!

Apparently someone thought Hexanedioic acid would be a good idea to taste Hexanedioic acid, so we know Hexanedioic acid has a tart taste, though I wouldn't recommend eating Hexanedioic acid, since Hexanedioic acid'll mess with your digestive system.
Also, Hexanedioic acid's not called an acid for nothing.
If you add Hexanedioic acid to water solutions, Hexanedioic acid becomes corrosive and can act just like the name suggests - an acid.
In fact, because Hexanedioic acid has two carboxylic acids attached at the ends, Hexanedioic acid can react with two bases.
Thus Hexanedioic acid is known as a dibasic acid.

Just in case you're thinking of inhaling the lovely white crystalline solid, Hexanedioic acid's definitely not recommended, since Hexanedioic acid irritates your lungs and can make you sneeze, cough, cough up blood, or can even cause asthma.
Although Hexanedioic acid is biodegradable, Hexanedioic acids formation can have environmental consequences.
One of the byproducts of Hexanedioic acid formation from benzene is nitrous oxide (N2O), a greenhouse gas.
Scientists however are working on environmentally friendly ways of producing Hexanedioic acid.

Melting Point: 153 °C
Solubility in water: Slightly soluble
Degree of solubility in water: 22 g/l 20 °C
Solubility (very soluble in): Alcohol
Solubility (soluble in): Acetone

Biological Properties of Hexanedioic acid:
-Cellular Locations:
-Cytoplasm
-Biospecimen Locations
-Blood
-Cerebrospinal Fluid (CSF)
-Feces
-Saliva
-Urine

Tissue Locations:
-Kidney
-Liver

Specifications of Hexanedioic acid:
Hexanedioic acid is available in the form of white crystalline powder (density of untamped powder: 0.63 - 0.65 g/cm³).
The storage should respect certain conditions:

Protected from humidity and bad weather conditions
Stored a well-ventilated area
Away from any source of heat and ignition.

Assay (acidimetric): ≥ 99.0 %
Melting range (lower value): ≥ 150 °C
Melting range (upper value): ≤ 154 °C
Identity (IR): passes test

Chemical Name or Material: Apidic acid
CAS Min: %98.5
Ash: 0.0002% max.
Molecular Formula: C6H10O4
MDL Number: MFCD00004420
Fieser: 01,15

Synonym: Hexanedioic acid, adipinic acid, 1,4-butanedicarboxylic acid, adilactetten, acifloctin, acinetten, 1,6-hexanedioic acid, molten Hexanedioic acid, kyselina adipova, adipinsaure german

SMILES: C(CCC(=O)O)CC(=O)O
Molecular Weight (g/mol): 146.142
CHEBI: 30832
Physical Form: Crystalline Powder
Boiling Point: 337.0°C
Melting Point: 151.0°C to 153.0°C
Flash Point: 196°C
Iron (Fe): 0.4ppm max.
Packaging: Plastic bottle
CAS: 124-04-9
CAS Max %: 100.0
Assay Percent Range: 99%
Linear Formula: HO2C(CH2)4CO2H
Beilstein: 02, 649
Merck Index: 15, 150
InChI Key: WNLRTRBMVRJNCN-UHFFFAOYSA-N
IUPAC Name: hexanedioic acid
Formula Weight: 146.14
Percent Purity: 99%
Color: White
Infrared Spectrum: Authentic
Nitrate: 4ppm max.
Water: 0.2% max.

Appearance: White powder or crystalline powder
Assay: 99.0-101.0%
Solubility: Passes test
Melting point: 151-154°C
Identity (IR): Passes test
Appearance of solution: Passes test
Chloride (Cl): Max 0.02%
Nitrate (NO3): Max 0.003%
Sulphate (SO4): Max 0.05%
Iron (Fe): Max 0.001%
Heavy metal (as Pb): Max 0.001%
Loss on drying: Max 0.2%
Sulphated ash: Max 0.1%

Information of Hexanedioic acid:
Product Number: A0161
Purity / Analysis Method: >99.0%(GC)(T)
Molecular Formula / Molecular Weight: C6H10O4 = 146.14
Physical State (20 deg.C): Solid
Reaxys Registry Number: 1209788
SDBS (AIST Spectral DB): 1456
Merck Index (14): 162
MDL Number: MFCD00004420

CAS number: 124-04-9
EC index number: 607-144-00-9
EC number: 204-673-3
Hill Formula: C₆H₁₀O₄
Molar Mass: 146.14 g/mol
HS Code: 2917 12 00
Quality Level: MQ200

Quality Level: 200
vapor density: 5 (vs air)
vapor pressure: 1 mmHg ( 159.5 °C)
assay: 99%
form: crystals
autoignition temp.: 788 °F
bp: 265 °C/100 mmHg (lit.)
mp: 151-154 °C (lit.)
solubility: H2O: soluble 23 g/L at 25 °C
SMILES string: OC(=O)CCCCC(O)=O

Molecular Weight: 146.14
XLogP3: 0.1
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 5
Exact Mass: 146.05790880
Monoisotopic Mass: 146.05790880
Topological Polar Surface Area: 74.6 Å²
Heavy Atom Count : 10
Formal Charge: 0
Complexity: 114
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Chemical formula: C6H10O4
Molar mass: 146.142 g·mol−1
Appearance: White crystals
Monoclinic prisms: Odor Odorless
Density: 1.360 g/cm3
Melting point: 152.1 °C (305.8 °F; 425.2 K)
Boiling point: 337.5 °C (639.5 °F; 610.6 K)
Solubility in water: 14 g/L (10 °C) 24 g/L (25 °C) 1600 g/L (100 °C)
Solubility: Very soluble in methanol, ethanol soluble in acetone, acetic acid slightly soluble in cyclohexane negligible in benzene, petroleum ether
log P: 0.08
Vapor pressure: 0.097 hPa (18.5 °C) = 0.073 mmHg
Acidity (pKa): 4.43, 5.41
Conjugate base: Adipate
Viscosity: 4.54 cP (160 °C)

Structure of Hexanedioic acid:
Crystal structure: Monoclinic

Related compounds of Hexanedioic acid:
Medium-chain fatty acid
Dicarboxylic acid or derivatives
Carboxylic acid
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Aliphatic acyclic compound

Related dicarboxylic acids:
glutaric acid
pimelic acid

hexanoic acid
Hexanedioic acid dihydrazide
hexanedioyl dichloride
hexanedinitrile
hexanediamide

Names of Hexanedioic acid:
Preferred IUPAC name
Hexanedioic acid

Other names of Hexanedioic acid:
Hexanedioic acid
Butane-1,4-dicarboxylic acid
Hexane-1,6-dioic acid
1,4-butanedicarboxylic acid
2 N2O → 2 N2 + O2

Synonyms of Hexanedioic acid:
Hexanedioic acid
hexanedioic acid
124-04-9
Adipinic acid
1,4-Butanedicarboxylic acid
Adilactetten
Acifloctin
Acinetten
1,6-Hexanedioic acid
Molten Hexanedioic acid
Kyselina adipova
Adipinsaure [German]
Acide adipique [French]
Kyselina adipova [Czech]
Hexanedioate
Adipinsaeure
FEMA No. 2011
Adi-pure
UNII-76A0JE0FKJ
NSC 7622
Hexanedioic acid [NF]
Hexan-1,6-dicarboxylate
MFCD00004420
76A0JE0FKJ
1,6-HEXANE-DIOIC ACID
CHEBI:30832
NSC7622
NSC-7622
Hexanedioic acid (NF)
NCGC00091345-01
E355
hexane-1,6-dioic acid
E-355
DSSTox_CID_1605
DSSTox_RID_76232
DSSTox_GSID_21605
Adipinsaure
Acide adipique
FEMA Number 2011
CAS-124-04-9
CCRIS 812
HSDB 188
EINECS 204-673-3
BRN 1209788
Adipinate
adipic-acid
Adipidic acid
Molten adipate
AI3-03700
hexane dioic acid
1,6-Hexanedioate
0L1
Hexanedioic acid, 99%
Neopentyl Glycol Flake
Hexanedioic acid-[13C6]
C6-140-polymorph-I
C6-180-polymorph-I
C6-220-polymorph-I
C6-260-polymorph-I
C6-298-polymorph-I
1, 6-Hexanedioic Acid
Hexanedioic acid, >=99%
WLN: QV4VQ
bmse000424
EC 204-673-3
SCHEMBL4930
CHEMBL1157
NCIOpen2_001004
NCIOpen2_001222
HOOC-(CH2)4-COOH
Hexanedioic acid, >=99.5%
4-02-00-01956
butane-1,4-dicarboxylic acid
BIDD:ER0342
INS No. 355
INS NO.355
DTXSID7021605
Hexanedioic acid, puriss., 99.8%
INS-355
Pharmakon1600-01301012
ZINC1530348
Tox21_111118
Tox21_202161
Tox21_300344
BBL011615
LMFA01170048
NSC760121
s3594
STL163338
AKOS000119031
Tox21_111118_1
CCG-230896
CS-W018238
HY-W017522
MCULE-1336748609
NSC-760121
NCGC00091345-02
NCGC00091345-03
NCGC00091345-04
NCGC00091345-05
NCGC00254389-01
NCGC00259710-01
AC-10343
BP-21150
BP-30248
Hexanedioic Acid, Butanedicarboxylic Acid
A0161
Hexanedioic acid, BioXtra, >=99.5% (HPLC)
Hexanedioic acid, SAJ special grade, >=99.5%
E 355
FT-0606810
Hexanedioic acid, Vetec(TM) reagent grade, >=99%
C06104
D08839
D70505
AB00988898-01
AB00988898-03
Q357415
SR-01000944270
J-005034
J-519542
SR-01000944270-2
Z57127533
Hexanedioic acid, certified reference material, TraceCERT(R)
F0001-0377
Hexanedioic acid, European Pharmacopoeia (EP) Reference Standard
1F1316F2-7A32-4339-8C2A-8CAA84696C95
Hexanedioic acid, United States Pharmacopeia (USP) Reference Standard
Hexanedioic acid, meets analytical specification of Ph.Eur., BP, E 355, 99.6-101.0% (calc. to the dried substance)

124-04-9
204-673-3
Hexanedioic acid
Adipinsäure
Asapic
Hexanedioic acid
Inipol DS
kwas adypinowy
kyselina adipová
MFCD00004420
1,4-butanedicarboxylic acid
1,6-HEXANEDIOIC ACID
1,6-HEXANE-DIOIC ACID
121311-78-2
19031-55-1
2,2,3,3,4,4,5,5-Octadeuteriohexanedioic acid
2-OxoHexanedioic acid
52089-65-3
Acifloctin
Acinetten
Adilactetten
Hexanedioic acid 100 Âµg/mL in Methanol
Hexanedioic acid FCC
adipicacid
adipinic acid
Butane-1,4-dicarboxylic acid
BUTANEDICARBOXYLIC ACID
Hexanedioic-3,3,4,4-d4 Acid
hydron
QV4VQ

MeSH of Hexanedioic acid:
adipate
Hexanedioic acid
Hexanedioic acid, calcium salt
Hexanedioic acid, Cu salt
Hexanedioic acid, Cu(+2) salt
Hexanedioic acid, Cu(+2) salt (1:1)
Hexanedioic acid, diammonium salt
Hexanedioic acid, disodium salt
Hexanedioic acid, Mg salt (1:1)
Hexanedioic acid, monoammonium salt
Hexanedioic acid, nickel salt
Hexanedioic acid, potassium salt
Hexanedioic acid, sodium salt
ammonium adipate
diammonium adipate
hexanedioic acid
magnesium adipate
sodium adipate