MENTHOL

Menthol is an organic compound, more specifically a monoterpenoid, made synthetically or obtained from the oils of corn mint, peppermint, or other mints.
Menthol is a waxy, clear or white crystalline substance, which is solid at room temperature and melts slightly above.

IUPAC Name: 5-Methyl-2-(propan-2-yl)cyclohexan-1-ol
CAS Number: 2216-51-5
EC Number: 218-690-9
Chemical formula: C10H20O

Other names: l-Menthol, (-)-menthol, 2216-51-5, Levomenthol, Menthomenthol, l-(-)-Menthol, Menthacamphor, Peppermint camphor, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol, U.S.P. Menthol, Levomentholum, Racementhol, (1r,2s,5r)-(-)-menthol, (-)-Menthyl alcohol, Menthol racemic, Hexahydrothymol, (1R)-(-)-Menthol, d,l-Menthol, (-)-(1R,3R,4S)-Menthol, (R)-(-)-Menthol, 89-78-1, D-(-)-Menthol, Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-, p-Menthan-3-ol, (-)-trans-p-Menthan-cis-ol, rac-Menthol, 1-Menthol, (L)-MENTHOL, Menthol(-), (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol, Menthol, (1R,3R,4S)-(-)-, (1R,3R,4S)-(-)-MENTHOL, Menthol, dl-, NCI-C50000, Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel-, 1R-Menthol, NSC 62788, (1R,2S,5R)-Menthol, 5-Methyl-2-(1-methylethyl)cyclohexanol, (1R,2S,5R)-2-isopropyl-5-methylcyclohexan-1-ol, BZ1R15MTK7, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexanol, (+/-)-Menthol, (1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol, (1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol, CHEMBL470670, YS08XHA860, DTXSID1020805, DTXSID1022180, CHEBI,15409, NSC2603, (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanol, Headache crystals, NSC-2603, FEMA No. 2665, MFCD00062979, NSC-62788, Menthol (VAN), Racementholum, Thymomenthol, Menthol, cis-1,3,trans-1,4-, Racementol, NSC 2603, (+-)-Menthol, I-menthol, Menthol racemique, Levomenthol; (-)-Menthol, Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1R-(1.alpha.,2.beta.,5.alpha.)]-, Menthol, l-, rel-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol, DTXCID802180, (1alpha,2beta,5alpha)-5-methyl-2(1-methylethyl)cyclohexanol, DTXCID101305276, MEGGEZONE, CAS-89-78-1, CCRIS 375, CAS-2216-51-5, l-Menthol (TN), CCRIS 3728, CCRIS 4666, HSDB 5662, SR-05000001936, (-)-p-Menthan-3-ol, EINECS 201-939-0, EINECS 218-690-9, EINECS 239-388-3, UNII-BZ1R15MTK7, (1R,2S,5R)-rel-2-Isopropyl-5-methylcyclohexanol, BRN 1902288, BRN 3194263, levomentol, UNII-YS08XHA860, (+-)-(1R*,3R*,4S*)-Menthol, AI3-52408, Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1.alpha.,2.beta.,5.alpha.)-, Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R-(1alpha,2beta,5alpha))-, CYCLOHEXANOL, 5-METHYL-2-(1-METHYLETHYL)-, (1R-(1.ALPHA.,2.BETA.,5.ALPHA.))-, L-Menthol natural, 1 -menthol, NCGC00159382-02, 98167-53-4, L-MENTHOLUM, Spectrum_000305, 5-Methyl-2-(1-methylethyl)cyclohexanol, (1alpha,2beta,5alpha)-, Menthol, (+/-)-, Spectrum2_000855, Spectrum3_001561, Spectrum5_001060, M0545, Menthol,3,trans-1,4-, pound - pound(c)-Menthol, EC 201-939-0, EC 218-690-9, SCHEMBL4613, (1R,2S,5S)-2-Isopropyl-5-methyl-cyclohexanol, BSPBio_003062, KBioSS_000785, 2-06-00-00052, 4-06-00-00151, MLS002207256, DivK1c_000820, MENTHOL RACEMATE [MI], SPECTRUM1503134, Menthol,3R,4S)-(-)-, SPBio_000869, GTPL2430, NPO-11, HMS502I22, KBio1_000820, KBio2_000785, KBio2_003353, KBio2_005921, KBio3_002562, NOOLISFMXDJSKH-KXUCPTDWSA-, (-)-Menthol, analytical standard, NINDS_000820, Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,3R,4S)-, HMS1922G13, HMS2092L14, HMS3885J18, Pharmakon1600-01503134, NSC62788, WLN, L6TJ AY1&1 BQ D1, BDBM50318482, CCG-40300, Cyclohexanol, 2-isopropyl-5-methyl-, Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1alpha,2beta,5alpha)-, NSC758395, s4714, AKOS016842647, (1R, 2S, 5R-)-(-)-Menthol, 1ST1669, BS-3863, DB00825, LMPR0102090001, NSC-758395, SDCCGMLS-0066659.P001, (-)-TRANS-P-METHAN-CIS-3-OL, IDI1_000820, WLN, L6TJ AY1&1 DQ D1 -L, FEMA NO. 2665, (-)-, SMR001306785, SBI-0051777.P002, NS00068027, NS00102112, S5868, EN300-92163, FEMA NO. 2665, (+/-)-, (+/-)-(1R*,3R*,4S*)-MENTHOL, (1R,2S,5R)-(-)-Menthol, synthetic pellets, C00400, Cyclohexanol, (1.alpha.,2.beta.,5.alpha.)-, D00064, D70313, (1R,2R,5S)-2-isopropyl-5-methyl-cyclohexanol, AB00052320_02, A843308, Q407418, Q-201316, SR-05000001936-1, SR-05000001936-2, (-)-Menthol, primary pharmaceutical reference standard, (1R,2S,5R)-(-)-Menthol, ReagentPlus(R), 99%, 2-Isopropyl-5-methylcyclohexanol-, (1R,2S,5R)- #, Cyclohexanol, [1R-(1.alpha.,2.beta.,5.alpha.)]-, (1R,2S,5R)-5-methyl-2-propan-2-yl-cyclohexan-1-ol, Z1255438640, (1R,2S,5R)-(-)-Menthol, Vetec(TM) reagent grade, 98%, 6C6A4A8C-A054-468C-A1F0-F29E39838CF2, (1R, 2S, 5R)-5-methyl-2-(1-methylethyl)cyclohexyl alcohol, Menthol, United States Pharmacopeia (USP) Reference Standard, (1R,2S,5R)-REL-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANOL, L-Menthol, Pharmaceutical Secondary Standard; Certified Reference Material, (-)-Menthol, puriss., meets analytical specification of Ph. Eur., BP, USP, 98.0-102.0%, (1R-(1-.alpha.,2-.beta.,5-.alpha.))-5-Methyl-2-(1-methylethyl)cyclohexanol, 114376-98-6

The main form of menthol occurring in nature is (−)-menthol, which is assigned the (1R,2S,5R) configuration.
Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. Menthol also acts as a weak κ-opioid receptor agonist.

Structure
Natural menthol exists as one pure stereoisomer, nearly always the (1R,2S,5R) form.
In the natural compound, the isopropyl group is in the trans orientation to both the methyl and hydroxyl groups.
Thus, it can be drawn in any of the ways.

The (+)- and (−)-enantiomers of menthol are the most stable among these based on their cyclohexane conformations. With the ring itself in a chair conformation, all three bulky groups can orient in equatorial positions.
The two crystal forms for racemic menthol have melting points of 28 °C and 38 °C.
Pure (−)-menthol has four crystal forms, of which the most stable is the α form, the familiar broad needles.

Biological properties
Menthol's ability to chemically trigger the cold-sensitive TRPM8 receptors in the skin is responsible for the well-known cooling sensation it provokes when inhaled, eaten, or applied to the skin.
In this sense, it is similar to capsaicin, the chemical responsible for the spiciness of hot chilis (which stimulates heat sensors, also without causing an actual change in temperature).

Menthol's analgesic properties are mediated through a selective activation of κ-opioid receptors.
Menthol blocks calcium channels and voltage-sensitive sodium channels, reducing neural activity that may stimulate muscles.

Some studies show that menthol acts as a GABAA receptor positive allosteric modulator and increases GABAergic transmission in PAG neurons.
Menthol has anesthetic properties similar to, though less potent than, propofol because it interacts with the same sites on the GABAA receptor.
Menthol may also enhance the activity of glycine receptors and negatively modulate 5-HT3 receptors and nAChRs.

Menthol is widely used in dental care as a topical antibacterial agent, effective against several types of streptococci and lactobacilli.
Menthol also lowers blood pressure and antagonizes vasoconstriction through TRPM8 activation.

Occurrence
Mentha arvensis (wild mint) is the primary species of mint used to make natural menthol crystals and natural menthol flakes. This species is primarily grown in the Uttar Pradesh region in India.

Menthol occurs naturally in peppermint oil (along with a little menthone, the ester menthyl acetate and other compounds), obtained from Mentha × piperita (peppermint).
Japanese menthol also contains a small percentage of the 1-epimer neomenthol.

Biosynthesis
The biosynthesis of menthol has been investigated in Mentha × piperita and the enzymes involved in have been identified and characterized.
It begins with the synthesis of the terpene limonene, followed by hydroxylation, and then several reduction and isomerization steps.

More specifically, the biosynthesis of (−)-menthol takes place in the secretory gland cells of the peppermint plant. The steps of the biosynthetic pathway are as follows:

Geranyl diphosphate synthase (GPPS) first catalyzes the reaction of IPP and DMAPP into geranyl diphosphate.
(−)-limonene synthase (LS) catalyzes the cyclization of geranyl diphosphate to (−)-limonene.
(−)-Limonene-3-hydroxylase (L3OH), using O2 and then nicotinamide adenine dinucleotide phosphate (NADPH) catalyzes the allylic hydroxylation of (−)-limonene at the 3 position to (−)-trans-isopiperitenol.
(−)-trans-Isopiperitenol dehydrogenase (iPD) further oxidizes the hydroxyl group on the 3 position using NAD+ to make (−)-isopiperitenone.
(−)-Isopiperitenone reductase (iPR) then reduces the double bond between carbons 1 and 2 using NADPH to form (+)-cis-isopulegone.
(+)-cis-Isopulegone isomerase (iPI) then isomerizes the remaining double bond to form (+)-pulegone.
(+)-Pulegone reductase (PR) reduces this double bond using NADPH to form (−)-menthone.
(−)-Menthone reductase (MR) then reduces the carbonyl group using NADPH to form (−)-menthol.

Production
Natural menthol is obtained by freezing peppermint oil.
The resultant crystals of menthol are then separated by filtration.

Total world production of menthol in 1998 was 12,000 tonnes of which 2,500 tonnes was synthetic.
In 2005, the annual production of synthetic menthol was almost double.
Prices are in the $10–20/kg range with peaks in the $40/kg region but have reached as high as $100/kg.
In 1985, it was estimated that China produced most of the world's supply of natural menthol, although it appears that India has pushed China into second place.

Menthol is manufactured as a single enantiomer (94% e.e.) on the scale of 3,000 tonnes per year by Takasago International Corporation.
The process involves an asymmetric synthesis developed by a team led by Ryōji Noyori, who won the 2001 Nobel Prize for Chemistry in recognition of his work.

The process begins by forming an allylic amine from myrcene, which undergoes asymmetric isomerisation in the presence of a BINAP rhodium complex to give (after hydrolysis) enantiomerically pure R-citronellal.
This is cyclised by a carbonyl-ene-reaction initiated by zinc bromide to isopulegol, which is then hydrogenated to give pure (1R,2S,5R)-menthol.

Another commercial process is the Haarmann–Reimer process (after the company Haarmann & Reimer, now part of Symrise) This process starts from m-cresol which is alkylated with propene to thymol.
This compound is hydrogenated in the next step.

Racemic menthol is isolated by fractional distillation.
The enantiomers are separated by chiral resolution in reaction with methyl benzoate, selective crystallisation followed by hydrolysis.

Racemic menthol can also be formed by hydrogenation of thymol, menthone, or pulegone.
In both cases with further processing (crystallizative entrainment resolution of the menthyl benzoate conglomerate) it is possible to concentrate the L-enantiomer, however this tends to be less efficient, although the higher processing costs may be offset by lower raw material costs.
A further advantage of this process is that D-menthol becomes inexpensively available for use as a chiral auxiliary, along with the more usual L-antipode.

Applications
Menthol is included in many products, and for a variety of reasons.

Cosmetic
In nonprescription products for short-term relief of minor sore throat and minor mouth or throat irritation e.g.: lip balms and cough medicines.
In some beauty products such as hair conditioners, based on natural ingredients (e.g., St. ⁠Ives).

Medical
As an antipruritic to reduce itching.
As a topical analgesic, it is used to relieve minor aches and pains, such as muscle cramps, sprains, headaches and similar conditions, alone or combined with chemicals such as camphor, eucalyptus oil or capsaicin.
In Europe, it tends to appear as a gel or a cream, while in the U.S., patches and body sleeves are very frequently used, e.g.: Tiger Balm, or IcyHot patches or knee/elbow sleeves.

As a penetration enhancer in transdermal drug delivery.
In decongestants for chest and sinuses (cream, patch or nose inhaler).
Examples: Vicks VapoRub, Mentholatum, Axe Brand, VapoRem, Mentisan.
In certain medications used to treat sunburns, as it provides a cooling sensation (then often associated with aloe).

Commonly used in oral hygiene products and bad-breath remedies, such as mouthwash, toothpaste, mouth and tongue sprays, and more generally as a food flavor agent; such as in chewing gum and candy.
In first aid products such as "mineral ice" to produce a cooling effect as a substitute for real ice in the absence of water or electricity (pouch, body patch/sleeve or cream).

Others
In aftershave products to relieve razor burn.
As a smoking tobacco additive in some cigarette brands, for flavor, and to reduce throat and sinus irritation caused by smoking.
Menthol also increases nicotine receptor density, increasing the addictive potential of tobacco products.
As a pesticide against tracheal mites of honey bees.
In perfumery, menthol is used to prepare menthyl esters to emphasize floral notes (especially rose).

In various patches ranging from fever-reducing patches applied to children's foreheads to "foot patches" to relieve numerous ailments (the latter being much more frequent and elaborate in Asia, especially Japan: some varieties use "functional protrusions", or small bumps to massage one's feet as well as soothing them and cooling them down).
As an antispasmodic and smooth muscle relaxant in upper gastrointestinal endoscopy.

Organic chemistry
In organic chemistry, menthol is used as a chiral auxiliary in asymmetric synthesis.
For example, sulfinate esters made from sulfinyl chlorides and menthol can be used to make enantiomerically pure sulfoxides by reaction with organolithium reagents or Grignard reagents.
Menthol reacts with chiral carboxylic acids to give diastereomic menthyl esters, which are useful for chiral resolution.

Menthol can be used as a catalyst for sodium production for the amateur chemist via the alcohol catalysed magnesium reduction process.
Menthol is potentially ergogenic (performance enhancing) for athletic performance in hot environments.

Reactions
Menthol reacts in many ways like a normal secondary alcohol. It is oxidised to menthone by oxidising agents such as chromic acid or dichromate, though under some conditions the oxidation can go further and break open the ring.
Menthol is easily dehydrated to give mainly 3-menthene, by the action of 2% sulfuric acid.
Phosphorus pentachloride (PCl5) gives menthyl chloride.

History
In the West, menthol was first isolated in 1771, by the German, Hieronymus David Gaubius.
Early characterizations were done by Oppenheim, Beckett, Moriya, and Atkinson.
Menthol was named by F. L. Alphons Oppenheim (1833–1877) in 1861.

Safety
The estimated lethal dose for menthol (and peppermint oil) in humans may be as low as 50–500 mg/kg, (LD50 Acute: 3300 mg/kg [Rat]. 3400 mg/kg [Mouse]. 800 mg/kg [Cat]).

Survival after doses of 8 to 9 g has been reported.
Overdose effects are abdominal pain, ataxia, atrial fibrillation, bradycardia, coma, dizziness, lethargy, nausea, skin rash, tremor, vomiting, and vertigo.

Molar mass: 156.269 g
Appearance: White or colorless crystalline solid
Odor: mint-licorice
Density: 0.890 g·cm

Melting point: 36–38 °C
Boiling point: 214.6 °C
Solubility in water: Slightly soluble
XLogP3-AA: 3

Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 1
Exact Mass: 156.151415257 g/mol

Monoisotopic Mass: 156.151415257 g/mol
Topological Polar Surface Area: 20.2Ų
Heavy Atom Count: 11
Complexity: 120

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 3
Undefined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Consumer Uses
Menthol is used in the following products: polishes and waxes, air care products, washing & cleaning products, biocides (e.g. disinfectants, pest control products), cosmetics and personal care products, perfumes and fragrances and pharmaceuticals.

Other release to the environment of Menthol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

Release to the environment of Menthol can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal). Other release to the environment of Menthol is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints), indoor use as processing aid and outdoor use as processing aid.
Menthol is intended to be released from scented: clothes, paper products, CDs, eraser and toys.

Widespread uses by professional workers
Menthol is used in the following products: washing & cleaning products, polishes and waxes and cosmetics and personal care products.
Menthol is used in the following areas: health services.

Menthol is used for the manufacture of: food products and chemicals.
Other release to the environment of Menthol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

Formulation or re-packing
Menthol is used in the following products: perfumes and fragrances, cosmetics and personal care products, pharmaceuticals and washing & cleaning products.
Release to the environment of Menthol can occur from industrial use: formulation of mixtures.

Uses at industrial sites
Menthol is used in the following products: washing & cleaning products, cosmetics and personal care products and laboratory chemicals.
Menthol is used in the following areas: printing and recorded media reproduction.

Menthol is used for the manufacture of: chemicals, food products, pulp, paper and paper products, rubber products and plastic products.
Release to the environment of Menthol can occur from industrial use: in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance.

Menthol is a chemical naturally found in peppermint and other mint plants, but it can also be made in a lab.
First added to tobacco in the 1920s and 1930s, menthol reduces the harshness of cigarette smoke and the irritation from nicotine.

Under the 2009 Family Smoking Prevention and Tobacco Control Act that gives the Food and Drug Administration authority over tobacco products, menthol was the only flavor allowed in cigarettes in sufficient quantity to be a "characterizing flavor".

Tobacco companies have relied on the soothing and cooling effects of menthol to make cigarettes more appealing to new smokers, youth, Black Americans and LGBTQ Americans among others. The marketing of menthol cigarettes has been targeted at Black Americans for decades.

More than 18.9 million people currently smoke menthol cigarettes.
Flavors, including menthol, are one of the primary reasons kids start using tobacco products.

Health Effects of Menthol
When inhaled, menthol can reduce airway pain and irritation from cigarette smoke and suppress coughing, giving smokers the illusion of breathing more easily. However, despite what some marketing messages may seem to suggest, menthol cigarettes offer no health benefits compared to non-menthol cigarettes.2 In fact, the minty taste and odor can mask the early warning symptoms of smoking-induced respiratory problems.3

Menthol cigarettes have also been found to increase both the likelihood of becoming addicted and also the degree of addiction.2,4 Scientific evidence also indicates that menthol smokers are less likely than non-menthol smokers to successfully quit smoking despite having a higher urge to end their tobacco dependence.5

A recent study quantified the disproportionate harms from menthol cigarettes to Black Americans, finding that menthol cigarettes were responsible for 1.5 million new smokers, 157,000 smoking-related premature deaths and 1.5 million life years lost among Black Americans from 1980-2018.

Disproportionately Impacted Populations
The tobacco industry has targeted their marketing for menthol cigarettes specifically to certain racial/ethnic groups, especially Black Americans since the 1950s.

Essential oils are derived from plants.
Their purpose is not exactly known, but some experts think that it could be a protective mechanism for the plant; others propose that they might attract pollinators.
Peppermint is a popular essential oil used alone and in combination with other essential oils.

Menthol is the main component of peppermint oil and is responsible for the noticeable cooling sensation.
Menthol is extracted from plants or synthesized and can be found in throat lozenges, intranasal inhalers, lotions, pain creams, foods, and many other products.

Some people think that the cooling sensation from menthol is caused by mechanical damage by menthol crystals or by evaporation (like when you touch rubbing alcohol), but this is not the case.
The cooling is an interaction on the molecular level with the calcium and channels in our bodies. 

Receptors that are responsible for feeling cold are triggered by menthol's effects on calcium and sodium channels and a cooling sensation occurs.
There are calcium and sodium channels in cell membranes throughout our bodies, and that is why we can see systemic toxicity after swallowing or inhaling concentrated amounts of menthol.
Serious effects include seizures, coma, and death.

Menthol can cause eye and skin irritation.
When used on the skin, menthol is typically diluted into a "carrier oil", lotion, or other vehicle.
If a high-percentage menthol product is applied to the skin, irritation and even chemical burns have been reported.
There are a few reports of people being very sensitive to menthol and having severe skin reactions to even small amounts.

Products that contain menthol are flammable. In 2000, the FDA added a warning against putting products with menthol near a flame, in hot water, or in a microwave oven.
There is additional warning about applying a menthol product to the skin and placing a heating pad over it.
The heat increases absorption through the skin. In one case, putting a heating pad on a menthol rub resulted in tissue death.

Some nasal inhalers contain menthol.
The menthol makes us feel as though we are breathing easier, but it does not actually help with congestion.
In fact, it appears that more inflammation develops.

Lastly, some researchers think that cigarettes with menthol might increase the risk of becoming addicted to smoking and might be more toxic than regular cigarettes. Nicotine replacement products used to stop smoking work for menthol cigarette smokers as well.

Menthol is a flavouring agent commonly used in cigarettes and other tobacco products.
Menthol cigarettes are used more frequently by younger smokers, women and ethnic minorities, and their use facilitates both initiation and continued smoking, leading to addiction. These issues have raised global concern.

To address this public health issue, the WHO Study Group on Tobacco Product Regulation (TobReg) has prepared this advisory note on menthol, which synthesizes recent studies on the prevalence and health effects of menthol in tobacco products.
Menthol provides evidence-based conclusions and recommendations for policy-makers and regulators, including a ban on menthol (and its analogues, derivatives and precursors) in cigarettes.

The organic compound Menthol occurs naturally within the Mentha arvensis botanical, which is the main Mint variety that is used to obtain Menthol Crystals as well as natural Menthol flakes.

In their natural state at room temperature, Menthol Crystals appear to be colorless or white, solid but small, brittle, satiny crystalline matter with a waxy texture.

Used in aromatherapy, Menthol Crystals promote easier breathing, temporarily relieve nasal congestion, soothe sore throats, alleviate fever symptoms, coughs, headaches, and sinus discomforts, support immunity, and stabilize the emotions.

Used cosmetically, Menthol Crystals contribute a cooling sensation to the skin, calm irritation, itching, and burning, eliminate blackheads and whiteheads, diminish the appearance of dark spots and age spots, and promote clearer skin. They also cleanse and moisturize the skin, leaving it looking radiant, firmer, and smoother.

Used in hair, Menthol Crystals regulate oil production, remove dandruff buildup, eliminate or reduce the number of lice and nits, repair damage, remove pollutants and excess sebum, alleviate inflammation and irritation, stimulate circulation, purify the strands, promote the hair’s natural luster, and encourage the growth of longer, stronger, and more lush hair.

Used medicinally, their cooling sensation makes Menthol Crystals ideal for addressing aches, pain, cramps, sprains, and irritation. They help relax muscles while easing tension headaches, nausea, dizziness, and they can be used as decongestant agents for their ability to promote the feeling of airways opening up.

Mint belongs to the family Lamiaceae and the genus Mentha. In the genus Mentha there are many species that grow varying in their chemical content, odor, and use. The oil obtained from the compound is used all over the world. The commonly cultivated species of mint are Peppermint, Japanese Mint/Menthol Mint, Spearmint, and Bergamot mint.

They all are herbaceous plants. The aerial stem and leaves together are the source of essential oil rich in carvone, menthol, linalyl acetate, and linalool. They are used in medicinal preparations and flavor industries.

The corn mint or Japanese originated from China and Brazil. Subsequently, India and China take over Brazil. India has taken the first position in the cultivation of this mint plant, mints are commercially cultivated in India. In northern India, Japanese mint-yielding menthol is grown, and Thailand and Vietnam grow mint but to a smaller extent. Peppermint is obtained from Mentha piperita, Chinese peppermint is also called Bohe, it is obtained from the leaves of Mentha piperita. We can also have chewed the leaves of Peppermint to eliminate bad breath and ease throat soreness. Peppermint is also used to treat small cuts, burns, wounds, and boils. Some countries, such as Egyptian, Asia, and Greek used Peppermint leaves in culinary applications.

Menthol is an organic compound made synthetically or derived from the peppermint or other mints. It is a crystalline and waxy substance white in color and is solid at room temperature.
The main component of peppermint oil is menthol which has local anesthetic properties and is mostly used to give relief from cuts, and sore throats.

Menthol is the compound obtained from peppermint oil, menthol crystals are steam distilled from Mentha Arvensis. These natural crystals are widely used due to their specific aroma, flavor, and cooling and tingling effect.
Menthol Crystals are used in cosmetics, perfumes, lotions, creams, analgesic balms, shampoos, and conditioners.

Menthol crystals are used for many purposes, it works to support your body in its natural process of healing. it changes the quality of your life.
Menthol reduces itching when applied to the affected area, we can use it by mixing it with a carrier oil or with aloe vera gel.

Menthol is a hair growth accelerator, we can use it by adding menthol crystals to hair oil.
Menthol increases the soap making by adding into your soap, Menthol crystal is completely mixed in the soaping oil, it can have reduced skin irritation.
Menthol crystals is used to treat nausea, due to motion sickness, this is because of peppermint used in making menthol, it is a natural carminative herb, which treats digestive problems.

Menthol has a wonderful odor of mint that’s why we can use menthol in making homemade air fresheners without any toxins.
Menthol is also used as a natural pesticide, we can use it in the garden around honey bee hives to prevents moths and other insects.

Menthol crystal also helps in sunburn; it calms sunburns when mixed with aloe vera gel.
Menthol also gives relief from razor burn, it is used by many industries in making after shave lotions.
Menthol can reduce fever by placing a very small amount of menthol crystal on the forehead or bottom of the feet.

Menthol reduces the inflammation from a sore throat, we can directly apply menthol to scraps, cuts, and bruises to reduce irritation and inflammation.
burning menthol crystals also repels bugs of every kind. That is a great way to reduce the dust mites in the house.
Menthol is used in many vapor rub, it has a cooling and tingling sensations that also opens up the sinuses.

Menthol can give relief from headaches. You can apply this mix over the temples, collarbone, cheekbones, and under nose before sleep.
Menthol will give relief from congestion and induce sleep and treat sinuses.
Menthol is used in aromatherapy, the minty fragrance of menthol is used in the treatment of anxiety, stress, and nervousness.

Menthol can cause eye and skin irritation, when used directly on the skin, we need to dilute the menthol crystal with carrier oil or lotions.
The menthol helps in preventing and treating various skin infections like acne, pimples, eczema, sunburns, and rashes.
Menthol is an active ingredient in mint, which provides a cooling, soothing, sensation to the skin. Mint is best for instant relief of itchy or irritated skin.

Menthol is an alcohol produced from mint oils or prepared synthetically.
Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils.
Menthol is a waxy, crystalline substance, clear or white in color, which is solid at room temperature and melts slightly above.

The main form of menthol occurring in nature is (-)-menthol, which is assigned the (1R,2S,5R) configuration. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation.

Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils.
Forming clear or white waxy, crystalline substance, menthol is typically solid at room temperature. (-)-Menthol is the naturally-occurring and main form of menthol, and is assigned the (1R,2S,5R) configuration.
Menthol mediates anesthetic properties and anti-irritating properties locally, thus it is widely used to relieve minor throat irritations.

Menthol is an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties.
When added to pharmaceuticals and foods, menthol functions as a fortifier for peppermint flavors.
Menthol also has a counterirritant effect on skin and mucous membranes, thereby producing a local analgesic or anesthetic effect.