SODIUM PERIODATE

Sodium periodate = Sodium Metaperiodate

CAS Number: 7790-28-5
EC Number: 232-197-6
Linear Formula: NaIO4
Molecular Weight: 213.89
IUPAC name: Sodium periodate
Other names: Sodium metaperiodate

Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion. 
Sodium periodate may also be regarded as the sodium salt of periodic acid. 
Like many periodates Sodium periodate can exist in two different forms: sodium metaperiodate, which has the formula NaIO4, and sodium orthoperiodate, normally this means sodium hydrogen periodate (Na2H3IO6) but the fully reacted sodium orthoperiodate salt, Na5IO6, can also be prepared. 
Sodium periodate is an useful oxidising agent.
Sodium periodate can refer to two different chemical compounds which are essentially sodium salts of the two varieties of periodate ion. 
Sodium metaperiodate (often abbreviated as m-periodate) has the formula NaIO4. 
Sodium orthoperiodate (often abbreviated as o-periodate) has the formula Na5IO6. 
Sodium periodate is useful in certain synthetic chemistries for the oxidative power of the periodate ion.
Density is 3,865 kg m-3. 
Sodium periodate is soluble in water. When heated, it decomposes to form sodium iodate, NaIO3 and oxygen. 
This decomposition reaction is catalyzed by the presence of manganese(IV) oxide.

Sodium periodate uses
Further information: Periodate § Reactions
Sodium periodate can be used in solution to open saccharide rings between vicinal diols leaving two aldehyde groups. 
This process is often used in labeling saccharides with fluorescent molecules or other tags such as biotin. 
Because the process requires vicinal diols, periodate oxidation is often used to selectively label the 3′-ends of RNA (ribose has vicinal diols) instead of DNA as deoxyribose does not have vicinal diols.
NaIO4 is used in organic chemistry to cleave diols to produce two aldehydes.

Sodium Metaperiodate is generally immediately available in most volumes. 
High purity, submicron and nanopowder forms may be considered. 
American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards. 
Typical and custom packaging is available. 
Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement.

Sodium periodate preparation
Classically, periodate was most commonly produced in the form of sodium hydrogen periodate (Na3H2IO6).
Sodium periodate is commercially available, but can also be produced by the oxidation of iodates with chlorine and sodium hydroxide.
Or, similarly, from iodides by oxidation with bromine and sodium hydroxide:
NaIO3 + Cl2 + 4 NaOH → Na3H2IO6 + 2 NaCl + H2O
NaI + 4 Br2 + 10 NaOH → Na3H2IO6 + 8 NaBr + 4 H2O
Modern industrial scale production involves the electrochemical oxidation of iodates, on a PbO2 anode, with the following standard electrode potential:
H5IO6 + H+ + 2 e− → IO−
3 + 3 H2O      E° = 1.6 V
Sodium metaperiodate can be prepared by the dehydration of sodium hydrogen periodate with nitric acid.
Na3H2IO6 + 2 HNO3 → NaIO4 + 2 NaNO3 + 2 H2O

Sodium periodate pplication
Generates quinones via glycol cleavage and oxidation of hydroquinones.

Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion. 
Sodium periodate may also be regarded as the sodium salt of periodic acid. 
Like many periodates Sodium periodate can exist in two different forms: sodium metaperiodate, which has the formula NaIO4, and sodium orthoperiodate, normally this means sodium hydrogen periodate (Na2H3IO6) but the fully reacted sodium orthoperiodate salt, Na5IO6, can also be prepared. 
Both salts are useful oxidising agents.

Structure
Sodium metaperiodate (NaIO4) forms tetragonal crystals (space group I41/a) consisting of slightly distorted IO−4 ions with average I–O bond distances of 1.775 Å; the Na+ ions are surrounded by 8 oxygen atoms at distances of 2.54 and 2.60 Å.
Sodium hydrogen periodate (Na2H3IO6) forms orthorhombic crystals (space group Pnnm). 
Iodine and sodium atoms are both surrounded by an octahedral arrangement of 6 oxygen atoms; however the NaO6 octahedron is strongly distorted. 
IO6 and NaO6 groups are linked via common vertices and edges.
Powder diffraction indicates that Na5IO6 crystallises in the monoclinic system (space group C2/m).

Sodium periodate is a chemical compound. 
Sodium periodates chemical formula can be NaIO4 (sodium metaperiodate) or Na5IO6 (sodium orthoiodate). 
Sodium periodate has sodium and periodate ions in it.

Sodium periodate properties
Sodium periodate is a colorless solid. 
Sodium periodate reacts with acids to make periodic acid. 
Sodium periodate breaks down when heated to make sodium iodate and oxygen gas. 
Sodium periodate is a strong oxidizing agent.

Sodium periodate preparation
Sodium periodate can be made by oxidation of sodium iodide with sodium hypochlorite in a nitric acid solution.

Sodium periodate uses
Sodium periodate can oxidize cellulose. 
Sodium periodate is also used as a biodegradable chemical in the human body. 
Sodium periodate is also used in organic chemistry reactions.

CAS Number: 7790-28-5 
CHEBI: 75226 
ChemSpider: 58683 
ECHA InfoCard: 100.029.270 
EC Number: 232-197-6
PubChem CID: 23667635
RTECS number: SD4550000
UNII: 98W4A29X43 
CompTox Dashboard (EPA): DTXSID30894075

Sodium periodate chemical Properties
Sodium periodate is a white powder
Sodium periodate Na2H3IO6, is formed by reaction of sodium iodate plus sodium hydroxide plus chlorine (sodium chloride also formed), and the periodate separates as crystals from the medium. 
In solution, Sodium periodate is stated, periodate gradually forms ozone and iodate at the ordinary temperatures.

Sodium periodate uses
Sodium Periodate is the sodium salt of periodic acid used to oxidize cellulose. 
Sodium Periodate oxidation is often used to selectively label RNA, saccharides and other compounds with vicinal diols.
Oxidimetric standard; determination of manganese.

Sodium periodate definition
ChEBI: An inorganic sodium salt having periodate as the counterion.
Thermo Scientific Pierce Sodium meta-Periodate is a gentle oxidizing agent that cleaves cis-diols in carbohydrate sugars to create amine-reactive aldehydes, providing many uses relating to the study and detection of glycoproteins.
Useful reagent for the oxidation of carbohydrates prior to labeling with biotin hydrazide

Features of Sodium meta-Periodate:
-Convert sugars in sialic acid and other glycosylation groups to reactive aldehydes
-Immobilize glycoproteins to a hydrazide-activated solid support
-Conjugate antibodies to glycoprotein enzymes, such as horseradish peroxidase
-Probe for cell-surface polysaccharides
-Detect carbohydrate-containing proteins using hydrazide-containing probes

Sodium meta-periodate converts cis-glycol groups in carbohydrates to amine-reactive aldehyde groups. 
Carbohydrate groups in glycoproteins are excellent sites for modification or crosslinking reactions because they allow the conjugation reaction to be directed away from amino acids in the polypeptide chain that could be critical for protein activity. 
Sodium meta-periodate cleaves bonds between adjacent carbon atoms that contain hydroxyl groups (cis-glycols), creating two aldehyde groups that are spontaneously reactive to amine- and hydrazide-activated labeling, immobilization supports and crosslinking reagents.

Sodium Metaperiodate known as Sodium salt of Periodic Acid, is available in white crystalline powder form, soluble in water [solubility in water: 14.4% @ 25°c]. 
Sodium periodate has Molecular Formula NaIO4. 
Sodium periodate is prepared industrially by oxidation of Sod. 
Iodate with Sodium hypochlorite. 
Sodium periodate is used as an Oxidizing agent in organic synthesis.

Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion. 
Sodium periodate may also be regarded as the sodium salt of periodic acid. Like all periodates it can exist in two different forms: sodium metaperiodate, which has the formula NaIO4, and sodium orthoperiodate, normally this means sodium hydrogen periodate (Na2H3IO6) but the fully reacted sodium orthoperiodate salt, Na5IO6, can also be prepared. Both salts are useful oxidising agents.
Sodium periodate can be used in solution to open saccharide rings between vicinal diols leaving two aldehyde groups. 
This process is often used in labeling saccharides with fluorescent molecules or other tags such as biotin. 
Because the process requires vicinal diols, periodate oxidation is often used to selectively label the 3'-termini of RNA (ribose has vicinal diols) instead of DNA as deoxyribose does not have vicinal diols.
NaIO4 is used in organic chemistry to cleave diols to produce two aldehydes.

How Sodium periodate works: 
NaIO4 works by forming bonds with alcohols to the iodine. 
In the second step, what happens is a kind of reverse cycloaddition (similar to what happens when an ozonide breaks down). 
This is a somewhat simplified version of the mechanism (skipping over the proton transfer). 
The key part here is the third diagram, where the cyclic iodate ester breaks down to give the ketone and aldehyde.

Sodium periodate purification Methods
Recrystallise Sodium periodate from hot water. 

SYNONYMS
Sodium metaperiodate.

Our sodium metaperiodate has important applications in the life sciences sector and the screen printing industry. 
In the life sciences sector, sodium metaperiodate’s ability to perform the classical “periodate 1, 2 diol cleavage” reaction with fine chemical intermediates that have adjacent hydroxyl groups is critical because the oxidation is specific; forming carbonyl compounds in high yields. 
This reaction is particularly important in forming dialdehyde functions for “working up” into pharmaceutical intermediates or for attaching functionalised polysaccharides to suitable substrates.

In addition the selective oxidation powers of sodium metaperiodate make it the ideal reagent for the reclamation of silk screens in the printing industry. 
The non-image portions of a design are normally blocked with a cured emulsion of gelatine or polyvinyl alcohol that is chemically resistant. 
Sodium metaperiodate selectively decomposes the cured emulsion so that it can be removed from the delicate and expensive silk screen, which can then be reused.

GENERAL PRECAUTIONS
Avoid skin and eye contact.
Avoid inhalation or ingestion.
Keep away from organic material.
Keep away from moisture.
Keep the container tightly closed.
Wash hands thoroughly after handling.

CHARACTERISTICS
Sodium periodate is White crystals or crystalline powder.

Sodium periodate description:
-Sodium Periodate
-Container Capacity 100 Gram
-Composition Less than Equal to 100 Percent Sodium Periodate
-Color White
-Temperature Rating 504 Deg F
-Melting Point 518 Deg F
-Freezing Point 518 Deg F
-pH Value 3.5 to 5.5 at 107 Gram per Liter
-Application For Laboratory Chemicals, Synthesis of substances
-Linear Formula NaIO4
-Molecular Weight 213.89 Gram
-Physical State Crystalline
-Odor Odorless
-Relative Density 3.86 Gram per Cubic Centimeter"

TREATMENTS
Skin ­ immediately remove contaminated clothing and wash the affected area with soap or mild detergent and large amounts of water until all evidence of the chemical has been removed (approximately 15 minutes). 
Wash contaminated clothing before re­use.
Eyes ­ immediately wash the affected eye with large amounts of water until all evidence of the chemical has been removed (approximately 15 minutes). 
If irritation or pain persist seek medical attention.
Inhalation ­ remove from the area of exposure to fresh air. 
If breathing has ceased apply artificial respiration. 
Keep warm and allow to rest. 
If irritation persists or develops seek medical attention.
Ingestion ­ wash out the mouth thoroughly with water and give water or milk to drink. 
Seek immediate medical advice.

The invention discloses a method for producing sodium periodate. 
The method comprises the steps of preparation of trisodium dihydrogen periodate, preparation of sodium periodate, crystallization and separation, centrifugal dehydration and drying, wherein the preparation step of the trisodium dihydrogen periodate sequentially comprises the steps of preparation of sodium hydrogen iodate, preparation of sodium iodate and oxidation with sodium persulfate. 
The trisodium dihydrogen periodate is obtained by reacting sodium chlorate and iodine in an aqueous solution to produce the sodium hydrogen iodate, neutralizing the sodium hydrogen iodate by using sodium hydroxide to obtain the sodium iodate and oxidizing the sodium iodate in the sodium hydroxide solution by using the sodium persulfate, so that the method for preparing the trisodium dihydrogen periodate by using chlorine, iodine and sodium hydroxide in the prior art is abandoned, and the production method is stable in reaction, easy to control and high in production safety degree. 
Compared with a chlorine oxidation method, the method has the advantages of low consumption of raw materials, small amount of discharged waste liquor and environment friendliness.

INCOMPATIBILITY
Sodium periodate absorbs moisture. 
Keep Sodium periodate away from moisture. 
Keep Sodium periodate away from reducing substances and organic material.

Sodium periodate STORAGE
Keep the Sodium periodate container tightly closed. 
Store Sodium periodate in a cool, dry atmosphere away from moisture and oxidisable material.

HANDLING
Use a fume hood to minimise exposure to Sodium periodate. 
Wear protective clothing. 
A long sleeved laboratory coat or gown, rubber gloves, safety goggles and a face mask as a minimum standard.

Sodium periodate can refer to two different chemical compounds which are essentially sodium salts of the two varieties of periodate ion. 
Sodium metaperiodate (often abbreviated as m-periodate) has the formula NaIO4. 
Sodium orthoperiodate (often abbreviated as o-periodate) has the formula Na5IO6. 
Both salts are useful in certain synthetic chemistries for the oxidative power of the periodate ion.

DISPOSAL
WEAR:
Rubber gloves, face shield and laboratory coat. 
A body shield should be available for the more active agents. 
Replace the face shield with self contained breathing apparatus for such agents as chlorine and bromine.

SPILLS:
Gas leak: if the valve is leaking because it cannot be closed, the gas can be bubbled through a reducer (sodium sulphite) and excess sodium bicarbonate solution. 
Be sure to include a trap in the line to prevent the solution being sucked back into the cylinder.
If this cannot be done the cylinder should be placed in or adjacent to a fume hood and left to bleed off. 
If the leak is in the valve assembly, a plastic bag can be fastened over the head of the cylinder which can then be taken outside or to a fume hood.
Liquid or solid: cover with a reducer (sodium thiosulphate, a bisulphite or a ferrous salt not carbon, sulphur or strong reducing agent). 
Mix well and spray with water. 
A sulphite or a ferrous salt will require addition of 3mol/l sulphuric acid to promote a rapid reduction. 
Scoop the slurry into a container of water and neutralise with soda ash. 
Discharge to sewer with a large excess of water. 
Wash the site thoroughly with a soap solution containing some reducer.

PACKAGE LOTS:
Add to a large volume of concentrated solution of reducer (sodium thiosulphate, a bisulphite or a ferrous salt and acidify with 3mol/l sulphuric acid). 
When the reduction is completed add soda ash or dilute hydrochloric acid to neutralise the solution. 
Discharge to sewer with a large excess of water.

Chemical formula NaIO4
Molar mass 213.8918 g/mol
Appearance white crystals
Density:
3.865 g/cm3 (anhydrous)
3/210 g/cm3
Melting point 300 °C (572 °F; 573 K) (anhydrous)
175 °C (347 °F; 448 K) (trihydrate) (decomposes)
Solubility in water soluble[clarification needed]
Solubility soluble in acids

Sodium periodate can be used to oxidize hydroxyl groups on adjacent carbon atoms, forming reactive aldehyde residues suitable for coupling with amine- or hydrazide-containing molecules. 
The reaction occurs with two adjacent secondary hydroxyls to cleave the carbon–carbon bond between them and create two terminal aldehyde groups. 
When one of the adjacent hydroxyls is a primary hydroxyl, reaction with periodate releases one molecule of formaldehyde and leaves a terminal aldehyde residue on the original diol compound. 
These reactions can be used to generate crosslinking sites in carbohydrates or glycoproteins for subsequent conjugation of amine-containing molecules by reductive amination. 
Sodium periodate also reacts with 2-aminoethanol derivatives—compounds containing a primary amine and a secondary hydroxyl group on adjacent carbon atoms. 
Oxidation cleaves the carbon–carbon bond, forming a terminal aldehyde group on the side that had the original hydroxyl residue. 
This reaction can be used to create reactive aldehydes on N-terminal serine residues of peptides

Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion. 
Sodium periodate may also be regarded as the sodium salt of periodic acid.

Grade: Technical
Other Names: Sodium metaperiodate
Form: Powder
Abbreviations: NaIO4

Melting point:300 °C (dec.) (lit.)
Boiling point:300°C
Density 3.865
storage temp. Store at +5°C to +30°C.
solubility H2O: 0.5 M at 20 °C, clear, colorless
form Solid
Specific Gravity4.174
color White to almost white
OdorOdorless
PH3.5-5.5 (25℃, 0.5M in H2O)
PH Range3.5 - 5.5
Oxidising PropertiesThe substance or mixture is classified as oxidizing with the subcategory 2
Water Solubility 80 g/L (20 ºC)
Sensitive Hygroscopic
Merck 14,8640
Stability:Stable. Incompatible with organic materials, combustible materials. Forms explosive mixtures with reducing agents, finely powdered metals, magnesium.

Sodium periodate, Sodium metaperiodate, Sodium m-periodate, Sodium (meta)periodate, Periodic acid, sodium salt, Periodate sodium
Sodium metaperiodate, or sodium m‐periodate, is a mild oxidant that is routinely used for the conversion of cis‐glycol groups in carbohydrates to reactive aldehdye groups.  
The reactive aldehyde groups are used in chemical conjugation procedures or detection of carbohydrates.  
For proteomic research, sodium m‐periodate is used for the oxidation of the carbohydrate moiety of glycoproteins and offers the advantage of modifying the sugar side chains as opposed to critical amino acids.
The resulting aldehydes can interact with primary amines to from Schiff’s bases, which in turn can be stabilized by reduction with sodium cyanoborohydride (Cat. # 786‐061, 786‐062) to form covalent amide bonds. 
Alternatively, the aldehydes can spontaneously react with hydrazide activated molecules to form relatively stable hydrazone bonds, which again can be stabilized with sodium cyanoborohydride.

STORAGE CONDITIONS
Shipped at ambient temperature. Upon receipt, store at room temperature.

PROPERTIES
-Synonyms: Sodium m‐periodate, sodium periodate
-Linear formula:NaIO4
-CAS #. 7790‐28‐5
-Molecular weight: 213.89
-Form: White  crystalline powder

Additional Reagent(s) Required
Oxidation Buffer: We recommend our Optimizer Buffer™ V (Cat. # BKC‐08) or 0.1M sodium acetate, pH 5.5.  
Neutral pH buffers, such as PBS, can be used but are less efficient than then slightly acidic conditions.  
Avoid buffers with primary amines, such as Tris or glycine, or sugars as these will compete in the reaction.

The oxidation of cellulose nanocrystal (CNC) by sodium periodate can generate aldehyde functions for crosslinking reactions or for further modification, which can extend the range of applications of CNC. 
In this paper, the effects of reaction conditions during the periodate oxidation of CNC, such as oxidant concentration, pH, temperature and oxidation time on the oxidized CNC yield and the aldehyde content, were investigated and an optimized reaction condition was identified. 
The generation of aldehyde groups on the CNC was confirmed by Fourier transform infrared spectroscopy analysis, and the decreased crystalline index was observed by X-ray diffraction. 
The transmission electron microscope observation showed the morphological changes of CNC after the oxidation. 
The oxidized CNC was used as a strength additive to paper, and the results showed that the dry tensile index was 32.6 % higher than the control sample, and the wet tensile index was reached to 3.08 N.m/g, at the oxidized CNC dosage of 1.2 %.

Sodium periodate (NaIO4), is a strong oxidizing agent mainly used for the oxidative cleavage of 1,2-diols (vicinal diols) forming aldehydes and ketones depending on the structure of the alcohol.

Quality Level: 200
grade: ACS reagent
assay
≥99.8%
99.8-100.3% dry basis (ACS specification)
form: crystalline powder
reaction suitability
reagent type: oxidant
impurities: ≤0.02% other halogens (as Cl)
pH: 3.5-5.5 (25 °C, 107 g/L)
mp: 300 °C (dec.) (lit.)
cation traces: Mn: ≤3 ppm
SMILES string: [Na+].[O-]I(=O)(=O)=O
InChI: 1S/HIO4.Na/c2-1(3,4)5;/h(H,2,3,4,5);/q;+1/p-1
InChI key: JQWHASGSAFIOCM-UHFFFAOYSA-M

Iodine is a nonmetallic halogen element in Group 17 of periodic table; atomic number 53; atomic mass 126.9; melting point ca 114 C; boiling point ca 184 C; specific gravity 4.93 g/cm3; oxidation states: 7,5,1,-1; [Kr] 4d10 5s2 5p5. 
Iodine is a nearly black poisonous, corrosive solid at room temperature and readily sublimes to a deep violet vapour, the colour of which is responsible for its name from Greek. 
Sodium periodate is insoluble in water, soluble in common solvents. 
Iodine is required in small amounts in human body for the function of the thyroid gland. 
Iodine forms many important compounds of iodine such as iodine(V)oxide, potassium iodide, iodine trichloride and iodoform of an Iodine containing organic compound.
The related name, iodate indicates any salt of iodic acid containing the IO3- radical; KIO3 (potassium iodate) and NaIO3 (sodium iodate) are the most important salts. 
Whereas, iodide indicates any compound of iodine with a more electropositive element or group such as such as CH3CH2I or any binary compound of iodine which may contain the I- radical and which may be considered to be derived from hydriodic acid (HI); KI and NaI are examples.
Dietary iodine is reduced to iodide, absorbed in the intestines, and later taken up from the bloodstream by the thyroid gland for incorporation into thyroid hormones. 
Iodine is applied in the treatment of thyrotoxic crisis to produce a thyroid gland of firm texture suitable for operation, it avoids the increased vascularity and friability of the gland with increased risk of haemorrhage. 
Iodine has powerful bactericidal activity. 
Sodium periodate is used is used for disinfecting skin and for the treatment of minor wounds and abrasions. 
Iodine has been used in the purification of drinking water in case of amoebicidal and bactericidal emergencies. 
Iodine is used as a component in germicides and disinfectants with surfactants to carry iodine. 
Iodine is used in the treatment of herpes simplex, keratoscleritis and preventing the development of goitre.
Inorganic iodide compounds are soluble in water and hygroscopic except a few inorganic iodides such as copper iodide. 
Their refractive indexes and specific gravities are higher than the corresponding chlorine and bromine analogues. 
The important iodides commercially are potassium iodide (KI), sodium iodide (NaI), hydrogen iodide (HI), and polyiodides.
Potassium and sodium Iodide are used in photography and as analytical reagents. 
They are used in the measurement of the energy of gamma rays, by measuring the amplitude of pulses of light generated by electrons which are excited by the gamma rays. 
They are used as nutrition supplements to prevent goitre and other iodine deficiency in human body. 
They are used in organic synthesis as well. Potassium iodide has been used as a mucolytic agent. 
Potassium iodide is used as a heat stabilizer and a catalyst in synthetic fiber manufacturing.
Hydriodic acid is the aqueous pale yellow solution of  gas hydrogen iodide; the solution of 59% hydrogen iodide has constant-boiling. 
Sodium periodate is a strong acid and reducing agent used as raw materials for pharmaceuticals. 
analytical reagent as well as in organic synthesis and making iodine salts.
Inorganic iodate compounds, prepared generally by the oxidation of iodine with iodic acid or by electrolytic oxidation of iodide solutions, are stable oxidizers at room temperature though they lose oxygen at higher temperatures. 
Iodic acid (hydrogen iodate), a white crystalline powder, is a strong inorganic acid; highly corrosive oxidizing agent; decomposes at 110 C. 
Sodium periodate is used as a reducing agent in organic synthesis. 
Metallic iodates are explosive or flammable when contact with organic combustible materials. 
The important iodates commercially are potassium iodate and calcium iodate; white, odorless crystalline powder soluble in water, insoluble in alcohol. 
Sodium periodate are used as analytical reagents and in the manufacture of disinfectants, antiseptics, deodorants, medicines and other iodine compounds as well as oxidation of sulphur dyes. 
Sodium periodate are used in baking ingredient conditioner and as animal feed and food supplement for the treatment of their deficiency.
Periodic acid is a white crystals; soluble in water and alcohol; losing water at 100 C. 
Sodium periodate and its salts (potassium and sodium) are widely used as powerful oxidising agent in organic synthesis.

Chemical Name: Sodium Periodate
Synonyms:
Periodic Acid (HIO4) Sodium Salt (8CI,9CI); Sodium Periodate (NaIO4) ; Monosodium Metaperiodate; Periodic Acid Sodium Salt; Sodium Metaperiodate; Sodium Metaperiodate (NaIO4);
CAS Number: 7790-28-5
Alternate CAS # : Free acid 13444-71-8
Molecular Formula: NaIO4
Appearance: White Solid
Melting Point: >300°C
Molecular Weight: 213.89
Storage: Refrigerator
Solubility: Water
Category: Standards; Inorganics; Miscellaneous;
Applications: Sodium Periodate is the sodium salt of periodic acid used to oxidize cellulose. 
Sodium Periodate oxidation is often used to selectively label RNA, saccharides and other compounds with vicinal diols.

CAS: 7790-28-5
Molecular Formula: INaO4
Molecular Weight (g/mol): 213.89
MDL Number: MFCD00003534
InChI Key: JQWHASGSAFIOCM-UHFFFAOYSA-M
Synonyms
sodium periodate, sodium metaperiodate, sodium m-periodate, sodiumperiodate, sodium meta periodate, periodic acid, sodium salt, sodium meta-periodate, periodic acid hio4 , sodium salt, periodate sodium, sodium penodate
PubChem CID: 23667635
ChEBI: CHEBI:75226
IUPAC Name: sodium;periodate
SMILES: [Na+].[O-][I](=O)(=O)=O

Sodium periodate was characterized as a primary chemical oxidant for the catalytic evolution of oxygen at neutral pH using a variety of water-oxidation catalysts. 
The visible spectra of solutions formed from Cp*Ir(bpy)SO4 during oxygen-evolution catalysis were measured. 
NMR spectroscopy suggests that the catalyst remains molecular after several turnovers with sodium periodate. 
Two of our [Cp*Ir(bis-NHC)][PF6]2 complexes, along with other literature catalysts, such as the manganese terpyridyl dimer, Hill’s cobalt polyoxometallate, and Meyer’s blue dimer, were also tested for activity. 
Sodium periodate was found to function only for water-oxidation catalysts with low overpotentials. 
This specificity is attributed to the relatively low oxidizing capability of sodium periodate solutions relative to solutions of other common primary oxidants. 
Studying oxygen-evolution catalysis by using sodium periodate as a primary oxidant may, therefore, provide preliminary evidence that a given catalyst has a low overpotential.

Hazard
Fire risk in contact with organic materials. 
Toxic by ingestion.

SUITABLE EXTINGUISHING MEDIA
Water spray, dry powder or carbon dioxide.

SPECIAL FIRE FIGHTING PROCEDURES
Keep up-wind to avoid fumes. 
Beware, risk of formation of toxic and corrosive gases. 
Avoid breathing fire vapours.

UNUSUAL FIRE & EXPLOSION HAZARDS
OXIDISING! May ignite other combustible materials. 
May develop highly toxic or corrosive fumes if heated.

PROTECTIVE MEASURES IN FIRE
Self contained breathing apparatus and full protective clothing must be worn in case of fire.

HEALTH HAZARD DATA
Sodium periodate is a strong oxidising agent and is very toxic. 
Sodium periodate is an eye and skin irritant.

INHALATION
Get medical attention if any discomfort continues. 
Keep the affected person warm and at rest.
Get prompt medical attention. 
In case of persistent throat irritation or coughing: Seek medical attention and bring these instructions. 
Unlikely route of exposure as the product does not contain volatile substances. 
Remove victim immediately from source of exposure.

INGESTION
DO NOT INDUCE VOMITING! NEVER MAKE AN UNCONSCIOUS PERSON VOMIT OR DRINK FLUIDS! 
Remove victim immediately from source of exposure. 
Get medical attention immediately! 
Provide rest, warmth and fresh air.

GENERAL INFORMATION
Waste is classified as hazardous waste. 
Disposal to licensed waste disposal site in accordance with the local Waste Disposal Authority.

DISPOSAL METHODS
Dispose of waste and residues in accordance with local authority requirements. 
Contact specialist disposal companies.

USAGE PRECAUTIONS
Keep Sodium periodate away from heat, sparks and open flame. 
Do not eat, drink or smoke when using the product. 
Container must be kept tightly closed.
Do not subject to grinding/shock/friction. 
WARNING: When subject to intense compression at temperatures above 140 °C Sodium Metaperiodate can undergo violent decomposition to form Sodium Iodate with the release of gaseous oxygen. 
This is significantly lower than the normal decomposition temperature of 270 °C. 
Where there is a potential for extreme compression during processing e.g. during milling, tabletting or agitated pan-drying operations the maximum processing temperature should be kept well below 140 °C to minimize the risk of decomposition.

STORAGE PRECAUTIONS
Oxidising material - Keep away from flammable and combustible materials. 
Store Sodium periodate in tightly closed original container in a dry and cool place.
Do not store Sodium periodate near heat sources or expose to high temperatures.

Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion. 
Sodium periodate may also be regarded as the sodium salt of periodic acid. 
Like many periodates Sodium periodate can exist in two different forms: sodium metaperiodate, which has the formula NaIO4, and sodium orthoperiodate, normally this means sodium hydrogen periodate (Na2H3IO6) but the fully reacted sodium orthoperiodate salt, Na5IO6, can also be prepared. 
Both salts are useful oxidising agents.

STORAGE CLASS
Oxidiser storage.

PERSONAL PRECAUTIONS
Use protective gloves, goggles and suitable protective clothing. 
Do not smoke, use open fire or other sources of ignition.

ENVIRONMENTAL PRECAUTIONS
Do not allow ANY environmental contamination.

SPILL CLEAN UP METHODS
Wear necessary protective equipment. 
Remove sources of ignition. 
Keep combustibles away from spilled material. 
Collect in containers and seal securely. 
Remove containers and flush area with water. 
Avoid dust formation.

Sodium periodate SKIN CONTACT
Remove contaminated clothing. Wash the skin immediately with soap and water. 
Get medical attention if irritation persists after washing.

Sodium periodateEYE CONTACT
Make sure to remove any contact lenses from the eyes before rinsing. 
Promptly wash eyes with plenty of water while lifting the eye lids. 
Continue to rinse for at least 15 minutes. 
Get medical attention urgently!

NOTES TO THE PHYSICIAN
No recommendation given, but first aid may still be required in case of accidental exposure, inhalation or ingestion of this chemical. 
If in doubt, GET MEDICAL ATTENTION PROMPTLY!

Sodium periodate
Sodium metaperiodate
7790-28-5
Sodium m-periodate
Sodium (meta)periodate
sodium meta-periodate
Periodic acid, sodium salt
sodium;periodate
Sodium meta periodate
UNII-98W4A29X43
MFCD00003534
Periodate sodium
sodiumperiodate
Periodic acid (HIO4), sodium salt (1:1)
98W4A29X43
Sodium periodate, 99%, for analysis
Periodic acid (HIO4), sodium salt
Sodium periodate, 99.8+%, ACS reagent
HSDB 7298
EINECS 232-197-6
sodium penodate
sodium periodat

Appearance (Colour) White
Appearance (Form) Crystalline powder
Solubility (Turbidity) 10% aq. solution    Clear
Solubility (Colour) 10% aq. solution    Colourless
Assay min. 99.5%
pH (5% aq. solution) 4.0 - 4.5
Loss on drying    max. 0.025%
Bromate, Bromide, Chlorate Chloride (Cl) max. 0.01%
Sulphate (SO4)    max. 0.01%
Acidity blank for determination of glycerol max. 0.2ml N%
Iodide (I) max. 0.001%
Manganese (Mn) max. 0.0003%
Calcium (Ca) max. 0.002%
Magnesium (Mg) max. 0.002%
Potassium (K) max. 0.005%

CAS No.    7790-28-5
Molecular formula NaIO4
Molecular weight 213.9
Description White fine Crystalline Powder
Assay ( Iodometric, Dry basis )    99.0 to 100.5 %
pH of 5% w/v Solution in water    4 to 4.5

STABILITY
Stable under normal temperature conditions. 
WARNING: When subject to intense compression at temperatures above 140 °C Sodium Metaperiodate can undergo violent decomposition to form Sodium Iodate with the release of gaseous oxygen. 
This is significantly lower than the normal decomposition temperature of 270 °C. 
Where there is a potential for extreme compression during processing e.g. during milling, tabletting or agitated pan-drying operations the maximum processing temperature should be kept well below 140 °C to minimize the risk of decomposition.

CONDITIONS TO AVOID
Avoid contact with acids. Generates toxic gas in contact with acid. 
Strong oxidiser - avoid contact with reducing agents. 
Avoid exposure to high temperatures or direct sunlight. 
Protect against physical damage and/or friction.

Sodium periodate HAZARDOUS POLYMERISATION
Will not polymerise.

Sodium periodate POLYMERISATION DESCRIPTION
Not relevant

MATERIALS TO AVOID
Flammable/combustible material. 
Strong acids. 
Strong reducing agents. 
Powdered metal.

Sodium periodate HAZARDOUS DECOMPOSITION PRODUCTS
Iodine

Sodium periodate PROCESS CONDITIONS
Provide eyewash station.

ENGINEERING MEASURES
Provide adequate general and local exhaust ventilation.

RESPIRATORY EQUIPMENT
No specific recommendation made, but respiratory protection may still be required under exceptional circumstances when excessive air contamination exists.

Sodium periodate HAND PROTECTION
Use protective gloves.

Sodium periodate EYE PROTECTION
Wear approved safety goggles.

OTHER PROTECTION
Wear appropriate clothing to prevent any possibility of liquid contact and repeated or prolonged vapour contact.

Sodium periodate HYGIENE MEASURES
DO NOT SMOKE IN WORK AREA! 
Wash hands at the end of each work shift and before eating, smoking and using the toilet. 
Promptly remove any clothing that becomes contaminated. 
Wash promptly with soap & water if skin becomes contaminated. 
Use appropriate skin cream to prevent drying of skin. 
When using Sodium periodate do not eat, drink or smoke.

Sodium periodate SKIN PROTECTION
Wear apron or protective clothing in case of contact.

sodium-m-periodate
Sodium iodate(VII)
sodium(meta)periodate
sodium-meta-periodate
INaO4
NaIO4
PubChem21354
sodium (meta) periodate
ACMC-1C1BE
Na I O4
EC 232-197-6
Sodium periodate, ACS grade
ARONIS24207
Lithium Chelate 0.2%, 40M
CHEBI:75226
DTXSID30894075
BCP04945
ANW-37125
AKOS005267138
AKOS015950617
BP-21195
R917
FT-0689066
Q281419

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