CAS Number: 10039-26-6
Molecular Weight: 360.32
EC number: 200-559-2
Hill Formula: C₁₂H₂₂O₁₁ * H₂O
Lactose monohydrate is a dairy product often used in packaged foods and other products for flavor and filler.
In most people, lactose monohydrate causes no side effects.
However, if you are lactose intolerant, Lactose monohydrate may cause some adverse reactions.
What is Lactose monohydrate?
Lactose monohydrate is the crystalline form of lactose, the main carb in cow’s milk.
Lactose is composed of the simple sugars galactose and glucose bonded together.
Lactose monohydrate exists in two forms that have different chemical structures — alpha- and beta-lactose.
Lactose monohydrate is produced by exposing alpha-lactose from cow’s milk to low temperatures until crystals form, then drying off any excess moisture.
Lactose monohydrate is a dry, white or pale yellow powder that has a slightly sweet taste and smells similar to milk.
Lactose (C12H22O11) is milk sugar.
Lactose monohydrate is a disaccharide composed of one galactose and one glucose molecule.
In the pharmaceutical industry, lactose is used to help form tablets because it has excellent compressibility properties.
Lactose monohydrate is also used to form a diluent powder for dry-powder inhalations.
Lactose may be listed as lactose hydrous, lactose anhydrous, lactose monohydrate, or lactose spray-dried.
People who are lactose intolerant do not have the enzymes needed to digest lactose.
Most medications do not contain enough lactose to cause lactose intolerance.
But some patients with severe lactose intolerance may experience symptoms.
Lactose can be found in birth control pills, and some OTC drugs to treat stomach acid or gas.
Patients who are specifically "allergic" to lactose (not just lactose intolerant) should not use tablets containing lactose, or ask their health care provider prior to use.
SUMMARY:
Lactose monohydrate is created by crystallizing lactose, the main sugar in cow’s milk, into a dry powder.
Where Is Lactose Monohydrate Found?
Lactose monohydrate appears in a wide range of foods, beverages, cosmetics, pharmaceuticals and even animal feed, per the Transparency Market Research report.
Lactose monohydrate has a bland taste and is often used as a stabilizer — and it has the perk of being less expensive but having a longer shelf life than real milk.
You'll find lactose monohydrate in:
-tablet capsules
-infant formula
-chocolates
-biscuits
-ready-to-make foods
-ice cream
-bread and other bakery products
Lactose monohydrate's also used as a filler in medicines and animal feed for its physical and chemical stability.
Uses of lactose monohydrate:
Lactose monohydrate is known as milk sugar in the food and pharmaceutical industries.
Lactose monohydrate has a long shelf life, slightly sweet taste, and it’s highly affordable and widely available.
What’s more, Lactose monohydrate easily mixes with numerous ingredients.
As such, Lactose monohydrate’s commonly used as a food additive and filler for drug capsules.
Lactose monohydrate’s primarily used for industrial purposes and not typically sold for home use.
Thus, you may see Lactose monohydrate on ingredient lists but won’t find recipes that call for it.
Fillers like lactose monohydrate bind to the active drug in a medication so that it can be formed into a pill or tablet that can be easily swallowed.
In fact, lactose in some form is used in over 20% of prescription medications and over 65% of over-the-counter drugs, such as certain birth control pills, calcium supplements, and acid reflux medications.
Lactose monohydrate is also added to infant formulas, packaged snacks, frozen meals, and processed cookies, cakes, pastries, soups, and sauces, as well as several other foods.
Lactose monohydrates primary purpose is to add sweetness or act as a stabilizer to help ingredients that don’t mix — such as oil and water — stay together.
Finally, animal feed often contains lactose monohydrate because it’s a cheap way to increase food bulk and weight.
SUMMARY:
Lactose monohydrate may be added to animal feed, medications, baby formulas, and packaged desserts, snacks, and condiments.
Lactose monohydrate acts as a sweetener, filler, or stabilizer.
Physicochemical Information of Lactose monohydrate:
Ignition temperature: 390 °C
Melting Point: 202 °C
pH value: 4.0 - 6.5 (100 g/l, H₂O, 20 °C)
Bulk density: 500 kg/m3
Solubility: 161 g/l
Lactose monohydrate is a dairy product often used in packaged foods and other products for flavor and filler.
KEYWORDS:
10039-26-6, 200-559-2, alpha-Lactose monohydrate, D-Lactose monohydrate, UNII-EWQ57Q8I5X, alpha-lactose hydrate, EWQ57Q8I5X, Respitose, MFCD00150747, Microtose
Possible side effects of Lactose monohydrate:
The Food and Drug Administration (FDA) considers lactose monohydrate safe for consumption in the amounts present in foods and medications.
However, some people have concerns about the safety of food additives.
Even though research on their downsides is mixed, some have been linked to adverse effects.
If you prefer to stay away from them, you may want to limit foods with lactose monohydrate.
What’s more, individuals with severe lactose intolerance may wish to avoid or limit their intake of lactose monohydrate.
People with this condition don’t produce enough of the enzyme that breaks down lactose in the intestines and may experience the following symptoms after consuming lactose:
-bloating
-excessive burping
-gas
-stomach pain and cramps
-diarrhea
While some have suggested that lactose-containing medications could cause unpleasant symptoms, research suggests that people with lactose intolerance can tolerate the small amounts of lactose monohydrate found in pills.
However, if you have this condition and are taking medications, you may wish to speak with your medical provider about lactose-free options, as it may not always be clear whether a drug harbors lactose.
Finally, some individuals may be allergic to the proteins in milk but can safely consume lactose and its derivatives.
In this case, Lactose monohydrate’s still important to consult a healthcare professional to ensure that products with lactose monohydrate are safe for you.
If you’re concerned about lactose monohydrate in food, be sure to carefully read food labels, especially on packaged desserts and ice creams that may use it as a sweetener.
Property of Lactose monohydrate:
Appearance : White, crystalline powder - powder
pH: pH (50g/l, 25 degrees C) : 4.0 - 6.0
Specific Rotation: +52.2 - +52.8 degrees (D/20 degrees C)
SUMMARY:
While lactose monohydrate is considered safe for most people, consuming Lactose monohydrate in excess may cause gas, bloating, and other issues for those with lactose intolerance.
Physical State:
Solid
Solubility:
Lactose monohydrate is soluble in water (warm) (0.1 g/mL), and ethanol (very slightly soluble).
Lactose monohydrate is insoluble in chloroform, and ether.
Storage:
Store at room temperature
Melting Point:
203.3° C (dec.)
Boiling Point:
667.9° C at 760 mmHg (Predicted)
Density:
1.53 g/cm3 at 20° C
Optical Activity:
α20/D +52°±2°, 22 hr, c = 10 in water
Product Information of Lactose monohydrate:
CAS number: 10039-26-6
EC number: 200-559-2
Hill Formula: C₁₂H₂₂O₁₁ * H₂O
Molar Mass: 360.32 g/mol
HS Code: 1702 11 00
Lactose monohydrate is a type of sugar found in milk.
Due to its chemical structure, Lactose monohydrate’s processed into a powder and used as a sweetener, stabilizer, or filler in the food and pharmaceutical industries.
You may see Lactose monohydrate on the ingredient lists of pills, infant formulas, and packaged sweet foods.
The bottom line:
Lactose monohydrate is a crystallized form of milk sugar.
Lactose monohydrate’s commonly used as a filler for medications and added to packaged foods, baked goods, and infant formulas as a sweetener or stabilizer.
This additive is widely considered safe and may not cause symptoms in those who are otherwise lactose intolerant.
However, those with severe lactose intolerance may wish to avoid products with this additive to be safe.
Synonyms: Milk sugar, Lactobiose
ph Value: 4.0 - 6.5 (100 g/l, H₂O, 20 °C)
Solubility: 161 g/l
Side Effects of Lactose Monohydrate:
Lactose monohydrate's important to know when lactose monohydrate is used in packaged goods or other foods you might eat if you have lactose intolerance or otherwise experience symptoms from dairy products.
Description of Lactose monohydrate:
Catalogue Number: 107657
Synonyms: Milk sugar, Lactobiose
Molecular Weight: 360.31
Hydrogen Bond Donor Count: 9
Hydrogen Bond Acceptor Count: 12
Rotatable Bond Count: 4
Exact Mass: 360.12677620
Monoisotopic Mass: 360.12677620
Topological Polar Surface Area: 191 Ų
Heavy Atom Count: 24
Formal Charge: 0
Complexity: 382
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 10
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes
Lactose, Monohydrate, Powder, NF is used to help form tablets because it has excellent compressibility properties and as a diluent powder for dry-powder inhalations.
Synonyms: 4-O-Beta-Galactopyranosyl-D-glucose ; Milk Sugar
This lactose is mostly used for tablet manufacturing using wet and dry granulation technologies.
Key Benefits of Lactose monohydrate:
Compressibility
Blending properties
Storage stability
Particle size distribution :
Specification (Air Jet Sieve) of Lactose monohydrate:
% < 45 µm : 44-72
% < 100 µm : 85-97
% < 150 µm : 96-100
% < 250 µm : 98-100
Other characteristics of Lactose monohydrate:
Poured density : 0.57 g/mL
Tapped density : 0.83 g/mL
Carr’s index : 32 %
Hausner ratio : 1.47
Milk sugar, Lactobiose
Empirical formula: C12H22O11 · H2O
Molar mass (M): 360,32 g/mol
Density (D): 1,525 g/cm³
Melting point (mp): 202 °C
WGK: 1
CAS No.: [10039-26-6]
EG-Nr.: 200-559-2
Storage condition of Lactose monohydrate:
Store at room temperature
Lactose monohydrate is soluble in water
Storage Condition :
Keep at RT.
CAS RN® :
5989-81-1
Molecular Formula :
C12H22O11・H2O
Molecular Weight :
360.31
Spec. rotation (α 20/D; 10 %; water; calc. on anhydrous substance):
+54.4 - +55.9 °
Heavy metals (as Pb):
≤ 5 ppm
Residual solvents (ICH Q3C):
excluded by the production process
Proteins and UV-absorbing impurities:
passes test
Sulfated ash:
≤ 0.1 %
Loss on drying (80 °C, 2 h):
≤ 0.5 %
Water:
4.5 - 5.5 %
Particle size (< 100 µm):
≤ 50 %
Particle size (> 250 µm):
≤ 2 %
Microbiological purity (Total aerobic microbial count (TAMC)):
≤ 100 CFU/g
Microbiological purity (Total yeast and mould count (TYMC)):
≤ 50 CFU/g
Lactose monohydrate
5989-81-1
alpha-Lactose monohydrate
alpha-D-Lactose monohydrate
64044-51-5
D-Lactose monohydrate
a-Lactose monohydrate
UNII-EWQ57Q8I5X
alpha-lactose hydrate
Lactose, monohydrate
LACTOSE,MONOHYDRATE
Lactose monohydrate [NF]
EWQ57Q8I5X
Respitose
a-D-Glucopyranose, 4-O-b-D-galactopyranosyl-, monohydrate
(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;hydrate
MFCD00150747
Lactose monohydrate (NF)
ALPHA-LACTOSEMONOHYDRATE
10039-26-6
Lactose Monohydrate (Alpha-Form)
Microtose
Pharmaose
(2S,3R,4R,5S,6R)-6-(Hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triol hydrate
Spherolac 100
Alpha-lactose,monohydrate
alpha-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-, monohydrate
Lactose (TN)
Lactose(Monohydrate)
Lactose (JP17)
(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydropyran-3-yl]oxy-tetrahydropyran-3,4,5-triol
SCHEMBL16787
D-Glucose, 4-O-beta-D-galactopyranosyl-, monohydrate
DTXSID1052828
alpha-D-Lactose monohydrate, ACS
CHEBI:189432
alpha-Lactose, analytical standard
AKOS015896871
FS-3862
NSC 760401
MALONICACIDDISODIUMSALTMONOHYDRATE
(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol hydrate
4-O-beta-D-Galactopyranosyl-alpha-D-glucose
CS-0128727
D03226
E80712
alpha-4-O-(beta-D-galactopyranosido)-D-glucopyranose
Q27277391
alpha-Lactose monohydrate, >=99% total lactose basis (GC)
UNII-J2B2A4N98G component WSVLPVUVIUVCRA-KPKNDVKVSA-N
4-O-beta-D-Galactopyranosyl-alpha-D-glucopyranose monohydrate
alpha-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-, hydrate
alpha-Lactose monohydrate, BioXtra, >=99% total lactose basis (GC)
alpha-Lactose monohydrate, suitable for cell culture, BioReagent
.alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-, hydrate (1:1)
66857-12-3
4-O-β-D-Galactopyranosyl-β-D-glucopyranose hydrate (1:1) [ACD/IUPAC Name]
4-O-β-D-Galactopyranosyl-β-D-glucopyranose, hydrate (1:1) [French] [ACD/IUPAC Name]
4-O-β-D-Galactopyranosyl-β-D-glucopyranosehydrat (1:1) [German] [ACD/IUPAC Name]
lactose monohydrate [NF]
β-D-Glucopyranose, 4-O-β-D-galactopyranosyl-, hydrate (1:1) [ACD/Index Name]
5989-81-1 [RN]
LACTOSE HYDRATE